International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Patterns in mortality associated with heart failure and lung cancer among older adults in the United States: An analysis of 20 years","authors":"Abdul Ahad ,&nbsp;Eeshal Fatima ,&nbsp;Wania Sultan ,&nbsp;Muhammad Haleem Nasar ,&nbsp;Adeena Jamil ,&nbsp;Muteia Shakoor ,&nbsp;Irfan Ullah ,&nbsp;M Chadi Alraies ,&nbsp;Naeif Almagal","doi":"10.1016/j.ijcrp.2024.200353","DOIUrl":"10.1016/j.ijcrp.2024.200353","url":null,"abstract":"<div><h3>Background</h3><div>Despite an established association between heart failure (HF) and lung cancer (LC), there is limited evidence available regarding mortality patterns among the older (≥65 years) population in the United States.</div></div><div><h3>Methods</h3><div>The mortality data, spanning 1999 to 2019, was surveyed using the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database with HF and LC identified as underlying or contributing causes of death. Crude and age-adjusted mortality rates (AAMR) were calculated per 100,000 individuals. Joinpoint regression was applied to establish annual percent changes (APCs) for the trends in years, demographics (sex, race), and geographical regions.</div></div><div><h3>Results</h3><div>Between 1999 and 2019, the overall AAMR slightly decreased from 13.0 to 11.4. However, the AAMRs significantly increased (APC: 6.37; 95 % CI: 3.39 to 8.23) from 2017 to 2019. Males had double the AAMRs compared to females (overall AAMR: 15.7 vs. 8.0), yet both sexes experienced a final incline in death rates. Among the distinct racial and ethnic groups, non-Hispanic (NH) Whites (11.9) and NH Black/African Americans (10.9) portrayed the highest AAMRs. Patients most commonly died in medical facilities (41.03 %). Geographical disparities were evident with higher AAMRs in non-metropolitan areas (14.3) and the Midwest (12.7). States with the highest fatality involved West Virginia, Oklahoma, Kentucky, Mississippi, and Arkansas.</div></div><div><h3>Conclusion</h3><div>The abrupt rise in overall mortality rates for HF and LC from 2017 to 2019 is noteworthy. A focused analysis of demographic and geographic disparities is warranted to address this emerging trend.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200353"},"PeriodicalIF":1.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatic heart disease burden and determinants in cardiac patients: A follow up care concern in Ethiopia","authors":"Hiwot Berhanu ,&nbsp;Elsah Tegene ,&nbsp;Morankar Sudhakar ,&nbsp;Tadesse Dukessa Gemechu ,&nbsp;Andualem Mossie","doi":"10.1016/j.ijcrp.2024.200352","DOIUrl":"10.1016/j.ijcrp.2024.200352","url":null,"abstract":"<div><div>Rheumatic heart disease (RHD) is a neglected tropical disease and remains one of the leading causes of cardiovascular-related deaths in Ethiopia. This study aims to assess the burden of RHD and identify its determinants in the country. A hospital-based cross-sectional study was employed from January 5 to April 15, 2023, among cardiac patients attending Jimma Medical Center. Socio-demographic data were collected using a structured interviewer-administered questionnaire and echocardiographic patterns were taken by senior cardiologists. Data were entered into Epidata Version 4.6 and exported to SPSS version 25.0 for analysis. Bivariable and multivariable logistic regressions were performed. A p value &lt; 0.05 was considered statistically significant. Accordingly, the most frequent morbidities were RHD (n = 95, 27.9 %), hypertensive heart disease (n = 92, 27.1 %), ischemic heart disease (n = 54, 15.9 %), and dilated cardiomyopathies (n = 54, 15.9 %). Further, female sex [AOR = 3.06: 95 % CI 1.73–5.47], using wood (biomass fuel) for cooking [AOR = 1.94: 95 % CI 1.10–3.42], history of malnutrition with follow-up at a health facility [AOR = 3.90: 95 % CI 2.22–6.86], dental caries [AOR = 2.09: 95 % CI 1.12–3.87], and living in crowded households [AOR = 2.02: 95 % CI 1.15–3.52] were identified as the determinants of RHD. This finding suggests that focusing on female healthcare, reducing biomass fuel exposure, improving nutritional status, providing regular dental care, and improving living conditions could help reduce the impacts of the disease. Moreover, conducting further research regularly will also benefit the community at large.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200352"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort","authors":"Carlos Iribarren ,&nbsp;Meng Lu ,&nbsp;Martha Gulati ,&nbsp;Nathan D. Wong ,&nbsp;Roberto Elosua ,&nbsp;Jamal S. Rana","doi":"10.1016/j.ijcrp.2024.200350","DOIUrl":"10.1016/j.ijcrp.2024.200350","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of this study was to examine the interplay of polygenic risk and individual lifestyle factors (and a composite score of lifestyle) as antecedents of CHD in a large multiethnic cohort.</div></div><div><h3>Methods</h3><div>We used <u>G</u>enetic <u>E</u>pidemiology <u>R</u>esource in Adult Health and <u>A</u>ging (GERA) cohort participants free of CHD at baseline (n = 60,568; 67 % female; 18 % non-European). The individual and joint associations of smoking, Mediterranean diet pattern, level of physical activity and polygenic risk with incident CHD were assessed using Cox regression adjusting for genetic ancestry and non-mediating risk factors. Hazard ratios (HRs) and number needed to treat (NNT) were estimated according to these lifestyle factors and polygenic risk categories. Strengths included large sample size, long-follow-up, ethnic diversity, a clinically-validated polygenic risk score (PRS), and rich phenotype information.</div></div><div><h3>Results</h3><div>After 14 years of follow-up, there were 3159 incident CHD events. We observed no statistically significant interactions between individual lifestyle factors and polygenic risk (all p &gt; 0.23). For individuals with a high genetic risk, moving from the worse lifestyle combination (no favorable lifestyle factors) to the best lifestyle combination (all three) is associated with 52 % lower rate of CHD. The NNT was highest in the low polygenic risk group (34), lowest in the high polygenic risk group [19] and in-between (Jin et al., 2011) [24] in the intermediate polygenic risk group.</div></div><div><h3>Conclusions</h3><div>Lifestyle and polygenic risk together influence the risk of incident CHD. Our results support consideration of polygenic risk in lifestyle interventions because those with high polygenic risk are likely to derive the most benefit.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200350"},"PeriodicalIF":1.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities and determinants of health on heart failure guideline-directed medical therapy adherence: All of us","authors":"Trinh Do ,&nbsp;Kyrillos Grace ,&nbsp;Dawn Lombardo ,&nbsp;Nathan D. Wong ,&nbsp;Andy Y. Lee","doi":"10.1016/j.ijcrp.2024.200351","DOIUrl":"10.1016/j.ijcrp.2024.200351","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) are challenging conditions to treat due to complex pathophysiology and associated comorbidities. However, recent trials have demonstrated improved outcomes with guideline-directed medical therapy (GDMT) for each subtype of heart failure.</div></div><div><h3>Objective</h3><div>We investigated the relationship of determinants of health and risk factors with GDMT use for HFrEF and HFpEF in a large, diverse US cohort.</div></div><div><h3>Methods</h3><div>Using the NIH-sponsored All of Us Program, we compared demographics, risk factors (e.g., hypertension, diabetes, smoking), and SDOH measures between HFrEF and HFpEF in US adults aged 18 years and older. We examined the proportions of HFrEF patients receiving fewer than four or all four GDMTs. HFpEF patients receiving two medications were compared with those receiving less than two recommended medications. Multiple logistic regression was used for data analysis.</div></div><div><h3>Result</h3><div>Of 6049 HFrEF patients, 5838 (97 %) received fewer than four GDMTs, and 210 (3 %) received quadruple therapy. Of 3774 HFpEF patients, 162 (4 %) were on 2/3 GDMT, and only 38 (1 %) were on all three recommended medications. Patients with ASCVD and diabetes had higher odds of being on more than half of the recommended GDMT for both HFrEF and HFpEF. Additionally, females had higher odds of being on 2/3 GDMT for HFpEF (1.46 [1.08, 2.00]). Race, income, education, and health insurance types did not predict GDMT optimization.</div></div><div><h3>Conclusion</h3><div>HFrEF and HFpEF GDMT remain underutilized. Future efforts to address comorbidities and system-wide healthcare interventions may improve heart failure GDMT.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200351"},"PeriodicalIF":1.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case detection of familial hypercholesterolemia using various criteria during an annual health examination in the workplace","authors":"Poranee Ganokroj ,&nbsp;Suwanna Muanpetch ,&nbsp;Nitt Hanprathet ,&nbsp;Wiroj Jiamjarasrangsi ,&nbsp;Weerapan Khovidhunkit","doi":"10.1016/j.ijcrp.2024.200349","DOIUrl":"10.1016/j.ijcrp.2024.200349","url":null,"abstract":"<div><h3>Background</h3><div>Early diagnosis and appropriate treatment of subjects with familial hypercholesterolemia (FH) could prevent cardiovascular disease (CAD).</div></div><div><h3>Objective</h3><div>We aimed to identify potential cases of FH during a workplace screening and to explore their clinical data.</div></div><div><h3>Method</h3><div>Personnel who attended an annual health examination were invited to answer a questionnaire and to provide consent to review their laboratory results. FH was clinically diagnosed using any one of the three standard criteria: Dutch Lipid Clinic Network (DLCN), Simon Broome (SB), and Make Early Diagnosis to Prevent Early Deaths (MEDPED). Clinical characteristics were compared between FH and unlikely FH subjects.</div></div><div><h3>Results</h3><div>Among 6607 participants, potential cases of FH were identified in 2.5 % by DLCN, 4.0 % by SB, and 0.8 % by MEDPED alone. Premature CAD, hypertension, and current smoking were significantly more common in potential FH subjects than in unlikely FH subjects. Potential FH subjects also had significantly higher body mass index, waist circumference, blood pressure, fasting plasma glucose and triglyceride levels than unlikely FH subjects. Among potential FH subjects, lipid-lowering medication was used in 28.4 %. The achievement of the LDL-C goal (&lt;100 mg/dL) in potential FH subjects was significantly lower than that in unlikely FH subjects (15 % vs. 28 %, respectively, P = 0.005) despite a higher rate of high-intensity statin use (25 % vs. 10 %, respectively, P = 0.002).</div></div><div><h3>Conclusion</h3><div>The workplace screening of FH detected a significant number of potential FH subjects with higher cardiovascular risk. This strategy identified individuals for whom intensification of both lifestyle modifications and pharmacological treatment should be a priority.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200349"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the timing of blood pressure medication really matter?","authors":"Yuan-Yuan Kang,&nbsp;Ji-Guang Wang","doi":"10.1016/j.ijcrp.2024.200348","DOIUrl":"10.1016/j.ijcrp.2024.200348","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200348"},"PeriodicalIF":1.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of glucose coefficient of variation for in-hospital mortality in acute myocardial infarction patients undergoing PCI: Insights from the MIMIC-IV database","authors":"Zixuan Zhang ,&nbsp;Mengmeng Ji ,&nbsp;Qingqing Zhao ,&nbsp;Luying Jiang ,&nbsp;Shilang Fan ,&nbsp;Houjuan Zuo","doi":"10.1016/j.ijcrp.2024.200347","DOIUrl":"10.1016/j.ijcrp.2024.200347","url":null,"abstract":"<div><h3>Background</h3><div>Acute myocardial infarction (AMI) carries a high short-term risk of death, even after percutaneous coronary intervention (PCI). Glucose variability (GV), measured by the glucose coefficient of variation (GluCV), is a potential risk factor for adverse outcomes. This study investigates GluCV's predictive value for in-hospital mortality in AMI patients undergoing PCI.</div></div><div><h3>Method</h3><div>This study involved 2325 AMI patients who were admitted to the ICU and underwent PCI from the MIMIC-IV database. Patients were categorized into quartiles based on GluCV: &lt;0.13, 0.13–0.20, 0.20–0.29, and ≥0.29. Multivariable logistic regression and Restricted cubic spline (RCS) analysis were employed to analyze the relationship between GluCV and in-hospital mortality. Mediation analysis was used to evaluate the role of GluCV in the relationship between disease complexity and severity.</div></div><div><h3>Results</h3><div>Among the 2325 patients, 203 (8.7 %) died during hospitalization. Higher GluCV was associated with increased in-hospital mortality. Adjusted odds ratios for mortality were 1.35 (95 % CI: 0.71–2.55), 1.91 (95 % CI: 1.04–3.51), and 3.32 (95 % CI: 1.83–6.02) for the second, third, and fourth groups, respectively. RCS analysis indicated a linear relationship between Log GluCV and mortality risk, with each 1 SD increase in Log GluCV associated with a 1.70-fold increase in mortality. Subgroup analysis showed a stronger relationship between GluCV and mortality in patients younger than 70. Mediation analysis indicated that GluCV partially mediates the effect of comorbidities on organ dysfunction.</div></div><div><h3>Conclusions</h3><div>GluCV is an important predictor of in-hospital mortality in AMI patients undergoing PCI. Managing GV to minimize fluctuations may improve patient prognosis.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200347"},"PeriodicalIF":1.9,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lifestyle risk factors on atrial fibrillation: Mechanisms and prevention approaches – A narrative review","authors":"Jasper R. Vermeer ,&nbsp;Johannes L.P.M. van den Broek ,&nbsp;Lukas R.C. Dekker","doi":"10.1016/j.ijcrp.2024.200344","DOIUrl":"10.1016/j.ijcrp.2024.200344","url":null,"abstract":"<div><div>Both the development and progression of atrial fibrillation (AF) are affected by a range of modifiable lifestyle risk factors. These key modifiable risk factors encompass obesity, hypertension, hypercholesterolemia, diabetes mellitus, smoking, chronic obstructive pulmonary disease, alcohol consumption, exercise, sedentary lifestyle and obstructive sleep apnoea. These lifestyle-dependent factors rarely exist in isolation, but rather exist together, exerting a complex influence on the development of AF. This comprehensive review elucidates the interplay and interdependency of these lifestyle factors in the arrhythmogenesis of AF, by exploring their role in AF substrate formation, modulating properties and triggering mechanisms. We emphasize the importance of targeted prevention strategies by discussing available literature on the effectiveness of treatment strategies targeting multiple risk factors. Additionally, the clinical impacts of integrated care, nurse-led care and mobile health are discussed in the context of lifestyle improvement. These management strategies have favourable applicability in both paroxysmal and persistent AF, and are also beneficial for patients receiving AF ablation. Despite the challenges accompanying lifestyle and prevention strategies, substantial benefits are apparent, such as improved quality of life and better ablation outcomes. This review further emphasizes the essential nature of awareness of appropriate lifestyle modifications as fundamental pillars in the management of individuals with AF.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200344"},"PeriodicalIF":1.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment optimisation for blood pressure with single-pill combinations in India (TOPSPIN) – Protocol design and baseline characteristics","authors":"Gaia Kiru ,&nbsp;Ambuj Roy ,&nbsp;Dimple Kondal ,&nbsp;Ambalam M. Chandrasekaran ,&nbsp;Somnath Mukherjee ,&nbsp;Bishav Mohan ,&nbsp;Kavita Singh ,&nbsp;Hyndavi Salwa ,&nbsp;Edmin Christa ,&nbsp;Ameeka Shereen Lobo ,&nbsp;Gayatri Mahajan ,&nbsp;Aman Khanna ,&nbsp;Amit Malviya ,&nbsp;Satish G. Patil ,&nbsp;Vinod K. Abichandani ,&nbsp;Bhupinder Singh ,&nbsp;Bal Kishan Gupta ,&nbsp;Balsubramaiam Yellapantula ,&nbsp;Dandge Shailendra ,&nbsp;Shantanu Sengupta ,&nbsp;Neil Poulter","doi":"10.1016/j.ijcrp.2024.200346","DOIUrl":"10.1016/j.ijcrp.2024.200346","url":null,"abstract":"<div><h3>Background</h3><div>The burden of over 300 million individuals living with hypertension in India is increasing steadily. Most current guidelines recommend initial combination therapy for effective blood pressure (BP) control. However, there is no randomised evidence to inform which combinations to use in the South Asian population, who account for over one-quarter of the world's population.</div></div><div><h3>Methods</h3><div>This multi-centre, single-blind, randomised, three-arm trial recruited men and women aged 30–79 years with hypertension. The trial compares the efficacy of commonly recommended single pill combinations (SPCs) of three drug classes – calcium channel blocker (amlodipine), ACE inhibitor (perindopril), and a thiazide-like diuretic (indapamide). The primary objective is to determine the most effective two-drug combination, initially at starting doses with forced up-titration at 2 months, in reducing 24-h ambulatory systolic blood pressure (ASBP) at 6 months. The trial has 85 % power to detect a difference of 3 mmHg in 24-h ASBP amongst the groups.</div><div>Participant recruitment took place from August 2022 to February 2024.</div></div><div><h3>Baseline results</h3><div>The 1981 participants (42.0 % women) enrolled had a mean age of 52.1 (SD 11.3) years and a mean body mass index of 26.5 (SD 4.2) kg/m2. 58.1 % of participants had a previous diagnosis of hypertension and 18.6 % of participants were known to diabetes. The mean ASBP was 135.6 (SD 17.0) mmHg, and the mean ambulatory diastolic BP was 84.5 (SD 10.9) mmHg.</div></div><div><h3>Conclusion</h3><div>The TOPSPIN trial is the first randomised evaluation of commonly used BP-lowering combination therapies in a South Asian population. The results have potentially significant implications for choosing first-line antihypertensive agents among Indians and the South Asian diaspora.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200346"},"PeriodicalIF":1.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003–2018 data","authors":"Qingping Zeng ,&nbsp;Mengqian Liao ,&nbsp;Yu Li ,&nbsp;Fei She ,&nbsp;Ping Zhang","doi":"10.1016/j.ijcrp.2024.200340","DOIUrl":"10.1016/j.ijcrp.2024.200340","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between dietary vitamin E intake and the risk of cardiovascular diseases, as well as cardiovascular and all-cause mortality, remains inconclusive. This study aimed to investigate these associations in a large, representative sample of the U.S. population.</div></div><div><h3>Methods</h3><div>We analyzed data from 39,293 participants in the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Dietary vitamin E intake was assessed using 24-h recall data. Outcomes included incident cardiovascular disease (CVD), CVD mortality, and all-cause mortality. We employed weighted logistic and Cox regression models, adjusting for potential confounders. Restricted cubic spline (RCS) analyses and were conducted to assess non-linear relationships.</div></div><div><h3>Results</h3><div>Compared to participants with a vitamin E intake of 4.08 mg or lower (lowest quartile), the multivariable-adjusted odds ratio for those with an intake of 9.86 mg or higher (highest quartile) was 0.57 (95 % CI, 0.50–0.64) for cardiovascular disease (P for trend &lt;0.01). The multivariable-adjusted hazard ratios for participants with a vitamin E intake of 9.86 mg or higher were 0.85 (95 % CI, 0.75–0.98) for all-cause mortality (P for trend = 0.04) and 0.96 (95 % CI, 0.76–1.21) for CVD mortality (P for trend &lt;0.001). RCS analyses revealed non-linear associations for most outcomes, including overall CVD, coronary heart disease, heart attack, stroke, and all-cause mortality (all P-nonlinear &lt;0.05).</div></div><div><h3>Conclusions</h3><div>In this large NHANES cohort, higher dietary intake of vitamin E was associated with reduced risks of cardiovascular disease and all-cause mortality. These findings suggest potential benefits of vitamin E-rich diets in cardiovascular health promotion and mortality reduction.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200340"},"PeriodicalIF":1.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11715117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}