The association between sugars sweetened beverages and glycemic profile among children and youth: A systematic review and dose-response meta-analysis

IF 2.1 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-06-14 DOI:10.1016/j.ijcrp.2025.200453

Mahdieh Abbasalizad Farhangi , Zeinab Nikniaz , Seyedeh-Tarlan Mirzohreh , Leila Nikniaz

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Abstract

Background

This study aimed to assess the effects of Sugar-Sweetened Beverages (SSBs) consumption on fasting serum insulin (FSI), fasting plasma glucose (FPG), and HOMA-IR levels among children.

Methods

Databases including PubMed/MEDLINE, Scopus, EMBASE, Cochrane Library, and Web of Science were searched up to March 2025. Observational studies reporting the connection of SSBs consumption with FPG, FSI, and HOMA-IR levels were included. STATA version 15 was used to analyze the data.

Results

11 studies with 22,713 subjects were included in this meta-analysis. Greater intake of SSBs was not significantly linked to higher fasting plasma glucose (WMD: 0.01; CI -0.04 –0.07; P = 0.63) and fasting serum insulin levels (WMD: 0.54; 95 % CI, −0.4, 1.49; P = 0.26). However, high SSBs consumption was significantly associated with a 0.21 increase in HOMA-IR in adolescents and children (WMD: 0.21; CI, 0.03–0.37; P = 0.02). In dose-response meta-analysis, no departure from linearity was detected between SSBs intake and changes in FPG, FSI, and HOMA-IR levels.

Conclusions

High SSBs intake was linked to increased HOMA-IR levels among adolescents and children. Further extensive prospective long-term interventions are suggested to confirm the detected associations.

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含糖饮料与儿童和青少年血糖状况之间的关系：一项系统综述和剂量反应荟萃分析

本研究旨在评估含糖饮料（SSBs）对儿童空腹血清胰岛素（FSI）、空腹血糖（FPG）和HOMA-IR水平的影响。方法检索截至2025年3月的PubMed/MEDLINE、Scopus、EMBASE、Cochrane Library、Web of Science等数据库。观察性研究报告了SSBs消费与FPG、FSI和HOMA-IR水平的关系。使用STATA version 15对数据进行分析。结果11项研究共纳入22,713名受试者。摄入更多SSBs与空腹血糖升高无显著相关(WMD: 0.01；Ci -0.04 -0.07；P = 0.63)和空腹血清胰岛素水平(WMD: 0.54；95% ci,−0.4,1.49；p = 0.26)。然而，高SSBs摄入量与青少年和儿童HOMA-IR增加0.21显著相关(WMD: 0.21；CI, 0.03 - -0.37;p = 0.02)。在剂量-反应荟萃分析中，SSBs摄入量与FPG、FSI和HOMA-IR水平的变化之间没有发现线性偏离。结论高SSBs摄入量与青少年和儿童HOMA-IR水平升高有关。进一步广泛的前瞻性长期干预建议，以确认检测到的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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