International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Impact of biological sex on heart transplant patients admitted to cardiac rehabilitation: A 10-year retrospective cohort study","authors":"Andrea Tedeschi ,&nbsp;Ignazio Cusmano ,&nbsp;Francesca Di Salvo ,&nbsp;Letizia Oreni ,&nbsp;Anastasia Toccafondi ,&nbsp;Monica Tavanelli ,&nbsp;Paola Grati ,&nbsp;Luca Mapelli ,&nbsp;Luisa Arrondini ,&nbsp;Gianmarco Cannadoro ,&nbsp;Matteo Gonella ,&nbsp;Chiara Barcella ,&nbsp;Leone Stilo ,&nbsp;Alessandro Verde ,&nbsp;Gabriella Masciocco ,&nbsp;Giacomo Ruzzenenti ,&nbsp;Marco Biolcati ,&nbsp;Andrea Garascia ,&nbsp;Nuccia Morici","doi":"10.1016/j.ijcrp.2024.200345","DOIUrl":"10.1016/j.ijcrp.2024.200345","url":null,"abstract":"<div><h3>Introduction</h3><div>Heart transplantation (HTx) serves as the gold-standard therapy for end-stage heart failure, yet patients often experience physical deconditioning and cognitive impairments post-surgery. Cardiac rehabilitation (CR) has shown promise in the HTx context. However, uncertainty surrounds the impact of biological sex. Accordingly, the aim of this paper was to investigate the impact of biological sex in a cohort of patients with HTx early admitted to a residential CR program.</div></div><div><h3>Methods</h3><div>This was a retrospective analysis involving patients who underwent HTx at Niguarda Hospital and who subsequently participated in a CR program at IRCCS Fondazione Don Gnocchi, Milan, Italy, between 2010 and 2022. The primary endpoint was time to event (in months), with an event defined as a composite outcome of whichever occurred first of death, allograft rejection, or cardiac allograft vasculopathy up to 30 months follow-up.</div></div><div><h3>Results</h3><div>In a total of 129 patients, 60 % male, and 40 % female, baseline characteristics presented comparably between the sexes. At 6 months, no significant sex differences were observed for the primary composite outcome. However, at 30 months, females exhibited a significantly lower incidence of the primary composite outcome and an increased survival rate. Multivariable analysis confirmed a protective effect of female sex against mortality (F vs. M, HR 0.164, 95 % CI 0.038–0.716, P = 0.0161).</div></div><div><h3>Conclusions</h3><div>Despite limitations, our findings emphasize that sex affects post-HTx long-term follow-up following CR discharge, with more favorable outcomes for female recipients. In an era of tailored management algorithms, it is imperative to take into account the gender gap even in cardiac rehabilitation.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200345"},"PeriodicalIF":1.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial","authors":"Paweł Maga ,&nbsp;Agnieszka Wachsmann-Maga ,&nbsp;Aleksandra Włodarczyk ,&nbsp;Mikołaj Maga ,&nbsp;Krzysztof Batko ,&nbsp;Katarzyna Bogucka ,&nbsp;Maria Kapusta ,&nbsp;Piotr Terlecki","doi":"10.1016/j.ijcrp.2024.200343","DOIUrl":"10.1016/j.ijcrp.2024.200343","url":null,"abstract":"<div><div>Leukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascular function in patients with chronic lower limb ischemia. This prospective observational study enrolled 50 consecutive patients undergoing endovascular treatment due to chronic lower limb ischemia (Rutherford 3). All participants were followed-up for one year (after 1, 3, 6 and 12 months), with a sequential assessment of urinary LTE4 and LTB4, as well as measures of endothelial and vascular function: Flow-Mediated Dilatation (FMD), Intima-Media Thickness (IMT), corrected Augmentation Index (AI75), Shear Rate (SR), Ankle-Brachial Index (ABI), Toe-Brachial Index (TBI). There was a significant relationship between LTE4 and measures of vascular function: FMD (R2 = 0.69, P &lt; 0.001), IMT (R2 = 0.12, P &lt; 0.01), AI75 (R2 = 0.43, P &lt; 0.001), SR (R2 = 0.48, P &lt; 0.001). Similar findings were noted for LTB4: FMD (R2 = 0.47, p &lt; 0.001), IMT (R2 = 0.23, P &lt; 0.001), AI75 (R2 = 0.61, P &lt; 0.001) and SR (R2 = 0.33, P &lt; 0.001). Alterations in parameters were significantly related: ΔLTE4 vs ΔFMD(R2 = 0.63, P &lt; 0.001), ΔSR (R2 = 0.42, P &lt; 0.001) and ΔLTB4 vs AI75(R2 = 0.40, P &lt; 0.001), SR(R2 = 0. 29, P &lt; 0.001). We conclude, that increasing concentrations of LTE4 and LTB4 are associated with impairment of vascular and endothelial function, which may lead to worse endovascular treatment clinical outcomes.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200343"},"PeriodicalIF":1.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 ESC Guidelines for the management of elevated blood pressure and hypertension – How practical is it for clinical practice?","authors":"Elisabeta Badila","doi":"10.1016/j.ijcrp.2024.200341","DOIUrl":"10.1016/j.ijcrp.2024.200341","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200341"},"PeriodicalIF":1.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketogenic diets are associated with an elevated risk of hypertension: Insights from a cross-sectional analysis of the NHANES 2007-2018.","authors":"Xiaolong Qu ,&nbsp;Yuping Liu ,&nbsp;Lei Huang ,&nbsp;Fang Wan","doi":"10.1016/j.ijcrp.2024.200342","DOIUrl":"10.1016/j.ijcrp.2024.200342","url":null,"abstract":"<div><h3>Background</h3><div>The ketogenic diet (KD) is widely used for weight loss in obese individuals; however, its potential impact on hypertension risk remains uncertain.</div></div><div><h3>Methods</h3><div>We used cross-sectional data from the 2007-2018 to National Health and Nutrition Examination Survey (NHANES) to investigate the association between the dietary ketogenic ratio (DKR) and hypertension prevalence. Dietary intake information was obtained through a comprehensive 24-hour dietary recall interview. The DKR values were computed using a specialized formula. Multiple logistic regression analysis was employed to examine this association, whereas nonlinear relationships were assessed using restricted cubic splines. Inflection points were determined using two-piecewise linear regression analysis. Subgroup analyses based on age were also performed.</div></div><div><h3>Results</h3><div>In a fully adjusted multivariate logistic regression model accounting for confounding variables, DKR was significantly associated with hypertension (OR, 1.24; 95% CI: 1.00-1.53; P = 0.045). Moreover, individuals in the highest quartile of DKR exhibited a significantly elevated risk of hypertension compared with those in the lowest quartile (OR, 1.15; 95% CI: 1.07-1.24; P &lt; 0.001). Additionally, restricted cubic spline analysis revealed a linear relationship between DKR and the risk of hypertension, with a turning point identified at 3.4 units on the measurement scale employed for this study's purposes. Subgroup analyses indicated that this association between DKR and hypertension was particularly pronounced among individuals aged ≥40 years, especially those age group–40-60.We further observed that a multivariate linear regression analysis revealed a significant positive correlation between DKR and DBP in a fully adjusted model(β, 0.42; 95% CI: 0.12-0.87; P = 0.018), indicating that as DKR increased, there was an accompanying increase in DBP. However, no significant correlation was found between SBP and DKR(β, 0.11; 95% CI: -0.37, 0.59; P = 0.655).</div></div><div><h3>Conclusion</h3><div>The KD may enhance susceptibility to hypertension in middle-aged and elderly populations in the United States, exhibiting a strong association with elevated diastolic blood pressure, while no significant correlation was observed with increased systolic blood pressure.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200342"},"PeriodicalIF":1.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world antithrombotic strategies in patients with atrial fibrillation and recently developed acute coronary syndrome","authors":"Hiroshi Iwata ,&nbsp;Katsumi Miyauchi ,&nbsp;Shuko Nojiri ,&nbsp;Yuji Nishizaki ,&nbsp;Yuichi Chikata ,&nbsp;Hiroyuki Daida","doi":"10.1016/j.ijcrp.2024.200339","DOIUrl":"10.1016/j.ijcrp.2024.200339","url":null,"abstract":"<div><h3>Background</h3><div>The antithrombotic strategy for patients with atrial fibrillation (AF) and coronary artery disease following percutaneous coronary intervention is shifting towards less intensive. Nevertheless, for patients with AF and acute coronary syndrome (ACS), an optimal antithrombotic strategy is yet to be established.</div></div><div><h3>Methods and results</h3><div>We conducted a multi-center cohort study involving 146 Japanese centers that had prospectively registered 460 patients with AF and ACS followed for 2 years. Primary endpoint was the composite of thrombotic and bleeding events, and secondary endpoints included heart failure hospitalization. At the time of study registration, 86 % of participants had received direct oral anticoagulants (DOACs) and 75 % had received aspirin-based triple antithrombotic therapy (TAT) between March 2017 and August 2019. Apixaban was the most frequently used DOAC (29 %). While the proportion of anticoagulants did not change according to the time course, the intensity of antiplatelets significantly attenuated over time (dual antiplatelet at baseline: 75 %, and at 2-years: 7 %). The cumulative incidence of the primary outcome measure was similar in patients with warfarin and DOACs. However, the risk of heart failure hospitalization was significantly higher in those with warfarin compared to DOACs (Hazard ratio: 2.8, 95 % confidence interval: 1.1–5.8, p = 0.022).</div></div><div><h3>Conclusions</h3><div>The present findings suggest the appropriate optimization of antithrombotic medication balancing in patients with AF and ACS in Japan by reducing the intensity of antiplatelets during the study period.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200339"},"PeriodicalIF":1.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic cardiomyopathy: pathophysiology, imaging assessment and therapeutical strategies","authors":"Vincenzo Rizza ,&nbsp;Lara Tondi ,&nbsp;Angelo Maria Patti ,&nbsp;Damiano Cecchi ,&nbsp;Massimo Lombardi ,&nbsp;Francesco Perone ,&nbsp;Marco Ambrosetti ,&nbsp;Manfredi Rizzo ,&nbsp;Domenico Cianflone ,&nbsp;Francesco Maranta","doi":"10.1016/j.ijcrp.2024.200338","DOIUrl":"10.1016/j.ijcrp.2024.200338","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is one of the most prevalent cardiovascular risk factors in the general population, being associated with high morbidity and socioeconomic burden. Diabetic cardiomyopathy (DCM) is a non-negligible complication of DM, whose pathophysiological fundaments are the altered cardiac metabolism, the hyperglycemia-triggered formation of advanced glycation end-products (AGEs) and the inflammatory milieu which are typical in diabetic patients. These metabolic abnormalities lead to cardiomyocytes apoptosis, interstitial fibrosis and mechanical cardiac dysfunction, which can be identified with non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance. This review aims to: 1) describe the major imaging features of DCM; 2) highlight how early identification of DCM-related anatomical and functional remodeling might allow patients’ therapy optimization and prognosis improvement.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200338"},"PeriodicalIF":1.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis","authors":"Zhiyu Gu ,&nbsp;Rui Zhang ,&nbsp;Weihong Chang ,&nbsp;Hongxuan Fan ,&nbsp;Zixuan Dou ,&nbsp;Peng Liu ,&nbsp;Aman Liu ,&nbsp;Boda Zhou","doi":"10.1016/j.ijcrp.2024.200337","DOIUrl":"10.1016/j.ijcrp.2024.200337","url":null,"abstract":"<div><h3>Aim</h3><div>Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFR_{Cystatin C}), and the difference between Cystatin C and creatinine based eGFR (eGFR_diff) has been suggested to be associated with cardiovascular disease. However, the association between eGFR_{Cystatin C},eGFR_diff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort.</div></div><div><h3>Methods</h3><div>We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFR_{Cystatin C} &amp; eGFR_diff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study.</div></div><div><h3>Results</h3><div>The cohort study included 2155 participants. Importantly, we simplified eGFR_diff classification into ≥0 and &lt; 0, and found that eGFR_diff≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m² of eGFR_{Cystatin C} had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFR_{Cystatin C} and HF, eGFR_diff and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFR_{Cystatin C} or low eGFR_diff groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF.</div></div><div><h3>Conclusion</h3><div>Both decreased eGFR_{Cystatin C} and eGFR_diff levels were associated with heart failure and poor survival, but the latter seems more obvious.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200337"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival","authors":"Mohammed Abusharekh,&nbsp;Jürgen Kampf,&nbsp;Iryna Dykun,&nbsp;Viktoria Backmann,&nbsp;Rolf Alexander Jánosi,&nbsp;Matthias Totzeck,&nbsp;Tienush Rassaf,&nbsp;Amir Abbas Mahabadi","doi":"10.1016/j.ijcrp.2024.200336","DOIUrl":"10.1016/j.ijcrp.2024.200336","url":null,"abstract":"<div><h3>Background</h3><div>Smoking has conflicting results on outcomes following acute myocardial infarction (AMI). We evaluated the independent influence of smoking status on patient outcomes.</div></div><div><h3>Methods</h3><div>We included patients with AMI undergoing invasive coronary angiography with available self-reported smoking status. The incidence of death of any cause was evaluated during a median follow-up of 1.14 years (range 0.36–3.40 years). Association between smoking status and long-term mortality was evaluated using multivariable adjusted Cox regression analysis.</div></div><div><h3>Results</h3><div>From 1612 AMI patients (aged 65.7 ± 13.3 years, 72.1 % male), 378 patients (23.4 %) were current-smokers, 311 (19.3 %) ex-smokers, and 923 (57.3 %) non-smokers. Compared with non-smokers, current-smokers were younger (68.5 ± 13.0 vs. 58.6 ± 12.5, p &lt; 0.0001) and more frequently presented with STEMI (21.6 % vs. 35,4 %, p &lt; 0.0001), while ex-smokers with similar frequency of STEMI-manifestation as non-smokers (22.5 %, p = 0.79) constituted an intermediate-group in terms of age (65.8 ± 11,6 years). Although smoking status was not significantly associated with long-term survival in unadjusted-analysis, active-smokers had 56 % higher long-term mortality than non-smokers when adjusting for age, gender, medications and other traditional risk factors, whereas ex-smokers possessed comparable survival probability (current-smokers: 1.56[1.14–2.14], p = 0.006, ex-smokers 1.16[0.84–1.59], p = 0.37). Current-smokers had unadjusted lower NT-proBNP and modestly higher absolute in-hospital left ventricular global longitudinal strain (LV GLS) values that did not differ among groups after the same adjustments (NT-proBNP: −0.08[-0.31; 0.15], p = 0.5, LV GLS: 0.65[-0.26; 1.55], p = 0.16).</div></div><div><h3>Conclusion</h3><div>Active smoking is associated with increased adjusted long-term mortality, earlier onset and more frequent manifestation as STEMI, compared to non-smoking. Comparable adjusted results for LV GLS and NT-proBNP between groups support the presence of the pseudoparadox.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200336"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis","authors":"Aman Goyal ,&nbsp;Haleema Qayyum Abbasi ,&nbsp;Yusra Mashkoor ,&nbsp;Abdul Moiz Khan ,&nbsp;Samia Aziz Sulaiman ,&nbsp;Mohamed Daoud ,&nbsp;Kamna Bansal","doi":"10.1016/j.ijcrp.2024.200334","DOIUrl":"10.1016/j.ijcrp.2024.200334","url":null,"abstract":"<div><h3>Background</h3><div>Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV. R Studio's meta package was used to pool risk ratios under the random-effects model, and statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Nine observational studies involving 45024 individuals were included in this analysis. Patients with AAV exhibited a significantly elevated risk of stroke (RR = 1.43, 95 % CI: 1.12–1.83, I2 = 62 %, p = 0.0048), myocardial infarction (RR = 1.49, 95 % CI: 1.25–1.79, <em>I</em>^<em>2</em> = 0 %, p &lt; 0.0001), ischemic heart disease (RR = 1.40, 95 % CI: 1.24–1.58, <em>I</em>^<em>2</em> = 1 %, p &lt; 0.0001), venous thromboembolism (RR = 2.57, 95 % CI: 1.70–3.90, <em>I</em>^<em>2</em> = 74 %, p &lt; 0.0001), and pulmonary embolism (RR = 3.53, 95 % CI: 2.82–4.42, <em>I</em>^<em>2</em> = 9 %, p &lt; 0.0001), deep vein thrombosis (RR: 4.21; 95 % CI: 2.00–8.86; p = 0.0002), heart failure (RR = 1.63, 95 % CI: 1.39–1.90, <em>I</em>^<em>2</em> = 0 %, p &lt; 0.0001), and cardiovascular disease-related mortality (RR = 1.79, 95 % CI: 1.07–3.00, I2 = 0 %, p = 0.0256) compared to patients without AAV.</div></div><div><h3>Conclusion</h3><div>This meta-analysis underscores a notable increase in adverse cardiovascular events among patients with AAV, underscoring the need for comprehensive cardiovascular care and diligent monitoring in this patient cohort.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200334"},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovation, simplification, and adherence to real life, 2024 ESC guidelines of elevated blood pressure and hypertension claimed for","authors":"Marco Ambrosetti,&nbsp;Monica Loguercio,&nbsp;Luigi Maresca,&nbsp;Chiara Meloni,&nbsp;Daniela Zaniboni","doi":"10.1016/j.ijcrp.2024.200335","DOIUrl":"10.1016/j.ijcrp.2024.200335","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200335"},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524001004/pdfft?md5=da01656bdee9cbf19235742f53bb48d2&pid=1-s2.0-S2772487524001004-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}