Small Science最新文献_第6页

Low Hysteresis Vanadium Dioxide Integrated on Silicon Using Complementary Metal-Oxide Semiconductor Compatible Oxide Buffer Layer. 利用互补金属氧化物半导体兼容氧化物缓冲层集成在硅上的低迟滞二氧化钒。

IF 11.1

Small Science Pub Date : 2024-10-30 eCollection Date: 2025-02-01 DOI: 10.1002/smsc.202400398

Swayam Prakash Sahoo, Matthieu Bugnet, Ingrid Cañero Infante, Victor Pierron, Laurence Méchin, Rebecca Cervasio, Pierre Hemme, Jean-Blaise Brubach, Pascale Roy, Luc G Fréchette, Anne D Lamirand, Bertrand Vilquin

{"title":"Low Hysteresis Vanadium Dioxide Integrated on Silicon Using Complementary Metal-Oxide Semiconductor Compatible Oxide Buffer Layer.","authors":"Swayam Prakash Sahoo, Matthieu Bugnet, Ingrid Cañero Infante, Victor Pierron, Laurence Méchin, Rebecca Cervasio, Pierre Hemme, Jean-Blaise Brubach, Pascale Roy, Luc G Fréchette, Anne D Lamirand, Bertrand Vilquin","doi":"10.1002/smsc.202400398","DOIUrl":"https://doi.org/10.1002/smsc.202400398","url":null,"abstract":"VO2 undergoes a metal-insulator transition (MIT) at ≈70 °C, which induces large variations in its electrical and wavelength-dependent optical properties. These features make VO2 a highly sought-after compound for optical, thermal, and neuromorphic applications. To foster the development of VO2-based devices for the microelectronic industry, it is also imperative to integrate VO2 on silicon. However, high lattice mismatch and the formation of silicates at the interface between VO2 and Si degrade the quality and functionality of VO2 films. Moreover, VO2's polymorphic nature and stable V-O phases pose integration issues. To address these challenges, the MIT of VO2 thin films integrated on Si with a complementary metal-oxide semiconductor-compatible Hf x Zr1-x O2 (HZO) buffer layer is investigated. Using in situ high-resolution X-ray diffraction and synchrotron far-infrared spectroscopy, combined with multiscale atomic and electronic structure characterizations, it is demonstrated that VO2 on the HZO buffer layer exhibits an unusually low thermal hysteresis of ≈4 °C. In these results, the influence of strain on M2 phase nucleation, which controls the hysteresis, is unraveled. Notably, the rate of phase transition is symmetric and does not change for the heating and cooling cycles, implying no incorporation of defects during cycling, and highlighting the potential of an HZO buffer layer for reliable operation of VO2-based devices.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400398"},"PeriodicalIF":11.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Perfect Imperfections of Perovskite Oxide Catalysts in the Aspect of Defect Equilibria. 钙钛矿氧化物催化剂在缺陷平衡方面的完美缺陷。

IF 11.1

Small Science Pub Date : 2024-10-26 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400386

Maria Christy, Seunggun Choi, Jiseok Kwon, Jinwoo Jeong, Ungyu Paik, Taeseup Song

{"title":"The Perfect Imperfections of Perovskite Oxide Catalysts in the Aspect of Defect Equilibria.","authors":"Maria Christy, Seunggun Choi, Jiseok Kwon, Jinwoo Jeong, Ungyu Paik, Taeseup Song","doi":"10.1002/smsc.202400386","DOIUrl":"https://doi.org/10.1002/smsc.202400386","url":null,"abstract":"ABX3 (X = O) perovskite oxides are an uprising class of alternative electrocatalysts in eminent technologies like electrocatalysis, photocatalysis, thermocatalysis, and energy storage. The perquisites of perovskite oxide catalysts encompass ordered atomic structure, structural/compositional extensibility, flexible electronic structure, lucrativeness, and so on. The ingenuity to precisely control and tune the inherent properties by reconstructing their crystal structure is particularly advantageous in electrocatalysis reactions like oxygen reduction and evolution reactions (ORR and OER). Incorporating multidimensional imperfections in the presumably perfect crystal structure of the perovskite catalysts is garnering booming attention among researchers. This concept can expertly influence the electronic structure and boost the reaction kinetics during electrocatalysis. Defects or imperfections are achieved by substituting A- and/or B-sites with heteroatoms or by oxygen vacancies. Defect engineering points to a promising new direction in the development of perovskite oxide catalysts. This work surveys the recent progress in defect engineering and how it plays a vital role in their design, and application in electrocatalysis, mainly ORR/OER. The architecture, dimensionality, and the types of perovskite oxides based on their cations, crystal structures, and stoichiometries are surveyed for a comprehensive understanding. This review aims to provide an extensive outlook on oxide perovskite catalysts concerning structural defects.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400386"},"PeriodicalIF":11.1,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmonic Observation of High-Density Nanoclustering in Low-Temperature H₂O. 低温H2O中高密度纳米簇的等离子体观测。

IF 11.1

Small Science Pub Date : 2024-10-24 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400427

Nu-Ri Park, Yedam Lee, Sang Yup Lee, Han-Na Kim, Myung-Ki Kim, Dong June Ahn

{"title":"Plasmonic Observation of High-Density Nanoclustering in Low-Temperature H2O.","authors":"Nu-Ri Park, Yedam Lee, Sang Yup Lee, Han-Na Kim, Myung-Ki Kim, Dong June Ahn","doi":"10.1002/smsc.202400427","DOIUrl":"https://doi.org/10.1002/smsc.202400427","url":null,"abstract":"There has been considerable scientific interest in comprehending the behavior and phase transitions of H2O at the nanoscale in low temperatures. Herein, a highly sensitive and nondestructive surface plasmonic detection system operated at low temperatures to investigate the real-time nanoscale variation in H2O density from a rapidly cooled thin ice layer formed at 77 K is employed. The nanoslit device exhibits a distinct plasmonic response at 180-250 K, correlated to an increase in the local density of H2O at the nanometer scale. Along with theoretical analyses, it is revealed that high-density H2O clusters form by vigorous aggregation of H2O molecules within the interphase liquid region between polymorphic ice crystals. The utilization of ice-active materials, known to inhibit ice growth, suppresses the initiation of such high-density nanoclustering at 180 K. These results contribute to the comprehension of the interplay between polymorphic crystals and density-variant interphases in low-temperature H2O systems.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400427"},"PeriodicalIF":11.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(4-Vinylpyridine)-Based Cubosomes: Synthesis, Assembly, and Loading Capabilities. 聚（4-乙烯基吡啶）基立方体体：合成、组装和装载能力。

IF 11.1

Small Science Pub Date : 2024-10-17 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400274

Marcel Schumacher, Nadine Tänzer, Marius G Braun, Manuel Trömer, Giada Quintieri, Mahima Goel, Markus Heidelmann, André H Gröschel

引用次数: 0

A Dual-Modal Memory Organic Electrochemical Transistor Implementation for Reservoir Computing. 一种用于储层计算的双模态存储有机电化学晶体管实现。

IF 11.1

Small Science Pub Date : 2024-10-16 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400415

Yuyang Yin, Shaocong Wang, Ruihong Weng, Na Xiao, Jianni Deng, Qian Wang, Zhongrui Wang, Paddy Kwok Leung Chan

{"title":"A Dual-Modal Memory Organic Electrochemical Transistor Implementation for Reservoir Computing.","authors":"Yuyang Yin, Shaocong Wang, Ruihong Weng, Na Xiao, Jianni Deng, Qian Wang, Zhongrui Wang, Paddy Kwok Leung Chan","doi":"10.1002/smsc.202400415","DOIUrl":"https://doi.org/10.1002/smsc.202400415","url":null,"abstract":"Neuromorphic computing devices offer promising solutions for next-generation computing hardware, addressing the high throughput data processing demands of artificial intelligence applications through brain-mimicking non-von Neumann architecture. Herein, PEDOT:Tos/PTHF-based organic electrochemical transistors (OECTs) with dual-modal memory functions-both short-term and long-term-are demonstrated. By characterizing memory levels and relaxation times, the device has been efficiently manipulated and switched between the two modes through coupled control of pulse voltage and duration. Both short-term and long-term memory functions are integrated within the same device, enabling its use as artificial neurons for the reservoir unit and synapses in the readout layer to build up a reservoir computing (RC) system. The performance of the dynamic neuron and synaptic weight update are benchmarked with classification tasks on hand-written digit images, respectively, both attaining accuracies above 90%. Furthermore, by modulating the device as both reservoir mode and synaptic mode, a full-OECT RC system capable of distinguishing electromyography signals of hand gestures is demonstrated. These results highlight the potential of simplified, homogeneous integration of dual-modal OECTs to form brain-like computing hardware systems for efficient biological signal processing across a broad range of applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400415"},"PeriodicalIF":11.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scanless Spectral Imaging of Terahertz Vortex Beams Generated by High-Resolution 3D-Printed Spiral Phase Plates. 高分辨率3d打印螺旋相板产生的太赫兹涡旋光束的无扫描光谱成像。

IF 11.1

Small Science Pub Date : 2024-10-16 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400352

Andreea Aura Paraipan, Diana Gonzalez-Hernandez, Innem V A K Reddy, Giacomo Balistreri, Luca Zanotto, Mostafa Shalaby, Roberto Morandotti, Carlo Liberale, Luca Razzari

{"title":"Scanless Spectral Imaging of Terahertz Vortex Beams Generated by High-Resolution 3D-Printed Spiral Phase Plates.","authors":"Andreea Aura Paraipan, Diana Gonzalez-Hernandez, Innem V A K Reddy, Giacomo Balistreri, Luca Zanotto, Mostafa Shalaby, Roberto Morandotti, Carlo Liberale, Luca Razzari","doi":"10.1002/smsc.202400352","DOIUrl":"https://doi.org/10.1002/smsc.202400352","url":null,"abstract":"Terahertz technology has experienced significant advances in the past years, leading to new applications in the fields of spectroscopy, imaging, and communications. This progress requires the development of dedicated optics to effectively direct, control and manipulate terahertz radiation. In this regard, 3D printing technologies have shown great potential, offering fast prototyping, high design flexibility, and good reproducibility. While traditional 3D printing techniques allow for the preparation of terahertz optical components operating at relatively low frequencies (<0.4 THz) due to their limited resolution, two-photon polymerization lithography (TPL) exhibits high detail resolution and low surface roughness and can thus potentially enable the fabrication of high-frequency terahertz devices. Here, as a proof of principle, spiral phase plates operating at 1 THz are designed and fabricated by means of TPL. Moreover, these samples are characterized via a rapid and scanless terahertz imaging technique customized to obtain a coherent hyperspectral analysis of the generated vortex beams at varying distances along propagation. Numerical simulations are also conducted for comparison with experiments, revealing a good agreement. Current limitations of the technique are found to be mainly related with terahertz loss in TPL polymers, and possible solutions are discussed.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400352"},"PeriodicalIF":11.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supported Binuclear Gold Phosphine Complexes as CO Oxidation Catalysts: Insights into the Formation of Surface-Stabilized Au Particles. 负载双核金膦配合物作为CO氧化催化剂：表面稳定金颗粒形成的见解。

IF 11.1

Small Science Pub Date : 2024-10-14 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400345

Fabian Rang, Tim Delrieux, Florian Maurer, Franziska Flecken, Jan-Dierk Grunwaldt, Schirin Hanf

{"title":"Supported Binuclear Gold Phosphine Complexes as CO Oxidation Catalysts: Insights into the Formation of Surface-Stabilized Au Particles.","authors":"Fabian Rang, Tim Delrieux, Florian Maurer, Franziska Flecken, Jan-Dierk Grunwaldt, Schirin Hanf","doi":"10.1002/smsc.202400345","DOIUrl":"https://doi.org/10.1002/smsc.202400345","url":null,"abstract":"Atomically precise gold phosphine complexes as precursors for supported Au catalysts tested in CO oxidation are presented. Using a variety of analytical techniques, including in situ and operando X-ray absorption spectroscopy, it is discovered that minor changes in the ligand of the molecular complexes result in significantly different activation behaviors of supported Au catalysts under reaction conditions. When using [Au2(μ2-POP)2]OTf2 (POP = tetraphenylphosphoxane) as single-source precursor, an active supported oxidation catalyst in second light-off is obtained, outperforming a commercial Au/TiO2 and a P-free Au/Al2O3 reference catalyst. Conversely, using [Au2(μ2-dppe)2]OTf2 (dppe = diphenylphosphinoethane) on alumina leads to a significant decrease in CO oxidation activity. This difference is attributed to the formation of P-containing ligand residues on the support in the case of [Au2(μ2-POP)2]OTf2/Al2O3, which enhances the thermal stability of the Au particles and affects the particle's electronic properties through charge transfer processes. This work provides insights into the dynamic ligand decomposition of molecular gold complexes under reaction conditions and demonstrates the delicate balance between the stabilization of Au particles, clusters, and complexes using ligands and the blocking of active sites. This knowledge will pave the way for the targeted use of molecular transition metal complexes as precursors in synthesizing surface-stabilized nanoparticles.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400345"},"PeriodicalIF":11.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Dynamics of a Soft Crystalline Covalent Organic Framework during Benzene and Cyclohexane Adsorption by in situ Powder X-ray Diffraction. 用原位粉末x射线衍射研究软晶共价有机骨架在苯和环己烷吸附过程中的动力学。

IF 11.1

Small Science Pub Date : 2024-10-12 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400277

Anna Mauri, Rebecca Vismara, Marco Moroni, Esther Roldán-Molina, Jorge A R Navarro, Simona Galli

{"title":"Investigating the Dynamics of a Soft Crystalline Covalent Organic Framework during Benzene and Cyclohexane Adsorption by in situ Powder X-ray Diffraction.","authors":"Anna Mauri, Rebecca Vismara, Marco Moroni, Esther Roldán-Molina, Jorge A R Navarro, Simona Galli","doi":"10.1002/smsc.202400277","DOIUrl":"https://doi.org/10.1002/smsc.202400277","url":null,"abstract":"Due to their similar boiling points, separation of benzene and cyclohexane mixtures is among the current challenging processes faced by the petrochemical industry. As recently assessed, the soft imine-based covalent organic framework [(TAM)(BDA)2] (COF-300; TAM = tetrakis(4-aminophenyl)methane, BDA = terephthaldehyde) possesses higher affinity for benzene than cyclohexane in both static conditions at 298 K and dynamic conditions in the range of 298-348 K. As shown in this contribution, in situ powder X-ray diffraction while dosing benzene and cyclohexane vapors in the range of 0.01-4.74 bar on the narrow-pore form of COF-300 confirmed the coherent switchability of its framework, unveiling the progressive formation of different intermediate- and large-pore forms. In addition, a basket of otherwise inaccessible key crystallochemical details-\"on/off\" structural-feature changes cooperating to adsorption, primary adsorption sites, and host-guest and guest-guest interactions-was successfully retrieved. Overall, these findings allowed to shed light on the framework dynamics underneath the previously observed selectivity toward benzene over cyclohexane, completing this case of study and providing relevant information for the design of new-generation adsorbents for this applicative context.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400277"},"PeriodicalIF":11.1,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules. 等离子体耦合用于低分子量分子的高灵敏度检测。

IF 11.1

Small Science Pub Date : 2024-10-09 eCollection Date: 2025-01-01 DOI: 10.1002/smsc.202400382

Alexa Guglielmelli, Rossella Zaffino, Giovanna Palermo, Liliana Valente, Dante Maria Aceti, Loredana Ricciardi, Arántzazu González-Campo, Raphael Pfattner, Núria Aliaga-Alcalde, Giuseppe Strangi

{"title":"Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules.","authors":"Alexa Guglielmelli, Rossella Zaffino, Giovanna Palermo, Liliana Valente, Dante Maria Aceti, Loredana Ricciardi, Arántzazu González-Campo, Raphael Pfattner, Núria Aliaga-Alcalde, Giuseppe Strangi","doi":"10.1002/smsc.202400382","DOIUrl":"https://doi.org/10.1002/smsc.202400382","url":null,"abstract":"This article presents a novel plasmonic sensing platform designed for the detection of low molecular weight molecules, offering significant advancements in diagnostic applications. The platform features a periodic array of gold nanodisks on a 20 nm thin silica layer, supported by a 100 nm thick gold substrate. By leveraging the coupling between localized and propagating surface plasmon resonances, this design significantly enhances the sensitivity and specificity of molecular detection. Finite element method simulations are conducted to characterize the optical properties and reflectance response of the nanodisks array in the visible to near-infrared range. Ellipsometric analysis is performed to measure the reflectance of the sample at various angles. Additionally, scanning near-field optical microscopy in reflectance mode validates the design by revealing well-defined plasmonic hot spots and interference patterns consistent with the simulated results. The findings demonstrate the platform's effectiveness in amplifying optical signals, achieving a limit of detection of 50 μM for molecules with a molecular weight of less than 1 KDa. This high sensitivity and specificity highlight the potential of the proposed plasmonic platform to advance the development of highly sensitive sensors for low molecular weight molecules, making it a valuable tool for diagnostics and precise molecular detection.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 1","pages":"2400382"},"PeriodicalIF":11.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming the Blood-Brain Barrier: Multifunctional Nanomaterial-Based Strategies for Targeted Drug Delivery in Neurological Disorders. 克服血脑屏障：神经系统疾病靶向药物递送的多功能纳米材料策略。

IF 11.1

Small Science Pub Date : 2024-10-06 eCollection Date: 2024-12-01 DOI: 10.1002/smsc.202400232

Callan D McLoughlin, Sarah Nevins, Joshua B Stein, Mehrdad Khakbiz, Ki-Bum Lee

{"title":"Overcoming the Blood-Brain Barrier: Multifunctional Nanomaterial-Based Strategies for Targeted Drug Delivery in Neurological Disorders.","authors":"Callan D McLoughlin, Sarah Nevins, Joshua B Stein, Mehrdad Khakbiz, Ki-Bum Lee","doi":"10.1002/smsc.202400232","DOIUrl":"https://doi.org/10.1002/smsc.202400232","url":null,"abstract":"The development of effective therapies for neurological disorders is a growing area of research due to the increasing prevalence of these conditions. Some neurological disorders that are prevalent and remain difficult to treat are glioma, neurodegenerative disease, ischemic stroke, and traumatic brain injury. Subsequently, the therapeutic efficacy of small molecules, proteins, and oligonucleotides remains a challenge due to the presence of the blood-brain barrier (BBB), a highly selective semipermeable membrane. To this end, multifunctional nanomaterials have emerged as promising vehicles for targeted drug delivery to the brain, due to their ability to transport therapeutics across the BBB selectively. The design of advanced nanomaterial-based drug delivery systems capable of overcoming the BBB is influenced by many factors, such as fabrication technique and surface modification. This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon-based nanostructures, capable of effectively passing the BBB. These materials cross the BBB via a variety of established transport mechanisms for targeted delivery of therapeutics to the brain. Moreover, the structure and function of the BBB are highlighted and the potential for nanotechnology to aid the treatment of neurological disorders based on their ability to undergo transcytosis into the brain is highlighted.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"4 12","pages":"2400232"},"PeriodicalIF":11.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0