Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-03-07 DOI:10.1016/j.ijcrp.2025.200392

Muhammad Abdullah Naveed , Sivaram Neppala , Himaja Dutt Chigurupati , Ahila Ali , Muhammad Omer Rehan , Ayman Fath , Bazil Azeem , Rabia Iqbal , Manahil Mubeen , Hamza Naveed , Muhammad Naveed Uz Zafar , Mushood Ahmed , Jamal S. Rana , Brijesh Patel

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引用次数: 0

Abstract

Background

Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue.

Objective

This study analyzed demographic trends and disparities in mortality rates due to AMI in malignancy among adults aged 65 and older from 1999 to 2020.

Methods

We used the CDC WONDER database to analyze Age-adjusted mortality rates (AAMRs) for AMI in malignancy patients (ICD-10 I21, C00-C97) from 1999 to 2020, stratifying by sex, race, geography, and metropolitan status. We calculated Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) using Joinpoint regression.

Results

Between 1999 and 2020, AMI in malignancy accounted for 172,691 deaths among adults aged ≥65 years, with the majority of deaths occurring in medical facilities (56.9 %). The overall AAMR for AMI in malignancy-related deaths decreased from 30.2 in 1999 to 14.2 in 2020, with an AAPC of −3.90 (p < 0.000001). Men showed higher AAMRs than women (28.6 vs. 12.3), with a more pronounced decrease in men (AAPC: 4.22, p < 0.000001) compared to women (AAPC: 3.78, p < 0.000001). Black individuals have the highest AAMR (22.7), followed by Whites (19.3). Arkansas had the highest AAMR (32.3), while Nevada had the lowest (8.1), with the Northeastern region having the highest regional AAMR (20.2), and nonmetropolitan areas had higher AAMRs.

Conclusion

This study reveals significant demographic disparities in mortality rates related to AMI in malignant older adults. These findings emphasize the need for targeted interventions and improved access to care.

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1999年至2020年美国老年（≥65岁）恶性肿瘤患者急性心肌梗死相关死亡率

恶性急性心肌梗死（AMI）是一个全球性的威胁，造成严重的死亡率和经济负担。它们具有共同的风险因素，突出了解决这一关键问题的紧迫性。目的本研究分析1999年至2020年65岁及以上成人恶性肿瘤急性心肌梗死死亡率的人口统计学趋势和差异。方法使用CDC WONDER数据库，分析1999 - 2020年恶性肿瘤患者（ICD-10 I21, C00-C97）急性心肌梗死的年龄调整死亡率（AAMRs），按性别、种族、地理和城市状况进行分层。我们使用连接点回归计算了平均年变化百分比（AAPCs）和每100,000年的年变化百分比（APCs），置信区间为95%。结果1999 - 2020年，65岁以上成人中恶性急性心肌梗死死亡172,691例，其中大部分死亡发生在医疗机构（56.9%）。恶性肿瘤相关死亡中AMI的总体AAMR从1999年的30.2降至2020年的14.2，AAPC为- 3.90 (p <；0.000001)。男性的aamr高于女性（28.6比12.3），男性的下降更为明显(AAPC: 4.22, p <；0.000001)，而女性(AAPC: 3.78, p <；0.000001)。黑人个体的AAMR最高（22.7），其次是白人（19.3）。阿肯色州的AAMR最高（32.3），而内华达州最低（8.1），东北部地区的AAMR最高（20.2），非大都市地区的AAMR更高。结论本研究揭示了老年恶性心肌梗死相关死亡率存在显著的人口统计学差异。这些发现强调需要有针对性的干预措施和改善获得护理的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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