International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Impact of COVID-19 on obesity-related cardiovascular mortality: Trends and disparities in the United States","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200439","DOIUrl":"10.1016/j.ijcrp.2025.200439","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200439"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low climate-patterned temperature and cardiovascular disease: Worldwide trends and implications for public health policy","authors":"Wenpeng You ,&nbsp;Jacob Sevastidis ,&nbsp;Frank Donnelly","doi":"10.1016/j.ijcrp.2025.200437","DOIUrl":"10.1016/j.ijcrp.2025.200437","url":null,"abstract":"<div><h3>Background</h3><div>Short-term cold spells and heat events are commonly considered risk factors for cardiovascular disease (CVD). This study quantitatively examined the effects of country-specific \"climate-patterned temperature\" (T_MP), measured as long-term mean temperature, on global CVD incidence.</div></div><div><h3>Methods</h3><div>Recently published country-specific data on CVD incidence and T_MP were analysed for statistical correlations at the population level using Microsoft Excel and SPSS. Confounding effects of humidity, aging, GDP PPP, obesity prevalence, and urbanization were controlled. Fisher r-to-z transformation compared correlation coefficients.</div></div><div><h3>Results</h3><div>Pearson's r and nonparametric analyses revealed a significant inverse correlation between T_MP and CVD incidence worldwide (r = −0.646 and −0.574, respectively, p &lt; 0.001). This relationship remained significant after controlling for confounders in a partial correlation model (r = −0.584, p &lt; 0.001). Multiple linear regression showed T_MP as a significant and independent predictor of CVD incidence (Beta = −0.384, p &lt; 0.001). Stepwise regression identified aging as the most influential factor (R² = 0.591), with T_MP and GDP PPP following, increasing R² to 0.731 and 0.747, respectively. Humidity, obesity prevalence, and urbanization were not significant predictors. T_MP had a stronger predictive effect on CVD incidence in high-income countries compared to low- and middle-income countries (z = 1.96 and 2.28 in Pearson's r and nonparametric models, respectively, p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Long-term lower mean temperature (T_MP) is a significant and independent risk factor for CVD worldwide, particularly in developed countries. T_MP should be considered in epidemiological studies of CVD.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200437"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A heart that cares: Providing utmost care to mothers with multiple pregnancies","authors":"Dalmacito A. Cordero Jr.","doi":"10.1016/j.ijcrp.2025.200434","DOIUrl":"10.1016/j.ijcrp.2025.200434","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200434"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic hearts: Machine learning uncovers the cardiovascular toll of heavy metals in the Philippine landscape","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200435","DOIUrl":"10.1016/j.ijcrp.2025.200435","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200435"},"PeriodicalIF":1.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased dietary acid load May elevate the risk of coronary artery disease severity: Findings from a cross-sectional study","authors":"Zeinab Ghorbani ,&nbsp;Fatemeh Dashti ,&nbsp;Zahra Saeedirad ,&nbsp;Amir Aris ,&nbsp;Marjan Mahdavi-Roshan ,&nbsp;Arsalan Salari","doi":"10.1016/j.ijcrp.2025.200423","DOIUrl":"10.1016/j.ijcrp.2025.200423","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade metabolic acidosis appears to play a role in the development of chronic disorders. This study aims to examine the relationship between Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) and the risk of severe coronary artery disease (CAD) in participants undergoing elective angiography.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, the data of 895 participants from the Nutrition Heshmat Registry (NUTHER) was collected. Dietary data were obtained using a validated food frequency questionnaire to calculate PRAL and NEAP. Participants were categorized into severe CAD (Gensini score≥60; n = 526) and non-severe CAD (Gensini score&lt;60; n = 369). Logistic regression was conducted to evaluate the odds ratio (OR) and 95 % confidence interval (95 %CI). Restricted cubic spline (RCS) regression was employed to explore potential nonlinear associations between PRAL, and NEAP and severe-CAD risk.</div></div><div><h3>Results</h3><div>After adjusting for potential confounding factors, participants in the third to fourth quartiles of energy-adjusted PRAL and NEAP exhibited higher odds of severe CAD that were approximately 1.62–1.80 times and 1.67–2.76 times greater, respectively, compared to those in the 1^stquartiles (4^thquartile ORs(95 %CI) for: PRAL: 1.62 (1.05, 2.51); and NEAP: 1.67 (1.07, 2.61) (P-for-trend&lt;0.021). RCS analysis showed a linear dose-response relationship between elevated PRAL and severe CAD risk (P-for-overall-trend = 0.0176; P-for-nonlinearity = 0.1552), and a nonlinear association between higher NEAP and increased severe CAD risk (P-for-overall-trend = 0.0001; P-for-nonlinearity = 0.006).</div></div><div><h3>Conclusion</h3><div>The findings indicate a significant association between higher dietary acid load and increased risk of severe CAD, suggesting that a more acidic diet may contribute to the progression of atherosclerosis. However, further prospective studies are necessary to validate these observations.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200423"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischaemic heart disease and cardiovascular mortality in the Philippines: Current status and strategic policy insights","authors":"Danilo V. Rogayan Jr. ,&nbsp;Denn Harry R. Reusia","doi":"10.1016/j.ijcrp.2025.200436","DOIUrl":"10.1016/j.ijcrp.2025.200436","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200436"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of coenzyme Q10 administration on blood pressure and heart rate in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Mehdi Karimi ,&nbsp;Samira Pirzad ,&nbsp;Farnaz Hooshmand ,&nbsp;Niyousha Shirsalimi ,&nbsp;Seyed Morteza Ali Pourfaraji","doi":"10.1016/j.ijcrp.2025.200424","DOIUrl":"10.1016/j.ijcrp.2025.200424","url":null,"abstract":"<div><h3>Background and objective</h3><div>Coenzyme Q10 is a naturally occurring antioxidant that has been suggested to improve cardiovascular health. Studies examining the effects of Q10 on blood pressure (BP) and heart rate (HR) have found inconsistent results. This meta-analysis aims to clarify the effects of Q10 administration on BP and HR in adults.</div></div><div><h3>Methods</h3><div>A comprehensive search of online databases was conducted until February 2025 to identify relevant randomized controlled trials (RCTs). Following screening, relevant data were extracted from the eligible studies. Statistical analyses were conducted using weighted mean differences (WMD) with 95 % confidence intervals (CI). Data analysis was performed using the \"meta\" package in R.</div></div><div><h3>Results</h3><div>The pooled analysis of 45 RCTs (48 effect sizes) showed that Q10 administration significantly reduced systolic BP (WMD: −3.44 mmHg; 95 %CI: [-5.13 to −1.55], <em>p</em> &lt; 0.01), while no significant effect was observed on diastolic BP (WMD: −1.13 mmHg; 95 %CI: [-2.16 – 0.50], <em>p</em> = 0.23) and HR (WMD: −0.10 bpm; 95 %CI: [-2.09 – 1.89], <em>p</em> = 0.44). Subgroup analysis indicated that lower doses (&lt;200 mg/day) and longer interventions (&gt;8 weeks) resulted in greater systolic BP reductions.</div></div><div><h3>Conclusion</h3><div>This meta-analysis indicates that CoQ10 supplementation may be an effective adjunctive therapy for reducing systolic blood pressure, especially at doses below 200 mg/day and with longer treatment durations. However, its impact on diastolic blood pressure and heart rate appears minimal. Given its favorable safety profile, CoQ10 could be considered as a supportive option in the management of hypertension, particularly for patients seeking non-pharmacological interventions or those with mild elevations in systolic BP.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200424"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study","authors":"Dongliang Chen ,&nbsp;Shengchen Liu ,&nbsp;Jian Li ,&nbsp;Yueyun Zhou,&nbsp;Tong Jing,&nbsp;Aizeretiaili Maimaiti,&nbsp;Fuhua Huang","doi":"10.1016/j.ijcrp.2025.200426","DOIUrl":"10.1016/j.ijcrp.2025.200426","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have identified correlations between autoimmune and aortic diseases; however, the causal connection between these conditions remains uncertain and lack of comprehensiveness. This study aimed to investigate the potential causal relationships between autoimmune and aortic diseases from a genetic perspective.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian randomization (MR) study was implemented to investigate the relationships between 17 common autoimmune diseases and aortic diseases. To serve as instrumental variables (IVs), we extracted single-nucleotide polymorphisms from both the genome-wide association study and the FinnGen databases. The inverse-variance weighted (IVW) approach was primarily employed to estimate causal links between autoimmune and aortic diseases. Several quality control assessments were conducted to maintain the rigor of the research, including heterogeneity tests, pleiotropy analyses, and sensitivity analyses.</div></div><div><h3>Results</h3><div>Our MR study revealed a link between Addison's disease and an elevated risk of thoracic aortic aneurysm. In addition, Sjögren's syndrome and polymyalgia rheumatica showed negative and positive correlations with aortic dissection respectively. Although each of these two correlations was not statistically significant in the alternative sensitivity analysis, the estimates were in the same direction. No signs of horizontal heterogeneity or pleiotropy were detected in sensitivity analyses among these associations. The remaining 14 autoimmune diseases did not demonstrate a causal relationship with aortic diseases.</div></div><div><h3>Conclusion</h3><div>An increasing risk of thoracic aortic aneurysms may be related to Addison's disease. In addition, Sjögren's syndrome exhibited a negative association, while polymyalgia rheumatica exhibited a positive association with aortic dissection.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200426"},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the rising death rates among older US citizens with heart failure and sepsis: Need for health-care policy reform","authors":"Abdul Ahad ,&nbsp;Eeshal Fatima ,&nbsp;Adeena Jamil ,&nbsp;Obaid Ur Rehman ,&nbsp;Irfan Ullah ,&nbsp;Raheel Ahmed ,&nbsp;Bernardo Cortese ,&nbsp;Michael E. Hall ,&nbsp;Mamas A. Mamas","doi":"10.1016/j.ijcrp.2025.200428","DOIUrl":"10.1016/j.ijcrp.2025.200428","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) patients, often multimorbid and immunocompromised, are particularly vulnerable to sepsis, which increases their risk for mortality. It is therefore crucial to understand the mortality patterns in older adults (≥65) with HF and sepsis for improving care strategies in the United States.</div></div><div><h3>Methods</h3><div>A cross-sectional evaluation of death certificates from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) was conducted to examine HF and sepsis mortality trends. For demographic and geographic subgroups, age-adjusted mortality rates (AAMR) per 100,000 older individuals, alongside annual percent change (APC) in AAMR with 95 % confidence intervals (CI), were derived.</div></div><div><h3>Results</h3><div>Throughout 1999 to 2019, 250,115 deaths associated with HF and sepsis were recorded among older adults, the majority being reported in medical facilities. The overall AAMR escalated from 28.8 in 1999 to 33.7 in 2019. AAMRs were more pronounced in men (33.9) than in women (25.5). Non-Hispanic (NH) Black/African American individuals exhibited the highest AAMRs (42.4). At the same time, NH Asian/Pacific Islanders reported the lowest (18.9). AAMRs were higher in non-metropolitan areas (31.4) and the Southern region (31.1). State-level disparities revealed the highest AAMRs in Mississippi (45.4) and the lowest in Arizona (12.1).</div></div><div><h3>Conclusion</h3><div>Mortality from HF and sepsis has increased over the last 20 years, with NH Black/African individuals demonstrating the greatest increases. Future studies should investigate the mechanisms underlying this increase, particularly focusing on the factors that drive disparities, to develop targeted interventions for vulnerable groups.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200428"},"PeriodicalIF":1.9,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sleep disorders in cardiovascular disease: Insights and future directions for Asia","authors":"John Patrick C. Toledo","doi":"10.1016/j.ijcrp.2025.200432","DOIUrl":"10.1016/j.ijcrp.2025.200432","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200432"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}