A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Marufa Mustari , Mohammad Abdul Hannan , Emran Ur Rashid Chowdhury , Sumon Rahman Chowdhury , Md. Abu Jar Gaffar , Swapan Kumar Singha , Choman Abdullah Mohana , Ershad Mondal , Md. Shahinur Rahman , Mohammad Motiur Rahman , Sourav Sarker , Md. Azizul Hoque , Md. Rashedul Islam , Md. Abdul Bari Robel , Shahryar Ahmad , Ahmed Ifrad Bin Raunak , Nur-A-Musabber , Md. Mostofa Kaisar , Shahjada Selim
{"title":"Cardiovascular risk in newly diagnosed patients with type 2 diabetes mellitus: a nationwide, facility-based, cross-sectional study in Bangladesh","authors":"A.B.M. Kamrul-Hasan , Muhammad Shah Alam , Marufa Mustari , Mohammad Abdul Hannan , Emran Ur Rashid Chowdhury , Sumon Rahman Chowdhury , Md. Abu Jar Gaffar , Swapan Kumar Singha , Choman Abdullah Mohana , Ershad Mondal , Md. Shahinur Rahman , Mohammad Motiur Rahman , Sourav Sarker , Md. Azizul Hoque , Md. Rashedul Islam , Md. Abdul Bari Robel , Shahryar Ahmad , Ahmed Ifrad Bin Raunak , Nur-A-Musabber , Md. Mostofa Kaisar , Shahjada Selim","doi":"10.1016/j.ijcrp.2025.200399","DOIUrl":"10.1016/j.ijcrp.2025.200399","url":null,"abstract":"<div><h3>Aims</h3><div>Evidence on cardiovascular (CV) risk stratification in Bangladeshi patients with type 2 diabetes mellitus (T2DM) who are asymptomatic for cardiovascular disease (CVD) is limited. This study aimed to assess the 10-year CV risk in newly diagnosed patients with T2DM.</div></div><div><h3>Methods</h3><div>In 2023, a cross-sectional study was carried out at endocrinology clinics in tertiary hospitals throughout Bangladesh, involving newly diagnosed patients with T2DM aged 25 to 84 who had no prior history of CVD and were asymptomatic for the condition. CV risk was assessed and classified using QRISK3.</div></div><div><h3>Results</h3><div>1617 newly diagnosed patients with T2DM (age 44.92 ± 11.84 years, male 49.5 %) were analyzed. Their median QRISK3 score was 11.0 %, with 46.5 % at low, 25.7 % at moderate, and 27.8 % at high 10-year CV risk, respectively. The QRISK3 score increased with age for both men and women, with men consistently scoring higher than women in every age group. Among the age groups 25–39, 40–64, and 65–84, the percentages of patients with high 10-year CV risk were 3.3 %, 34.0 %, and 94.5 %, respectively. The median relative risk (RR) of CVD was 4.3. RR decreased with age for both sexes, and men had a lower RR than women across all age groups. A sleep duration of 6–9 h was associated with a lower 10-year CV risk.</div></div><div><h3>Conclusions</h3><div>Many newly diagnosed Bangladeshi patients with T2DM have substantial CV risk. QRISK3 can assist clinicians in predicting 10-year CV risk and choosing appropriate treatments to prevent CVD.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200399"},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Holistic health: A key to managing atrial fibrillation","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200402","DOIUrl":"10.1016/j.ijcrp.2025.200402","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200402"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing the dangers of high sodium intake for a better health","authors":"Dalmacito A. Cordero Jr.","doi":"10.1016/j.ijcrp.2025.200403","DOIUrl":"10.1016/j.ijcrp.2025.200403","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200403"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reducing premature mortality from cardiovascular diseases in low and middle income countries: The role of Polypill in public health policy","authors":"Sadaf G. Sepanlou , SeyedehFatemeh Mousavi , Hossein Poustchi , Fatemeh Malekzadeh , Gholamreza Roshandel , Reza Malekzadeh","doi":"10.1016/j.ijcrp.2025.200400","DOIUrl":"10.1016/j.ijcrp.2025.200400","url":null,"abstract":"<div><div>Premature deaths account for about half of all fatalities in developing countries. In low- and middle-income countries, cardiovascular diseases have consistently been the primary cause of premature mortality for men and women during the past three decades.</div><div>Current evidence indicates that fixed-dose combination therapy, the so-called Polypill, effectively reduces the burden of cardiovascular diseases, with greater benefits observed in combinations that include aspirin. Polypill demonstrates high adherence and an acceptable safety profile, with adverse drug events being comparable between the groups receiving treatment and those in the control group.</div><div>Therefore, this paper advocates for the broader implementation of Polypill in low and middle-income countries, emphasizing its efficacy in the primary and secondary prevention of cardiovascular diseases. The strategy could also benefit high-risk groups with special conditions, such as non-alcoholic fatty liver disease and chronic kidney disease. The cost-effectiveness of Polypill and its potential to address health inequities in low and middle-income countries underscore its value as a public health strategy. Policymakers are encouraged to consider Polypill as a viable option to enhance cardiovascular health outcomes and reduce premature deaths in low-resource settings.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200400"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between electronic cigarette use and cardiovascular disease among a United States representative population","authors":"Humza Naqvi , Charles Searles","doi":"10.1016/j.ijcrp.2025.200401","DOIUrl":"10.1016/j.ijcrp.2025.200401","url":null,"abstract":"<div><div>Electronic cigarettes have become increasingly popular, and many people use them as a safer alternative to conventional cigarettes. However, the impact of electronic cigarette use on cardiovascular health is uncertain. Here, we queried national survey data to examine the relationship between electronic cigarette use and self-reported cardiovascular disease, and we identified an association between electronic cigarette use and angina and MI but not stroke or CHF.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200401"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing the cardiometabolic risks of adolescents in developing countries","authors":"Dalmacito A. Cordero Jr","doi":"10.1016/j.ijcrp.2025.200398","DOIUrl":"10.1016/j.ijcrp.2025.200398","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200398"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of preventive strategies on IHD mortality in Alzheimer's disease","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200397","DOIUrl":"10.1016/j.ijcrp.2025.200397","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200397"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The multifaceted significance of miR-155 in cardiovascular pathologies: Diagnostic and therapeutic implications","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200395","DOIUrl":"10.1016/j.ijcrp.2025.200395","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200395"},"PeriodicalIF":1.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoying He , Jingyi Xiao , Yan Wang , Christopher Reid , Dan Xu , Hua Hong
{"title":"Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study","authors":"Xiaoying He , Jingyi Xiao , Yan Wang , Christopher Reid , Dan Xu , Hua Hong","doi":"10.1016/j.ijcrp.2025.200394","DOIUrl":"10.1016/j.ijcrp.2025.200394","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between dyslipidemia and cerebral atrophy in Chinese health check-up population.</div></div><div><h3>Methods</h3><div>67,526 participants underwent routine health check-ups at the health management center of the First Affiliated Hospital of Sun Yat-Sen University (FAH-SYSU) in Guangzhou for two years (2022-2023) in this cross-sectional study. Cerebral atrophy was determined by expert physicians based on non-contrast scans of Head Magnetic Resonance Imaging (MRI), Magnetic Resonance Angiography (MRA) and/or Head Computed Tomography (CT). The levels of Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured and classified by quartiles into four categories, respectively. The multivariable logistic regression model was used to obtain the odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>A total of 1,661 participants were included with ages from 18 to 93 years. Among 1,661 participants, 121 (7.28%) had cerebral atrophy. On multivariate analysis, TC and LDL-C were not associated with cerebral atrophy, although TC and LDL-C were lower in the subgroup with cerebral atrophy.</div></div><div><h3>Conclusions</h3><div>This cross-sectional study conducted in China is the first to identify that health check-up examinees with cerebral atrophy had lower levels of TC and LDL-C raising the possible association between lower levels of TC and LDL-C with cerebral atrophy, and possible cognitive dysfunction. Future study is planned to overcome the existing limitation and address the lack of statistically significant association between TC and LDL-C levels with cerebral atrophy and possible dementia.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200394"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Henrik Hagström , Linda Nyström Hagfors , Rikard Hedelin , Mattias Brunström , Krister Lindmark
{"title":"Low carbohydrate high fat-diet in real life; A descriptive analysis of cardiovascular risk factors","authors":"Henrik Hagström , Linda Nyström Hagfors , Rikard Hedelin , Mattias Brunström , Krister Lindmark","doi":"10.1016/j.ijcrp.2025.200384","DOIUrl":"10.1016/j.ijcrp.2025.200384","url":null,"abstract":"<div><h3>Aims</h3><div>Low Carbohydrate High Fat (LCHF) diets are popular for weight loss or glucose control. The main source of energy in such diets is fat but the composition of nutrients varies This study aims to investigate dietary variations in a real-world LCHF population and its associations with cardiovascular risk factors.</div></div><div><h3>Methods</h3><div>We recruited 100 volunteers who considered themselves adherent to a LCHF diet. Their last 14 days of dietary intake was assessed using diet history interviews. Validation of energy intake against expenditure was made using activity monitors. Predictive variables for the linear regression models were selected using stepwise bidirectional assessment of Akaike information criterion (AIC).</div></div><div><h3>Results</h3><div>Energy intake (E%) from carbohydrates was low, 8.7 E%, and fat was the main replacement. Dietary cholesterol was associated with higher total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Dietary sodium intake was associated with higher blood pressure. Protein intake was associated with lower diastolic blood pressure but also with lower HDL. The intake of dietary fibre was associated with lower LDL and total cholesterol but with higher hemoglobin A1c (HbA1c). The intake of carbohydrates and saturated fatty acids (SFA) was not associated with any of the outcome variables.</div></div><div><h3>Conclusion</h3><div>In this LCHF population, variations in intake of carbohydrates and saturated fatty acids could not predict any aspects of the cardiovascular risk profile. Lower fibre intake and higher cholesterol and sodium intake predicted a less favorable cardiovascular risk profile.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200384"},"PeriodicalIF":1.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}