International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"The multifaceted significance of miR-155 in cardiovascular pathologies: Diagnostic and therapeutic implications","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200395","DOIUrl":"10.1016/j.ijcrp.2025.200395","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200395"},"PeriodicalIF":1.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study","authors":"Xiaoying He ,&nbsp;Jingyi Xiao ,&nbsp;Yan Wang ,&nbsp;Christopher Reid ,&nbsp;Dan Xu ,&nbsp;Hua Hong","doi":"10.1016/j.ijcrp.2025.200394","DOIUrl":"10.1016/j.ijcrp.2025.200394","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between dyslipidemia and cerebral atrophy in Chinese health check-up population.</div></div><div><h3>Methods</h3><div>67,526 participants underwent routine health check-ups at the health management center of the First Affiliated Hospital of Sun Yat-Sen University (FAH-SYSU) in Guangzhou for two years (2022-2023) in this cross-sectional study. Cerebral atrophy was determined by expert physicians based on non-contrast scans of Head Magnetic Resonance Imaging (MRI), Magnetic Resonance Angiography (MRA) and/or Head Computed Tomography (CT). The levels of Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured and classified by quartiles into four categories, respectively. The multivariable logistic regression model was used to obtain the odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 1,661 participants were included with ages from 18 to 93 years. Among 1,661 participants, 121 (7.28%) had cerebral atrophy. On multivariate analysis, TC and LDL-C were not associated with cerebral atrophy, although TC and LDL-C were lower in the subgroup with cerebral atrophy.</div></div><div><h3>Conclusions</h3><div>This cross-sectional study conducted in China is the first to identify that health check-up examinees with cerebral atrophy had lower levels of TC and LDL-C raising the possible association between lower levels of TC and LDL-C with cerebral atrophy, and possible cognitive dysfunction. Future study is planned to overcome the existing limitation and address the lack of statistically significant association between TC and LDL-C levels with cerebral atrophy and possible dementia.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200394"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low carbohydrate high fat-diet in real life; A descriptive analysis of cardiovascular risk factors","authors":"Henrik Hagström ,&nbsp;Linda Nyström Hagfors ,&nbsp;Rikard Hedelin ,&nbsp;Mattias Brunström ,&nbsp;Krister Lindmark","doi":"10.1016/j.ijcrp.2025.200384","DOIUrl":"10.1016/j.ijcrp.2025.200384","url":null,"abstract":"<div><h3>Aims</h3><div>Low Carbohydrate High Fat (LCHF) diets are popular for weight loss or glucose control. The main source of energy in such diets is fat but the composition of nutrients varies This study aims to investigate dietary variations in a real-world LCHF population and its associations with cardiovascular risk factors.</div></div><div><h3>Methods</h3><div>We recruited 100 volunteers who considered themselves adherent to a LCHF diet. Their last 14 days of dietary intake was assessed using diet history interviews. Validation of energy intake against expenditure was made using activity monitors. Predictive variables for the linear regression models were selected using stepwise bidirectional assessment of Akaike information criterion (AIC).</div></div><div><h3>Results</h3><div>Energy intake (E%) from carbohydrates was low, 8.7 E%, and fat was the main replacement. Dietary cholesterol was associated with higher total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Dietary sodium intake was associated with higher blood pressure. Protein intake was associated with lower diastolic blood pressure but also with lower HDL. The intake of dietary fibre was associated with lower LDL and total cholesterol but with higher hemoglobin A1c (HbA1c). The intake of carbohydrates and saturated fatty acids (SFA) was not associated with any of the outcome variables.</div></div><div><h3>Conclusion</h3><div>In this LCHF population, variations in intake of carbohydrates and saturated fatty acids could not predict any aspects of the cardiovascular risk profile. Lower fibre intake and higher cholesterol and sodium intake predicted a less favorable cardiovascular risk profile.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200384"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in the prevalence of circulatory disease risk factors among U.S. adults from the National Health Interview Survey database (2019–2022)","authors":"Farah Yasmin ,&nbsp;Abdul Moeed ,&nbsp;Hafsah Alim Ur Rahman ,&nbsp;Muhammad Ahmed Ali Fahim ,&nbsp;Afia Salman ,&nbsp;Maryam Shaharyar ,&nbsp;Rohan Kumar Ochani ,&nbsp;Afsana Ansari Shaik ,&nbsp;Muhammad Sohaib Asghar ,&nbsp;M. Chadi Alraies","doi":"10.1016/j.ijcrp.2025.200393","DOIUrl":"10.1016/j.ijcrp.2025.200393","url":null,"abstract":"<div><h3>Introduction</h3><div>Circulatory diseases are the leading cause of mortality in the United States (U.S)., making it crucial to understand trends and disparities in the prevalence of cardiovascular risk factors including diabetes, obesity, smoking, and hyperlipidemia.</div></div><div><h3>Methods</h3><div>Data from the Centers for Disease Control and Prevention (CDC)'s National Health Interview Survey (NHIS) database was analyzed for adults aged 18 and older from 2019 to 2022. Prevalence percentages and Annual Percentage Changes (APCs) were calculated using regression analysis with Joinpoint, with 95 % confidence intervals (CI). The data was stratified by year, gender, age, race, nativity, veteran status, social vulnerability, employment status, and geographic distribution.</div></div><div><h3>Results</h3><div>Among circulatory disease risk factors, obesity had the highest prevalence remaining consistent across all years. The highest obesity rates were observed amongst females, those aged 45–64, and Black or African American adults, with regional peaks in the South and Midwest. High Cholesterol, the second most prevalent risk factor, rose significantly from 20.1 % to 22 % [APC: 3.3175∗ (95 % CI: 1.1417 to 5.5416)] with males [APC: 3.3175∗ (95 % CI: 1.1417 to 5.5416)] and females [APC: 3.1315∗ (95 % CI: 3.0191 to 3.2428)] both showing significant increases over time. Furthermore, those aged &gt;65 yrs and White adults in addition to those residing in the Northeast and South revealed the highest rates. Smoking rates remained steady, with a higher male prevalence which showed a significant decrease [APC: −5.0336∗ (95 % CI: −9.156 to −0.6731)] over time. Diabetes prevalence was stable, with males, adults aged 64 and above, American Indians and Black or African American adults and those residing in the southern region consistently showing the highest rates of incidence.</div></div><div><h3>Conclusion</h3><div>Significant disparities and increasing trends in risk factors for circulatory diseases have been identified, highlighting the need for targeted interventions, particularly for high-risk groups such as males, older adults, veterans, and the unemployed.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200393"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020","authors":"Muzamil Akhtar ,&nbsp;Hanzala Ahmed Farooqi ,&nbsp;Rayyan Nabi ,&nbsp;Javed Iqbal ,&nbsp;Sabahat Ul Ain Munir Abbasi ,&nbsp;Muhammad Rashid ,&nbsp;Syed Khurram Mushtaq Gardezi ,&nbsp;David P. Ripley ,&nbsp;Raheel Ahmed","doi":"10.1016/j.ijcrp.2025.200390","DOIUrl":"10.1016/j.ijcrp.2025.200390","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic heart diseases (IHD) and Alzheimer's Disease (AD) significantly contribute to mortality in aging population. Understanding mortality trends where these conditions overlap is crucial for developing targeted interventions for vulnerable populations.</div></div><div><h3>Methods</h3><div>We analyzed CDC WONDER mortality data from 1999 to 2020 for individuals aged ≥45 years. IHD and AD mortality were identified using ICD-10 codes I20-I25 and G30, respectively. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed by gender, race, region, place of death and state. Joinpoint regression was used to calculate annual percentage changes (APC) with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>A total of 171,080 deaths were attributed to IHD in individuals with AD from 1999 to 2020. The AAMR decreased from 10.6 in 1999 to 4.1 in 2020, with a significant decline between 2004 and 2014 (APC: −7.73; 95 % CI: −8.42 to −7.24). Females exhibited higher overall AAMR compared to males (Females: 6.8 vs. Males: 6.4). Individuals of Non-Hispanic (NH) White ancestry had the highest AAMR (6.8), followed by those of NH Black (6.5) and Hispanic ancestry (5.9). The West region reported the highest AAMR at 7.9, while the Midwest had the lowest at 6.3. Oklahoma recorded the highest state-level AAMR (10.9), while Utah had the lowest (3.2).</div></div><div><h3>Conclusions</h3><div>IHD mortality in individuals with AD declined significantly, with disparities by gender, race, and geography. These findings underscore the need for tailored public health approaches to address the evolving burden of IHD in AD patients.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200390"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020","authors":"Muhammad Abdullah Naveed ,&nbsp;Sivaram Neppala ,&nbsp;Himaja Dutt Chigurupati ,&nbsp;Ahila Ali ,&nbsp;Muhammad Omer Rehan ,&nbsp;Ayman Fath ,&nbsp;Bazil Azeem ,&nbsp;Rabia Iqbal ,&nbsp;Manahil Mubeen ,&nbsp;Hamza Naveed ,&nbsp;Muhammad Naveed Uz Zafar ,&nbsp;Mushood Ahmed ,&nbsp;Jamal S. Rana ,&nbsp;Brijesh Patel","doi":"10.1016/j.ijcrp.2025.200392","DOIUrl":"10.1016/j.ijcrp.2025.200392","url":null,"abstract":"<div><h3>Background</h3><div>Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue.</div></div><div><h3>Objective</h3><div>This study analyzed demographic trends and disparities in mortality rates due to AMI in malignancy among adults aged 65 and older from 1999 to 2020.</div></div><div><h3>Methods</h3><div>We used the CDC WONDER database to analyze Age-adjusted mortality rates (AAMRs) for AMI in malignancy patients (ICD-10 I21, C00-C97) from 1999 to 2020, stratifying by sex, race, geography, and metropolitan status. We calculated Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) using Joinpoint regression.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, AMI in malignancy accounted for 172,691 deaths among adults aged ≥65 years, with the majority of deaths occurring in medical facilities (56.9 %). The overall AAMR for AMI in malignancy-related deaths decreased from 30.2 in 1999 to 14.2 in 2020, with an AAPC of −3.90 (p &lt; 0.000001). Men showed higher AAMRs than women (28.6 vs. 12.3), with a more pronounced decrease in men (AAPC: 4.22, p &lt; 0.000001) compared to women (AAPC: 3.78, p &lt; 0.000001). Black individuals have the highest AAMR (22.7), followed by Whites (19.3). Arkansas had the highest AAMR (32.3), while Nevada had the lowest (8.1), with the Northeastern region having the highest regional AAMR (20.2), and nonmetropolitan areas had higher AAMRs.</div></div><div><h3>Conclusion</h3><div>This study reveals significant demographic disparities in mortality rates related to AMI in malignant older adults. These findings emphasize the need for targeted interventions and improved access to care.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200392"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study","authors":"Xiaodong Li ,&nbsp;Yarong Ma ,&nbsp;Qiulin Jiang ,&nbsp;Huizhi Zhan ,&nbsp;Xiaolei Sun","doi":"10.1016/j.ijcrp.2025.200388","DOIUrl":"10.1016/j.ijcrp.2025.200388","url":null,"abstract":"<div><h3>Background</h3><div>Circulating amino acid levels can be altered in arterial aneurysms and dissection, but the relationships between them is unclear. The present study investigated the causal relationship between circulating amino acid levels and arterial aneurysms and dissection via bidirectional two-sample Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>A bidirectional two-sample MR analysis was used. Forward analysis was performed with amino acid levels as the exposure and arterial aneurysms and dissection as outcomes. Reverse analysis was performed with arterial aneurysms and dissection as exposures and circulating amino acid levels as outcomes. MR data were analyzed using five analytical methods: the inverse-variance weighted (IVW), MR‒Egger, weighted median, simple, and weighted methods. IVW was used as the main analytical method, and the other methods were used for supplementary analyses. Heterogeneity was assessed using Cochran's Q test, and horizontal pleiotropy was assessed using intercepts from MR‒Egger regression. The genome-wide association study (GWAS) data for circulating amino acids were obtained from the IEU open GWAS database and the GWAS Catalog database. The GWAS data for arterial aneurysms and dissection were obtained from the Finngen consortium database version R10.</div></div><div><h3>Results</h3><div>The tyrosine level was negatively correlated with other aneurysms (P = 0.00211, OR: 0.57, 95 % CI: 0.40, 0.82). Aortic dissection decreased the circulating glycine level (P = 0.00168, OR: 0.98, 95 % CI: 0.98, 0.99).</div></div><div><h3>Conclusion</h3><div>Through bidirectional MR analysis, we found that tyrosine level was negatively correlated with other aneurysms and that aortic dissection reduced circulating glycine. Our findings support a possible interaction between circulating amino acid levels and arterial aneurysms and dissection.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200388"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehospitalization, mortality and associated variables in primary care patients with heart failure and preserved ejection fraction after first hospitalization","authors":"Victoria Cendrós ,&nbsp;Mar Domingo ,&nbsp;Elena Navas ,&nbsp;Miguel Ángel Muñoz ,&nbsp;Antoni Bayés-Genís ,&nbsp;José María Verdú-Rotellar","doi":"10.1016/j.ijcrp.2025.200391","DOIUrl":"10.1016/j.ijcrp.2025.200391","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a paucity of studies providing insights into the progression of primary care patients with heart failure and preserved ejection fraction (HFpEF).</div></div><div><h3>Objetive</h3><div>To investigate the characteristics associated with mortality and rehospitalizations in primary care patients with heart failure and preserved ejection fraction (HFpEF), previously hospitalized.</div></div><div><h3>Methods</h3><div>Retrospective cohort study that included primary care patients with previous heart failure (HF) hospitalization and ejection fraction ≥50 of 328 primary care centers of Catalonia. Demographic, comorbidities, clinical, and treatment variables were collected. Outocomes: Mortality and HF rehospitalization. Adjusted Cox regression models were performed.</div></div><div><h3>Results</h3><div>Study included 2895 patients. Mean age was 77(SD 9.7) years, 57 % were female. Mean follow up was 2.0[1.0–9.0] years. A total of 864(29.8 %) patients died, 831(28.7 %) were hospitalized. Mortality was associated with male sex(HR 1.26, 95 % CI 1.06–1.49), age &gt;75 years(HR 2.76, 95 % CI 2.24–3.39), Charlson Index(HR 2.03, 95 % CI 1.21–3.42), body mass index(BMI) ≤30 kg/m²(HR 1.44, 95 % CI 1.22–1.69) and loop diuretics(HR 1.36, 95 % CI 1.11–1.65); hemoglobin levels(HR 0.87, 95 % CI 95 % 0.82–0.91) were protective. HF rehospitalization was associated with male sex(HR 1.14, 95 % CI 1.03–1.33), age &gt;75 years(HR 1.37, 95 % CI 1.17–1.61), atrial fibrillation(HR 1.44, 95 % CI 1.25–1.67), and loop diuretics(HR 1.37, 95 % CI 1.15–1.63). Hemoglobin(HR 0.91, 95 % CI 0.87–0.95) were protective.</div></div><div><h3>Conclusion</h3><div>High proportion of HFpEF patients were hospitalized or died at 5 years follow up. Comorbidities, demographic, analytical and treatment variables played a relevant role as prognostic factors.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200391"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis","authors":"Lei Yang ,&nbsp;Fang-Xiao Hu ,&nbsp;Kun Wang ,&nbsp;Zhi-Zheng Wang ,&nbsp;Jie Yang","doi":"10.1016/j.ijcrp.2025.200387","DOIUrl":"10.1016/j.ijcrp.2025.200387","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a primary risk factor for cardiovascular and cerebrovascular diseases. A number of studies have suggested that sleep duration play an important role in the development of hypertension. Hypertension in young and middle-aged individuals is characterized by low awareness and treatment rates, increasing the risk of adverse events. To further elucidate the relationship between sleep duration and hypertension risk in young and middle-aged individuals, we conducted a meta-analysis.</div></div><div><h3>Methods</h3><div>This study searched PubMed, Embase, and the Cochrane Library from January 2003 to November 5, 2023. Data analysis was performed using STATA 17. Using Q test and I2-statistic, heterogeneity test for the included studies was conducted. Potential small-sample effects were evaluated based on the symmetry of funnel plots, and publication bias in included studies was evaluated using Egger's test.</div></div><div><h3>Results</h3><div>Data analysis of sleep duration was conducted for 16 studies, which revealed that both long sleep duration (OR, 1.10; 95 % CI, 1.05–1.15) and short sleep duration (RR: 1.10, 95 % CI: 1.05 to 1.15) were associated with hypertension in young and middle-aged individuals, particularly in Asian populations.</div></div><div><h3>Conclusions</h3><div>This meta-analysis revealed an association between sleep duration (short [&lt;7 h] and long [≥9 h]) and the development of hypertension in young and middle-aged adults, particularly in Asian populations. Sleep is a behavior that can be modified. Clinicians and health professionals should be encouraged to intensify efforts to promote healthy sleep for all and reduce the occurrence of high blood pressure in young and middle-aged individuals.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200387"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social epidemiology of cardiometabolic risk factors in early adolescents","authors":"Jason M. Nagata ,&nbsp;Christiane K. Helmer ,&nbsp;Jennifer H. Wong ,&nbsp;Seohyeong Lee ,&nbsp;Sydnie K. Domingue ,&nbsp;Patrick Low ,&nbsp;Abubakr A.A. Al-shoaibi ,&nbsp;Joan E. Shim ,&nbsp;Kyle T. Ganson ,&nbsp;Alexander Testa ,&nbsp;Orsolya Kiss ,&nbsp;Holly C. Gooding ,&nbsp;Erin E. Dooley ,&nbsp;Kelley Pettee Gabriel ,&nbsp;Fiona C. Baker","doi":"10.1016/j.ijcrp.2025.200382","DOIUrl":"10.1016/j.ijcrp.2025.200382","url":null,"abstract":"<div><h3>Background</h3><div>To estimate associations between sociodemographic factors and cardiometabolic risk factors among a demographically diverse sample of U.S. adolescents aged 10–14 years.</div></div><div><h3>Methods</h3><div>This study analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 1412), Years 2 and 3 (2018–2021). Cardiometabolic risk factors including hemoglobin A1c and cholesterol (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C) were assessed. Multivariable linear regression models were conducted to estimate the associations between sociodemographic factors (age, sex, race and ethnicity, household income, and parental education) and cardiometabolic risk factors (hemoglobin A1c, TC, HDL-C, and non-HDL-C).</div></div><div><h3>Results</h3><div>The average hemoglobin A1c level was 5.2 % (±0.4 %), the average TC level was 156.6 (±28.9) mg/dL, and the average HDL-C level was 56.0 (±12.9) mg/dL. Out of our sample, 0.5 % had diabetes (hemoglobin A1c ≥ 6.5 %), 7.6 % had high TC (≥200 mg/dL), and 7.4 % had low HDL-C (&lt;40 mg/dL). Older age was associated with lower TC, HDL-C, and non-HDL-C levels. Male sex was associated with higher hemoglobin A1c (beta coefficient [B] 0.04; 95 % confidence interval [CI], 0.00, 0.08; p = 0.037) and lower TC (B −3.14; 95 % CI, −6.17, −0.11; p = 0.042) compared to female sex. Black and Native American race and ethnicity were associated with higher hemoglobin A1c compared to White race. Higher household income was associated with higher TC and HDL-C.</div></div><div><h3>Conclusion</h3><div>This study of a diverse population of early adolescents identified sociodemographic differences in hemoglobin A1c and cholesterol levels that can inform clinical and public health interventions.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200382"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}