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Corrigendum to “Drug discovery targeting Nav1.8: Structural insights and therapeutic potential” [Curr Opin Chem Biol 83 (2024) 102538] 针对 Nav1.8 的药物发现：结构见解和治疗潜力》[Curr Opin Chem Biol 83 (2024) 102538] 更正
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-11-25 DOI: 10.1016/j.cbpa.2024.102546
Huan Wang , Jian Huang , Jie Zang , Xueqin Jin , Nieng Yan
{"title":"Corrigendum to “Drug discovery targeting Nav1.8: Structural insights and therapeutic potential” [Curr Opin Chem Biol 83 (2024) 102538]","authors":"Huan Wang , Jian Huang , Jie Zang , Xueqin Jin , Nieng Yan","doi":"10.1016/j.cbpa.2024.102546","DOIUrl":"10.1016/j.cbpa.2024.102546","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102546"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic ion channels in biomembranes 生物膜中的合成离子通道。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-11-20 DOI: 10.1016/j.cbpa.2024.102544
Ai Kohata , Kazushi Kinbara
{"title":"Synthetic ion channels in biomembranes","authors":"Ai Kohata ,&nbsp;Kazushi Kinbara","doi":"10.1016/j.cbpa.2024.102544","DOIUrl":"10.1016/j.cbpa.2024.102544","url":null,"abstract":"<div><div>Ion transport across cell membranes is crucial in maintaining ion homeostasis in cells. Synthetic molecules that can mimic the functions of natural ion channel proteins would possess great potential as therapeutic agents by promoting apoptosis or interfering with autophagic processes through perturbing the intracellular pH or inducing oxidative and osmotic stresses. However, little is known about the underlying mechanisms in terms of direct correlation between ion transport and biological functions. This review summarizes recent progress in the area of synthetic transmembrane ion transport systems, focusing on the channel type, with an emphasis on their bioapplications as anticancer agents.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102544"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Illuminating anions in biology with genetically encoded fluorescent biosensors 用基因编码荧光生物传感器照亮生物学中的阴离子。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1016/j.cbpa.2024.102548
Mariah A. Cook , Shelby M. Phelps , Jasmine N. Tutol , Derik A. Adams, Sheel C. Dodani
{"title":"Illuminating anions in biology with genetically encoded fluorescent biosensors","authors":"Mariah A. Cook ,&nbsp;Shelby M. Phelps ,&nbsp;Jasmine N. Tutol ,&nbsp;Derik A. Adams,&nbsp;Sheel C. Dodani","doi":"10.1016/j.cbpa.2024.102548","DOIUrl":"10.1016/j.cbpa.2024.102548","url":null,"abstract":"<div><div>Anions are critical to all life forms. Anions can be absorbed as nutrients or biosynthesized. Anions shape a spectrum of fundamental biological processes at the organismal, cellular, and subcellular scales. Genetically encoded fluorescent biosensors can capture anions in action across time and space dimensions with microscopy. The firsts of such technologies were reported more than 20 years for monoatomic chloride and polyatomic cAMP anions. However, the recent boom of anion biosensors illuminates the unknowns and opportunities that remain for toolmakers and end users to meet across the aisle to spur innovations in biosensor designs and applications for discovery anion biology. In this review, we will canvas progress made over the last three years for biologically relevant anions that are classified as halides, oxyanions, carboxylates, and nucleotides.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102548"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foldamer-mediated transport across phospholipid bilayers 折叠体介导的磷脂双层转运
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-11-30 DOI: 10.1016/j.cbpa.2024.102549
Iqra Zubair , Luis Martínez-Crespo , Simon J. Webb
{"title":"Foldamer-mediated transport across phospholipid bilayers","authors":"Iqra Zubair ,&nbsp;Luis Martínez-Crespo ,&nbsp;Simon J. Webb","doi":"10.1016/j.cbpa.2024.102549","DOIUrl":"10.1016/j.cbpa.2024.102549","url":null,"abstract":"<div><div>Crucial physiological processes, like neural communication and muscle contraction, are mediated by protein channels in cell membranes. These natural channels typically have a central hydrophilic pore with tightly defined dimensions, which can be opened or closed (‘gated’) by external stimuli. Mimicking natural ion channels using synthetic molecules is a long-standing goal in artificial channel research. Although current synthetic channels have not yet achieved the same combination of high activity, high selectivity, and gating as natural channels, foldamers offer a new approach. Foldamers are unnatural oligomers that fold into defined three-dimensional shapes, similar to the way that natural polypeptides fold into secondary structures. With defined shapes and often multi-nanometre dimensions, foldamers have become valuable tools to mimic the behaviour of natural proteins in membranes. This review highlights selected recent examples of foldamer channels, examples that indicate how foldamer architectures may lead to controllable channels with high activity and selectivity.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102549"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling 通过自旋标记实现膜蛋白结构生物电子顺磁共振波谱。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-12-21 DOI: 10.1016/j.cbpa.2024.102564
Anokhi Shah , Joshua L. Wort , Yue Ma , Christos Pliotas
{"title":"Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling","authors":"Anokhi Shah ,&nbsp;Joshua L. Wort ,&nbsp;Yue Ma ,&nbsp;Christos Pliotas","doi":"10.1016/j.cbpa.2024.102564","DOIUrl":"10.1016/j.cbpa.2024.102564","url":null,"abstract":"<div><div>Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the investigation of biomacromolecules, emerging as a keystone approach in structural biology. Increasingly, PDS is applied to study highly complex integral membrane protein systems, such as mechanosensitive ion channels, transporters, G-protein coupled receptors, ion pumps, and outer membrane proteins elucidating their dynamics and revealing conformational ensembles. Indeed, PDS offers a platform to study intermediate or lowly-populated states that are otherwise invisible to other modern methods, such as X-ray crystallography, cryo-EM, and hydrogen-deuterium exchange-mass spectrometry. Importantly, advances in spin labelling strategies welcome a new era of membrane protein investigation under near-native or in-cell conditions. Here, we review recent integral membrane protein PDS applications, and highlight well-suited, emerging spin labelling strategies that show promise for future studies.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102564"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovering microbiota functions via chemical probe incorporation for targeted sequencing 通过化学探针结合发现微生物群功能，用于靶向测序
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-11-30 DOI: 10.1016/j.cbpa.2024.102551
Natalie Falco , Matthew E. Griffin
{"title":"Discovering microbiota functions via chemical probe incorporation for targeted sequencing","authors":"Natalie Falco ,&nbsp;Matthew E. Griffin","doi":"10.1016/j.cbpa.2024.102551","DOIUrl":"10.1016/j.cbpa.2024.102551","url":null,"abstract":"<div><div>Our microbiota plays crucial roles in immune development and homeostasis and has been implicated in virtually all major diseases of the 21st century. Nevertheless, our understanding of the exact microbial functions that underlie these correlations remains extremely limited, due in large part to the difficulty of profiling cellular activities within non-model organisms and complex communities. Over the past decade, new flow cytometric approaches have been developed to distinguish specific microbial populations based on their interactions with metabolite analogs, modified biomolecules, and reactive compounds. By selecting and separating active microbes via fluorescence-activated cell sorting, PRobe INcorporation for Targeted sequencing (PRINT-seq) has inspired innovative approaches to identify and characterize functional members of our microbiota. Here, we provide a broad overview of this evolving technology and summarize how this method has been recently employed as a diagnostic fingerprint for diverse microbial activities.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102551"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered metallobiocatalysts for energy–relevant reactions 用于能源相关反应的工程金属生物催化剂
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-11-25 DOI: 10.1016/j.cbpa.2024.102545
Ryan M. Kosko , Kaye L. Kuphal , Alison A. Salamatian , Kara L. Bren
{"title":"Engineered metallobiocatalysts for energy–relevant reactions","authors":"Ryan M. Kosko ,&nbsp;Kaye L. Kuphal ,&nbsp;Alison A. Salamatian ,&nbsp;Kara L. Bren","doi":"10.1016/j.cbpa.2024.102545","DOIUrl":"10.1016/j.cbpa.2024.102545","url":null,"abstract":"<div><div>Engineering metallobiocatalysts is a promising approach to addressing challenges in energy-relevant electrocatalysis and photocatalysis. The design freedom provided by semisynthetic and fully synthetic approaches to catalyst design allows researchers to demonstrate how structural modifications can improve selectivity and activity of biocatalysts. Furthermore, the provision of a superstructure in many metallobiocatalysts facilitates active-site microenvironment engineering. Recurring themes include the role of the biomolecular scaffold in enhancing reactivity in water and catalyst robustness, the impact of the outer sphere on reactivity, and the importance of tuning system components in full system optimization. In this perspective, recent strategies to design and modify novel biocatalysts, understand proton and electron transfer mechanisms, and tune system activity by modifying catalysts and system conditions are highlighted within the field of energy-related catalysis. Opportunities in this field include developing robust structure–function relationships to support approaches to engineering second-sphere interactions and identifying ways to enhance biocatalyst activity over time.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102545"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in acid-degradable and enzyme-cleavable linkers for drug delivery 酸可降解和酶可切割药物传递连接体的研究进展。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI: 10.1016/j.cbpa.2024.102552
Sheng Zhao , Na Yu , Hesong Han , Shutao Guo , Niren Murthy
{"title":"Advances in acid-degradable and enzyme-cleavable linkers for drug delivery","authors":"Sheng Zhao ,&nbsp;Na Yu ,&nbsp;Hesong Han ,&nbsp;Shutao Guo ,&nbsp;Niren Murthy","doi":"10.1016/j.cbpa.2024.102552","DOIUrl":"10.1016/j.cbpa.2024.102552","url":null,"abstract":"<div><div>Drug delivery vectors have the potential to improve the efficacy of therapeutics, including small molecules and nucleic acid-based drugs. However, challenges remain in developing linkages that enable the precise and efficient release of therapeutic cargo in response to mildly acidic environments or lysosomal enzymes. This review highlights recent advances in acid-degradable acetal/ketal and enzyme-cleavable linkages for endolysosomal release. These innovations include the developments of azido-acetal linkers with improved stability and hydrolysis kinetics, organocatalytic trans-isopropenylation for synthesizing asymmetric ketals and their applications in drug delivery, and enzyme-cleavable linkers activated by cathepsin B or <em>β</em>-galactosidase.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102552"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142789441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small molecules as modulators of phage–bacteria interactions 小分子作为噬菌体与细菌相互作用的调节剂。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2024-12-29 DOI: 10.1016/j.cbpa.2024.102566
Joel W.H. Wong , Emily P. Balskus
{"title":"Small molecules as modulators of phage–bacteria interactions","authors":"Joel W.H. Wong ,&nbsp;Emily P. Balskus","doi":"10.1016/j.cbpa.2024.102566","DOIUrl":"10.1016/j.cbpa.2024.102566","url":null,"abstract":"<div><div>Bacteriophages (phages) play a critical role in microbial ecology and evolution. Their interactions with bacteria are influenced by a complex network of chemical signals derived from a wide range of sources including both endogenous bacterial metabolites and exogenous environmental compounds. In this review, we highlight two areas where small molecules play a pivotal role in modulating phage behaviors. First, we discuss how temperate phages respond to various chemical cues that influence the lysis-lysogeny decision, describing recent advances in our understanding of noncanonical cues. Second, we examine the diverse array of small molecules that disrupt phage infection, potentially serving as bacterial defense strategies against their long-standing competitors. Collectively, this growing body of research highlights the intricate molecular mechanisms governing phage-bacteria dynamics, offering new perspectives on the chemical language shaping microbial communities.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102566"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide toxins as tools in ion channel biology 肽毒素作为离子通道生物学的工具。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-02-01 Epub Date: 2025-01-03 DOI: 10.1016/j.cbpa.2024.102568
Sucheta Bandyopadhyay , Satyajit Mishra , Jeet Kalia
{"title":"Peptide toxins as tools in ion channel biology","authors":"Sucheta Bandyopadhyay ,&nbsp;Satyajit Mishra ,&nbsp;Jeet Kalia","doi":"10.1016/j.cbpa.2024.102568","DOIUrl":"10.1016/j.cbpa.2024.102568","url":null,"abstract":"<div><div>Animal venom contains ion channel-targeting peptide toxins that inflict paralysis or pain. The high specificity and potency of these toxins for their target ion channels provides enticing opportunities for their deployment as tools in channel biology. Mechanistic studies on toxin-mediated ion channel modulation have yielded landmark breakthroughs in our understanding of channel architectures and gating mechanisms. Toxins have been recently repurposed as powerful structural biology probes to obtain structures of ion channels in elusive toxin-stabilized conformations providing unprecedented insights into channel gating. Insightful glimpses of protein–lipid interactions provided by some of these structures have served as blueprints for electrophysiology-based studies aimed at elucidating the functional roles of these interactions. Moreover, toxins appended with fluorophores have been used for clinical, biophysical, and cell biology-based studies. Herein, we summarize the contributions of ion channel-targeting toxins as tools in voltage-gated ion channel and transient receptor potential channel biology.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"84 ","pages":"Article 102568"},"PeriodicalIF":6.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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