Small Science最新文献_第7页

Design and Functionality of Trypsin-Triggered, Expandable Bovine Serum Albumin-Polyethylene Glycol Diacrylate Hydrogel Actuators 胰蛋白酶触发的可扩张牛血清白蛋白-聚乙二醇二丙烯酸酯水凝胶致动器的设计与功能

IF 12.7

Small Science Pub Date : 2024-07-21 DOI: 10.1002/smsc.202400214

Yuchen Liu, Luai R. Khoury

{"title":"Design and Functionality of Trypsin-Triggered, Expandable Bovine Serum Albumin-Polyethylene Glycol Diacrylate Hydrogel Actuators","authors":"Yuchen Liu, Luai R. Khoury","doi":"10.1002/smsc.202400214","DOIUrl":"https://doi.org/10.1002/smsc.202400214","url":null,"abstract":"Expandable shape-morphing hydrogels that ensure prolonged site residence, have tailored mechanical integrity and tunability, are biocompatible to minimize side effects and can release drugs over an extended time remain challenging to achieve. Herein, a new class of enzyme-triggered bovine serum albumin and polyethylene glycol diacrylate hybrid hydrogels is presented, contributing to advancements in controlled drug-model release and actuation. These hydrogels combine the intrinsic properties of proteins with the resilience of synthetic polymers, offering a versatile application platform. Central to our research is the trypsin-induced simultaneous functionality of controlled drug model release and dynamic shape changes under physiological trypsin concentrations (0.01% w/v). These hydrogels display tailored mechanical and physical properties and microstructure, which are crucial for biomedical devices, soft robotics, and tissue engineering applications. Additionally, the hydrogels effectively control the release of fluorescein isothiocyanate, a model drug, indicating their potential for highly targeted drug delivery, particularly in the gastrointestinal tract. The study also highlights the significant effect of shape-morphing on drug release rates under physiological trypsin concentrations. These findings suggest that enzyme-responsive hybrid protein-polymer hydrogel actuators with tailored mechanical and physical properties can enhance the precision of drug delivery in biomedical applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141737509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management 开发用于抗菌药物传输的微针：伤口感染管理应用综述

IF 12.7

Small Science Pub Date : 2024-07-21 DOI: 10.1002/smsc.202400158

Hanif Haidari, Richard Bright, Yunlong Yu, Krasimir Vasilev, Zlatko Kopecki

{"title":"Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management","authors":"Hanif Haidari, Richard Bright, Yunlong Yu, Krasimir Vasilev, Zlatko Kopecki","doi":"10.1002/smsc.202400158","DOIUrl":"https://doi.org/10.1002/smsc.202400158","url":null,"abstract":"Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug delivery while complemented with noninvasiveness and patient compliance. Currently, the topical application of antimicrobials restricts the delivery of drugs to the critical areas of the wound bed, largely due to barriers posed by the necrotic tissue, scab formation, and bacterial biofilms, which severely diminish the bioavailability of the therapeutics. MNs have enabled efficient and targeted delivery to overcome many chronic wound challenges. Over the past decade, significant progress has been made to develop MNs with unique properties tailored for the delivery of vaccines, anticancer, and antimicrobials. As ongoing research continues to refine MN design, material properties, and drug formulations, the potential for revolutionizing antimicrobial drug delivery for efficacy, patient experience, and therapeutic outcomes remains at the forefront of scientific research. In this review, insights are provided into the latest progress, current developments, and the diverse applications of MNs for antimicrobial drug delivery. Herein, the translational potential of MNs is highlighted and a perspective on the current challenges associated with clinical translation is provided. Furthermore, this review aids in identifying research gaps while empowering and contributing to the future implementation of cutting-edge delivery systems to effectively tackle antimicrobial resistance.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141737510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning the Immune Cell Response through Surface Nanotopography Engineering 通过表面纳米形貌工程调节免疫细胞反应

IF 12.7

Small Science Pub Date : 2024-07-21 DOI: 10.1002/smsc.202400227

Raïssa Rathar, David Sanchez-Fuentes, Hugo Lachuer, Valentin Meire, Aude Boulay, Rudy Desgarceaux, Fabien P. Blanchet, Adrian Carretero-Genevrier, Laura Picas

{"title":"Tuning the Immune Cell Response through Surface Nanotopography Engineering","authors":"Raïssa Rathar, David Sanchez-Fuentes, Hugo Lachuer, Valentin Meire, Aude Boulay, Rudy Desgarceaux, Fabien P. Blanchet, Adrian Carretero-Genevrier, Laura Picas","doi":"10.1002/smsc.202400227","DOIUrl":"https://doi.org/10.1002/smsc.202400227","url":null,"abstract":"Dendritic cells (DCs) are central regulators of the immune response by detecting inflammatory signals, aberrant cells, or pathogens. DC-mediated immune surveillance requires morphology changes to adapt to the physical and biochemical cues of the external environment. These changes are assisted by a dynamic actin cytoskeleton–membrane interface connected to surface receptors that will trigger signaling cascades. In recent years, the development of synthetic immune environments has allowed to investigate the impact of the external environment in the immune cell response. In this direction, the bioengineering of functional topographical features should make it possible to establish how membrane morphology modulates specific cellular functions in DCs. Herein, the engineering of one-dimensional nanostructured SiO2 surfaces by soft-nanoimprint lithography to manipulate the membrane morphology of ex vivo human DCs is reported. Super-resolution microscopy and live-cell imaging studies show that vertical pillar topographies promote the patterning and stabilization of adhesive actin-enriched structures in DCs. Furthermore, vertical topographies stimulate the spatial organization of innate immune receptors and regulate the Syk- and ERK-mediated signaling pathways across the cell membrane. In conclusion, engineered SiO2 surface topographies can modulate the cellular response of ex vivo human immune cells by imposing local plasma membrane nano-deformations.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile Synthesis of Hemin Derivatives with Modulated Aggregation Behaviour and Enhanced Nitric‐Oxide Scavenging Properties as New Therapeutics for Breast Cancer 轻松合成具有调节聚集行为和增强一氧化氮清除特性的血红素衍生物，作为乳腺癌的新疗法

IF 11.1

Small Science Pub Date : 2024-07-16 DOI: 10.1002/smsc.202400237

A. M. Alsharabasy, D. Cherukaraveedu, J. Warneke, Ziyan Warneke, J. Galán‐Mascarós, Sharon A. Glynn, Pau Farràs, Abhay Pandit

{"title":"Facile Synthesis of Hemin Derivatives with Modulated Aggregation Behaviour and Enhanced Nitric‐Oxide Scavenging Properties as New Therapeutics for Breast Cancer","authors":"A. M. Alsharabasy, D. Cherukaraveedu, J. Warneke, Ziyan Warneke, J. Galán‐Mascarós, Sharon A. Glynn, Pau Farràs, Abhay Pandit","doi":"10.1002/smsc.202400237","DOIUrl":"https://doi.org/10.1002/smsc.202400237","url":null,"abstract":"\u0000Nitric oxide (•NO) plays various pathophysiological roles in breast cancer, significantly influencing the migration of tumour cells through concentration gradients. Therefore, modulating •NO levels via selective scavenging presents a promising approach to treating aggressive •NO‐dependent cancers, such as triple‐negative breast cancer (TNBC). Hemin emerges as a potential scavenger of •NO; however, its metalloporphyrin molecules tend to aggregate in physiological solutions, which limits its biomedical applications. To address this, a modification strategy is employed to minimize aggregation and protect against physiological oxidative degradation while preserving •NO‐scavenging properties. This is achieved through a simple chemical transformation that involves hemin conjugation to aromatic residues, tyrosine, and tyramine via carbodiimide reactions. These derivatives exhibit altered electronic properties and oxidation potential compared to hemin, alongside reduced aggregation tendencies and retained •NO‐binding affinity in aqueous solutions. Furthermore, depending on the type of hemin derivative, there is an associated inhibition of TNBC cell migration. These model hemin compounds demonstrate varying •NO‐binding affinities and resistance levels to oxidative degradation and aggregation, offering insights into the design of •NO‐scavenging molecules with enhanced properties for cancer treatment.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":11.1,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Nanotechnology‐Mediated Noninvasive Transdermal and Topical Delivery of Proteins 纳米技术介导的非侵入性经皮和局部输送蛋白质的最新进展

IF 11.1

Small Science Pub Date : 2024-07-16 DOI: 10.1002/smsc.202400175

Junghyeon Ko, Jeong‐Uk Kim, Subin Choi, Ye‐Sol Kim, Su‐Bin Park, Joo‐Young Kim, Hyeon‐Jin Kim, Young‐Sun Lee, Young‐Hyeon An, Nathaniel S. Hwang

引用次数: 0

Engineering Tumor‐Specific Nanotheranostic Agent with MR Image‐Guided NIR‐II & ‐III Photodynamic Therapy to Combat Against Deeply Seated Orthotopic Glioblastoma 肿瘤特异性纳米otheranostic制剂与核磁共振成像引导的近红外-II和-III光动力疗法共同对抗深位原位胶质母细胞瘤

IF 11.1

Small Science Pub Date : 2024-07-14 DOI: 10.1002/smsc.202400191

Karthik Nuthalapati, Raviraj Vankayala, Munusamy Shanmugam, Suresh Thangudu, Chi‐Shiun Chiang, Kuo Chu Hwang

{"title":"Engineering Tumor‐Specific Nanotheranostic Agent with MR Image‐Guided NIR‐II & ‐III Photodynamic Therapy to Combat Against Deeply Seated Orthotopic Glioblastoma","authors":"Karthik Nuthalapati, Raviraj Vankayala, Munusamy Shanmugam, Suresh Thangudu, Chi‐Shiun Chiang, Kuo Chu Hwang","doi":"10.1002/smsc.202400191","DOIUrl":"https://doi.org/10.1002/smsc.202400191","url":null,"abstract":"Glioblastoma multiforme (GBM) is one of the most aggressive, incurable, and difficult‐to‐treat malignant brain tumor with very poor survival rates. The gold standard in treating GBMs includes neurosurgical resection of the tumor, followed by the chemotherapy and radiotherapy. However, these strategies remain ineffective in treating patients with GBMs, as tumor recurrence always occur in most cases. Therefore, it remains a grand challenge to develop an effective strategy to combat orthotopic glioblastoma with simultaneous imaging capabilities to monitor the therapeutic outcomes. To tackle this challenge, this study demonstrates, for the first time, that a tumor‐specific europium hexaboride (EuB6)‐based nanomedicine surface‐modified with RGD‐K peptide to target αvβ3 integrin receptors overexpressed on the glioblastoma cells. Further, EuB6@RGD‐K NPs are able to exert theranostic capabilities to effectively diagnose and combat difficult‐to‐treat orthotopic glioblastoma tumors using NIR‐II 1064 nm and NIR‐III 1550 nm photodynamic therapy (NIR PDT) effects. In the in vivo experiments, the average half‐life of 55 d for mice treated with EuB6@RGD‐K NPs and exposed to NIR‐III 1550 nm light irradiation is far higher than that of EuB6@RGD‐K NPs exposed to NIR‐II 1064 nm light irradiation (25 d), PBS‐treated mice (20 d) and EuB6@RGD‐K NPs‐treated mice (no light irradiation, 18 d). To the best of our knowledge, this work represents the first example for destructing murine brain tumors via multi‐functional tumor‐specific europium hexaboride‐based nanotheranostic agent to mediate MR imaging‐guided NIR‐II/‐III photodynamic therapy.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":11.1,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141650422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microcavity-Enhanced Polarization Photodetection in Antimony Selenide Nanotube-Based Near-Infrared Photodetectors 基于硒化锑纳米管的近红外光电探测器中的微腔增强偏振光电探测技术

IF 12.7

Small Science Pub Date : 2024-07-12 DOI: 10.1002/smsc.202400216

Songqing Zhang, Khalil As’Ham, Han Wang, Wenwu Pan, Ibrahim Al-Ani, Huijia Luo, Junliang Liu, Yongling Ren, Haroldo Takashi Hattori, Andrey E. Miroshnichenko, Lorenzo Faraone, Wen Lei

{"title":"Microcavity-Enhanced Polarization Photodetection in Antimony Selenide Nanotube-Based Near-Infrared Photodetectors","authors":"Songqing Zhang, Khalil As’Ham, Han Wang, Wenwu Pan, Ibrahim Al-Ani, Huijia Luo, Junliang Liu, Yongling Ren, Haroldo Takashi Hattori, Andrey E. Miroshnichenko, Lorenzo Faraone, Wen Lei","doi":"10.1002/smsc.202400216","DOIUrl":"https://doi.org/10.1002/smsc.202400216","url":null,"abstract":"This study presents the polarization photodetection enhancement in Sb2Se3 nanotube (NT)-based near-infrared (NIR) photodetectors through simulation-based and experimental investigations. High-quality single-crystal Sb2Se3 NTs are grown via chemical vapor deposition and characterized by using multiple techniques. The optical simulation reveals a remarkable difference in the light absorption ratio (specifically, absorption along the NT/nanowire (NW) against absorption perpendicular to the NT/NW) between Sb2Se3 NT and NW of the same size in the NIR region. The complementary photodetection experiments present that the fabricated Sb2Se3 NT photodetector demonstrates enhanced polarization photodetection in the NIR range, as indicated by a significantly increased dichroic ratio (3.03 at 850 nm) compared to that of similar-sized NW counterpart (1.81 at 850 nm). Additionally, the Sb2Se3 NT photodetector exhibits exceptional performance, with a high responsivity of 4.18 A W−1 and specific detectivity of 8.94 × 1010 Jones under 830 nm light illumination. This study provides a comprehensive understanding of the microcavity resonance effect and its role in polarization photodetection enhancement, highlighting the potential of self-assembled Sb2Se3 NTs in high-performance near-infrared polarized photodetection and other relevant applications.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal Sight: A Position-Sensitive Detector for a Pinpoint Heat Spot 红外热像仪精确定位热斑的位置敏感探测器

IF 12.7

Small Science Pub Date : 2024-07-11 DOI: 10.1002/smsc.202400091

Jun Peng, Pai Zhao, Rakshith Venugopal, Kristian Deneke, Stefanie Haugg, Robert Blick, Robert Zierold

{"title":"Thermal Sight: A Position-Sensitive Detector for a Pinpoint Heat Spot","authors":"Jun Peng, Pai Zhao, Rakshith Venugopal, Kristian Deneke, Stefanie Haugg, Robert Blick, Robert Zierold","doi":"10.1002/smsc.202400091","DOIUrl":"https://doi.org/10.1002/smsc.202400091","url":null,"abstract":"Precise positioning is a never-ending goal in both fundamental science and technology. Recent decades of advancements in high-precision position detection have predominantly relied on photoelectric effects for light detection in semiconductors. Herein, a different approach is proposed: The thermoelectric-based position-sensitive detector (T-PSD) concept is designed to detect single heat spots arising from various energy sources, including electromagnetic radiation, electrons, and macroscopic mechanical heat. The T-PSD concept is initially derived mathematically from the fundamental principles of heat conduction and the Seebeck effect. Subsequently, it is proved by finite element simulation in both 1D and 2D configurations. Following this theoretical groundwork, T-PSD prototypes are fabricated and subjected to positional detection using various stimuli such as CO2 laser beam, hot soldering tip, and electron beam. In the prototypes, structured aluminum-doped zinc oxide thermoelectric thin films, prepared via atomic layer deposition, are outfitted with voltage probes, enabling the measurement of thermoelectric voltages as a function of position and the intensity or temperature of the heat spot. Furthermore, practical decoding strategies are introduced to infer the position from the measured signals. The T-PSD in this article showcases considerable promise in high-precision position detection such as (quasi-)particle tracking and precision machinery, offering an alternative concept in PSD design.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":null,"pages":null},"PeriodicalIF":12.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Lasting Hydrogen Evolution and Efficient Dew Harvest Realized via Electrospinning Polyvinylidene Fluoride Membrane on Hybrid Hydrogels 通过在混合水凝胶上电纺丝聚偏氟乙烯膜实现长效氢进化和高效露水收集

IF 12.7

Small Science Pub Date : 2024-07-10 DOI: 10.1002/smsc.202470025

Jie Yu, Mengmeng Chen, Neng Hu, Weijia Wang, Lin Lei, Huiqing Fan, Peter Müller-Buschbaum, Qi Zhong

引用次数: 0

Enhanced Efficacy of a TLR3 Agonist Delivered by Cowpea Chlorotic Mottle Virus Nanoparticles 豇豆萎黄斑驳病病毒纳米颗粒释放的 TLR3 激动剂的增效作用

IF 12.7

Small Science Pub Date : 2024-07-10 DOI: 10.1002/smsc.202470021

Eunkyeong Jung, Anahid Foroughishafiei, Young Hun Chung, Nicole F. Steinmetz

引用次数: 0