发布求助
文献互助 智能选刊 最新文献

Current Opinion in Chemical Biology最新文献

筛选
英文 中文
Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition 最近的研究进展揭示了金属团在群体感应、抗菌活性和镧系元素获取方面的功能
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-19 DOI: 10.1016/j.cbpa.2025.102604
Ghazal Kamyabi, Erica L. Debley, Elizabeth M. Nolan
{"title":"Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition","authors":"Ghazal Kamyabi,&nbsp;Erica L. Debley,&nbsp;Elizabeth M. Nolan","doi":"10.1016/j.cbpa.2025.102604","DOIUrl":"10.1016/j.cbpa.2025.102604","url":null,"abstract":"<div><div>Metallophores are metal-chelating secondary metabolites that bacteria, fungi, and other organisms produce to acquire essential metal nutrients from their environment. This review highlights some recent discoveries in the field: the role of yersiniabactin in quorum sensing, the capacity of aspergillomarasmine A to inhibit bacterial Ni uptake, and the identification of methylolanthanin, a novel metallophore that enables bacterial lanthanide acquisition.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102604"},"PeriodicalIF":6.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion transport across biological membranes 离子在生物膜上的传输
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-18 DOI: 10.1016/j.cbpa.2025.102606
Robin S. Bon, Matthew J. Langton
{"title":"Ion transport across biological membranes","authors":"Robin S. Bon,&nbsp;Matthew J. Langton","doi":"10.1016/j.cbpa.2025.102606","DOIUrl":"10.1016/j.cbpa.2025.102606","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102606"},"PeriodicalIF":6.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical tools to study and modulate glycan-mediated host-bacteria interactions 研究和调节聚糖介导的宿主-细菌相互作用的化学工具
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-04 DOI: 10.1016/j.cbpa.2025.102603
Divya Bhargava , Aniqa Chowdhury , Danielle H. Dube
{"title":"Chemical tools to study and modulate glycan-mediated host-bacteria interactions","authors":"Divya Bhargava ,&nbsp;Aniqa Chowdhury ,&nbsp;Danielle H. Dube","doi":"10.1016/j.cbpa.2025.102603","DOIUrl":"10.1016/j.cbpa.2025.102603","url":null,"abstract":"<div><div>Glycans cover the surfaces of all cells, where they are poised to mediate a two-way discourse between bacteria and host cells. In some instances, glycan-mediated interactions foster a symbiotic state, and in others, they tip the balance toward disease. Chemical biology approaches have begun to reveal the roles of glycans in host-bacteria interactions and provide novel pathways to modulate these interactions. Here, we highlight recent advances in the development and application of chemical biology tools to delineate the roles of glycans in bacterial adhesion, bacterial evasion of the host immune system, host recognition of bacterial cells, and endogenous mechanisms to maintain symbiosis. Further, we present glycan-based strategies to disrupt host-pathogen interactions and to promote the growth of beneficial bacteria.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102603"},"PeriodicalIF":6.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale 探测配体诱导的局部稳定性转移：一种在蛋白质组学尺度上识别靶蛋白和结合位点的敏感方法
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-05-31 DOI: 10.1016/j.cbpa.2025.102602
Keyun Wang , Yanan Li , Yanni Ma , Mingliang Ye
{"title":"Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale","authors":"Keyun Wang ,&nbsp;Yanan Li ,&nbsp;Yanni Ma ,&nbsp;Mingliang Ye","doi":"10.1016/j.cbpa.2025.102602","DOIUrl":"10.1016/j.cbpa.2025.102602","url":null,"abstract":"<div><div>Deciphering ligand-induced structural alterations represents a critical frontier in functional proteomics, offering transformative potential for both target identification and mechanistic understanding of ligand actions. Therefore, it is of great interest to develop robust proteomic approaches to uncover the binding relationship between ligands and the targeting proteins. The ligand modification-free approaches have the advantages of bypassing chemical modification and thus are broadly applicable to diverse ligands. Herein, in this review, we will introduce some recent methodology advancements for modification-free approaches in the identification of interactions between ligands and proteins. Especially, we will focus on a newly developed method, peptide-centric local stability assay (PELSA), which was designed to probe the ligand-induced local stability shifts and was demonstrated to have high sensitivity in revealing the binding regions at proteome level. The continued refinement and wider implementation of such technologies are expected to revolutionize fundamental research related with ligand–protein interactions.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102602"},"PeriodicalIF":6.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural and artificial siderophores: Iron-based applications and beyond 天然和人工铁载体：铁基应用及其他
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-05-23 DOI: 10.1016/j.cbpa.2025.102601
Zih-Jheng Lin, Cheng-Yu Fang, Tsung-Shing Andrew Wang
{"title":"Natural and artificial siderophores: Iron-based applications and beyond","authors":"Zih-Jheng Lin,&nbsp;Cheng-Yu Fang,&nbsp;Tsung-Shing Andrew Wang","doi":"10.1016/j.cbpa.2025.102601","DOIUrl":"10.1016/j.cbpa.2025.102601","url":null,"abstract":"<div><div>Siderophores are iron chelators secreted by microorganisms to scavenge iron from the environment. Natural siderophores have gained remarkable importance because their conjugates can be applied as antibiotics and diagnostic imaging agents. By utilizing the iron uptake system of microorganisms, functional molecules such as antibiotics or imaging agents can be delivered into cells. Notably, artificial siderophores have also been developed to increase stability and broaden metal chelating diversity. Various strategies, including backbone fine-tuning, artificial chelation moieties, and direct metal swapping, can be employed. Therefore, artificial siderophores can bind biorelated metals or radioactive isotopes, expanding their biological and medical applications. The aim of this review is to introduce recent advances in natural and artificial siderophore applications and highlight future challenges in this area of research.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102601"},"PeriodicalIF":6.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity 在探测选定的细胞器阳离子的水平和通量以及细胞器的机械敏感性方面的最新进展
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-05-03 DOI: 10.1016/j.cbpa.2025.102600
Taufiq Rahman , Sandip Patel
{"title":"Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity","authors":"Taufiq Rahman ,&nbsp;Sandip Patel","doi":"10.1016/j.cbpa.2025.102600","DOIUrl":"10.1016/j.cbpa.2025.102600","url":null,"abstract":"<div><div>Electrochemical gradients exist not only across the plasma membrane (PM) but also across membranes of organelles. Various endomembrane-localised ion channels and transporters have been identified, the activity of which is critical for organellar (and also cellular) ionic homeostasis that underpins diverse cellular processes. Aberrant organellar ion flux underlies several diseases, identifying organellar channels and transporters as potential drug targets. Therefore, the need for probing the functions of these proteins in situ cannot be overemphasised. The acidic interior of a few organelles as well as the dynamic nature of most organelles historically presented challenges for reliable estimation of luminal ionic concentrations. But there have been significant methodological and technical advancements by now, allowing measurement of levels of specific ions within these organelles as well as their flux across endomembranes with increasing precision. Evidence also continues to amass reporting mechanosensitivity of the endomembranes and its physiological significance. Here we highlight some recent developments in tools and techniques for measuring the levels and movement of some selected organellar cations as well as organellar mechanosensitivity.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102600"},"PeriodicalIF":6.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport 编辑概述：转化细胞内递送：大分子运输的创新
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-04-28 DOI: 10.1016/j.cbpa.2025.102599
Jean-Philippe Pellois
{"title":"Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport","authors":"Jean-Philippe Pellois","doi":"10.1016/j.cbpa.2025.102599","DOIUrl":"10.1016/j.cbpa.2025.102599","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102599"},"PeriodicalIF":6.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Unusual enzyme reactions in natural products biosynthesis 社论：天然产物生物合成中不寻常的酶反应
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-04-26 DOI: 10.1016/j.cbpa.2025.102597
Taifo Mahmud, Ikuro Abe
{"title":"Editorial: Unusual enzyme reactions in natural products biosynthesis","authors":"Taifo Mahmud,&nbsp;Ikuro Abe","doi":"10.1016/j.cbpa.2025.102597","DOIUrl":"10.1016/j.cbpa.2025.102597","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102597"},"PeriodicalIF":6.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical strategies for targeting lipid pathways in bacterial pathogens 针对细菌病原体脂质途径的化学策略
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-04-19 DOI: 10.1016/j.cbpa.2025.102596
Alyssa M. Carter , Emily C. Woods , Matthew Bogyo
{"title":"Chemical strategies for targeting lipid pathways in bacterial pathogens","authors":"Alyssa M. Carter ,&nbsp;Emily C. Woods ,&nbsp;Matthew Bogyo","doi":"10.1016/j.cbpa.2025.102596","DOIUrl":"10.1016/j.cbpa.2025.102596","url":null,"abstract":"<div><div>Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has been limited development of antibiotics with new mechanisms of action, highlighting our need to identify processes that can be targeted by next generation therapeutics. Recent advancements in our understanding of the roles that lipids play in key bacterial processes suggest that these biomolecules are a potentially valuable site for disruption by therapeutic agents. Specifically, the success of a pathogen depends on its ability to make fatty acids <em>de novo</em> or scavenge lipids from its host. This review focuses on recent advances using chemical biology tools for defining and disrupting lipid pathways in bacteria.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102596"},"PeriodicalIF":6.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems 从自然和工程光合内共生系统的分子和生化见解
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-04-18 DOI: 10.1016/j.cbpa.2025.102598
Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta
{"title":"Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems","authors":"Jay E. Cournoyer ,&nbsp;Bidhan C. De ,&nbsp;Angad P. Mehta","doi":"10.1016/j.cbpa.2025.102598","DOIUrl":"10.1016/j.cbpa.2025.102598","url":null,"abstract":"<div><div>Mitochondria and chloroplasts evolved through the transformation of bacterial endosymbionts established within the host cells. Studies on these organelles have provided several phylogenetic and biochemical insights related to this remarkable evolutionary transformation. Additionally, comparative studies between naturally existing endosymbionts and present-day organelles have allowed us to identify important common features of endosymbiotic evolution. In this review, we discuss hallmarks of photosynthetic endosymbiotic systems, particularly focusing on some of the fascinating molecular changes that occur in the endosymbiont and the host as the endosymbiont/host chimera evolves and transforms endosymbionts into organelles; these include the following: (i) endosymbiont genome minimization and host/endosymbiont gene transfer, (ii) protein import/export systems, (iii) metabolic crosstalk between the endosymbiont, (iv) alterations to the endosymbiont peptidoglycan, and (v) host-controlled replication of endosymbionts/organelles. We discuss these hallmarks in the context of naturally existing photosynthetic endosymbiotic systems and present-day chloroplasts. Further, we also briefly discuss laboratory efforts to engineer endosymbiosis between photosynthetic bacteria and host cells, the lessons learned from these studies, future directions of these studies, and their implications on evolutionary biology and synthetic biology.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102598"},"PeriodicalIF":6.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信