International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Trends in coronary artery disease mortality among hyperlipidemic patients: Geographic, gender, and racial insights from CDC WONDER data (1999–2020)","authors":"Muhammad Abdullah Naveed ,&nbsp;Sivaram Neppala ,&nbsp;Himaja Dutt Chigurupati ,&nbsp;Bazil Azeem ,&nbsp;Ahila Ali ,&nbsp;Faizan Ahmed ,&nbsp;Sabin Zafar ,&nbsp;Muhammad Omer Rehan ,&nbsp;Rabia Iqbal ,&nbsp;Manahil Mubeen ,&nbsp;Hassaan Abid ,&nbsp;Anum Mubasher ,&nbsp;Timir Paul","doi":"10.1016/j.ijcrp.2025.200416","DOIUrl":"10.1016/j.ijcrp.2025.200416","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease (CAD) in hyperlipidemia is a significant cause of mortality among adults in the United States. This study investigates trends in CAD-related mortality in hyperlipidemia among adults aged 25 and older, focusing on geographic, gender, and racial/ethnic disparities from 1999 to 2020.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted using the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) were calculated per 100,000 persons, stratified by year, sex, race/ethnicity, and geographical region.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, CAD in hyperlipidemia led to 407,667 deaths among US adults aged 25+. The AAMR for CAD in hyperlipidemia rose from 4.1 in 1999 to 12.1 in 2020, with an AAPC of 4.44 (95 % CI: 3.69 to 5.48, p &lt; 0.000001). Men had higher AAMRs (12.4) than women (5.6), with significant increases for both sexes over time. Racial/ethnic disparities showed the highest AAMRs in Whites (8.9), followed by American Indians/Alaska Natives (8.6). Geographically, AAMRs varied from 3.8 in Alabama to 16.0 in Vermont, with the Midwest showing the highest rates (9.7). Nonmetropolitan areas exhibited higher AAMRs (9.6) than metropolitan areas (8.3), with a more significant increase in nonmetropolitan areas (AAPC: 5.82, p &lt; 0.000001).</div></div><div><h3>Conclusion</h3><div>This study highlights significant disparities in CAD in hyperlipidemia-related mortality among US adults by race, gender, and geography. The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200416"},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving multimorbidity patterns among ageing adults with cardiovascular disease continuum in Southwest China: A longitudinal cohort study","authors":"Xiaoya Qi ,&nbsp;Ziyue Zhang ,&nbsp;Meng Jia ,&nbsp;Yangping Zhang ,&nbsp;Shuang Feng ,&nbsp;Ruixue Bai ,&nbsp;Siyao Wang ,&nbsp;Jinning Mao ,&nbsp;Shu Su","doi":"10.1016/j.ijcrp.2025.200417","DOIUrl":"10.1016/j.ijcrp.2025.200417","url":null,"abstract":"<div><h3>Background</h3><div>The progression of multimorbidity in Chinese ageing adults with cardiovascular diseases remains inadequately understood. This study investigates the longitudinal evolution of cardiovascular disease continuum (CVDC)-related multimorbidity patterns in this population.</div></div><div><h3>Methods</h3><div>The observational study analyzed medical examination reports from individuals aged 65 and older who underwent regular physical examinations during January 1, 2010 to December 31, 2022 at the Second Affiliated Hospital of Chongqing Medical University. Multimorbidity patterns of CVDC were examined. The construction of the multimorbidity network was based on Spearman correlation analyses to visualize the evolution of gender differences. Odds ratios (ORs) for developing multimorbidity in CVDC in compared to non-CVDC were calculated. Survival analysis and multivariate cox proportional hazards regression were performed to estimate the cumulative probability and identify risk factors for multimorbidity.</div></div><div><h3>Results</h3><div>A total of 10,052 eligible individuals with 1835 (18.26 %) diagnosed with CVDC at baseline were included. The strongest positive correlation was observed between CVDC and obesity related diseases during both the initial (r_males = 0.208, r_females = 0.244) and final (r_males = 0.312, r_females = 0.248) examinations. Survival analysis revealed that the cumulative probability of multimorbidity of metabolic diseases in hypertension, dyslipidemia and atherosclerosis had increased over time; the corresponding adjusted HRs (95 % CIs) were 1.322 (1.219, 1.433), 1.553 (1.413, 1.706), and 1.460 (1.361, 1.567), respectively. The increasing risks of CVDC-related multimorbidity were primarily attributable to salty dietary habit (AHR = 1.336, 95 % CI: 1.239, 1.411).</div></div><div><h3>Conclusions</h3><div>Multimorbidity patterns and disease networks associated with CVDC have become more complex over time, especially with metabolic diseases. A high-salty diet significantly increased the risk of CVDC-related multimorbidity.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200417"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A heart for the Islands: The role of fixed-dose combination therapy in the Philippines’ fight against premature CVD deaths","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200420","DOIUrl":"10.1016/j.ijcrp.2025.200420","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) remains the leading cause of premature mortality in the Philippines, disproportionately affecting low-income and underserved populations. Fixed-dose combination therapy, or the Polypill, has emerged as an evidence-based, cost-effective strategy for both primary and secondary prevention of CVD, particularly in low- and middle-income countries. This article explores the relevance and potential impact of Polypill implementation within the Philippine healthcare system. With high rates of treatment non-adherence, fragmented care delivery, and barriers to medication access, the Polypill offers a simplified, once-daily regimen that improves adherence and reduces major cardiovascular events. Its integration into the country's Universal Health Care (UHC) framework could significantly reduce health disparities, prevent costly hospitalizations, and improve cardiovascular outcomes nationwide. Special attention is given to high-risk groups such as those with chronic kidney disease and non-alcoholic fatty liver disease. We advocate for the inclusion of the Polypill in national treatment guidelines, essential medicines lists, and community health initiatives to address the growing burden of CVD in the Philippines. Broader adoption of this strategy can play a transformative role in enhancing cardiovascular health and reducing premature deaths in resource-limited settings.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200420"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing hypertension and obesity in the Philippines: Collaborative effort by the public and other institutions","authors":"Dalmacito A. Cordero","doi":"10.1016/j.ijcrp.2025.200419","DOIUrl":"10.1016/j.ijcrp.2025.200419","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200419"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins for secondary prevention in women with atherosclerotic vascular disease: A nation-wide analysis of 24,665 women hospitalized for coronary, cerebrovascular or peripheral artery disease","authors":"Gregor Verček ,&nbsp;Tjaša Furlan ,&nbsp;Dalibor Gavrić ,&nbsp;Mitja Lainščak ,&nbsp;Jerneja Farkaš Lainščak ,&nbsp;Irena Ograjenšek ,&nbsp;Petra Došenović Bonča ,&nbsp;Borut Jug","doi":"10.1016/j.ijcrp.2025.200415","DOIUrl":"10.1016/j.ijcrp.2025.200415","url":null,"abstract":"<div><h3>Background</h3><div>Statin therapy is recommended for secondary prevention of atherosclerotic vascular disease (ASCVD) based on randomized trials, which enrolled mostly men with coronary artery disease (CAD), whereas women and patients with cerebrovascular (CVD) and peripheral artery disease (PAD) were under-represented. We analyzed the effectiveness of statin therapy uptake in a nation-wide cohort of women hospitalized for ASCVD.</div></div><div><h3>Methods</h3><div>Women hospitalized for CAD, CVD, or PAD, including aortic disease, between 2015 and 2021 were retrospectively identified by linking the national hospital database, medicines reimbursement claims, and national mortality registry. The association of statin uptake within 30 days post-discharge with clinical outcomes (all-cause mortality and cardiovascular hospitalizations) was assessed by Kaplan-Meier curves and Cox proportional hazards regression model with propensity score-derived inverse probability of treatment weights and a 30-day landmark period.</div></div><div><h3>Results</h3><div>We included 24,665 women with ASCVD – 14,419 with CAD, 5,427 with CVD, and 4,819 with PAD. Overall, the median age was 73 (64–81) years. The rates of statin uptake were 50 % for women with CAD, 60 % for CVD and 28 % for PAD. Statin therapy uptake was associated with a reduction in all-cause mortality and cardiovascular hospitalizations across all three major types of ASCVD: hazard ratio (HR) 0.88, 95 % confidence interval (CI) 0.83–0.93, p = 0.001 for CAD, HR 0.87, 95 % CI 0.80–0.94, p = 0.006 for PAD, and HR 0.72, 95 % CI 0.66–0.78, p &lt; 0.001 for CVD.</div></div><div><h3>Conclusion</h3><div>Statin therapy is associated with reduced all-cause mortality and cardiovascular hospital readmissions in women with all major types of ASCVD.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200415"},"PeriodicalIF":1.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between blood pressure control levels and long-term patency of saphenous vein grafts after coronary artery bypass grafting: a retrospective case-control study","authors":"Meng Deng ,&nbsp;Didi Wen ,&nbsp;Yujie Song ,&nbsp;Linli Zhao ,&nbsp;Yang Cui ,&nbsp;Jialin Xin ,&nbsp;Rui Liu ,&nbsp;Yufeng Qiu ,&nbsp;Dongxu Yan ,&nbsp;Wei Yi ,&nbsp;Minwen Zheng ,&nbsp;Yang Sun","doi":"10.1016/j.ijcrp.2025.200414","DOIUrl":"10.1016/j.ijcrp.2025.200414","url":null,"abstract":"<div><h3>Background</h3><div>The impact of aggressive blood pressure (BP) control (&lt;130/80 mmHg) on vein graft disease progression following coronary artery bypass grafting remains unclear. This study evaluated the relationship between BP control on long-term graft patency in patients with hypertension post -coronary artery bypass grafting (CABG).</div></div><div><h3>Methods</h3><div>This retrospective, single-center, non-blinded case-control study initially enrolled 500 patients who underwent CABG at the Department of Cardiovascular Surgery, Xijing Hospital. Among them, 311 patients with comorbid hypertension and underwent coronary computed tomography angiography (CCTA) within three years postoperatively. Ultimately, 276 patients completed the follow-up of third year postoperatively and were included in the final statistical analysis. We conducted the correlation analysis between the BP control of the patients and the patency of long-term graft patency.</div></div><div><h3>Results</h3><div>Three years post-CABG, BP remained higher in the occlusion group (P &lt; 0.05). The utilization rates of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) and calcium channel blockers (CCB) were higher in the non-occlusion group (68.11 % vs. 52.75 %, <em>P</em> = 0.013; 62.16 % vs. 48.35 %, <em>P</em> = 0.029). Logistic regression identified postoperative BP as an independent risk factor for vein graft occlusion (per patient, odds ratio [OR], 3.098; 95 % confidence interval [CI] 1.841–5.214, <em>P</em> &lt; 0.001; per graft, OR, 2.600; 95 % CI 1.738–3.889, <em>P</em> &lt; 0.001). No significant correlation was found between antihypertensive regimens and long-term vein graft patency.</div></div><div><h3>Conclusions</h3><div>Patients with hypertension whose BP was above 130/80 mmHg after CABG were more likely to develop vein graft restenosis. No significant correlation was observed between postoperative antihypertensive regimen and long-term vein graft patency post-CABG.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200414"},"PeriodicalIF":1.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between educational attainment and blood pressure in older adults: a study of two Finnish generational cohorts born 20 years apart","authors":"Adriana Lääti ,&nbsp;Oskari Somerpalo ,&nbsp;Konsta Teppo ,&nbsp;Jenni Vire ,&nbsp;Matti Viitanen ,&nbsp;Ville Langén","doi":"10.1016/j.ijcrp.2025.200412","DOIUrl":"10.1016/j.ijcrp.2025.200412","url":null,"abstract":"<div><h3>Background</h3><div>This study compares the association between educational attainment and blood pressure (BP) in two Finnish cohorts of older adults, born 20 years apart.</div></div><div><h3>Methods</h3><div>All 70-year-old residents of Turku, Finland, were surveyed in 1990 (1920-born TUVA cohort) and in 2010 (1940-born UTUVA cohort). Associations between education and BP were assessed using first ANOVA and post-hoc Tukey tests and then multiple linear regression, adjusted for age, gender, smoking, and body mass index. Analyses included 668 TUVA and 862 UTUVA participants.</div></div><div><h3>Results</h3><div>In the TUVA cohort (67.7 % women, mean age 70.9), 77.7 % had primary education only, compared to 54.1 % in the UTUVA cohort (59.6 % women, mean age 71.4). ANOVA revealed a significant association between education level and diastolic BP in the UTUVA cohort (p = 0.04). All other ANOVA results were non-significant (p ≥ 0.14). Tertiary education did not have a significant association with BP (p ≥ 0.0544). In regression analyses, each additional year of education in UTUVA correlated with a 0.36 mmHg decrease in systolic BP (p = 0.01) and a 0.32 mmHg decrease in diastolic BP (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The 1920-born cohort demonstrated no significant differences in BP across education levels, whereas in the cohort born in 1940, higher education was associated with significant but small reductions in BP. These findings suggest that education may be linked to BP, but the absolute differences across education levels are modest. The relationship between education and BP is complex, influenced by lifestyle choices and healthcare access, and requires further exploration.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200412"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining maternal and fetal outcomes across various subtypes of hypertension during pregnancy","authors":"Laith Alhuneafat ,&nbsp;Fares Ghanem ,&nbsp;Sneha Nandy ,&nbsp;Sana Khan ,&nbsp;Anushree Puttur ,&nbsp;Ahmad Jabri ,&nbsp;Alaq Haddad ,&nbsp;Bhavadharini Ramu ,&nbsp;Bethany Sabol ,&nbsp;Jessica Schultz ,&nbsp;Selma Carlson","doi":"10.1016/j.ijcrp.2025.200413","DOIUrl":"10.1016/j.ijcrp.2025.200413","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal morbidity and mortality worldwide. It includes chronic hypertension (CH), gestational hypertension (GH), preeclampsia (PRE), and CH with superimposed preeclampsia (SPE).We aim to assess in-hospital maternal and fetal outcomes of women in each of these groups in comparison to normotensive controls.</div></div><div><h3>Methods</h3><div>Study sample included women in the National Inpatient Sample dataset from 2016 to 2020 who were categorized into the 4 groups of HDP as described above. They were compared to normotensive pregnancies for maternal and fetal outcomes using regression analysis after adjusting for age, race, C-section status, and comorbidities.</div></div><div><h3>Results</h3><div>The study dataset from October 2015–December 2020 included 19,089,780 delivery admissions with 2,771,809 (14.5 %) of patients affected by HDP. The HDP groups were distributed as follows: GH - 38 %, PRE - 32 %, SPE - 11 %, and CH - 19 %. Women with PRE, SPE, and CH had significantly higher rates of mortality, circulatory shock, peripartum cardiomyopathy, acute kidney injury, preterm labor, stillbirth, and cerebrovascular events as compared to normotensive patients, while GH did not. Specifically, maternal mortality was highest in the SPE group (adjusted odds ratio [aOR] 3.16), followed by PRE (aOR 2.91) and CH (aOR 2.42). Additionally, all HDP groups had higher rates of small for gestational age and significant bleeding as compared to normotensive patients.</div></div><div><h3>Conclusions</h3><div>Pregnant patients with CH, PRE, and SPE experience higher rates of adverse maternal and fetal outcomes during their delivery admission when compared to normotensive patients. Understanding the graded risk differences across HDP subtypes may enable more tailored interventions, optimizing maternal and fetal outcomes for those at highest risk.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200413"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Too much or too little: The U-shaped link between sleep duration and hypertension risk in Asian populations","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200411","DOIUrl":"10.1016/j.ijcrp.2025.200411","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200411"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising hypertension among young adults: Addressing risk perception and promoting prevention","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200409","DOIUrl":"10.1016/j.ijcrp.2025.200409","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200409"},"PeriodicalIF":1.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}