International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020","authors":"Muzamil Akhtar ,&nbsp;Hanzala Ahmed Farooqi ,&nbsp;Rayyan Nabi ,&nbsp;Javed Iqbal ,&nbsp;Sabahat Ul Ain Munir Abbasi ,&nbsp;Muhammad Rashid ,&nbsp;Syed Khurram Mushtaq Gardezi ,&nbsp;David P. Ripley ,&nbsp;Raheel Ahmed","doi":"10.1016/j.ijcrp.2025.200390","DOIUrl":"10.1016/j.ijcrp.2025.200390","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic heart diseases (IHD) and Alzheimer's Disease (AD) significantly contribute to mortality in aging population. Understanding mortality trends where these conditions overlap is crucial for developing targeted interventions for vulnerable populations.</div></div><div><h3>Methods</h3><div>We analyzed CDC WONDER mortality data from 1999 to 2020 for individuals aged ≥45 years. IHD and AD mortality were identified using ICD-10 codes I20-I25 and G30, respectively. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed by gender, race, region, place of death and state. Joinpoint regression was used to calculate annual percentage changes (APC) with 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>A total of 171,080 deaths were attributed to IHD in individuals with AD from 1999 to 2020. The AAMR decreased from 10.6 in 1999 to 4.1 in 2020, with a significant decline between 2004 and 2014 (APC: −7.73; 95 % CI: −8.42 to −7.24). Females exhibited higher overall AAMR compared to males (Females: 6.8 vs. Males: 6.4). Individuals of Non-Hispanic (NH) White ancestry had the highest AAMR (6.8), followed by those of NH Black (6.5) and Hispanic ancestry (5.9). The West region reported the highest AAMR at 7.9, while the Midwest had the lowest at 6.3. Oklahoma recorded the highest state-level AAMR (10.9), while Utah had the lowest (3.2).</div></div><div><h3>Conclusions</h3><div>IHD mortality in individuals with AD declined significantly, with disparities by gender, race, and geography. These findings underscore the need for tailored public health approaches to address the evolving burden of IHD in AD patients.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200390"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020","authors":"Muhammad Abdullah Naveed ,&nbsp;Sivaram Neppala ,&nbsp;Himaja Dutt Chigurupati ,&nbsp;Ahila Ali ,&nbsp;Muhammad Omer Rehan ,&nbsp;Ayman Fath ,&nbsp;Bazil Azeem ,&nbsp;Rabia Iqbal ,&nbsp;Manahil Mubeen ,&nbsp;Hamza Naveed ,&nbsp;Muhammad Naveed Uz Zafar ,&nbsp;Mushood Ahmed ,&nbsp;Jamal S. Rana ,&nbsp;Brijesh Patel","doi":"10.1016/j.ijcrp.2025.200392","DOIUrl":"10.1016/j.ijcrp.2025.200392","url":null,"abstract":"<div><h3>Background</h3><div>Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue.</div></div><div><h3>Objective</h3><div>This study analyzed demographic trends and disparities in mortality rates due to AMI in malignancy among adults aged 65 and older from 1999 to 2020.</div></div><div><h3>Methods</h3><div>We used the CDC WONDER database to analyze Age-adjusted mortality rates (AAMRs) for AMI in malignancy patients (ICD-10 I21, C00-C97) from 1999 to 2020, stratifying by sex, race, geography, and metropolitan status. We calculated Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) using Joinpoint regression.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, AMI in malignancy accounted for 172,691 deaths among adults aged ≥65 years, with the majority of deaths occurring in medical facilities (56.9 %). The overall AAMR for AMI in malignancy-related deaths decreased from 30.2 in 1999 to 14.2 in 2020, with an AAPC of −3.90 (p &lt; 0.000001). Men showed higher AAMRs than women (28.6 vs. 12.3), with a more pronounced decrease in men (AAPC: 4.22, p &lt; 0.000001) compared to women (AAPC: 3.78, p &lt; 0.000001). Black individuals have the highest AAMR (22.7), followed by Whites (19.3). Arkansas had the highest AAMR (32.3), while Nevada had the lowest (8.1), with the Northeastern region having the highest regional AAMR (20.2), and nonmetropolitan areas had higher AAMRs.</div></div><div><h3>Conclusion</h3><div>This study reveals significant demographic disparities in mortality rates related to AMI in malignant older adults. These findings emphasize the need for targeted interventions and improved access to care.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200392"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study","authors":"Xiaodong Li ,&nbsp;Yarong Ma ,&nbsp;Qiulin Jiang ,&nbsp;Huizhi Zhan ,&nbsp;Xiaolei Sun","doi":"10.1016/j.ijcrp.2025.200388","DOIUrl":"10.1016/j.ijcrp.2025.200388","url":null,"abstract":"<div><h3>Background</h3><div>Circulating amino acid levels can be altered in arterial aneurysms and dissection, but the relationships between them is unclear. The present study investigated the causal relationship between circulating amino acid levels and arterial aneurysms and dissection via bidirectional two-sample Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>A bidirectional two-sample MR analysis was used. Forward analysis was performed with amino acid levels as the exposure and arterial aneurysms and dissection as outcomes. Reverse analysis was performed with arterial aneurysms and dissection as exposures and circulating amino acid levels as outcomes. MR data were analyzed using five analytical methods: the inverse-variance weighted (IVW), MR‒Egger, weighted median, simple, and weighted methods. IVW was used as the main analytical method, and the other methods were used for supplementary analyses. Heterogeneity was assessed using Cochran's Q test, and horizontal pleiotropy was assessed using intercepts from MR‒Egger regression. The genome-wide association study (GWAS) data for circulating amino acids were obtained from the IEU open GWAS database and the GWAS Catalog database. The GWAS data for arterial aneurysms and dissection were obtained from the Finngen consortium database version R10.</div></div><div><h3>Results</h3><div>The tyrosine level was negatively correlated with other aneurysms (P = 0.00211, OR: 0.57, 95 % CI: 0.40, 0.82). Aortic dissection decreased the circulating glycine level (P = 0.00168, OR: 0.98, 95 % CI: 0.98, 0.99).</div></div><div><h3>Conclusion</h3><div>Through bidirectional MR analysis, we found that tyrosine level was negatively correlated with other aneurysms and that aortic dissection reduced circulating glycine. Our findings support a possible interaction between circulating amino acid levels and arterial aneurysms and dissection.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200388"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehospitalization, mortality and associated variables in primary care patients with heart failure and preserved ejection fraction after first hospitalization","authors":"Victoria Cendrós ,&nbsp;Mar Domingo ,&nbsp;Elena Navas ,&nbsp;Miguel Ángel Muñoz ,&nbsp;Antoni Bayés-Genís ,&nbsp;José María Verdú-Rotellar","doi":"10.1016/j.ijcrp.2025.200391","DOIUrl":"10.1016/j.ijcrp.2025.200391","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a paucity of studies providing insights into the progression of primary care patients with heart failure and preserved ejection fraction (HFpEF).</div></div><div><h3>Objetive</h3><div>To investigate the characteristics associated with mortality and rehospitalizations in primary care patients with heart failure and preserved ejection fraction (HFpEF), previously hospitalized.</div></div><div><h3>Methods</h3><div>Retrospective cohort study that included primary care patients with previous heart failure (HF) hospitalization and ejection fraction ≥50 of 328 primary care centers of Catalonia. Demographic, comorbidities, clinical, and treatment variables were collected. Outocomes: Mortality and HF rehospitalization. Adjusted Cox regression models were performed.</div></div><div><h3>Results</h3><div>Study included 2895 patients. Mean age was 77(SD 9.7) years, 57 % were female. Mean follow up was 2.0[1.0–9.0] years. A total of 864(29.8 %) patients died, 831(28.7 %) were hospitalized. Mortality was associated with male sex(HR 1.26, 95 % CI 1.06–1.49), age &gt;75 years(HR 2.76, 95 % CI 2.24–3.39), Charlson Index(HR 2.03, 95 % CI 1.21–3.42), body mass index(BMI) ≤30 kg/m²(HR 1.44, 95 % CI 1.22–1.69) and loop diuretics(HR 1.36, 95 % CI 1.11–1.65); hemoglobin levels(HR 0.87, 95 % CI 95 % 0.82–0.91) were protective. HF rehospitalization was associated with male sex(HR 1.14, 95 % CI 1.03–1.33), age &gt;75 years(HR 1.37, 95 % CI 1.17–1.61), atrial fibrillation(HR 1.44, 95 % CI 1.25–1.67), and loop diuretics(HR 1.37, 95 % CI 1.15–1.63). Hemoglobin(HR 0.91, 95 % CI 0.87–0.95) were protective.</div></div><div><h3>Conclusion</h3><div>High proportion of HFpEF patients were hospitalized or died at 5 years follow up. Comorbidities, demographic, analytical and treatment variables played a relevant role as prognostic factors.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200391"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis","authors":"Lei Yang ,&nbsp;Fang-Xiao Hu ,&nbsp;Kun Wang ,&nbsp;Zhi-Zheng Wang ,&nbsp;Jie Yang","doi":"10.1016/j.ijcrp.2025.200387","DOIUrl":"10.1016/j.ijcrp.2025.200387","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a primary risk factor for cardiovascular and cerebrovascular diseases. A number of studies have suggested that sleep duration play an important role in the development of hypertension. Hypertension in young and middle-aged individuals is characterized by low awareness and treatment rates, increasing the risk of adverse events. To further elucidate the relationship between sleep duration and hypertension risk in young and middle-aged individuals, we conducted a meta-analysis.</div></div><div><h3>Methods</h3><div>This study searched PubMed, Embase, and the Cochrane Library from January 2003 to November 5, 2023. Data analysis was performed using STATA 17. Using Q test and I2-statistic, heterogeneity test for the included studies was conducted. Potential small-sample effects were evaluated based on the symmetry of funnel plots, and publication bias in included studies was evaluated using Egger's test.</div></div><div><h3>Results</h3><div>Data analysis of sleep duration was conducted for 16 studies, which revealed that both long sleep duration (OR, 1.10; 95 % CI, 1.05–1.15) and short sleep duration (RR: 1.10, 95 % CI: 1.05 to 1.15) were associated with hypertension in young and middle-aged individuals, particularly in Asian populations.</div></div><div><h3>Conclusions</h3><div>This meta-analysis revealed an association between sleep duration (short [&lt;7 h] and long [≥9 h]) and the development of hypertension in young and middle-aged adults, particularly in Asian populations. Sleep is a behavior that can be modified. Clinicians and health professionals should be encouraged to intensify efforts to promote healthy sleep for all and reduce the occurrence of high blood pressure in young and middle-aged individuals.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200387"},"PeriodicalIF":1.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social epidemiology of cardiometabolic risk factors in early adolescents","authors":"Jason M. Nagata ,&nbsp;Christiane K. Helmer ,&nbsp;Jennifer H. Wong ,&nbsp;Seohyeong Lee ,&nbsp;Sydnie K. Domingue ,&nbsp;Patrick Low ,&nbsp;Abubakr A.A. Al-shoaibi ,&nbsp;Joan E. Shim ,&nbsp;Kyle T. Ganson ,&nbsp;Alexander Testa ,&nbsp;Orsolya Kiss ,&nbsp;Holly C. Gooding ,&nbsp;Erin E. Dooley ,&nbsp;Kelley Pettee Gabriel ,&nbsp;Fiona C. Baker","doi":"10.1016/j.ijcrp.2025.200382","DOIUrl":"10.1016/j.ijcrp.2025.200382","url":null,"abstract":"<div><h3>Background</h3><div>To estimate associations between sociodemographic factors and cardiometabolic risk factors among a demographically diverse sample of U.S. adolescents aged 10–14 years.</div></div><div><h3>Methods</h3><div>This study analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 1412), Years 2 and 3 (2018–2021). Cardiometabolic risk factors including hemoglobin A1c and cholesterol (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C) were assessed. Multivariable linear regression models were conducted to estimate the associations between sociodemographic factors (age, sex, race and ethnicity, household income, and parental education) and cardiometabolic risk factors (hemoglobin A1c, TC, HDL-C, and non-HDL-C).</div></div><div><h3>Results</h3><div>The average hemoglobin A1c level was 5.2 % (±0.4 %), the average TC level was 156.6 (±28.9) mg/dL, and the average HDL-C level was 56.0 (±12.9) mg/dL. Out of our sample, 0.5 % had diabetes (hemoglobin A1c ≥ 6.5 %), 7.6 % had high TC (≥200 mg/dL), and 7.4 % had low HDL-C (&lt;40 mg/dL). Older age was associated with lower TC, HDL-C, and non-HDL-C levels. Male sex was associated with higher hemoglobin A1c (beta coefficient [B] 0.04; 95 % confidence interval [CI], 0.00, 0.08; p = 0.037) and lower TC (B −3.14; 95 % CI, −6.17, −0.11; p = 0.042) compared to female sex. Black and Native American race and ethnicity were associated with higher hemoglobin A1c compared to White race. Higher household income was associated with higher TC and HDL-C.</div></div><div><h3>Conclusion</h3><div>This study of a diverse population of early adolescents identified sociodemographic differences in hemoglobin A1c and cholesterol levels that can inform clinical and public health interventions.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200382"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between racial residential segregation and hypertensive disorders of pregnancy among Black women: The Coronary Artery Risk Development in Young Adults Study","authors":"Leah V. Dodds ,&nbsp;Daniel J. Feaster ,&nbsp;Kiarri N. Kershaw ,&nbsp;Erica P. Gunderson ,&nbsp;Tatjana Rundek ,&nbsp;Michael Paidas ,&nbsp;Tali Elfassy","doi":"10.1016/j.ijcrp.2025.200381","DOIUrl":"10.1016/j.ijcrp.2025.200381","url":null,"abstract":"<div><h3>Introduction</h3><div>Black women are at greater risk of hypertensive disorders of pregnancy (HDP). Racial residential segregation (RRS) drives racial health disparities. This study investigates the association between RRS and the onset of HDP among Black parous women in the U.S.</div></div><div><h3>Methods</h3><div>The Coronary Artery Risk Development in Young Adults study is a cohort of Black and White adults aged 18–30 from four U.S. cities, recruited in 1985 and followed for over 30 years. RRS was measured using the local Getis-Ord Gi∗ statistic, categorizing neighborhoods as high (Gi∗ &gt;1.96), medium (Gi∗ 0–1.96), or low (Gi∗ &lt;0). Among Black women with at least one post-baseline pregnancy, HDP was self-reported as gestational hypertension, preeclampsia, or eclampsia. Generalized mixed models determined the association between RRS and HDP, for pregnancies (n = 941) nested within Black women (n = 598), and adjusting for age, follow-up time, time to pregnancy, education, income, BMI, physical activity, smoking, hypertension, baseline parity, and cumulative pregnancies.</div></div><div><h3>Results</h3><div>The mean age was 23.1 years (SD: 3.6), with 22.7 % reporting HDP in at least one pregnancy. The cumulative incidence of HDP was 23.0 % in high, 20.6 % in medium, and 23.7 % in low RRS neighborhoods. Fully adjusted models showed no significant association between medium RRS (OR: 1.11; [95 % CI: 0.52, 2.40]) or low RRS (OR: 0.94; [95 % CI: 0.42, 2.16]) compared with high RRS and HDP.</div></div><div><h3>Conclusions</h3><div>RRS was not associated with HDP among Black women. Future research should consider multifaceted factors through which racial segregation may relate to maternal outcomes.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200381"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using eosinophil response to predict cardiovascular outcomes in patients with ST- elevation myocardial infarction who undergo primary percutaneous coronary intervention","authors":"Joyce Lim ,&nbsp;Trent Williams ,&nbsp;Lucy Murtha ,&nbsp;Nishani Mabotuwana ,&nbsp;Conagh Kelly ,&nbsp;Doan Ngo ,&nbsp;Andrew Boyle","doi":"10.1016/j.ijcrp.2025.200383","DOIUrl":"10.1016/j.ijcrp.2025.200383","url":null,"abstract":"<div><h3>Objective</h3><div>Eosinophils have been implicated in mediating the inflammatory response after ST-elevation myocardial infarction (STEMI), but its role as a biomarker predicting major adverse cardiovascular events (MACE) remains unclear. We aimed to evaluate the predictive value of eosinophil response on 30-day and 1-year MACE post primary percutaneous coronary intervention (PCI) after STEMI.</div></div><div><h3>Methods</h3><div>Single centre retrospective cohort study of STEMI patients undergoing PCI. Eosinophil response was defined as the change in peripherally circulating eosinophils cell count at admission minus 48 h post primary PCI. Primary endpoints were 30-day and 1-year MACE. Receiver operating characteristic (ROC) curves were created to identify optimal cut-off predicting MACE. Multivariate logistic regression analyses were used to determine if the ROC cut-off was an independent predictor of MACE.</div></div><div><h3>Results</h3><div>Of the 366 patients in this study (median age 61 years [53.0–71.0]; 267 males [73 %]), 41 patients (11.2 %) and 78 patients (21.3 %) developed MACE at 30-days and 1-year. The optimal ROC curve cut-off predicting MACE was an eosinophil response of greater than −0.05 × 10^9/L (ΔEos &gt; −0.05). It had a sensitivity, specificity, and positive and negative predictive value of 83, 39, 6 and 98 % for 30-day MACE, and 74, 39, 19 and 88 % for 1-year MACE. An ΔEos &gt; −0.05 change was associated with a threefold higher likelihood of MACE at 30-days (<em>OR</em> 3.1<em>, 95 % CI</em> 1.04–9.07<em>, p=</em>0.042), but not 1-year</div></div><div><h3>Conclusion</h3><div>An eosinophil response of −0.05 × 10^9L at 48 h following primary PCI post STEMI is highly sensitive at predicting 30-day MACE, and in its absence, holds a high negative predictive value.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200383"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease risk assessment, exercise training, and management of complications in patients with chronic kidney disease","authors":"Francesco Perone ,&nbsp;Marco Bernardi ,&nbsp;Monica Loguercio ,&nbsp;Francesca Jacoangeli ,&nbsp;Silvia Velardi ,&nbsp;Theodora Metsovitis ,&nbsp;Federica Ramondino ,&nbsp;Matteo Ruzzolini ,&nbsp;Marco Ambrosetti","doi":"10.1016/j.ijcrp.2025.200386","DOIUrl":"10.1016/j.ijcrp.2025.200386","url":null,"abstract":"<div><div>Patients with chronic kidney disease are at high and very high risk of cardiovascular disease. As estimated glomerular filtration rate declines, the incidence and severity of risk factors, complications, and atherosclerotic cardiovascular events increase. In this scenario, tailored assessment is the key to evaluate the severity of chronic kidney disease and estimate cardiovascular disease risk. Personalized stratification differentiates patients with chronic kidney disease without diabetes mellitus or established atherosclerotic cardiovascular disease in their management and beneficial treatment. Exercise intensity assessment and prescription is suggested to propose specific and safe recommendations for physical activity, training, and cardiac rehabilitation. Programs are based on a combination of endurance and resistance exercise and should be adapted to very high risk chronic kidney disease and haemodialysis patients and after kidney transplantation. Appropriate management of cardiovascular complications in these patients, such as risk factors, heart failure, arrhythmias, and coronary artery disease, is essential to ensure the best treatment and improve the prognosis. Therefore, we propose a critical and comprehensive review to suggest how to manage patients with chronic kidney disease in clinical practice and, specifically, with regard to cardiovascular risk assessment, exercise training prescription, and management of complications.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200386"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-lowering prescription patterns after a non-fatal acute coronary syndrome: A retrospective cohort study","authors":"Cristina Gavina ,&nbsp;Daniel Seabra Carvalho ,&nbsp;Marta Afonso-Silva ,&nbsp;Inês Costa ,&nbsp;Ana Sofia Freitas ,&nbsp;Mariana Canelas-Pais ,&nbsp;Nuno Lourenço-Silva ,&nbsp;Tiago Taveira-Gomes ,&nbsp;Francisco Araújo","doi":"10.1016/j.ijcrp.2025.200385","DOIUrl":"10.1016/j.ijcrp.2025.200385","url":null,"abstract":"<div><h3>Background</h3><div>After an acute atherosclerotic cardiovascular event, high-intensity lipid-lowering therapy (LLT) is needed to reduce recurrence risk. This study aimed to describe LLT prescription patterns and LDL-C levels change after non-fatal acute coronary syndrome (ACS) events and to determine if the recommended goals for LDL-C levels were achieved.</div></div><div><h3>Methods</h3><div>Retrospective cohort study using electronic health records (EHR) of Unidade Local de Saúde de Matosinhos between 2015 and 2023. Participants were adults aged 40–80 years, with a non-fatal ACS hospitalization between 2016 and 2022 (index date); ≥1 general practice appointment in the three years before ACS; and one-year follow-up post-ACS. Sub-analyses focused on gender, age (&lt;and ≥65 years), and whether patients met LDL-C control (55 mg/dL) at one-year post-ACS.</div></div><div><h3>Results</h3><div>Of 544 patients, 270 (49.6 %) were under 65 years, and 164 (30.1 %) were females. Before the ACS, 71.1 % of men and 56.7 % of women had no previous LLT prescription and younger patients showed poorer LDL-C control (132(IQR 64)mg/dL) than older patients (102(IQR 50)mg/dL). One-year post-ACS, only 11.3 % of males and 8.5 % of females met LDL-C target. The proportion of patients without LLT decreased from 66.7 % at baseline to 13.6 % post-ACS. High-intensity LLT prescriptions increased from 2.4 % to 16.5 %, while moderate-intensity LLT remained predominant (65.8 %). Still, 89.5 % of patients had uncontrolled LDL-C levels.</div></div><div><h3>Conclusion</h3><div>Despite initiating/intensifying LLT, one year after ACS most patients did not achieve LDL-C goals. This indicates a significant gap in guideline implementation in clinical practice.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"25 ","pages":"Article 200385"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}