Small Science最新文献_第5页

Functionalized Nanoporous Biocarbon with High Specific Surface Area Derived from Waste Hardwood Chips for CO₂ Capture and Supercapacitors. 高比表面积的功能化纳米多孔生物碳从废硬木屑中提取，用于二氧化碳捕获和超级电容器。

IF 8.3

Small Science Pub Date : 2025-06-24 eCollection Date: 2025-09-01 DOI: 10.1002/smsc.202500174

Jibi Kunjumon, Ajanya Maria Ruban, Harleen Kaur, Davidson Sajan, Sanje Mahasivam, Vipul Bansal, Gurwinder Singh, Ajayan Vinu

{"title":"Functionalized Nanoporous Biocarbon with High Specific Surface Area Derived from Waste Hardwood Chips for CO2 Capture and Supercapacitors.","authors":"Jibi Kunjumon, Ajanya Maria Ruban, Harleen Kaur, Davidson Sajan, Sanje Mahasivam, Vipul Bansal, Gurwinder Singh, Ajayan Vinu","doi":"10.1002/smsc.202500174","DOIUrl":"10.1002/smsc.202500174","url":null,"abstract":"Waste biomass has aroused increasing interest in the production of low-cost materials for CO2 adsorption and supercapacitors. One of the primary facets in this regard is to develop nanoporous carbons with controlled porosity and high surface area. Herein, waste wood chips are used to synthesize nanoporous biocarbons via a solid-state KOH-based chemical activation. The synthesized materials presented high surface area (3686.10 m2 g-1), large pore volume (1.88 cm3 g-1), and tunable pore sizes. As a porous solid adsorbent, the optimized material adsorbs 5.59 mmoles of CO2 per gram at 0 °C/1 bar, which is elevated to 37.47 mmoles g-1 at 0 °C/30 bar along with a good CO2/N2 selectivity within a range ≈25-35 and also displays high recyclability of >99%. Electrochemically, in a three-electrode setup, a high specific capacitance of 261.5 F g-1/0.5 A g-1 is observed. For a two-electrode setup, a reasonable specific capacitance of 91.67 F g-1/0.5 A g-1, energy and power densities (18.33 Wh kg-1 and 2274.94 kW kg-1), and 87.5% capacity retention after 10 000 cycles are obtained. A low-cost and noncomplicated synthesis and high performance of materials for CO2 adsorption and supercapacitors make a strong case for their high promise in these fields.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500174"},"PeriodicalIF":8.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air-Stable Lithiation of MoS₂ for Direct-Bandgap Multilayers. 直接带隙多层MoS2的空气稳定锂化。

IF 8.3

Small Science Pub Date : 2025-06-23 eCollection Date: 2025-09-01 DOI: 10.1002/smsc.202500186

Qi Fu, Yichi Zhang, Jichuang Shen, Siyuan Hong, Jie Wang, Chen Wang, Jingyi Shen, Wei Kong, Guolin Zheng, Jun Yan, Jie Wu, Changxi Zheng

{"title":"Air-Stable Lithiation of MoS2 for Direct-Bandgap Multilayers.","authors":"Qi Fu, Yichi Zhang, Jichuang Shen, Siyuan Hong, Jie Wang, Chen Wang, Jingyi Shen, Wei Kong, Guolin Zheng, Jun Yan, Jie Wu, Changxi Zheng","doi":"10.1002/smsc.202500186","DOIUrl":"10.1002/smsc.202500186","url":null,"abstract":"Due to its sizable direct bandgap and strong light-matter interactions, the preparation of monolayer MoS2 has attracted significant attention and intensive research efforts. However, multilayer MoS2 is largely overlooked because of its optically inactive indirect bandgap caused by interlayer coupling. It is highly desirable to modulate and decrease the interlayer coupling so that each layer in multilayer MoS2 can exhibit a monolayer-like direct-gap behavior. Herein, the nanoprobe-controlled fabrication of LixMoS2-based multilayers is demonstrated, exhibiting a direct bandgap and strong photoluminescence emission from tightly bound excitons and trions. The fabrication of LixMoS2 multilayers is facilitated by the newly developed Li-ion platform, featuring tip-induced Li intercalation, doping patterning with a spatial resolution of 517 nm, air stability, and rewritability. Ultralow frequency Raman characterizations reveal that controlled Li intercalation effectively transforms multilayer MoS2 into the stack of multiple monolayers, leading to a 26-fold enhancement of photoluminescence compared to a monolayer. The intercalation result is different from existing observations of transforming MoS2 multilayers into metallic phases. This work not only provides a highly controllable Li-ionic engineering platform for studying Li-material interactions and developing novel ionic electronics but also offers an intriguing direct-bandgap semiconductor for optoelectronic applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500186"},"PeriodicalIF":8.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noble Metals Doping in Lead-Free Double Perovskite Single Crystals: Achieving Near-Infrared to X-ray Broadband Photodetection. 在无铅双钙钛矿单晶中掺杂贵金属：实现近红外到x射线的宽带光探测。

IF 8.3

Small Science Pub Date : 2025-06-23 eCollection Date: 2025-08-01 DOI: 10.1002/smsc.202500135

Donato Valli, Roel Vanden Brande, Vincent Herreman, Qianrui Li, Giacomo Romolini, Jim Jui-Kai Chen, Muhammed Shameem K M, Bob Van Hout, Li Sun, Qing Zhao, Bapi Pradhan, Johan Hofkens, Elke Debroye

{"title":"Noble Metals Doping in Lead-Free Double Perovskite Single Crystals: Achieving Near-Infrared to X-ray Broadband Photodetection.","authors":"Donato Valli, Roel Vanden Brande, Vincent Herreman, Qianrui Li, Giacomo Romolini, Jim Jui-Kai Chen, Muhammed Shameem K M, Bob Van Hout, Li Sun, Qing Zhao, Bapi Pradhan, Johan Hofkens, Elke Debroye","doi":"10.1002/smsc.202500135","DOIUrl":"10.1002/smsc.202500135","url":null,"abstract":"Semiconductor materials capable of broadband photodetection, spanning X-rays to near-infrared (NIR), are essential for applications in medical imaging, industrial inspection, security, and telecommunications. Conventional photodetectors like Si, Ge, InGaAs, and amorphous Se (a-Se) often encounter tradeoffs in efficiency or cost-effectiveness. Halide perovskites (HPs) offer competitive or superior optoelectronic properties with low-cost, solution-based processing. However, lead-based HPs pose toxicity and stability challenges, while lead-free tin-based HPs suffer from Sn2+ oxidation and structural degradation. The lead-free double perovskite Cs2AgBiBr6 has emerged as a stable, nontoxic alternative for X-ray and visible-light photodetection. Despite its advantages, its high bandgap (≈1.9 eV) limits NIR absorption. This study explores doping Cs2AgBiBr6 with noble metal cations (Au3+, Pd2+, and Ir3+) to lower its absorption onset and enhance its photodetection capabilities across a broad spectrum. The results demonstrate that noble metal doping can overcome the intrinsic limitations of pristine Cs2AgBiBr6, enabling efficient photodetection from X-rays to the NIR range. This approach highlights a viable pathway for developing next-generation broadband photodetectors that combine nontoxicity, stability, and wide-spectrum sensitivity.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 8","pages":"2500135"},"PeriodicalIF":8.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Milk-Derived Injectable Wound Dressing with Sequential Photoactivatable Antibacterial Property through In Situ Biomineralization. 通过原位生物矿化具有顺序光激活抗菌性能的乳源性注射伤口敷料。

IF 8.3

Small Science Pub Date : 2025-06-23 eCollection Date: 2025-09-01 DOI: 10.1002/smsc.202500026

Qinchao Zhu, Xuhao Zhou, Zhidan Wang, Daxi Ren, Tanchen Ren

{"title":"Milk-Derived Injectable Wound Dressing with Sequential Photoactivatable Antibacterial Property through In Situ Biomineralization.","authors":"Qinchao Zhu, Xuhao Zhou, Zhidan Wang, Daxi Ren, Tanchen Ren","doi":"10.1002/smsc.202500026","DOIUrl":"10.1002/smsc.202500026","url":null,"abstract":"The emergence of drug-resistant bacteria due to excessive antibiotic use has drawn increasing attention to inorganic nanoparticles for their broad-spectrum antibacterial properties. Here, a \"green\" strategy for the simultaneous in situ synthesis of silver nanoparticles (AgNPs) during the photocrosslinking process of casein hydrogels is described. The in situ photoactivated biomineralization of AgNPs provides noticeable stability and antibacterial activity, with high photothermal effect during a sequential near-infrared laser activation. The milk-derived casein is screened out due to its great biomineralization capability and wound healing activity. Casein-AgNP hydrogel dressing shows low swelling, good mechanical properties, and nice biocompatibility. In animal experiments, casein-AgNP hydrogel accelerates wound repair and tissue regeneration after bacterial infection by regulating immune response. Our work shows that sequential photoactivation served as a promising strategy for antiinfectious wound treatment, and casein hydrogel stood as a potential candidate for in situ biomineralization.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500026"},"PeriodicalIF":8.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarization-Dependent Multiphoton-Excited Self-Trapped Emission in Alloyed 0D Rb₇Bi₃Cl₁₆ Metal Halides via Sb³⁺ Doping. Sb3+掺杂下合金0D Rb7Bi3Cl16金属卤化物的偏振相关多光子激发自捕获发射

IF 8.3

Small Science Pub Date : 2025-06-21 eCollection Date: 2025-09-01 DOI: 10.1002/smsc.202500261

Si Xiao, Haixia Zhu, Yao Liu, Zhaozhe Chen, Defeng Xu, Weichang Zhou, Zhihui Chen, Shan Liang, Hui Tong, Xueyi Guo, Jun He

{"title":"Polarization-Dependent Multiphoton-Excited Self-Trapped Emission in Alloyed 0D Rb7Bi3Cl16 Metal Halides via Sb3+ Doping.","authors":"Si Xiao, Haixia Zhu, Yao Liu, Zhaozhe Chen, Defeng Xu, Weichang Zhou, Zhihui Chen, Shan Liang, Hui Tong, Xueyi Guo, Jun He","doi":"10.1002/smsc.202500261","DOIUrl":"10.1002/smsc.202500261","url":null,"abstract":"Regulating the electronic structure by doping can promote photoluminescence emission of low-dimensional metal halides for developing white-light-emitting devices. Here, 0D metal halides Rb7Bi3Cl16 have achieved a transition from nonluminescence to effective self-trapped excitons (STEs) emission after Sb3+ ion doping at room temperature. The femtosecond transient absorption spectrum reveals the nonradiative recombination was suppressed, whose lifetimes change from 93.9 ps to 3.6 ns after doping Sb3+ ion. Moreover, the Rb7Bi3Cl16:Sb3+ exhibits polarization-dependent two-photon photoluminescence and three-photon photoluminescence in the excitation wavelength range of 900-1200 nm, which further confirmed that STEs emission is extrinsic STEs by lattice deformation rather than defects. This work suggests that Sb3+ ion doping can effectively improve the luminescence properties of low-dimensional metal halides and promote the application potential in high-order nonlinear photoelectric field.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500261"},"PeriodicalIF":8.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Annealed Piezoelectric Films on Flexible Glass. 柔性玻璃上的光退火压电薄膜。

IF 8.3

Small Science Pub Date : 2025-06-20 eCollection Date: 2025-09-01 DOI: 10.1002/smsc.202500227

Juliette Cardoletti, Longfei Song, Adrian-Marie Philippe, Stéphanie Girod, Barbara Malič, Emmanuel Defay, Sebastjan Glinšek

{"title":"Light-Annealed Piezoelectric Films on Flexible Glass.","authors":"Juliette Cardoletti, Longfei Song, Adrian-Marie Philippe, Stéphanie Girod, Barbara Malič, Emmanuel Defay, Sebastjan Glinšek","doi":"10.1002/smsc.202500227","DOIUrl":"10.1002/smsc.202500227","url":null,"abstract":"The functionalization of thin, flexible glass with piezoelectric oxides is a pathway toward transparent electromechanical devices. The crystallization of lead zirconate titanate thin films on thick, rigid glass is previously demonstrated using flash lamp annealing to selectively anneal the films, without damaging the substrates. In this work, a 2-step process suitable for Schott AF 32 eco glass and Corning Willow glass is developed, both 100 μm thick, the latter of which is compatible with roll-to-roll processes. Herein, demonstration is done of: 1) the importance of heat management during flash lamp annealing; and 2) a method to orient perovskite thin films during their crystallization by flash lamp annealing. With this process, the 540 nm thick lead zirconate titanate thin films with morphotropic phase boundary composition display a relative permittivity ε r of 330, a dielectric loss of 8.4% and a piezoelectric coefficient <math> <mrow> <mrow><msub><mi>e</mi> <mrow><mn>33</mn> <mtext>,f</mtext></mrow> </msub> </mrow> </mrow> </math> of 5.5 C m-2. This work demonstrates the feasibility of transparent piezoelectric films, which has a potential to opening the way to flexible and invisible devices.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 9","pages":"2500227"},"PeriodicalIF":8.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer. 放射标记纳米凝胶：从多模态成像到癌症的联合治疗。

IF 8.3

Small Science Pub Date : 2025-06-19 eCollection Date: 2025-08-01 DOI: 10.1002/smsc.202400298

Sanchita Ghosh, Weibo Cai, Rubel Chakravarty

{"title":"Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer.","authors":"Sanchita Ghosh, Weibo Cai, Rubel Chakravarty","doi":"10.1002/smsc.202400298","DOIUrl":"10.1002/smsc.202400298","url":null,"abstract":"Advancements in nanotechnology over the past few decades have offered tremendous possibilities toward cancer theranostics. Radiolabeled nanogels (NGs) represent a promising nanoplatform in this direction, offering a multifunctional toolset for both imaging and therapeutic interventions. This review encapsulates the progressions and potential of radiolabeled NGs in the realm of cancer research. Firstly, multifunctional radiolabeled NGs serve as potent contrast agents for multimodality imaging, enabling precise visualization of tumor sites through various techniques such as positron emission tomography, single-photon emission computed tomography, optical imaging and magnetic resonance imaging. Furthermore, by incorporating more than one therapeutic payload such as chemotherapeutic drugs, nucleic acids, and/or therapeutic radionuclides, they enable synergistic treatment modalities that address the heterogeneity of cancer cells and their microenvironment. This combination approach allows for enhanced therapeutic efficacy while minimizing systemic toxicity, addressing challenges associated with conventional cancer therapies. Furthermore, the radiolabeling of NGs provides a means for real-time monitoring of therapeutic distribution and pharmacokinetics, offering valuable insights into treatment response and optimization. Overall, radiolabeled NGs represent a promising platform for the integration of multimodality imaging and combination therapy in the fight against cancer with increased efficacy, reduced toxicity, and improved patient outcomes.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 8","pages":"2400298"},"PeriodicalIF":8.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Nanoengineered Shape-Memory Hemostat". 更正“纳米工程形状记忆止血器”。

IF 11.1

Small Science Pub Date : 2025-06-12 eCollection Date: 2025-07-01 DOI: 10.1002/smsc.202500274

引用次数: 0

Hyaluronic Acid-Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis. 玻尿酸修饰脂质体用于肺内递送伊马替尼：炎症后肺纤维化的靶向治疗。

IF 8.3

Small Science Pub Date : 2025-06-10 eCollection Date: 2025-08-01 DOI: 10.1002/smsc.202500144

Sara Bozzini, Valeria Bincoletto, Laura Pandolfi, Roberta Fusco, Rosanna Di Paola, Salvatore Cuzzocrea, Ilaria Andreana, Barbara Rolando, Eleonora Bozza, Cecilia Bagnera, Manuela Monti, Barbara Stella, Federica Meloni, Silvia Arpicco

{"title":"Hyaluronic Acid-Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis.","authors":"Sara Bozzini, Valeria Bincoletto, Laura Pandolfi, Roberta Fusco, Rosanna Di Paola, Salvatore Cuzzocrea, Ilaria Andreana, Barbara Rolando, Eleonora Bozza, Cecilia Bagnera, Manuela Monti, Barbara Stella, Federica Meloni, Silvia Arpicco","doi":"10.1002/smsc.202500144","DOIUrl":"10.1002/smsc.202500144","url":null,"abstract":"Nanotechnology allows drugs to be delivered locally and specific cells to be targeted, leading to a promising new therapeutic approach for interstitial lung fibrosis. Hyaluronic acid (HA)-decorated imatinib-loaded liposomes (LIP-HA44700-Im) are developed to target CD44 positive cells for the inhalation treatment of fibrogenic lung disorders. LIP-HA44700-Im are assessed for their uptake and biological activity on respiratory effectors that are related to CD44 expression and compared to undecorated liposomes (LIP). LIP-HA44700-Im uptake is significantly higher than that of LIP, and most of the internalized LIP-HA44700-Im are colocalized with cellular endosomes. LIP-HA44700-Im also reduce lung fibroblasts viability. After 24 h, LIP-HA44700-Im are able to impair collagen 1a1 release and c-Abl phosphorylation. Based on in vitro data, it has been assessed whether the intratracheal administration of LIP-HA44700-Im is able to prevent lung fibrosis in a mouse bleomycin model. The local administration of LIP-HA44700-Im is associated with a significant decrease in alveolar inflammation, lung fibrosis, collagen deposition, and TGF-β expression. LIP-HA44700-Im target and deliver imatinib to lung pathogenic cells in vitro and represent a promising therapeutic option for the local treatment of fibrogenic lung disorders, although further development is required. These in vivo results confirm the validity of targeted nano-based treatment for inflammatory-driven lung fibrogenesis.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 8","pages":"2500144"},"PeriodicalIF":8.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization of Enzyme-Polymer Hybrids and Nanozymes Through Electrostatic Interactions: Toward Multicatalytic Microreactors with Controlled Nanoarchitecture. 通过静电作用固定化酶-聚合物杂化物和纳米酶：纳米结构可控的多催化微反应器。

IF 8.3

Small Science Pub Date : 2025-06-10 eCollection Date: 2025-08-01 DOI: 10.1002/smsc.202500167

Aitor Ontoria, Irene Alonso-Sampedro, Yixuan Yan, Ayşe Latif, Ben F Spencer, Aitor Larrañaga, Ana Beloqui, Christos Tapeinos

{"title":"Immobilization of Enzyme-Polymer Hybrids and Nanozymes Through Electrostatic Interactions: Toward Multicatalytic Microreactors with Controlled Nanoarchitecture.","authors":"Aitor Ontoria, Irene Alonso-Sampedro, Yixuan Yan, Ayşe Latif, Ben F Spencer, Aitor Larrañaga, Ana Beloqui, Christos Tapeinos","doi":"10.1002/smsc.202500167","DOIUrl":"10.1002/smsc.202500167","url":null,"abstract":"The optimal allocation of catalysts and their precise compartmentalization are vital to ensure efficient cascade reactions. The layer-by-layer approach offers the possibility of assembling various building blocks onto templates of different sizes and shapes, thus representing a powerful tool for fabricating multicatalytic reactors with controlled nanoarchitecture. However, this process usually relies on electrostatic interactions between building blocks, which means a limitation when working with natural enzymes. Accordingly, both the loading capacity and control over membrane architecture are compromised by the inherent surface charge of the enzymes. Here, this study introduces a modular strategy to assemble engineered enzyme-polymer hybrids and inorganic nanozymes onto colloidal templates, giving rise to multicatalytic reactors. The surface charge of the engineered enzyme-polymer hybrids can be finely tuned, allowing their à-la-carte assembly into multilayer membranes. Following this approach, the distance between catalytic units and their arrangement on colloidal templates at the nano- and micrometer scale can be precisely controlled, resulting in optimized configurations with enhanced cascade efficiency. The synthesized multicatalytic reactors can reduce the metabolic activity of human pancreatic stellate cells, confirming their functional activity in biological microenvironments and highlighting their potential for biomedical applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 8","pages":"2500167"},"PeriodicalIF":8.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0