[17]卢-金纳米杂化物在癌症放射治疗中的应用。

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Small Science Pub Date : 2024-12-12 eCollection Date: 2025-05-01 DOI:10.1002/smsc.202400550

Mathilde Ponchelle, Marek Pruszyński, Edmond Gravel, Eric Doris

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引用次数: 0

摘要

以镥-177 （177Lu）为基础的放射性药物的内部放射性核素治疗已成为核医学和肿瘤学领域的一种有前途的方法。将放射性镧系元素与高原子序数的金属纳米粒子（如金）结合，通过放大过程增强了镥的放射毒性。不同的研究小组已经在体外和体内研究了铟金纳米杂化物，以破译物理化学、放射化学和生物因素，这些因素将使肿瘤中的选择性和最佳剂量沉积成为可能。本文综述了文献中开发的用于局部增强内部放射治疗效果的177Lu-gold定制方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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¹⁷⁷Lu-Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer.

Internal radionuclide therapy using lutetium-177 (¹⁷⁷Lu)-based radiopharmaceuticals has emerged as a promising approach in the field of nuclear medicine and oncology. Combining the radioactive lanthanide with high atomic number metal nanoparticles such as gold potentiates the radiotoxicity of lutetium by an amplification process. ¹⁷⁷Lu-gold nanohybrids have been investigated by various research groups, both in vitro and in vivo, to decipher the physicochemical, radiochemical, and biological factors that would enable selective and optimal dose deposition in tumors. This review focuses on ¹⁷⁷Lu-gold tailored approaches that are developed in the literature to locally enhance internal radiotherapeutic effects.

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来源期刊

Small Science

CiteScore

14.00

自引率

2.40%

发文量

期刊介绍： Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.