International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Implications for global health of heart failure and lung cancer mortality trends in aging populations","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200373","DOIUrl":"10.1016/j.ijcrp.2025.200373","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200373"},"PeriodicalIF":1.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaping illusions: The hidden risks of E-cigarette use among young Filipinos and adolescents in Latin America","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200375","DOIUrl":"10.1016/j.ijcrp.2025.200375","url":null,"abstract":"<div><div>The study \"E-cigarette use among adolescents in Latin America\" reveals a high prevalence of e-cigarette use among teenagers, with a pooled mean of 18.9 %. This highlights the misconception that e-cigarettes are safer than traditional smoking and calls for focused public health initiatives to combat this growing problem. The study aims to examine the prevalence of e-cigarette use among Latin American teenagers, identify contributing factors, and guide public health initiatives to reduce the hazards associated with vaping. Its methodology comprises the following steps: first, a comprehensive assessment of the body of research on teen e-cigarette use was carried out; second, information on prevalence rates and related variables from multiple studies was gathered. Finally, the pooled mean prevalence was computed to give a bigger picture of the problem. The findings suggest that e-cigarettes, particularly for minors, may prolong nicotine dependency without providing a true cessation pathway. Social and cultural factors also complicate understanding how young Filipinos vape. The study underscores the need for well-informed public health initiatives to reduce the dangers of teen vaping.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200375"},"PeriodicalIF":1.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models","authors":"Jichao Wu ,&nbsp;Die Huang ,&nbsp;Jiefang Li ,&nbsp;Jingxing Yi ,&nbsp;Yu Lei ,&nbsp;Jun Yin","doi":"10.1016/j.ijcrp.2025.200372","DOIUrl":"10.1016/j.ijcrp.2025.200372","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease (CVD) is a leading cause of death globally, with its incidence and mortality rates continuing to rise. While commonly used biomarkers such as low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood glucose are widely applied, they have certain limitations. This study investigates the lymphocyte-to-monocyte ratio (LMR), a simple immune biomarker associated with inflammation, to assess whether it can serve as a new marker for predicting chronic inflammation in cardiovascular disease, and compares it to traditional biomarkers.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, utilizing a cohort of 1518 participants with a median follow-up period of 150 months. During this time, 522 participants died, including 166 from cardiovascular disease. We employed various statistical methods, including weighted Cox proportional hazards models, restricted cubic spline models, and time-varying receiver operating characteristic curves, to examine the association between LMR and mortality risk.</div></div><div><h3>Results</h3><div>The analysis revealed an L-shaped relationship between LMR and the incidence of cardiovascular disease. Lower LMR levels were negatively correlated with all-cause and cardiovascular mortality. The XGBoost model yielded the best performance metrics (AUC and F1 scores), and SHAP value analysis indicated that LMR significantly contributes to CVD outcomes. Non-linear analyses confirmed a stable negative correlation between LMR and all-cause mortality.</div></div><div><h3>Conclusion</h3><div>The study concludes that LMR is a simple and practical indicator for predicting cardiovascular disease and its mortality. Low levels of LMR significantly increase the risk of both cardiovascular disease and all-cause mortality in patients.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200372"},"PeriodicalIF":1.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999–2020)","authors":"Humza Saeed ,&nbsp;Uzair Majeed ,&nbsp;Minahil Iqbal ,&nbsp;Sufyan Shahid ,&nbsp;Anum Touseef Hussain ,&nbsp;Hammad Ahmad Iftikhar ,&nbsp;Momina Riaz Siddiqui ,&nbsp;Iftikhar Ali Ch ,&nbsp;Salman Khalid ,&nbsp;Naeem Khan Tahirkheli","doi":"10.1016/j.ijcrp.2025.200371","DOIUrl":"10.1016/j.ijcrp.2025.200371","url":null,"abstract":"<div><h3>Background</h3><div>Cancer patients are at an increased risk for the incidence and complications of acute myocardial infarction (AMI) due to shared risk factors and treatment-related adverse effects. Mortality trends for AMI-related deaths in adult cancer patients in the U.S. remain unexplored.</div></div><div><h3>Methodology</h3><div>This study used CDC WONDER data for death certificates from 1999 to 2020, identifying U.S. adults (≥25 years) with cancer (ICD-10: C00-D49) who died of AMI (ICD-10: I21) as the underlying cause. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated and stratified by gender, age, race, and geographic location.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, there were 109,462 AMI-related deaths in adult cancer patients. The AAMR decreased from 4.3 per 100,000 in 1999 to 1.4 in 2020. A significant decline occurred from 1999 to 2015 (APC: 6.65; 95 % CI: 6.95 to −6.40; p &lt; 0.001), followed by a stable trend from 2015 to 2020 (APC: 1.36; 95 % CI: 2.69 to 0.91; p = 0.152). Men had higher AAMRs than women (3.5 vs. 1.5). AAMRs were highest in older adults (10.5) compared to middle-aged (0.7) and young adults (0.1). Racial disparities showed the highest AAMRs in non-Hispanic (NH) Black patients (2.7), followed by NH Whites (2.4), NH American Indian/Alaska Native (1.6), Hispanic/Latino (1.3), and NH Asian/Pacific Islander (1.1). Non-metropolitan areas had higher AAMRs than metropolitan areas (2.8 vs. 2.2).</div></div><div><h3>Conclusions</h3><div>This analysis highlights a significant decline in AMI-related mortality among cancer patients in the U.S., with persistent disparities by gender, age, race and geographical location.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200371"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris","authors":"Binbing Shi ,&nbsp;Xiaotong Wang ,&nbsp;Tongneng Xue ,&nbsp;Jie Liu ,&nbsp;Wanling Wu ,&nbsp;Yuanyuan Luo ,&nbsp;Hong Zhu ,&nbsp;Defeng Pan","doi":"10.1016/j.ijcrp.2025.200367","DOIUrl":"10.1016/j.ijcrp.2025.200367","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between plasma miR-146a expression levels, severity of coronary lesions, and clinical prognosis in patients with unstable angina pectoris (UAP).</div></div><div><h3>Methods</h3><div>A total of 100 patients with UAP and 100 controls were selected for assessment of plasma miRNA-146a expression levels. We assessed the severity of coronary lesions in patients with UAP using the Gensini score. Additionally, we analyzed the correlation between miR-146a expression and the degree of coronary artery stenosis in patients with UAP. The incidence of major adverse cardiovascular events (MACEs) was followed-up for 48 months after hospitalization and discharge. The median grouping method was employed to categorize patients into high- and low-expression groups based on their miR-146a levels. Thereafter, the incidence of MACEs in these groups was analyzed using the Kaplan–Meier method.</div></div><div><h3>Results</h3><div>The plasma expression level of miR-146a in the UAP group was 1.8-fold greater than that in the control group (Z = 6.970, P &lt; 0.001) and correlated with the severity of coronary lesions; a high expression level was associated with a higher Gensini score (P &lt; 0.05). Patients with high miR-146a expression levels showed a significantly higher incidence of MACEs than those with low miR-146a expression levels (log-rank test: P = 0.004).</div></div><div><h3>Conclusion</h3><div>Plasma miR-146a expression levels in patients with UAP correlated with the severity of coronary lesions, and patients with high miR-146a expression levels had poorer clinical prognoses than those with lower expression levels.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200367"},"PeriodicalIF":1.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High glucose affects the cardiac function of diabetic Akita mice by inhibiting cardiac ATP synthase beta subunit","authors":"Yuanfang Ma ,&nbsp;Guang Wang ,&nbsp;Jing Li","doi":"10.1016/j.ijcrp.2025.200369","DOIUrl":"10.1016/j.ijcrp.2025.200369","url":null,"abstract":"<div><h3>Object</h3><div>To explore the mechanism of diabetic cardiomyopathy that hyperglycemia may affect the cardiac function by inhibiting the expression of ATPase β subunit.</div></div><div><h3>Method</h3><div>Cardiac function, fibrosis levels, and the expression of the ATPase β subunit were observed in Akita mice-a diabetes mice model without lipid metabolism disorders-—using morphological, molecular biology, and echocardiographic analyses compared to wild-type mice. The study revealed a connection between the decreased ATPase β subunit and the development of diabetic myocardial injury. Furthermore, study on primary culture of cardiomyocytes hints that the effect of high glucose on myocardium and ATP are related to the decrease of the expression of ATP synthase β subunit.</div></div><div><h3>Result</h3><div>With the increase of hyperglycemia time, the heart function of akita mice decreased, AV peak and estimated weight of left ventricle were statistically less than that of wild-type mice, the left ventricular ejection fraction was not statistically different from that of the control group; the E/A ratio of akita mice decreased significantly with age, but did shows significant cardiac dysfunction at the end of the experiment; collagen deposition increased in the heart of akita mice. In the cell level, the protein level of ATPase β subunit in primary cultured cardiomyocytes decreased significantly after high glucose treatment.</div></div><div><h3>Conclusion</h3><div>Hyperglycemia may affect the cardiac function by affecting the expression of ATPase β subunit in cardiomyocytes, which may be one of the mechanisms of diabetic cardiomyopathy.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200369"},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of percutaneous coronary intervention vs coronary artery bypass graft for left main coronary artery disease in patients with prior cerebrovascular disease: A systematic review, meta-analysis and meta-regression","authors":"Muhammad Hamza Shuja ,&nbsp;Firzah Shakil ,&nbsp;Syed Hassaan Ali ,&nbsp;Qazi Shurjeel Uddin ,&nbsp;Ayesha Noman ,&nbsp;Javed Iqbal ,&nbsp;Muhammad Ahmed ,&nbsp;Faiza Sajid ,&nbsp;Haya Waseem Ansari ,&nbsp;Syed Ahmed Farhan ,&nbsp;Huzaifa Ul Haq Ansari ,&nbsp;Syed Husain Farhan ,&nbsp;Muhammad Moiz Nasir ,&nbsp;Sana Qazi ,&nbsp;Muhammad Majid","doi":"10.1016/j.ijcrp.2025.200370","DOIUrl":"10.1016/j.ijcrp.2025.200370","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies suggest similar cardiovascular (CV) benefits for either percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) in patients with left main coronary artery disease (LMCAD). However, limited data exist on the influence of prior cerebrovascular disease (CEVD). Thus, we aim to compare the CV outcomes in patients with LMCAD and prior CEVD, undergoing either PCI or CABG.</div></div><div><h3>Methods</h3><div>A comprehensive search from (January 2000 to August 2024) identified three relevant studies. Outcomes analyzed included all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE), myocardial infarction (MI), and risk of stroke in patients undergoing either PCI or CABG for LMCAD. Data analysis employed a random effects model and presented hazard ratios (HR) along with their 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>Three studies involving 760 patients (361 PCI, 399 CABG) were included. PCI was associated with a significantly higher risk of MACCE (HR = 2.56; 95 % CI = 1.23–5.37; p = 0.01; I² = 86 %) and MI (HR = 2.97; 95 % CI = 1.72–5.13; p &lt; 0.0001; I² = 0 %) compared to CABG. No significant differences were observed in all-cause mortality (HR = 1.35; 95 % CI = 0.92–1.98; p = 0.12; I² = 0 %) or recurrent stroke (HR = 0.83; 95 % CI = 0.40–1.70; p = 0.60; I² = 1 %). The risk of repeat revascularization was higher in PCI, though not statistically significant (HR = 3.44; 95 % CI = 0.50–23.60; p = 0.21; I² = 70 %).</div></div><div><h3>Conclusion</h3><div>PCI significantly elevates the risk of MACCE and MI in patients with LMCAD and prior CEVD compared to CABG. However, risks of all-cause mortality, repeat stroke, and revascularization were non-significant. Comorbidities may drive the elevated risk, underscoring the need for tailored strategies in this population.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200370"},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital tool for self-reporting cardiovascular risk factors: The RADICAL study","authors":"José Ferreira Santos ,&nbsp;Inês Castela ,&nbsp;Sara Gamboa Madeira ,&nbsp;Sofia Furtado ,&nbsp;Hugo Vieira Pereira ,&nbsp;Diana Teixeira ,&nbsp;Hélder Dores","doi":"10.1016/j.ijcrp.2025.200368","DOIUrl":"10.1016/j.ijcrp.2025.200368","url":null,"abstract":"<div><h3>Aims</h3><div>Cardiovascular diseases remain the leading cause of death worldwide. Risk stratification and early interventions are essential to overcome this reality. The <strong>RADICAL Study</strong> <em>(</em><strong><em>R</em></strong><em>isk</em> <strong><em>A</em></strong><em>ssessment via</em> <strong><em>D</em></strong><em>igital</em> <strong><em>I</em></strong><em>nput for</em> <strong><em>C</em></strong><em>ardiovascular</em> <strong><em>A</em></strong><em>nd</em> <strong><em>L</em></strong><em>ifestyle Factors)</em> aimed to evaluate the prevalence of self-reported cardiovascular risk factors in individuals without known cardiovascular disease using a digital tool.</div></div><div><h3>Methods and results</h3><div>A digital self-reported cardiovascular risk stratification tool, comprising 23 questions about classical and lifestyle cardiovascular risk factors, was completed by 4149 individuals aged 40–69 years (median age 53.0 [47.0; 60.0] years; 78 % women). Among the cardiovascular risk factors, 40.9 % reported hypercholesterolemia, 26.8 % hypertension, 17.3 % smoking, 5.8 % diabetes, 58.4 % physical inactivity, 19.4 % obesity, 33.7 % sleep less than 7 h/night, and 12.1 % had composite dietary risk factors. Most of the participants (89.9 %) referred having at least one of the eight cardiovascular risk factors. Women had 27 % higher odds of having at least one cardiovascular risk factor compared to men (OR = 1.27, 95 % CI [1.00, 1.60]). Participants aged 50–59 years also had higher odds of having at least one CV risk factor compared to those aged 40–49 years (OR = 1.35, 95 % CI [1.07, 1.70]).</div></div><div><h3>Conclusion</h3><div>The RADICAL Study reveals a high prevalence of cardiovascular risk factors in adults without known cardiovascular disease. Beyond the relevance of traditional risk factors, such as hypercholesterolemia and hypertension, the results regarding physical activity, dietary and sleeping habits are concerning. A self-reported cardiovascular risk identification digital tool could be feasible and help to improve cardiovascular prevention.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200368"},"PeriodicalIF":1.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of the severity of rheumatic mitral stenosis using dimensionless index and its association with outcomes","authors":"Ryan Leow ,&nbsp;Tony Yi-Wei Li ,&nbsp;Meei-Wah Chan ,&nbsp;William KF. Kong ,&nbsp;Kian-Keong Poh ,&nbsp;Ivandito Kuntjoro ,&nbsp;Ching-Hui Sia ,&nbsp;Tiong-Cheng Yeo","doi":"10.1016/j.ijcrp.2025.200366","DOIUrl":"10.1016/j.ijcrp.2025.200366","url":null,"abstract":"<div><h3>Introduction</h3><div>The severity of mitral stenosis (MS) is commonly assessed using mitral valve area (MVA) measured with transthoracic echocardiography (TTE). The dimensionless index (DI) of mitral valve (MV) was recently studied in degenerative MS. We evaluated DI MV in rheumatic MS and studied its relationship with clinical outcomes.</div></div><div><h3>Methods</h3><div>We studied 406 cases of rheumatic MS in a retrospective single centre cohort study, with 174 in a derivation cohort, 121 in a TTE validation cohort, and 111 in a transoesophageal echocardiography (TEE) validation cohort. DI MV was calculated by dividing the left ventricular outflow tract pulsed-wave Doppler time-velocity integral (TVI) by the MV continuous-wave Doppler TVI. DI MV was compared against MV area using the two-dimensional planimetry, pressure half-time and continuity equation methods, or, in the TEE validation cohort, TEE-derived three-dimensional planimetry. Severe MS was defined as an MV area ≤1.5 cm². Outcomes pertaining to all-cause death and mitral valve intervention were studied in the former two cohorts.</div></div><div><h3>Results</h3><div>All-in-all, 231 patients (56.9 %) across the three cohorts had severe MS. In the derivation cohort, ROC analysis showed that DI MV could accurately classify MS severity (AUC = 0.838, 95 % CI, 0.780–0.897, <em>p</em> &lt; 0.001). DI MV ≤ 0.25 and DI MV ≥ 0.40 had high specificity for identifying severe (93.7 %) and non-severe MS (93.7 %) respectively. In the validation cohorts, these respectively showed similar specificity for identifying severe (93.8 %) and non-severe MS (91.4 %). In the derivation and TTE validation cohorts, the median follow up duration was 6.32 years (interquartile range, 4.22–10.3 years) with 90 deaths (30.5 %) and 50 patients (17.0 %) undergoing MV intervention. DI MV was univariately significant (HR = 0.075, 95 % CI 0.0215–0.378, <em>p</em> = 0.002) in Cox regression for a composite outcome of death and MV intervention. DI MV remained independently associated with the composite outcome in multivariate analysis.</div></div><div><h3>Conclusion</h3><div>DI MV can help rule-in or rule-out severe MS with high specificity, and is independently associated with composite outcomes of death and MV intervention.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200366"},"PeriodicalIF":1.9,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory bowel disease is associated with an increased risk of cardiovascular events in a sex and age-dependent manner: A historical cohort study","authors":"Noa Cohen-Heyman ,&nbsp;Gabriel Chodick","doi":"10.1016/j.ijcrp.2025.200363","DOIUrl":"10.1016/j.ijcrp.2025.200363","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between inflammatory bowel diseases (IBD) and the risk of ischemic heart diseases (IHD) remains a subject of debate. In this study, we sought to investigate the association between IBD and long-term risk of IHD in a substantial cohort of IBD patients.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study we utilized data from a state-mandated provider in Israel (Maccabi Healthcare Services). We identified all eligible patients diagnosed with IBD between 1/1990 and 7/2021 that were individually matched by sex-and-birth date to 10 MHS members with no indication of IBD. Study population was followed through the data until 12/2021 to examine the occurrence of IHD events.</div></div><div><h3>Results</h3><div>A total of 14,768 IBD patients (6144 UC, 8624 CD) and 120338 matched non-IBD individuals were eligible for the analysis. Over a mean follow-up of 10.5 years, 285 (1.9 %) of participants with IBD and 1175 (1.0 %) of the reference group experienced our composite outcome, representing an HR of 1.98 (95%CI: 1.74–2.25). When stratified by sex, risk of IHD associated with IBD in males (HR = 1.82; 95 % CI: 1.52–2.17), whereas a negative association was noted among female patients (HR = 0.72; 95%CI: 0.55–0.95). Study results were generally unchanged when analyses were limited to patients with CD, UC, patients on steroids, and patients on immunosuppressants.</div></div><div><h3>Conclusions</h3><div>Our study reveals a notable excess risk of IHD in male patients with IBD. Further research is needed to better elucidate the mechanisms involved in this relationship.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"24 ","pages":"Article 200363"},"PeriodicalIF":1.9,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}