Current Opinion in Chemical Biology最新文献

Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity 在探测选定的细胞器阳离子的水平和通量以及细胞器的机械敏感性方面的最新进展

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-05-03 DOI: 10.1016/j.cbpa.2025.102600

Taufiq Rahman , Sandip Patel

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引用次数: 0

Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport 编辑概述：转化细胞内递送：大分子运输的创新

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-28 DOI: 10.1016/j.cbpa.2025.102599

Jean-Philippe Pellois

引用次数: 0

Editorial: Unusual enzyme reactions in natural products biosynthesis 社论：天然产物生物合成中不寻常的酶反应

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-26 DOI: 10.1016/j.cbpa.2025.102597

Taifo Mahmud, Ikuro Abe

引用次数: 0

Chemical strategies for targeting lipid pathways in bacterial pathogens 针对细菌病原体脂质途径的化学策略

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-19 DOI: 10.1016/j.cbpa.2025.102596

Alyssa M. Carter , Emily C. Woods , Matthew Bogyo

引用次数: 0

Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems 从自然和工程光合内共生系统的分子和生化见解

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-18 DOI: 10.1016/j.cbpa.2025.102598

Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta

{"title":"Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems","authors":"Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta","doi":"10.1016/j.cbpa.2025.102598","DOIUrl":"10.1016/j.cbpa.2025.102598","url":null,"abstract":"<div><div>Mitochondria and chloroplasts evolved through the transformation of bacterial endosymbionts established within the host cells. Studies on these organelles have provided several phylogenetic and biochemical insights related to this remarkable evolutionary transformation. Additionally, comparative studies between naturally existing endosymbionts and present-day organelles have allowed us to identify important common features of endosymbiotic evolution. In this review, we discuss hallmarks of photosynthetic endosymbiotic systems, particularly focusing on some of the fascinating molecular changes that occur in the endosymbiont and the host as the endosymbiont/host chimera evolves and transforms endosymbionts into organelles; these include the following: (i) endosymbiont genome minimization and host/endosymbiont gene transfer, (ii) protein import/export systems, (iii) metabolic crosstalk between the endosymbiont, (iv) alterations to the endosymbiont peptidoglycan, and (v) host-controlled replication of endosymbionts/organelles. We discuss these hallmarks in the context of naturally existing photosynthetic endosymbiotic systems and present-day chloroplasts. Further, we also briefly discuss laboratory efforts to engineer endosymbiosis between photosynthetic bacteria and host cells, the lessons learned from these studies, future directions of these studies, and their implications on evolutionary biology and synthetic biology.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102598"},"PeriodicalIF":6.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opportunities in exploring chemical biology tools for better strategies against Candida albicans 探索化学生物学工具的机会，以更好地对抗白色念珠菌

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-04 DOI: 10.1016/j.cbpa.2025.102595

Lanxin Li, Yuan Qiao

引用次数: 0

Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141 “细菌二萜合成酶：机械酶学和工程生物合成的新机遇”的更正[当前观点化学生物，16 (2012)132-141

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-03-26 DOI: 10.1016/j.cbpa.2025.102594

Michael J. Smanski , Ryan M. Peterson , Sheng-Xiong Huang , Ben Shen

引用次数: 0

Recent advances in de novo designed metallopeptides as tailored enzyme mimics 重新设计金属肽作为定制酶模拟物的最新进展。

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-03-20 DOI: 10.1016/j.cbpa.2025.102586

Salvatore La Gatta, Vincent L. Pecoraro

引用次数: 0

Redirecting the host immune response to bacterial infection with antibody-recruiting molecules (ARMs) 用抗体招募分子（ARMs）重定向宿主对细菌感染的免疫反应。

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-03-20 DOI: 10.1016/j.cbpa.2025.102585

Priscilla Dzigba , Megan A. Seth , Mallary C. Greenlee-Wacker , Benjamin M. Swarts

引用次数: 0

Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes 非细胞毒性催化酶功能模拟物，包括氰化物中毒解毒剂

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-03-12 DOI: 10.1016/j.cbpa.2025.102584

Sigridur G. Suman

{"title":"Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes","authors":"Sigridur G. Suman","doi":"10.1016/j.cbpa.2025.102584","DOIUrl":"10.1016/j.cbpa.2025.102584","url":null,"abstract":"<div><div>Functional mimics of enzymes have a long history with bioinorganic chemists. Early motivation for creating these mimics was strongly based on the study of the enzyme reaction mechanisms. In more recent times, interest in functional mimics has expanded to catalytic metallodrugs, where the mimics are deliberately designed for specific catalytic reactions intended for therapeutic purposes. <em>In vivo,</em> noncytotoxic catalysis targets reactions designed to activate prodrugs. Natural or <em>de novo</em> proteins were developed for artificial enzyme catalysis of Diels–Alder reactions, or as artificial oxygenase mimics. Novel sulfur-rich catalytic superoxide dismutase (SOD) mimics were discovered as antioxidants. Detoxification of elevated levels of cyanide where the natural rhodanese enzyme becomes inefficient in turnover rates and bioavailability is particularly attractive for sulfur-rich molybdenum clusters. This brief overview includes metal catalysts performing abiotic reactions <em>in vivo</em> disguised by attachment to cell surfaces, as artificial enzymes, and interesting new sulfur-rich complexes performing SOD reactions or neutralizing cyanide.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102584"},"PeriodicalIF":6.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0