International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Ketogenic diets are associated with an elevated risk of hypertension: Insights from a cross-sectional analysis of the NHANES 2007-2018.","authors":"Xiaolong Qu ,&nbsp;Yuping Liu ,&nbsp;Lei Huang ,&nbsp;Fang Wan","doi":"10.1016/j.ijcrp.2024.200342","DOIUrl":"10.1016/j.ijcrp.2024.200342","url":null,"abstract":"<div><h3>Background</h3><div>The ketogenic diet (KD) is widely used for weight loss in obese individuals; however, its potential impact on hypertension risk remains uncertain.</div></div><div><h3>Methods</h3><div>We used cross-sectional data from the 2007-2018 to National Health and Nutrition Examination Survey (NHANES) to investigate the association between the dietary ketogenic ratio (DKR) and hypertension prevalence. Dietary intake information was obtained through a comprehensive 24-hour dietary recall interview. The DKR values were computed using a specialized formula. Multiple logistic regression analysis was employed to examine this association, whereas nonlinear relationships were assessed using restricted cubic splines. Inflection points were determined using two-piecewise linear regression analysis. Subgroup analyses based on age were also performed.</div></div><div><h3>Results</h3><div>In a fully adjusted multivariate logistic regression model accounting for confounding variables, DKR was significantly associated with hypertension (OR, 1.24; 95% CI: 1.00-1.53; P = 0.045). Moreover, individuals in the highest quartile of DKR exhibited a significantly elevated risk of hypertension compared with those in the lowest quartile (OR, 1.15; 95% CI: 1.07-1.24; P &lt; 0.001). Additionally, restricted cubic spline analysis revealed a linear relationship between DKR and the risk of hypertension, with a turning point identified at 3.4 units on the measurement scale employed for this study's purposes. Subgroup analyses indicated that this association between DKR and hypertension was particularly pronounced among individuals aged ≥40 years, especially those age group–40-60.We further observed that a multivariate linear regression analysis revealed a significant positive correlation between DKR and DBP in a fully adjusted model(β, 0.42; 95% CI: 0.12-0.87; P = 0.018), indicating that as DKR increased, there was an accompanying increase in DBP. However, no significant correlation was found between SBP and DKR(β, 0.11; 95% CI: -0.37, 0.59; P = 0.655).</div></div><div><h3>Conclusion</h3><div>The KD may enhance susceptibility to hypertension in middle-aged and elderly populations in the United States, exhibiting a strong association with elevated diastolic blood pressure, while no significant correlation was observed with increased systolic blood pressure.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200342"},"PeriodicalIF":1.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic cardiomyopathy: pathophysiology, imaging assessment and therapeutical strategies","authors":"Vincenzo Rizza ,&nbsp;Lara Tondi ,&nbsp;Angelo Maria Patti ,&nbsp;Damiano Cecchi ,&nbsp;Massimo Lombardi ,&nbsp;Francesco Perone ,&nbsp;Marco Ambrosetti ,&nbsp;Manfredi Rizzo ,&nbsp;Domenico Cianflone ,&nbsp;Francesco Maranta","doi":"10.1016/j.ijcrp.2024.200338","DOIUrl":"10.1016/j.ijcrp.2024.200338","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is one of the most prevalent cardiovascular risk factors in the general population, being associated with high morbidity and socioeconomic burden. Diabetic cardiomyopathy (DCM) is a non-negligible complication of DM, whose pathophysiological fundaments are the altered cardiac metabolism, the hyperglycemia-triggered formation of advanced glycation end-products (AGEs) and the inflammatory milieu which are typical in diabetic patients. These metabolic abnormalities lead to cardiomyocytes apoptosis, interstitial fibrosis and mechanical cardiac dysfunction, which can be identified with non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance. This review aims to: 1) describe the major imaging features of DCM; 2) highlight how early identification of DCM-related anatomical and functional remodeling might allow patients’ therapy optimization and prognosis improvement.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200338"},"PeriodicalIF":1.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis","authors":"Zhiyu Gu ,&nbsp;Rui Zhang ,&nbsp;Weihong Chang ,&nbsp;Hongxuan Fan ,&nbsp;Zixuan Dou ,&nbsp;Peng Liu ,&nbsp;Aman Liu ,&nbsp;Boda Zhou","doi":"10.1016/j.ijcrp.2024.200337","DOIUrl":"10.1016/j.ijcrp.2024.200337","url":null,"abstract":"<div><h3>Aim</h3><div>Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFR_{Cystatin C}), and the difference between Cystatin C and creatinine based eGFR (eGFR_diff) has been suggested to be associated with cardiovascular disease. However, the association between eGFR_{Cystatin C},eGFR_diff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort.</div></div><div><h3>Methods</h3><div>We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFR_{Cystatin C} &amp; eGFR_diff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study.</div></div><div><h3>Results</h3><div>The cohort study included 2155 participants. Importantly, we simplified eGFR_diff classification into ≥0 and &lt; 0, and found that eGFR_diff≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m² of eGFR_{Cystatin C} had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFR_{Cystatin C} and HF, eGFR_diff and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFR_{Cystatin C} or low eGFR_diff groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF.</div></div><div><h3>Conclusion</h3><div>Both decreased eGFR_{Cystatin C} and eGFR_diff levels were associated with heart failure and poor survival, but the latter seems more obvious.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200337"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival","authors":"Mohammed Abusharekh,&nbsp;Jürgen Kampf,&nbsp;Iryna Dykun,&nbsp;Viktoria Backmann,&nbsp;Rolf Alexander Jánosi,&nbsp;Matthias Totzeck,&nbsp;Tienush Rassaf,&nbsp;Amir Abbas Mahabadi","doi":"10.1016/j.ijcrp.2024.200336","DOIUrl":"10.1016/j.ijcrp.2024.200336","url":null,"abstract":"<div><h3>Background</h3><div>Smoking has conflicting results on outcomes following acute myocardial infarction (AMI). We evaluated the independent influence of smoking status on patient outcomes.</div></div><div><h3>Methods</h3><div>We included patients with AMI undergoing invasive coronary angiography with available self-reported smoking status. The incidence of death of any cause was evaluated during a median follow-up of 1.14 years (range 0.36–3.40 years). Association between smoking status and long-term mortality was evaluated using multivariable adjusted Cox regression analysis.</div></div><div><h3>Results</h3><div>From 1612 AMI patients (aged 65.7 ± 13.3 years, 72.1 % male), 378 patients (23.4 %) were current-smokers, 311 (19.3 %) ex-smokers, and 923 (57.3 %) non-smokers. Compared with non-smokers, current-smokers were younger (68.5 ± 13.0 vs. 58.6 ± 12.5, p &lt; 0.0001) and more frequently presented with STEMI (21.6 % vs. 35,4 %, p &lt; 0.0001), while ex-smokers with similar frequency of STEMI-manifestation as non-smokers (22.5 %, p = 0.79) constituted an intermediate-group in terms of age (65.8 ± 11,6 years). Although smoking status was not significantly associated with long-term survival in unadjusted-analysis, active-smokers had 56 % higher long-term mortality than non-smokers when adjusting for age, gender, medications and other traditional risk factors, whereas ex-smokers possessed comparable survival probability (current-smokers: 1.56[1.14–2.14], p = 0.006, ex-smokers 1.16[0.84–1.59], p = 0.37). Current-smokers had unadjusted lower NT-proBNP and modestly higher absolute in-hospital left ventricular global longitudinal strain (LV GLS) values that did not differ among groups after the same adjustments (NT-proBNP: −0.08[-0.31; 0.15], p = 0.5, LV GLS: 0.65[-0.26; 1.55], p = 0.16).</div></div><div><h3>Conclusion</h3><div>Active smoking is associated with increased adjusted long-term mortality, earlier onset and more frequent manifestation as STEMI, compared to non-smoking. Comparable adjusted results for LV GLS and NT-proBNP between groups support the presence of the pseudoparadox.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200336"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis","authors":"Aman Goyal ,&nbsp;Haleema Qayyum Abbasi ,&nbsp;Yusra Mashkoor ,&nbsp;Abdul Moiz Khan ,&nbsp;Samia Aziz Sulaiman ,&nbsp;Mohamed Daoud ,&nbsp;Kamna Bansal","doi":"10.1016/j.ijcrp.2024.200334","DOIUrl":"10.1016/j.ijcrp.2024.200334","url":null,"abstract":"<div><h3>Background</h3><div>Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV. R Studio's meta package was used to pool risk ratios under the random-effects model, and statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Nine observational studies involving 45024 individuals were included in this analysis. Patients with AAV exhibited a significantly elevated risk of stroke (RR = 1.43, 95 % CI: 1.12–1.83, I2 = 62 %, p = 0.0048), myocardial infarction (RR = 1.49, 95 % CI: 1.25–1.79, <em>I</em>^<em>2</em> = 0 %, p &lt; 0.0001), ischemic heart disease (RR = 1.40, 95 % CI: 1.24–1.58, <em>I</em>^<em>2</em> = 1 %, p &lt; 0.0001), venous thromboembolism (RR = 2.57, 95 % CI: 1.70–3.90, <em>I</em>^<em>2</em> = 74 %, p &lt; 0.0001), and pulmonary embolism (RR = 3.53, 95 % CI: 2.82–4.42, <em>I</em>^<em>2</em> = 9 %, p &lt; 0.0001), deep vein thrombosis (RR: 4.21; 95 % CI: 2.00–8.86; p = 0.0002), heart failure (RR = 1.63, 95 % CI: 1.39–1.90, <em>I</em>^<em>2</em> = 0 %, p &lt; 0.0001), and cardiovascular disease-related mortality (RR = 1.79, 95 % CI: 1.07–3.00, I2 = 0 %, p = 0.0256) compared to patients without AAV.</div></div><div><h3>Conclusion</h3><div>This meta-analysis underscores a notable increase in adverse cardiovascular events among patients with AAV, underscoring the need for comprehensive cardiovascular care and diligent monitoring in this patient cohort.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200334"},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovation, simplification, and adherence to real life, 2024 ESC guidelines of elevated blood pressure and hypertension claimed for","authors":"Marco Ambrosetti,&nbsp;Monica Loguercio,&nbsp;Luigi Maresca,&nbsp;Chiara Meloni,&nbsp;Daniela Zaniboni","doi":"10.1016/j.ijcrp.2024.200335","DOIUrl":"10.1016/j.ijcrp.2024.200335","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200335"},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524001004/pdfft?md5=da01656bdee9cbf19235742f53bb48d2&pid=1-s2.0-S2772487524001004-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of classic cardiovascular risk factors with myocardial infarction and ischemic stroke: A cross sectional analysis of the Shiraz Heart Study","authors":"Haleh Ghaem ,&nbsp;Mohammad Javad Zibaeenezhad ,&nbsp;Mehrab Sayadi ,&nbsp;Sheida Khosravaniardakani ,&nbsp;Nader Parsa ,&nbsp;Iman Razeghian-Jahromi","doi":"10.1016/j.ijcrp.2024.200332","DOIUrl":"10.1016/j.ijcrp.2024.200332","url":null,"abstract":"<div><h3>Background</h3><p>Myocardial infarction (MI) and ischemic stroke are the leading deadly clinical outcomes globally. This study aimed to investigate the association of classic cardiovascular risk factors with MI and ischemic stroke in a general population.</p></div><div><h3>Methods</h3><p>This cross-sectional study used the baseline data of the Shiraz Heart Study, a prospective cohort that investigate risk factors of coronary heart disease in a general population of Iran. Middle-aged citizens of 40–70 years old were included. Univariable and multivariable logistic regression analysis was performed to explore the association between sociodemographic, clinical, and metabolic factors and prevalent MI and stroke.</p></div><div><h3>Results</h3><p>Out of 7225 adults, 1.9 % (n = 135) had prior MI or stroke. Multiple logistic regression revealed that age≥60 years (aOR: 2.22, 95 % CI 1.45–3.20; <em>P</em> &lt; 0.001), male sex (aOR: 3.82, 95 % CI 2.56–5.71; <em>P</em> &lt; 0.001), history of hypertension (aOR: 1.71, 95 % CI 1.18–2.50; <em>P</em> &lt; 0.005), history of hyperlipidemia (aOR: 2.42, 95 % CI 1.68–3.48; <em>P</em> &lt; 0.001), having four 1st degree family members with sudden cardiac death (aOR: 26.28, 95 % CI 0.59–432.09; <em>P</em> &lt; 0.022), and having a 1st degree family member with history of cardiovascular disease (aOR: 1.69, 95 % CI 1.13–2.54; <em>P</em> &lt; 0.001) were associated with prior MI and stroke. Unlike high-density lipoprotein (<em>P</em> = 0.723) and triglyceride (<em>P</em> = 0.643), there were significant differences in the levels of fasting blood sugar (<em>P</em> &lt; 0.001), total cholesterol (<em>P</em> &lt; 0.001), and low-density lipoprotein (<em>P</em> &lt; 0.001) between those with and without history of MI/stroke.</p></div><div><h3>Conclusions</h3><p>Being aged ≥60 years, history of hypertension and hyperlipidemia along with familial history of CVD and sudden cardiac death were in association with MI and stroke.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200332"},"PeriodicalIF":1.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000977/pdfft?md5=e3712ad5fc4d79dee43ea651bcfea682&pid=1-s2.0-S2772487524000977-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and self-care practice among patients with hypertension in tertiary public hospitals of Addis Ababa, Ethiopia: A multicenter cross-sectional study","authors":"Freweini Gebremeskel Gebresilase ,&nbsp;Yohannes Ayalew Bekele ,&nbsp;Ketema Bizuwork Gebremedhin ,&nbsp;Boka Dugassa Tolera","doi":"10.1016/j.ijcrp.2024.200333","DOIUrl":"10.1016/j.ijcrp.2024.200333","url":null,"abstract":"<div><h3>Introduction</h3><p>Globally, hypertension is the leading cause of death due to its related complications. Patients’ knowledge and self-care practice in hypertension is crucial for achieving optimal blood pressure control and prevention of related complications. This study aimed to evaluate the level of knowledge and self-care practice among hypertensive patients in Addis Ababa, Ethiopia.</p></div><div><h3>Methods</h3><p>A facility-based cross-sectional study was conducted among 413 hypertensive patients using simple random sampling methods. A face-to-face interview was administered using a structured questionnaire. Data was analyzed using SPSS version 27.0. Frequency percentage, and mean were calculated. Multivariable logistic regression was used to identify the association between predictors and outcome variables.</p></div><div><h3>Results</h3><p>Out of 413 respondents, 46.0 % (95 % CI: 40–50 %) and 40.9 % (95 % CI: 36–46 %) had poor knowledge and self-care practice respectively. Being married (AOR = 1.92, 95 % CI:1.19–3.06, <em>P</em> = 0.007)<strong>,</strong> higher education [AOR = 7.38 (95 % CI: 2.29–23.78), <em>P</em> &lt; 0.001); family history (AOR = 3.68, 95 % CI: 2.28–5.94, <em>P</em> &lt; 0.001); getting information from healthcare providers (AOR = 3.17, 95 % CI: 1.46–6.87, <em>P</em> = 0.003) were significantly associated with knowledge of hypertension. Being female (AOR: 0.62,95 % CI: 0.39–0.97, <em>P</em> = 0.033), owing sphygmomanometer (AOR: 4.41,95 % CI: 2.40–8.13, <em>P</em> &lt; 0.001) were associated with self-care practice towards hypertension.</p></div><div><h3>Conclusion</h3><p>The overall knowledge and self-care practice of respondents was low. Gender, marital status, educational level, family history, source of information, and owing sphygmomanometer were determinant factors. Improving patients’ awareness and self-care practice is essential for prevention and control of hypertension.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200333"},"PeriodicalIF":1.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000989/pdfft?md5=45f49b5a559913a46316cd5df76792bf&pid=1-s2.0-S2772487524000989-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and cardiovascular disease: Risk assessment, physical activity, and management of complications","authors":"Francesco Perone ,&nbsp;Luigi Spadafora ,&nbsp;Alessandra Pratesi ,&nbsp;Giulia Nicolaio ,&nbsp;Barbara Pala ,&nbsp;Giulia Franco ,&nbsp;Matteo Ruzzolini ,&nbsp;Marco Ambrosetti","doi":"10.1016/j.ijcrp.2024.200331","DOIUrl":"10.1016/j.ijcrp.2024.200331","url":null,"abstract":"<div><div>The patient with obesity is at risk of developing cardiovascular disease and risk factors. Obesity negatively impacts prognosis and increases cardiovascular morbidity and mortality. Therefore, a comprehensive risk assessment is needed to define the cardiovascular risk of the patient and, thus, a tailored management and treatment. Chronic and successful management of these patients involves the evaluation of the various therapeutic strategies available (comprehensive lifestyle intervention, weight-loss medications, and bariatric surgery) and the diagnosis and treatment of cardiovascular complications (coronary artery disease, heart failure, and atrial fibrillation). Cardiac rehabilitation in patients with obesity is showing beneficial effect and a positive impact on weight loss, cardiovascular risk factors, mental health, functional capacity, and adherence to lifestyle interventions and pharmacological treatment. Long-term weight loss and maintenance represent a key objective during the management of the patient with obesity to reduce the risk of future adverse events. Multidisciplinary management and interventions are necessary to prevent and reduce overall cardiovascular risk and mortality. The aim of our review is to propose a comprehensive, critical and updated overview regarding risk assessment, physical activity, and the management of cardiovascular complications in patient with obesity.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200331"},"PeriodicalIF":1.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000965/pdfft?md5=be3ecb5e960d2c23df0809815eba6c34&pid=1-s2.0-S2772487524000965-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between grip strength, walking pace and incident peripheral artery disease: A prospective study of 430,886 UK biobank participants","authors":"Duqiu Liu ,&nbsp;Chenxing Yang ,&nbsp;Gang Liu ,&nbsp;Tianyu Guo ,&nbsp;Sen Liu ,&nbsp;Yi Guo ,&nbsp;Jinjie Xiong ,&nbsp;Ru Chen ,&nbsp;Shan Deng","doi":"10.1016/j.ijcrp.2024.200330","DOIUrl":"10.1016/j.ijcrp.2024.200330","url":null,"abstract":"<div><h3>Background and aims</h3><p>Patients with peripheral artery disease (PAD) presented overall muscle weakness and reduced physical performance. Previous study focused on the impact of muscle weakness on outcomes of established PAD, however the relationship between compromised muscle function and incident PAD remained unclear.</p></div><div><h3>Methods</h3><p>A prospective study involving 430,886 participants aged 40–69 y from UK biobank was conducted. The main outcome was incident PAD. Grip strength and walking pace were used as indicators for muscle function. Grip strength was measured using a Jamar J00105 hydraulic hand dynamometer, while walking pace was self-reported by the participants. Cox proportional hazard models were employed to investigate the relationship between grip strength, walking pace, and incident PAD.</p></div><div><h3>Results</h3><p>A total of 430,886 individuals were included in the final analysis. The mean age of the participants were 56.44 years, and 55.3 % were female. Over a median follow-up period of 13.81 years, 5,661 participants developed PAD. Higher grip strength, whether absolute or relative, exhibited a dose-dependent inverse association with incident PAD. Each 1 kg increment in absolute grip strength and each 0.01 kg/kg increase in relative grip strength were associated with reduced PAD risk by 2 % (HR: 0.98; 95 % CI [0.97–0.98]) and 83 % (HR: 0.17; 95 % CI [0.13–0.23]), respectively. Slow walking pace significantly correlated with increased PAD risk, while brisk walking pace was associated with decreased PAD risk.</p></div><div><h3>Conclusion</h3><p>Absolute grip strength, relative grip strength and walking pace were inversely associated with the risk of incident PAD.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200330"},"PeriodicalIF":1.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000953/pdfft?md5=c24edaa56d5e1daa600dea4a2a4f2b9c&pid=1-s2.0-S2772487524000953-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}