International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Three-decade analysis of regional disparities in metabolic risk factor related ischemic heart disease mortality: Contrasting trends between South Asia and North America","authors":"Bilawal Nadeem ,&nbsp;Koravich Lorlowhakarn ,&nbsp;Saad Ur Rahman ,&nbsp;Muhammad Talha ,&nbsp;Sarju Ganatra ,&nbsp;Sourbha S. Dani","doi":"10.1016/j.ijcrp.2025.200425","DOIUrl":"10.1016/j.ijcrp.2025.200425","url":null,"abstract":"<div><h3>Background</h3><div>The impact of metabolic risk factors on ischemic heart disease (IHD) exhibits substantial regional variability. This study aims to analyze three-decade mortality trends in two contrasting regions of North America (NA) and South Asia (SA), focusing on age- and gender-specific variations.</div></div><div><h3>Methods</h3><div>Data from the Global Burden of Disease (GBD) database [1990–2021] were employed in Joinpoint Regression Program to compute the Annual Percent Changes (APC) and Average Annual Percent Changes (AAPC). Mortality rate trends were disaggregated by age and gender and subsequently compared both within and between the NA and SA populations, with statistical significance set at P &lt; 0.05. Results were graphically represented, with mortality rates per 100,000 on the y-axis and years on the x-axis.</div></div><div><h3>Results</h3><div>An overall decline in mortality rates was noted in NA, whereas SA displayed an overall increase. Age-specific stratification revealed that older adults in NA had a higher baseline mortality rate and experienced a more pronounced decline compared to younger adults. In contrast, older adults in SA exhibited a significant increase in mortality rates, whereas younger adults showed no significant change. Gender-specific analysis indicated substantial reductions in mortality rates for both males and females in NA, while SA males demonstrated a sharper increase, and SA females experienced no significant change.</div></div><div><h3>Conclusions</h3><div>Our study revealed divergent trends in metabolic risk factor-related IHD mortality between NA and SA, with significant variations observed across age and gender groups emphasizing the necessity of investigating the socioeconomic, environmental, and genetic determinants driving these disparities.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200425"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localizing global strategies: A kidney-heart-centered framework for cardiovascular risk reduction in Filipino CKD patient","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200429","DOIUrl":"10.1016/j.ijcrp.2025.200429","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200429"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing health literacy through cardiac rehabilitation: Insights and future directions","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200427","DOIUrl":"10.1016/j.ijcrp.2025.200427","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200427"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence: Enhancing diagnosis and treatment plans for acute coronary syndrome","authors":"Dalmacito A. Cordero Jr.","doi":"10.1016/j.ijcrp.2025.200430","DOIUrl":"10.1016/j.ijcrp.2025.200430","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200430"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep epidemic in the Philippines: A silent driver of cardiovascular risk","authors":"Danilo V. Rogayan Jr. ,&nbsp;Edna M. Padre","doi":"10.1016/j.ijcrp.2025.200431","DOIUrl":"10.1016/j.ijcrp.2025.200431","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200431"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of cardiovascular disease and sepsis related mortality in the United States, 1999 to 2019: A CDC WONDER Database Analysis","authors":"Shehroze Tabassum ,&nbsp;Faraz Azhar ,&nbsp;Aimen Shafiq ,&nbsp;Muneeba Ahsan ,&nbsp;Aroma Naeem ,&nbsp;Farhan Naeem ,&nbsp;Hafeez Ul Hassan Virk ,&nbsp;Abdul Mannan Khan Minhas ,&nbsp;Dmitry Abramov ,&nbsp;M Chadi Alraies","doi":"10.1016/j.ijcrp.2025.200421","DOIUrl":"10.1016/j.ijcrp.2025.200421","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis and cardiovascular disease (CVD) are common conditions, and both contribute to mortality. The objective of our study is to explore the contemporary mortality trends associated with CVD and sepsis among patients ≥25 years in the United States (US).</div></div><div><h3>Methods</h3><div>We conducted an analysis of death data using CDC WONDER, extracting age-adjusted mortality rates (AAMR) per 100,000 for mortality with an underlying or contributing diagnosis of both CVD and sepsis. Trends by age, gender, ethnicity and race, census region, and metropolitan status were analyzed. Joinpoint regression calculated the annual percent change (APC) for AAMR with 95 % CI.</div></div><div><h3>Results</h3><div>From 1999 to 2019, there were a total of 1,601,794 deaths related to CVD and sepsis. The AAMR related to both CVD and sepsis showed an overall decrease from 1999 to 2019 (1999: 37.9; 95 % CI: 37.6 to 38.1 vs. 2019: 35.4; 95 % CI: 35.2 to 35.7). Men had consistently higher AAMRs compared to women (Men: 41.5; 95 % CI: 41.4 to 41.6 vs. Women: 31.3; 95 % CI: 31.2 to 31.4). Non-Hispanic Black or African American individuals and adults aged ≥65 had the highest CVD and sepsis-related AAMRs. Similarly, the AAMRs were highest in the Northeastern region and among residents of metropolitan areas.</div></div><div><h3>Conclusion</h3><div>Though there has been a reduction in CVD and sepsis-related deaths among patients, significant disparities remain across various demographic groups, underscoring the need for continued research.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200421"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multiple complications of pregnancy and risk of cardiovascular disease in a large cohort","authors":"Jingyi Li ,&nbsp;Qingping Xue ,&nbsp;Yingru Li ,&nbsp;Yidan Dong ,&nbsp;Qingqing Ouyang ,&nbsp;Peiqi Zhang ,&nbsp;Xinyue Yu ,&nbsp;Yunhaonan Yang ,&nbsp;Shuo Li ,&nbsp;Fan Li ,&nbsp;Tianlei Wang ,&nbsp;Jian Chen ,&nbsp;Xiong-Fei Pan","doi":"10.1016/j.ijcrp.2025.200422","DOIUrl":"10.1016/j.ijcrp.2025.200422","url":null,"abstract":"<div><h3>Background</h3><div>Previous research assessed the relationship between individual complications of pregnancy and risk of cardiovascular disease (CVD). However, complications of pregnancy frequently coexist, and their synergistic effects may potentially amplify the maternal cardiovascular risk. This study aimed to assess the joint effect of multiple complications of pregnancy on future CVD in women.</div></div><div><h3>Methods</h3><div>We included 157,034 women aged 40–69 years with at least one live birth from the UK Biobank. Cox proportional hazards models were used to assess the joint association between six pregnancy complications (gestational diabetes mellitus, hypertensive disorders of pregnancy, stillbirth, miscarriage, low birth weight, and macrosomia) and subsequent cardiovascular outcomes. Subgroup analyses were performed to examine the effects of pregnancy complications on CVD across different subgroups.</div></div><div><h3>Results</h3><div>Compared to those without pregnancy complications, women with three or more complications had higher risks of total CVD (hazard ratio: 1.66; 95 % confidence interval: 1.40–1.96), coronary artery disease (1.79; 1.39–2.32), stroke (1.73; 1.12–2.70), atherosclerotic cardiovascular disease (ASCVD) (1.90; 1.54–2.34), and non-ASCVD (1.65; 1.34–2.04). A stronger association was noted in women aged 40–49 years for total CVD (2.35; 1.64–3.37) than other age groups. In addition, the associations between multiple complications of pregnancy and total CVD were partly mediated by hypertension, dyslipidemia, and diabetes in middle life (proportion of mediation: 7.8 %, 2.5 %, and 11.6 %).</div></div><div><h3>Conclusions</h3><div>Women with a higher number of pregnancy complications demonstrated progressively increased risks of cardiovascular outcomes, which were partly mediated by hypertension, dyslipidemia, and diabetes in middle life. These findings underscore the importance of monitoring CVD in women with multiple complications of pregnancy.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200422"},"PeriodicalIF":1.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between urinary and blood heavy metal exposure and heart failure in elderly adults: Insights from an interpretable machine learning model based on NHANES (2003–2020)","authors":"Yang Yuting ,&nbsp;Deng Shan","doi":"10.1016/j.ijcrp.2025.200418","DOIUrl":"10.1016/j.ijcrp.2025.200418","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between heavy metal exposure and heart failure is complex and poorly understood. This study employs machine learning techniques to model these associations in a population aged 50 years and older from the National Health and Nutrition Examination Survey (NHANES). Our findings emphasize the need for continued investigation into the mechanisms of these associations and highlight the importance of monitoring and regulatory measures to mitigate heavy metal exposure in populations at risk.</div></div><div><h3>Methods</h3><div>Five machine learning models were evaluated, with Gradient Boosting Decision Trees (GBDT) selected as the optimal model based on accuracy, interpretability, and ability to capture nonlinear relationships. Model performance was assessed through various metrics, and interpretability was enhanced using SHAP (SHapley Additive exPlanations), permuted Feature Importance, Individual Conditional Expectation (ICE), and Partial Dependence Plots (PDP).</div></div><div><h3>Results</h3><div>The GBDT model achieved an accuracy of 0.78, with a sensitivity of 0.93 and an AUC of 0.92. Our analysis revealed that higher levels of urinary iodine, blood cadmium, urinary cobalt, urinary tungsten, and urinary arsenic acid were significantly associated with heart failure. Synergistic effects involving age and body mass index (BMI) were also observed, further strengthening these associations.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200418"},"PeriodicalIF":1.9,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in coronary artery disease mortality among hyperlipidemic patients: Geographic, gender, and racial insights from CDC WONDER data (1999–2020)","authors":"Muhammad Abdullah Naveed ,&nbsp;Sivaram Neppala ,&nbsp;Himaja Dutt Chigurupati ,&nbsp;Bazil Azeem ,&nbsp;Ahila Ali ,&nbsp;Faizan Ahmed ,&nbsp;Sabin Zafar ,&nbsp;Muhammad Omer Rehan ,&nbsp;Rabia Iqbal ,&nbsp;Manahil Mubeen ,&nbsp;Hassaan Abid ,&nbsp;Anum Mubasher ,&nbsp;Timir Paul","doi":"10.1016/j.ijcrp.2025.200416","DOIUrl":"10.1016/j.ijcrp.2025.200416","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease (CAD) in hyperlipidemia is a significant cause of mortality among adults in the United States. This study investigates trends in CAD-related mortality in hyperlipidemia among adults aged 25 and older, focusing on geographic, gender, and racial/ethnic disparities from 1999 to 2020.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted using the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) were calculated per 100,000 persons, stratified by year, sex, race/ethnicity, and geographical region.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, CAD in hyperlipidemia led to 407,667 deaths among US adults aged 25+. The AAMR for CAD in hyperlipidemia rose from 4.1 in 1999 to 12.1 in 2020, with an AAPC of 4.44 (95 % CI: 3.69 to 5.48, p &lt; 0.000001). Men had higher AAMRs (12.4) than women (5.6), with significant increases for both sexes over time. Racial/ethnic disparities showed the highest AAMRs in Whites (8.9), followed by American Indians/Alaska Natives (8.6). Geographically, AAMRs varied from 3.8 in Alabama to 16.0 in Vermont, with the Midwest showing the highest rates (9.7). Nonmetropolitan areas exhibited higher AAMRs (9.6) than metropolitan areas (8.3), with a more significant increase in nonmetropolitan areas (AAPC: 5.82, p &lt; 0.000001).</div></div><div><h3>Conclusion</h3><div>This study highlights significant disparities in CAD in hyperlipidemia-related mortality among US adults by race, gender, and geography. The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200416"},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving multimorbidity patterns among ageing adults with cardiovascular disease continuum in Southwest China: A longitudinal cohort study","authors":"Xiaoya Qi ,&nbsp;Ziyue Zhang ,&nbsp;Meng Jia ,&nbsp;Yangping Zhang ,&nbsp;Shuang Feng ,&nbsp;Ruixue Bai ,&nbsp;Siyao Wang ,&nbsp;Jinning Mao ,&nbsp;Shu Su","doi":"10.1016/j.ijcrp.2025.200417","DOIUrl":"10.1016/j.ijcrp.2025.200417","url":null,"abstract":"<div><h3>Background</h3><div>The progression of multimorbidity in Chinese ageing adults with cardiovascular diseases remains inadequately understood. This study investigates the longitudinal evolution of cardiovascular disease continuum (CVDC)-related multimorbidity patterns in this population.</div></div><div><h3>Methods</h3><div>The observational study analyzed medical examination reports from individuals aged 65 and older who underwent regular physical examinations during January 1, 2010 to December 31, 2022 at the Second Affiliated Hospital of Chongqing Medical University. Multimorbidity patterns of CVDC were examined. The construction of the multimorbidity network was based on Spearman correlation analyses to visualize the evolution of gender differences. Odds ratios (ORs) for developing multimorbidity in CVDC in compared to non-CVDC were calculated. Survival analysis and multivariate cox proportional hazards regression were performed to estimate the cumulative probability and identify risk factors for multimorbidity.</div></div><div><h3>Results</h3><div>A total of 10,052 eligible individuals with 1835 (18.26 %) diagnosed with CVDC at baseline were included. The strongest positive correlation was observed between CVDC and obesity related diseases during both the initial (r_males = 0.208, r_females = 0.244) and final (r_males = 0.312, r_females = 0.248) examinations. Survival analysis revealed that the cumulative probability of multimorbidity of metabolic diseases in hypertension, dyslipidemia and atherosclerosis had increased over time; the corresponding adjusted HRs (95 % CIs) were 1.322 (1.219, 1.433), 1.553 (1.413, 1.706), and 1.460 (1.361, 1.567), respectively. The increasing risks of CVDC-related multimorbidity were primarily attributable to salty dietary habit (AHR = 1.336, 95 % CI: 1.239, 1.411).</div></div><div><h3>Conclusions</h3><div>Multimorbidity patterns and disease networks associated with CVDC have become more complex over time, especially with metabolic diseases. A high-salty diet significantly increased the risk of CVDC-related multimorbidity.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200417"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}