Ahlam Safdar Hussain , Sumantra Kumar De , Griff Chatwin , Maryam Shahzad , Eeshal Zulfiqar , Vaisnavy Govindasamy , Megha Goel , Muhammad Muneeb Arshad , Mohib Naseer , Syed Rizwan Bokhari , Muhammad Atif Rauf , Sundas Hasan , Mushood Ahmed , Raheel Ahmed
{"title":"Regional and demographic variations in diabetes mellitus and myocardial infarction mortality among US adults: A retrospective observational analysis from 1999 to 2023","authors":"Ahlam Safdar Hussain , Sumantra Kumar De , Griff Chatwin , Maryam Shahzad , Eeshal Zulfiqar , Vaisnavy Govindasamy , Megha Goel , Muhammad Muneeb Arshad , Mohib Naseer , Syed Rizwan Bokhari , Muhammad Atif Rauf , Sundas Hasan , Mushood Ahmed , Raheel Ahmed","doi":"10.1016/j.ijcrp.2025.200456","DOIUrl":"10.1016/j.ijcrp.2025.200456","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with diabetes mellitus (DM) are at an increased risk of having myocardial infarction (MI). We aim to identify the trends in the mortality rates from DM and MI among US adults stratified by demographic and geographical parameters.</div></div><div><h3>Methods</h3><div>The CDC-WONDER database was used to extract death certificate data for adults aged ≥25 years. Crude mortality rates (CMR) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated, and temporal trends were identified by calculating annual percent change (APC) using JoinPoint regression analysis.</div></div><div><h3>Results</h3><div>From 1999 to 2023, a total of 712,921 DM and MI-related deaths were reported among adults in the United States. The AAMR significantly declined from 18.99 in 1999 to 10.20 in 2018 Following this, the AAMR rose to 12.27 in 2021, with an APC of 7.2 (95 % CI: 4.7 to 8.9). This was followed by a decline in AAMR to the pre-pandemic levels (AAMR: 9.6 in 2023). The AAMR for males was considerably higher compared to women throughout the study period (16.5 vs. 10.2). Non-Hispanic Black or African American people had the highest AAMR (19.5), followed by Hispanic or Latino people (15.3), NH white people (12.5), and NH other populations (11.2). Southern region and rural areas experienced higher mortality rates compared to urban areas.</div></div><div><h3>Conclusion</h3><div>We observed decreasing trends in DM and myocardial infarction-related deaths throughout the study period, however, a surge was noted during the COVID-19 pandemic. Mortality is higher among men, NH black populations, and rural areas.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200456"},"PeriodicalIF":1.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association between sugars sweetened beverages and glycemic profile among children and youth: A systematic review and dose-response meta-analysis","authors":"Mahdieh Abbasalizad Farhangi , Zeinab Nikniaz , Seyedeh-Tarlan Mirzohreh , Leila Nikniaz","doi":"10.1016/j.ijcrp.2025.200453","DOIUrl":"10.1016/j.ijcrp.2025.200453","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to assess the effects of Sugar-Sweetened Beverages (SSBs) consumption on fasting serum insulin (FSI), fasting plasma glucose (FPG), and HOMA-IR levels among children.</div></div><div><h3>Methods</h3><div>Databases including PubMed/MEDLINE, Scopus, EMBASE, Cochrane Library, and Web of Science were searched up to March 2025. Observational studies reporting the connection of SSBs consumption with FPG, FSI, and HOMA-IR levels were included. STATA version 15 was used to analyze the data.</div></div><div><h3>Results</h3><div>11 studies with 22,713 subjects were included in this meta-analysis. Greater intake of SSBs was not significantly linked to higher fasting plasma glucose (WMD: 0.01; CI -0.04 –0.07; P = 0.63) and fasting serum insulin levels (WMD: 0.54; 95 % CI, −0.4, 1.49; P = 0.26). However, high SSBs consumption was significantly associated with a 0.21 increase in HOMA-IR in adolescents and children (WMD: 0.21; CI, 0.03–0.37; P = 0.02). In dose-response meta-analysis, no departure from linearity was detected between SSBs intake and changes in FPG, FSI, and HOMA-IR levels.</div></div><div><h3>Conclusions</h3><div>High SSBs intake was linked to increased HOMA-IR levels among adolescents and children. Further extensive prospective long-term interventions are suggested to confirm the detected associations.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200453"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Harnessing artificial intelligence for early prediction of cardiogenic shock and mortality in acute coronary syndrome patients","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200448","DOIUrl":"10.1016/j.ijcrp.2025.200448","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200448"},"PeriodicalIF":1.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zejun Yang , Yunting Liang , Liu He , Le Zhou , Xiaodong Peng , Yiwei Lai , Cong Yuan , Xiaoxia Liu , Ning Zhou , Weihua Zhang , Caihua Sang , Qian Tong , Xin Du , Jianzeng Dong , Changsheng Ma
{"title":"Walking as a viable alternative to moderate-to-vigorous physical activity for improving cardiovascular outcomes in coronary artery disease patients","authors":"Zejun Yang , Yunting Liang , Liu He , Le Zhou , Xiaodong Peng , Yiwei Lai , Cong Yuan , Xiaoxia Liu , Ning Zhou , Weihua Zhang , Caihua Sang , Qian Tong , Xin Du , Jianzeng Dong , Changsheng Ma","doi":"10.1016/j.ijcrp.2025.200452","DOIUrl":"10.1016/j.ijcrp.2025.200452","url":null,"abstract":"<div><h3>Background</h3><div>Home-based cardiac rehabilitation is recommended for coronary artery disease (CAD) patients, while exercise is the most important component. There is lack of evidence on whether walking alone can improve cardiovascular prognosis in CAD patients, particularly those unable to tolerate moderate-to-vigorous physical activity (MVPA).</div></div><div><h3>Methods</h3><div>Participants with diagnosed CAD from the UK Biobank with baseline PA assessment were included. PA data, including total PA, MVPA, and walking, were collected using the International Physical Activity Questionnaire, and expressed as the total metabolic equivalent of tasks minutes per week. We accessed the association between PA and cardiovascular composite outcome (cardiac death, heart failure hospitalization, non-fatal myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting) and all-cause mortality.</div></div><div><h3>Result</h3><div>Over a median follow-up of 13.5 years, incidence of all-cause mortality (21.6, 16.7, 15.9, 15.6 per 1000 person-years) and cardiovascular composite events (20.6, 17.8, 17.8, 17.2 per 1000 person-years) decreased with increasing time of total PA in 19,074 patients. Notably, for patients who did not meet AHA/ESC/WHO recommendations, achieving an adequate amount of walking (100 min/week) reduced risk of cardiovascular composite outcome (HR = 0.84, 95 %CI [0.71–0.99], p = 0.038) and all-cause mortality (HR = 0.84, 95 %CI [0.77–0.91], p < 0.001). In patients with lower levels of PA, replacing 30 min per day of sedentary behavior with walking or MVPA reduced all-cause mortality risk.</div></div><div><h3>Conclusion</h3><div>In this large cohort, prolonged exercise duration, including total PA, MVPA and walking, may reduce the cardiovascular risks for CAD patients. For patients unable to tolerate MVPA, walking may serve as a suitable alternative.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200452"},"PeriodicalIF":1.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Agam , David Vadsholt , Kristian Kragholm , Lauge Klement Moltke Østergaard , Peter Bisgaard Stæhr , Gitte Nielsen , Henrik Vadmann
{"title":"Association between cardiac rehabilitation and LDL-levels, adherence to guideline-recommended medication and mortality rate after myocardial infarction","authors":"Ahmad Agam , David Vadsholt , Kristian Kragholm , Lauge Klement Moltke Østergaard , Peter Bisgaard Stæhr , Gitte Nielsen , Henrik Vadmann","doi":"10.1016/j.ijcrp.2025.200444","DOIUrl":"10.1016/j.ijcrp.2025.200444","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to identify three-month and one year mortality rate, LDL level and adherence to guideline-recommended medication in patients with myocardial infarct (MI) receiving cardiac rehabilitation (CR) compared to patients who do not.</div></div><div><h3>Method</h3><div>In this retrospective study, patients hospitalized in North Denmark Regional Hospital in Hjoerring (capture population 200.000) with acute coronary syndrome between January 1st, 2017, to December 31st, 2021, were included. Baseline characteristics, initial treatment of revascularization and all-cause mortality were examined through the Danish National Patient Registry, the Regional Cardiac Rehabilitation Database, and medical chart review. Patients were grouped by revascularization (yes/no) during hospitalization and CR. Adjusted Cox proportional regression model was used to assess differences in mortality and LDL levels.</div></div><div><h3>Results</h3><div>A total of 1209 myocardial infarction (MI) survivors were included in this study. A total of 1209 myocardial infarction (MI) survivors were included. Significant LDL reductions at 6- and 12-month follow-ups were observed in patients receiving both cardiac rehabilitation (CR) and lipid-modifying therapy at baseline (p = .001), but not in those without CR. In revascularized patients, use of multiple antithrombotic agents was lower in the no CR group at three months (57.1 % vs 78.8 %, p = .002) and one year (60 % vs 78.5 %, p = .010). Three-month mortality rate was higher among patients who did not undergo CR, both in the revascularization group (19 % vs 2 %, p = 0.001) and the non-revascularization group (18 % vs 3 %, p = 0.001).</div></div><div><h3>Conclusion</h3><div>Patients undergoing CR were associated with lower LDL-levels, higher adherence to guideline-recommended medication and lower mortality rate at three-month follow-up.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200444"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From popularity to peril? Evaluating cardiovascular risks of low-carbohydrate high-fat diets across diverse populations","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200447","DOIUrl":"10.1016/j.ijcrp.2025.200447","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200447"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pernille Lunde , Hanne Søberg Finbråten , Are Hugo Pripp , Birgitta Blakstad Nilsson , Jostein Grimsmo , Asta Bye
{"title":"Effect of a mHealth intervention on health literacy in patients completing cardiac rehabilitation: A randomized controlled trial with one- and five-year follow-up","authors":"Pernille Lunde , Hanne Søberg Finbråten , Are Hugo Pripp , Birgitta Blakstad Nilsson , Jostein Grimsmo , Asta Bye","doi":"10.1016/j.ijcrp.2025.200445","DOIUrl":"10.1016/j.ijcrp.2025.200445","url":null,"abstract":"<div><h3>Background and aims</h3><div>Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve both treatment adherence and HL. This study aimed to examine the effect of a one-year mHealth intervention on HL and to compare HL changes between the intervention- and the control group.</div></div><div><h3>Methods</h3><div>This randomized controlled trial included patients completing cardiac rehabilitation, who were randomly allocated to either an intervention group receiving individualized follow-up via an app for one year or a control group receiving usual care. From one-year follow-up to the five-year follow-up, both groups received usual care. HL was measured using the HLS-Q12. Mixed model for repeated measurements and Wilcoxon signed rank test were used to analyse differences between groups, while paired sample <em>t</em>-test and Kendall's Tau b correlation analysed within-group changes.</div></div><div><h3>Results</h3><div>A total of 113 patients were included in the study. No statistically significant differences between the groups were found in total HLS-Q12 score or at item level at any follow-up. However, a statistically significant within-group improvement was observed in the intervention group for the total score (mean change of 2.5 ± 4.6, p < 0.01) and several HLS-Q12 items from baseline to one-year follow-up.</div></div><div><h3>Conclusions</h3><div>The one-year mHealth intervention did not show an effect on HL levels at one- or five-year follow-ups. However, significant within-group HL improvement from baseline to one-year follow-up suggests that mHealth interventions may have the potential to enhance HL.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200445"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between asthma and cardiovascular disease among a United States representative population","authors":"Humza Naqvi , Charles D. Searles","doi":"10.1016/j.ijcrp.2025.200451","DOIUrl":"10.1016/j.ijcrp.2025.200451","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200451"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The hidden burden: Inflammatory bowel disease and cardiovascular mortality in underreported populations","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200449","DOIUrl":"10.1016/j.ijcrp.2025.200449","url":null,"abstract":"<div><div>Recent data from the United States reveal a rising trend in mortality linked to inflammatory bowel disease (IBD) and cardiovascular disease (CVD), with pronounced disparities across age, sex, race, and geography. This commentary reappropriates those findings within the context of the Philippines and other low- and middle-income countries (LMICs), where chronic inflammation remains underdiagnosed and health systems are ill-equipped to address its cardiovascular consequences. While CVD is already the leading cause of death in the Philippines, the compounding effects of inflammatory disorders like IBD are largely overlooked. Drawing parallels from U.S. patterns, we highlight how rural-urban divides, healthcare inaccessibility, and poor disease surveillance may fuel similar trends in LMICs. We call for integrated screening strategies, improved chronic disease registries, and cross-disciplinary approaches that recognize inflammation as a key driver of cardiovascular risk. The global burden of cardiovascular disease cannot be fully addressed without confronting the silent role of systemic inflammation.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200449"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}