Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.

IF 8.3 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Small Science Pub Date : 2025-02-20 eCollection Date: 2025-05-01 DOI:10.1002/smsc.202400498

Zaiyong Zheng, Shuang Zhu, Xiaobo Wang, Haoran Wu, Min Fu, Houxiang Hu, Zhanjun Gu, Chunxiang Zhang

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Abstract

Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, the circulatory system stands out as particularly vulnerable, drawing additional attention to its cardiac toxicity. To address the cardiovascular nanotoxicity and further promote the safe use of nanotechnology, a comprehensive review of the cardiotoxicity induced by nanomaterials is provided. The review begins by identifying the current research trends and hotspots in this field via a bibliometric analysis. Subsequently, based on the objectively obtained research hotspots, the mechanism of cardiovascular nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, and cell death, is reviewed and discussed. Finally, current strategies for the mitigation of nanotoxicity are also proposed. The objective of this review is to assist readers in understanding the mechanism of cardiotoxicity induced by nanomaterials and to facilitate their safe application for human health.

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纳米材料致心脏毒性机制的研究综述。

纳米材料在日常生活中得到了广泛的应用。然而，由于其独特的性质，纳米材料也显示出潜在的副作用。在受纳米材料影响的各种器官中，循环系统特别脆弱，引起了对其心脏毒性的额外关注。为了解决心血管纳米毒性问题，进一步促进纳米技术的安全使用，本文对纳米材料引起的心脏毒性进行了全面的综述。本文首先通过文献计量学分析确定了当前该领域的研究趋势和热点。随后，根据客观获得的研究热点，从暴露途径、膜损伤、离子干扰、氧化应激、炎症和细胞死亡等方面对心血管纳米毒性的机制进行了综述和讨论。最后，还提出了当前减轻纳米毒性的策略。这篇综述的目的是帮助读者了解纳米材料引起心脏毒性的机制，并促进其在人类健康方面的安全应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small Science

CiteScore

14.00

自引率

2.40%

发文量

期刊介绍： Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.