International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Circulating protein biomarkers and their association with vulnerable plaque characteristics – a PROSPECT II substudy","authors":"Tania Sharma ,&nbsp;Akiko Maehara ,&nbsp;Michael Maeng ,&nbsp;Lars Kjøller-Hansen ,&nbsp;Thomas Engstrøm ,&nbsp;Ori Ben-Yehuda ,&nbsp;Mitsuaki Matsumura ,&nbsp;Ole Fröbert ,&nbsp;Jonas Persson ,&nbsp;Rune Wiseth ,&nbsp;Alf Inge Larsen ,&nbsp;Sasha Koul ,&nbsp;Rebecca Rylance ,&nbsp;Gary S. Mintz ,&nbsp;Ziad A. Ali ,&nbsp;Stefan K. James ,&nbsp;Gregg W. Stone ,&nbsp;David Erlinge","doi":"10.1016/j.ijcrp.2025.200440","DOIUrl":"10.1016/j.ijcrp.2025.200440","url":null,"abstract":"<div><h3>Background</h3><div>In the PROSPECT-II study, near infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) was used to characterize atherosclerotic plaques in the coronary arteries. NIRS-derived lipid core burden index (LCBI) and IVUS-derived plaque burden (PB) were able to identify plaques strongly associated with adverse cardiovascular events.</div></div><div><h3>Aim</h3><div>Our aim was to identify biomarkers associated with LCBI or PB in the coronary arteries.</div></div><div><h3>Methods</h3><div>898 patients with recent myocardial infarction underwent percutaneous coronary intervention. Blood samples to analyze plasma levels of 179 proteins associated with cardiovascular disease were procured and a combined NIRS-IVUS catheter was used to analyze the coronary arteries. Adjusted linear regression models were calculated between the biomarkers and the outcomes of interest, adjusted for multiplicity testing. Kaplan-Meier survival curves of biomarkers divided by median were assessed with the log-rank test. Adjusted Cox proportional models were calculated for major adverse cardiovascular events.</div></div><div><h3>Results</h3><div>A total of 24 proteins were associated with PB and 28 proteins with LCBI. Eight of these biomarkers were associated with both increased pan-coronary LCBI and PB; IL-18R1, CSF-1, VEGFA, EN-RAGE, cathepsin D, PCSK9, transferrin receptor protein 1 and OPN. After adjusting for multiplicity, angiopoietin like 3 (ANGPTL3) retained its association with LCBI, and IL-18R1 and CSF-1 retained their association with PB.</div></div><div><h3>Conclusion</h3><div>We were able to identify distinct biomarker patterns associated with PB and LCBI. IL-18R1 and CSF-1 had a strong relationship with PB. ANGPTL3 was associated with lipid rich plaques but not with PB, supporting its role in lipid accumulation and development of vulnerable plaques.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200440"},"PeriodicalIF":1.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India","authors":"P.B. Jayagopal ,&nbsp;C.N. Manjunath ,&nbsp;A. Jabir ,&nbsp;Sridhar L. Sastry ,&nbsp;Veena Nanjappa ,&nbsp;P.R. Vaidyanathan ,&nbsp;Johny Joseph ,&nbsp;Soma Sekhar Ghanta ,&nbsp;P. Manokar ,&nbsp;Nitin Kabra ,&nbsp;Dharmendra Jain ,&nbsp;Vinod Sharma ,&nbsp;Trinath Kumar Mishra ,&nbsp;R. Badri Narayanan ,&nbsp;Narendra Jathappa ,&nbsp;Gautam Rege ,&nbsp;Sunil Modi ,&nbsp;S.N. Routray ,&nbsp;T.R. Raghu ,&nbsp;Rabin Chakraborty ,&nbsp;V.K. Chopra","doi":"10.1016/j.ijcrp.2025.200441","DOIUrl":"10.1016/j.ijcrp.2025.200441","url":null,"abstract":"<div><h3>Background</h3><div>Real-world investigations focused on gender-associated characteristics of Acute Heart failure (AHF) are lacking. The current study, from a national heart failure registry, aims to investigate gender-based patterns and outcomes among AHF patients in India.</div></div><div><h3>Methods</h3><div>This prospective Indian College of Cardiology National Heart Failure Registry enrolled patients admitted with AHF in 17 centres from 2019 to 2021. Demographics, aetiology, co-morbidities, laboratory investigations, electrocardiogram, and echo parameters were captured. In-hospital 30-day and one-year mortality rates were recorded. The prescription and adherence to the three Guideline Directed Medical Therapy (GDMT) prescription in 2019–2021 were also captured at discharge. Mortality rate Gender-based comparisons were tested at a 5 % level of significance.</div></div><div><h3>Results</h3><div>The study enrolled 5182 AHF patients, 66.7 % male (M) and 33.3 % female (F). The mean age of the male (M) population was 60.9 ± 13.3, and the female (F) population was 62.8 ± 14 years. Women had a higher prevalence of heart failure with preserved ejection fraction (HFpEF)(F:12.9 %, M:7.3 %;<em>P</em> &lt; 0.0001), hypertension (F: 57.2 %, M: 52.4 %; <em>P</em> = 0.0011) and arrhythmia (F:15.2 %, M:11.7 %;<em>P</em> = 0.0005). Men had a higher incidence of ischemic heart disease (M:76.2 %, F:67.5 %; <em>P</em> &lt; 0.001). Adherence to Renin-angiotensin-aldosterone system (RAAS) inhibitors, Beta-blockers and Mineralocorticoid receptor antagonists (MRAs) was low (18.8 % (M); 15.9 % (F)). The mortality rate, in-hospital mortality was 6.9 % (M:6.5 %, F:7.7 %), up to one-month was 11.8 % (M:11.6 %, F:12.3 %) or one-year was 18.1 % (M:17.8 %, F:18.6 %).</div></div><div><h3>Conclusion</h3><div>Women represent one-third of the population with AHF. Hypertension and HFpEF were more common in women, while ischemic heart disease was more prevalent in men. No gender-based differences were observed in the mortality outcomes. Both groups had low GDMT adherence. This calls for effective strategies to improve HF care in the country.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200441"},"PeriodicalIF":1.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and disparities in inflammatory bowel disease and cardiovascular disease-related mortality in the United States from 1999 to 2023: A CDC WONDER analysis","authors":"Syed Anjum Gardezi ,&nbsp;Nakul Sachdeva ,&nbsp;Insiya Mohammed Rampurawala ,&nbsp;Akalanka Ranasinghe ,&nbsp;Muhammad Umair Shehzad ,&nbsp;Kieran Gill ,&nbsp;Raheel Qureshi ,&nbsp;Ashish Gupta ,&nbsp;Ali Hasan ,&nbsp;Muzammil Farhan ,&nbsp;Azeem Hassan ,&nbsp;Eeshal Zulfiqar ,&nbsp;Mushood Ahmed ,&nbsp;Raheel Ahmed","doi":"10.1016/j.ijcrp.2025.200438","DOIUrl":"10.1016/j.ijcrp.2025.200438","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with inflammatory Bowel Disease (IBD) may face an increased risk of cardiovascular disease (CVD) due to chronic systemic inflammation and vascular dysfunction. While advancements in treatment have improved IBD management, its impact on cardiovascular mortality remains unclear. This study aims to analyze trends in IBD- and CVD-related mortality in the U.S. from 1999 to 2023, identifying high-risk populations based on age, sex, race, and geography.</div></div><div><h3>Methods</h3><div>Mortality data for individuals aged 25 years and older from 1999 to 2023 were obtained from the CDC WONDER database. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated. Temporal trends were assessed using Joinpoint regression analysis to estimate the annual percent change (APC) and average annual percent change (AAPC) in mortality rates.</div></div><div><h3>Results</h3><div>Between 1999 and 2023, a total of 41,635 deaths were identified related to IBD and CVD among adults aged 25 years and older. The overall AAMR remained relatively stable from 1999 to 2018 before increasing sharply from 0.67 in 2018 to 1.03 in 2021 [APC: 15.63∗ (95 % CI: 11.66, 17.91); p = 0.0004], after which it plateaued through 2023. Males consistently exhibited higher AAMRs than females throughout the study period (Males: 1.10 vs. Females: 0.90 in 2023). When stratified by race, the highest AAMR was observed in NH White populations, followed by NH Black or African American individuals (1.21 vs. 0.64 in 2023). Regionally, the highest mortality was observed in the West, followed by the Midwest, the Northeast, and lastly, the South (AAMR of 1.02, 1.08, 0.87, and 0.97, respectively, in 2023). Rural areas (0.74) exhibited consistently higher AAMRs than urban areas (0.69) from 1999 to 2020. Mortality rates increased with age, with the highest burden observed in individuals aged 85 years and older.</div></div><div><h3>Conclusion</h3><div>IBD- and CVD-related mortality has risen in the U.S., with the highest burden among males, NH White individuals, and older adults. Targeted interventions and enhanced cardiovascular screening are needed to reduce mortality in high-risk populations.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200438"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on obesity-related cardiovascular mortality: Trends and disparities in the United States","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200439","DOIUrl":"10.1016/j.ijcrp.2025.200439","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200439"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A heart that cares: Providing utmost care to mothers with multiple pregnancies","authors":"Dalmacito A. Cordero Jr.","doi":"10.1016/j.ijcrp.2025.200434","DOIUrl":"10.1016/j.ijcrp.2025.200434","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200434"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic hearts: Machine learning uncovers the cardiovascular toll of heavy metals in the Philippine landscape","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200435","DOIUrl":"10.1016/j.ijcrp.2025.200435","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200435"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased dietary acid load May elevate the risk of coronary artery disease severity: Findings from a cross-sectional study","authors":"Zeinab Ghorbani ,&nbsp;Fatemeh Dashti ,&nbsp;Zahra Saeedirad ,&nbsp;Amir Aris ,&nbsp;Marjan Mahdavi-Roshan ,&nbsp;Arsalan Salari","doi":"10.1016/j.ijcrp.2025.200423","DOIUrl":"10.1016/j.ijcrp.2025.200423","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade metabolic acidosis appears to play a role in the development of chronic disorders. This study aims to examine the relationship between Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) and the risk of severe coronary artery disease (CAD) in participants undergoing elective angiography.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, the data of 895 participants from the Nutrition Heshmat Registry (NUTHER) was collected. Dietary data were obtained using a validated food frequency questionnaire to calculate PRAL and NEAP. Participants were categorized into severe CAD (Gensini score≥60; n = 526) and non-severe CAD (Gensini score&lt;60; n = 369). Logistic regression was conducted to evaluate the odds ratio (OR) and 95 % confidence interval (95 %CI). Restricted cubic spline (RCS) regression was employed to explore potential nonlinear associations between PRAL, and NEAP and severe-CAD risk.</div></div><div><h3>Results</h3><div>After adjusting for potential confounding factors, participants in the third to fourth quartiles of energy-adjusted PRAL and NEAP exhibited higher odds of severe CAD that were approximately 1.62–1.80 times and 1.67–2.76 times greater, respectively, compared to those in the 1^stquartiles (4^thquartile ORs(95 %CI) for: PRAL: 1.62 (1.05, 2.51); and NEAP: 1.67 (1.07, 2.61) (P-for-trend&lt;0.021). RCS analysis showed a linear dose-response relationship between elevated PRAL and severe CAD risk (P-for-overall-trend = 0.0176; P-for-nonlinearity = 0.1552), and a nonlinear association between higher NEAP and increased severe CAD risk (P-for-overall-trend = 0.0001; P-for-nonlinearity = 0.006).</div></div><div><h3>Conclusion</h3><div>The findings indicate a significant association between higher dietary acid load and increased risk of severe CAD, suggesting that a more acidic diet may contribute to the progression of atherosclerosis. However, further prospective studies are necessary to validate these observations.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200423"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischaemic heart disease and cardiovascular mortality in the Philippines: Current status and strategic policy insights","authors":"Danilo V. Rogayan Jr. ,&nbsp;Denn Harry R. Reusia","doi":"10.1016/j.ijcrp.2025.200436","DOIUrl":"10.1016/j.ijcrp.2025.200436","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200436"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of coenzyme Q10 administration on blood pressure and heart rate in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Mehdi Karimi ,&nbsp;Samira Pirzad ,&nbsp;Farnaz Hooshmand ,&nbsp;Niyousha Shirsalimi ,&nbsp;Seyed Morteza Ali Pourfaraji","doi":"10.1016/j.ijcrp.2025.200424","DOIUrl":"10.1016/j.ijcrp.2025.200424","url":null,"abstract":"<div><h3>Background and objective</h3><div>Coenzyme Q10 is a naturally occurring antioxidant that has been suggested to improve cardiovascular health. Studies examining the effects of Q10 on blood pressure (BP) and heart rate (HR) have found inconsistent results. This meta-analysis aims to clarify the effects of Q10 administration on BP and HR in adults.</div></div><div><h3>Methods</h3><div>A comprehensive search of online databases was conducted until February 2025 to identify relevant randomized controlled trials (RCTs). Following screening, relevant data were extracted from the eligible studies. Statistical analyses were conducted using weighted mean differences (WMD) with 95 % confidence intervals (CI). Data analysis was performed using the \"meta\" package in R.</div></div><div><h3>Results</h3><div>The pooled analysis of 45 RCTs (48 effect sizes) showed that Q10 administration significantly reduced systolic BP (WMD: −3.44 mmHg; 95 %CI: [-5.13 to −1.55], <em>p</em> &lt; 0.01), while no significant effect was observed on diastolic BP (WMD: −1.13 mmHg; 95 %CI: [-2.16 – 0.50], <em>p</em> = 0.23) and HR (WMD: −0.10 bpm; 95 %CI: [-2.09 – 1.89], <em>p</em> = 0.44). Subgroup analysis indicated that lower doses (&lt;200 mg/day) and longer interventions (&gt;8 weeks) resulted in greater systolic BP reductions.</div></div><div><h3>Conclusion</h3><div>This meta-analysis indicates that CoQ10 supplementation may be an effective adjunctive therapy for reducing systolic blood pressure, especially at doses below 200 mg/day and with longer treatment durations. However, its impact on diastolic blood pressure and heart rate appears minimal. Given its favorable safety profile, CoQ10 could be considered as a supportive option in the management of hypertension, particularly for patients seeking non-pharmacological interventions or those with mild elevations in systolic BP.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200424"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sleep disorders in cardiovascular disease: Insights and future directions for Asia","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200432","DOIUrl":"10.1016/j.ijcrp.2025.200432","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200432"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}