International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Impact of cardiovascular risk factors and cardiac diseases on mortality in patients with moderate to severe ARDS: A retrospective cohort study","authors":"Arnaud Gacouin ,&nbsp;Pauline Guillot ,&nbsp;Flora Delamaire ,&nbsp;Alexia Le Corre ,&nbsp;Quentin Quelven ,&nbsp;Nicolas Terzi ,&nbsp;Jean Marc Tadié ,&nbsp;Adel Maamar","doi":"10.1016/j.ijcrp.2024.200318","DOIUrl":"10.1016/j.ijcrp.2024.200318","url":null,"abstract":"<div><h3>Background</h3><p>Histor<strong>y</strong> of coronary artery disease (CAD) and/or atrial fibrillation (AF) and/or valvular replacement (VR) are prevalent among patients admitted to intensive care units (ICUs). The impact of these conditions on outcomes in patients with acute respiratory distress syndrome (ARDS) remains insufficiently explored.</p></div><div><h3>Methods</h3><p>We performed a retrospective study on prospectively collected data from patients with ARDS and a PaO₂/FiO₂ ratio ≤150 mmHg. Patients were admitted between January 2006 and March 2022. We used multivariable logistic regression analysis. The primary outcome was 1-year mortality from admission to the ICU; secondary outcomes included mortality at 28 days and 90 days.</p></div><div><h3>Results</h3><p>Among 1.033 patients, 181 (17.5 %) had a history of CAD and/or AF and/or VR. History of CAD and/or AF and/or VR was independently associated with 1-year mortality (Odds-Ratio (OR) = 2.59, 95 % confidence interval (CI) 1.76–3.82, p &lt; 0.001), with mortality at 90 days (OR = 1.87, 95 % CI 1.27–2.76, p = 0.001), but not with mortality at 28 days (OR = 1.40, 95 % CI 0.93–2.11, p = 0.10). In sensitivity analyses, history of CAD and/or AF and/or VR remained independently associated with 1-year mortality in ICU survivors (OR = 3.58, 95 % CI = 2.41–7.82, p &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>History of CAD and/or AF and/or VR was associated with mortality in ARDS. Prompt referral to cardiologists for comprehensive management post-ICU discharge may be warranted to optimize outcomes in this vulnerable population.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200318"},"PeriodicalIF":1.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000837/pdfft?md5=fae1bf66386575f1e714cb3701a1e3cb&pid=1-s2.0-S2772487524000837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for post-thrombotic syndrome after thrombolysis therapy for acute deep venous thrombosis of lower extremities","authors":"Yi Zheng ,&nbsp;Chunli Cao ,&nbsp;Gang Chen ,&nbsp;Siming Li ,&nbsp;Maolin Ye ,&nbsp;Liang Deng ,&nbsp;Qiyi Li","doi":"10.1016/j.ijcrp.2024.200319","DOIUrl":"10.1016/j.ijcrp.2024.200319","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of the research is to explore post-thrombotic syndrome (PTS) after catheter-directed thrombolysis (CDT) treatment for acute lower extremity deep vein thrombosis (DVT) risk factors.</p></div><div><h3>Methods</h3><p>We retrospectively selected 171 patients with acute lower extremity DVT undergoing CDT treatment, collected clinical data of the patients, grouped them according to the follow-up results of 1 year after treatment, and included patients with PTS into the concurrent group and patients who did not develop PTS assigned to the unconcurrent group. Univariate analysis and Logistic regression were applied to analyze the risk factors of PTS after catheterization and thrombolytic therapy for acute lower extremity DVT. We applied R4.2.3 software to build three hybrid machine-learning models, including a nomogram, decision tree, and random forest with independent influencing factors as predictive variables.</p></div><div><h3>Results</h3><p>The incidence of PTS after CDT in acute lower extremity DVT was 36.84 %. BMI &gt;24.33 kg/m², disease time &gt;7 d, mixed DVT, varicose vein history, stress treatment time&gt;6.5 months, and filter category were independent risk factors for PTS after CDT treatment for acute lower extremity DVT. The AUC value predicted by the random forest model was higher than that of the nomogram model (Z = -2.337, <em>P</em> = 0.019) and the decision tree model (Z = -2.995, <em>P</em> = 0.003).</p></div><div><h3>Conclusion</h3><p>The occurrence of PTS after CDT treatment of acute lower extremity DVT is closely related to many factors, and the established random forest model had the best effect in predicting PTS complicated with PTS.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200319"},"PeriodicalIF":1.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000849/pdfft?md5=b578f8fdb799a508db118ce407dd857a&pid=1-s2.0-S2772487524000849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in maternal cardiovascular parameters and their impact on uterine and fetal circulation in hypertensive pregnancies and fetal growth restriction","authors":"Tatjana Maseliene ,&nbsp;Guoda Zukiene ,&nbsp;Anna Laurinaviciene ,&nbsp;Dalia Breskuviene ,&nbsp;Diana Ramasauskaite ,&nbsp;Vilma Dzenkeviciute","doi":"10.1016/j.ijcrp.2024.200316","DOIUrl":"10.1016/j.ijcrp.2024.200316","url":null,"abstract":"<div><h3>Objective</h3><p>To examine potential alterations in maternal cardiovascular parameters in hypertensive pregnancies with or without fetal growth restriction (FGR) in comparison to uncomplicated normotensive pregnancies, and to determine the correlation between maternal cardiovascular parameters and changes in umbilical and uterine artery circulation.</p></div><div><h3>Materials and methods</h3><p>This study enrolled 73 pregnant women starting from the 20th week of gestation, categorized into three groups: hypertensive conditions (pregnancy-induced hypertension, preeclampsia or eclampsia, n = 30), hypertensive conditions with FGR (n = 8) and a control group of healthy normotensive pregnant women (n = 35). All participants underwent echocardiography to assess cardiac output and calculate peripheral vascular resistance. Additionally, fetal biometric measurements and Doppler ultrasound examinations of the uterine and umbilical artery were performed. The results were standardized into gestational age-adjusted <em>z</em>-scores.</p></div><div><h3>Results</h3><p>The mean pulsatility index (PI) of the uterine artery (1.36, p &lt; 0.001) and umbilical artery PI <em>z-</em>scores (1.32, p &lt; 0.001) showed significant increases in the hypertensive conditions + FGR group. Maternal cardiac output <em>z</em>-scores were notably lower in both the hypertensive + FGR group (−2.62, p = 0.001) and the hypertensive group (−2.49, p &lt; 0.001). Peripheral vascular resistance was significantly elevated in the hypertensive + FGR group (7.43, p &lt; 0.001) and the hypertensive group (6.06, p &lt; 0.001). There was a positive correlation between maternal peripheral vascular resistance and uterine artery PI (R² = 0.172; p = 0.0004), and a negative correlation between cardiac output and uterine artery PI (R² = 0.067; p = 0.031). However, significant correlation between maternal cardiovascular parameters and umbilical artery PI was not identified.</p></div><div><h3>Conclusions</h3><p>Maternal cardiac output exhibits a significant decrease whereas peripheral vascular resistance increases in hypertensive pregnancies, irrespective of the presence of FGR. Both uterine and umbilical artery PI notably increase when hypertensive pregnancies are accompanied by FGR. A positive correlation exists between maternal peripheral vascular resistance and uterine artery PI, as well as a negative correlation between maternal cardiac output and uterine artery PI. However, changes in maternal cardiovascular parameters do not exhibit significant correlations with umbilical artery PI.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200316"},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000813/pdfft?md5=92436ccb40828c45df5cdc70125a5ddf&pid=1-s2.0-S2772487524000813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent cardiovascular risks following pneumonia in inpatient and outpatient settings: A register-based cohort study","authors":"Xia Li ,&nbsp;Shuang Wang ,&nbsp;Keye Wu ,&nbsp;Chunbao Mo ,&nbsp;Furong Li ,&nbsp;Zhiyuan Cheng ,&nbsp;Fengchao Liang ,&nbsp;Jing Zheng ,&nbsp;Dongfeng Gu","doi":"10.1016/j.ijcrp.2024.200317","DOIUrl":"10.1016/j.ijcrp.2024.200317","url":null,"abstract":"<div><h3>Background</h3><p>The elevated long-term cardiovascular disease (CVD) risks associated with pneumonia have been observed among inpatients, yet the risks associated with outpatients are less understood.</p></div><div><h3>Methods</h3><p>We used register-based data and a matched cohort design, including 98,354 pneumonia inpatients and 44,486 outpatients, as well as a 5-fold number of matched healthy controls. Associations between pneumonia presentation (in inpatient and outpatient settings) and long-term CVD risks were measured by rate difference and hazard ratio (HR) using Poisson and Cox regressions in a time-dependent manner.</p></div><div><h3>Results</h3><p>During a maximum follow-up period of 5.7 years of ischemic heart disease (IHD), heart failure (HF), and stroke were documented among pneumonia inpatients.</p><p>Relative to healthy controls, pneumonia patients showed increased risks of IHD, HF, and stroke. Women and young inpatients demonstrated stronger associations of CVD with pneumonia; inpatients aged 60 years or older showed the highest excessive CVD risks.</p></div><div><h3>Conclusions</h3><p>Pneumonia demanding outpatient and inpatient cares are intermediate-term and long-term risk factors of incident CVDs respectively, underscoring the need to plan setting-specific and time-dependent CVD-preventive cares following pneumonia presentation.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200317"},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000825/pdfft?md5=3b269598e316eaf26506353015389b30&pid=1-s2.0-S2772487524000825-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141954044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced predictive performance of the GRACE risk score by incorporating lipoprotein(a) for major adverse cardiac events in acute myocardial infarction patients undergoing PCI","authors":"Xuelin Cheng ,&nbsp;Ming Liu ,&nbsp;Qizhe Wang ,&nbsp;Yaxin Xu ,&nbsp;Ru Liu ,&nbsp;Xiaopan Li ,&nbsp;Hong Jiang ,&nbsp;Sunfang Jiang","doi":"10.1016/j.ijcrp.2024.200315","DOIUrl":"10.1016/j.ijcrp.2024.200315","url":null,"abstract":"<div><h3>Background</h3><p>As scientific research advances, the landscape of detection indicators and methodologies evolves continuously. Our current study aimed to identify some novel perioperative indicators that can enhance the predictive accuracy of the Global Registry of Acute Coronary Events (GRACE) score for the in-hospital major adverse cardiovascular events (MACEs) in patients with acute myocardial infarction.</p></div><div><h3>Methods</h3><p>A total of 647 adult patients with AMI admitted to the emergency department were consecutively enrolled in the retrospective research starting from June 2016 to September 2019. The endpoint was in-hospital MACE. Stepwise regression analysis and multivariate logistic regression were performed to select the indicators for the union model established by nomogram. Bootstrap with 1000 replicates was chosen as the internal validation of the union model. The area under the receiver operating curve (AUC) and calibration plot were used to evaluate the discrimination and calibration. Decision curve analysis (DCA) was performed to evaluate the clinical sufficiency of the nomogram. Akaike's information criterion (AIC) and Bayesian Information Criterion (BIC) were used to evaluate the goodness of fit.</p></div><div><h3>Results</h3><p>Lipoprotein(a) combined with serum uric acid, fasting blood glucose, and hemoglobin could improve the GRACE risk score. The AUC of the union model was 0.86, which indicated a better discriminative ability than the GRACE risk score alone (AUC, 0.81; <em>P</em> &lt; 0.05). The calibration plots of the union model showed favorable consistency between the prediction of the model and actual observations, which was better than the GRACE risk score. DCA plots suggested that the union model had better clinical applicability than the GRACE risk score.</p></div><div><h3>Conclusion</h3><p>Lipoprotein(a) has shown promise in augmenting the predictive capability of the GRACE risk score, however, it may be beneficial to integrate it with other commonly used indicators.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200315"},"PeriodicalIF":1.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000801/pdfft?md5=058b68efe11240c05148dd6a70e23d9c&pid=1-s2.0-S2772487524000801-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141954674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health literacy in patients participating in cardiac rehabilitation: A prospective cohort study with pre-post-test design","authors":"Pernille Lunde ,&nbsp;Jostein Grimsmo ,&nbsp;Birgitta Blakstad Nilsson ,&nbsp;Asta Bye ,&nbsp;Hanne Søberg Finbråten","doi":"10.1016/j.ijcrp.2024.200314","DOIUrl":"10.1016/j.ijcrp.2024.200314","url":null,"abstract":"<div><h3>Background and aims</h3><p>Adherence to recommendations regarding medical treatment and healthy behaviour serve as a significant challenge for patients experiencing a cardiac event. Optimizing the patients’ health literacy (HL) may be crucial to meet this challenge and has gained increased focus the last decade. Despite cardiac rehabilitation (CR) being a central part of the treatment of patients experiencing a cardiac event, such programs have not been evaluated regarding HL. Therefore, the aim of this study was to describe and evaluate HL in patients participating in CR.</p></div><div><h3>Methods</h3><p>A prospective cohort study with pre-post-test design of patients participating in CR. Data were collected at program admission and completion (August 2017–June 2018). Patients from three different CR-programs were included. Descriptive and inferential statistics were applied to describe and evaluate HL and change in HL across categories of demographical variables and type of rehabilitation.</p></div><div><h3>Results</h3><p>In total, 113 patients attending CR were included. A statistically significant increase in HL was observed from pre-to post-CR (mean change: 2.24 ± 3.68 (<em>p</em> &lt; 0.001)). Patients attending 12-weeks outpatients CR-program had statistically significant higher HL, both at pre- and post-CR, compared to those attending one-week residential CR.</p></div><div><h3>Conclusions</h3><p>Participation in CR statistically significantly improves HL. Overall, judging health information was found as the most difficult aspect of HL, both at pre- and post-CR. This should be emphasized in secondary prevention to overcome barriers related to adherence to medical treatment and healthy behaviour.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200314"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000795/pdfft?md5=ed0bfd167ee1e3f7773eeb8f0d24ab77&pid=1-s2.0-S2772487524000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interesting case series of ticagrelor induced long QTc","authors":"Alireza Farzaei ,&nbsp;Entezar Mehrabi Nasab ,&nbsp;Yaser Jenab ,&nbsp;Alireza Amirzadegan ,&nbsp;Alireza Khodayari Javazm ,&nbsp;Mokhtar Eisvand ,&nbsp;Fateme Hajzeinolabedini ,&nbsp;Ali Bozorgi","doi":"10.1016/j.ijcrp.2024.200311","DOIUrl":"10.1016/j.ijcrp.2024.200311","url":null,"abstract":"<div><p>This case series explores three patients who underwent percutaneous coronary intervention (PCI) and experienced prolonged QT intervals under treatment with Ticagrelor. The first case was a female who presented with chest pain and received a Xience stent. The second case involved a male patient who received two Xience stents. The third case was that of a male patient with LAD stenosis. All three patients received Ticagrelor and exhibited prolonged QTc intervals on their electrocardiograms (ECGs), which was resolved after switching to Clopidogrel. Thus far, the potential impact of Ticagrelor on QT prolongation has not been adequately addressed in the literature. It is hypothesized that Ticagrelor can block adenosine uptake by red blood cells, which may explain QTc prolongation. The results of this case series indicate that Ticagrelor may prolong QTc intervals. Consequently, it is imperative that clinicians are aware of this previously unlisted side effect and that patients are closely monitored while seeking alternative medications to manage the condition.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200311"},"PeriodicalIF":1.9,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400076X/pdfft?md5=bb2b5e1efee2d6a54ca806a446ea1dc2&pid=1-s2.0-S277248752400076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of polypills in cardiovascular disease management: Benefits vs challenges","authors":"Yamaan Adil,&nbsp;Shanezehra Siddiqui","doi":"10.1016/j.ijcrp.2024.200313","DOIUrl":"10.1016/j.ijcrp.2024.200313","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200313"},"PeriodicalIF":1.9,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000783/pdfft?md5=8c09cc71982f7fa6735ed6b8167b09b4&pid=1-s2.0-S2772487524000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of stress hormones and the risk of cardiovascular diseases systematic review and meta-analysis","authors":"Szu-Ying Tsai ,&nbsp;Jui-Yun Hsu ,&nbsp;Ching-Huang Lin ,&nbsp;Yen-Chun Kuo ,&nbsp;Chi-Han Chen ,&nbsp;Hsing-Yuan Chen ,&nbsp;Shu-Jung Liu ,&nbsp;Kuo-Liong Chien","doi":"10.1016/j.ijcrp.2024.200305","DOIUrl":"10.1016/j.ijcrp.2024.200305","url":null,"abstract":"<div><h3>Background</h3><p>The roles of endogenous stress hormones (norepinephrine, epinephrine, and cortisol) in cardiovascular diseases have been discussed. However, the higher versus lower level of stress hormones in relation to cardiovascular risks remained uncertain.</p></div><div><h3>Methods</h3><p>We searched databases from their inception to 31, March 2023. We conducted a meta-analysis to estimate the effect of higher to lower level of stress hormones with random effect model. Subgroup and meta-regression analysis were done to clarify the heterogeneity.</p></div><div><h3>Results</h3><p>In total, 33 studies involving 43641 participants were included. With regard to cardiovascular disease risks, a higher risk for individuals with higher level of all stress hormones (risk ratio (RR), 1.63; 95 % Confidence intervals (CIs): 1.36, 1.97) was noted compared with lower level of all stress hormones. The meta-regression showed that as the follow-up year increased per year, the impact of higher level of all stress hormones on the risk of cardiovascular disease declined significantly (RR, −0.09; 95 % CIs: 0.15, −0.03, p = 0.006). A significantly higher risk of cardiovascular diseases for individuals with higher level of norepinephrine (RR, 1.68; 95 % CIs: 1.37, 2.06), with higher level of epinephrine (RR, 1.58; 95 % CIs: 1.10, 2.26), and with higher level of cortisol (RR, 1.60; 95 % CIs: 1.04, 2.26) were noted compared with a lower level of each stress hormone.</p></div><div><h3>Conclusion</h3><p>Higher levels of stress hormones were significantly associated with higher risks of cardiovascular diseases compared with lower levels of stress hormones.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200305"},"PeriodicalIF":1.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000709/pdfft?md5=248a134c730ba9ff34f11283f5a5d3d0&pid=1-s2.0-S2772487524000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative impact of components of high residual risk on the long-term prognosis after AMI","authors":"Gian Francesco Mureddu ,&nbsp;Paola D'Errigo ,&nbsp;Stefano Rosato ,&nbsp;Pompilio Faggiano ,&nbsp;Gabriella Badoni ,&nbsp;Roberto Ceravolo ,&nbsp;Vito Altamura ,&nbsp;Mirko Di Martino ,&nbsp;Marco Ambrosetti ,&nbsp;Fabrizio Oliva ,&nbsp;Paola Ciccarelli ,&nbsp;Giovanni Baglio","doi":"10.1016/j.ijcrp.2024.200310","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200310","url":null,"abstract":"<div><h3>Background</h3><p>The reduction in long-term mortality after acute myocardial infarction (AMI) is less pronounced than that of in-hospital mortality among patients with AMI complicated by heart failure (HF) and/or in those with a high residual thrombotic risk (HTR).</p></div><div><h3>Aim</h3><p>To investigate the relative prognostic significance of HTR and HF in AMI survivors.</p></div><div><h3>Methods</h3><p>This retrospective cohort study enrolled patients admitted for AMI in 2014–2015 in all Italian hospitals. HTR was defined as at least one of the following conditions: previous AMI, ischemic stroke or other vascular disease, type 2 diabetes, renal failure. Patients were classified into four categories: uncomplicated AMI; AMI with HTR; AMI with HF and AMI with both HTR and HF (HTR + HF). Cox proportional hazard model was used to evaluate the impact of HTR, HF and HTR + HF on the 5-year prognosis. A time-varying coefficient analysis was performed to estimate the 5-year trend of HR for major averse cardiac and cerebrovascular events (MACCE).</p></div><div><h3>Results</h3><p>a total of 174.869 AMI events were identified. The adjusted 5-year HR for MACCE was 1.74 (p &lt; 0.0001) and 1.75 (p &lt; 0.0001) in HTR and HF patients vs uncomplicated patients, respectively. The coexistence of HTR and HF furtherly increased the risk of MACCE (HR = 2.43, p &lt; 0.0001) over the first 3 years after AMI.</p></div><div><h3>Conclusion</h3><p>Either HRT and HF confer an increased 5-year hazard of MACCE after AMI. The coexistence of HTR and HF doubled the overall 5-year risk of MACCE after AMI.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200310"},"PeriodicalIF":1.9,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000758/pdfft?md5=631ba80830f06f4b9b7beffcfd155973&pid=1-s2.0-S2772487524000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}