Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-03-07 DOI:10.1016/j.ijcrp.2025.200390

Muzamil Akhtar , Hanzala Ahmed Farooqi , Rayyan Nabi , Javed Iqbal , Sabahat Ul Ain Munir Abbasi , Muhammad Rashid , Syed Khurram Mushtaq Gardezi , David P. Ripley , Raheel Ahmed

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Abstract

Background

Ischemic heart diseases (IHD) and Alzheimer's Disease (AD) significantly contribute to mortality in aging population. Understanding mortality trends where these conditions overlap is crucial for developing targeted interventions for vulnerable populations.

Methods

We analyzed CDC WONDER mortality data from 1999 to 2020 for individuals aged ≥45 years. IHD and AD mortality were identified using ICD-10 codes I20-I25 and G30, respectively. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were analyzed by gender, race, region, place of death and state. Joinpoint regression was used to calculate annual percentage changes (APC) with 95 % confidence intervals (CI).

Results

A total of 171,080 deaths were attributed to IHD in individuals with AD from 1999 to 2020. The AAMR decreased from 10.6 in 1999 to 4.1 in 2020, with a significant decline between 2004 and 2014 (APC: −7.73; 95 % CI: −8.42 to −7.24). Females exhibited higher overall AAMR compared to males (Females: 6.8 vs. Males: 6.4). Individuals of Non-Hispanic (NH) White ancestry had the highest AAMR (6.8), followed by those of NH Black (6.5) and Hispanic ancestry (5.9). The West region reported the highest AAMR at 7.9, while the Midwest had the lowest at 6.3. Oklahoma recorded the highest state-level AAMR (10.9), while Utah had the lowest (3.2).

Conclusions

IHD mortality in individuals with AD declined significantly, with disparities by gender, race, and geography. These findings underscore the need for tailored public health approaches to address the evolving burden of IHD in AD patients.

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1999年至2020年美国阿尔茨海默病患者缺血性心脏病死亡率趋势

背景：缺血性心脏病（IHD）和阿尔茨海默病（AD）是导致老年人死亡的重要因素。了解这些疾病重叠的死亡率趋势对于为弱势群体制定有针对性的干预措施至关重要。方法分析1999 - 2020年CDC WONDER项目中年龄≥45岁人群的死亡率数据。IHD和AD死亡率分别使用ICD-10代码I20-I25和G30进行鉴定。计算了每10万人的年龄调整死亡率（AAMR），并按性别、种族、地区、死亡地点和州分析了趋势。采用连接点回归计算年百分比变化（APC），置信区间为95%。结果1999年至2020年，AD患者的IHD死亡人数为171,080人。AAMR由1999年的10.6下降到2020年的4.1，其中2004 - 2014年呈显著下降趋势(APC: - 7.73；95% CI:−8.42 ~−7.24)。与男性相比，女性表现出更高的总体AAMR（女性：6.8 vs男性：6.4）。非西班牙裔白人（NH）个体的AAMR最高（6.8），其次是NH黑人（6.5）和西班牙裔（5.9）。西部地区的AAMR最高，为7.9，而中西部地区最低，为6.3。俄克拉荷马州的AAMR最高（10.9），而犹他州最低（3.2）。结论AD患者的hd死亡率显著下降，存在性别、种族和地域差异。这些发现强调，需要有针对性的公共卫生方法来解决AD患者IHD不断变化的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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