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Editorial overview: Editorial of molecular imaging 编辑概述：分子成像编辑
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1016/j.cbpa.2025.102618
Jefferson Chan, Martin J. Schnermann
{"title":"Editorial overview: Editorial of molecular imaging","authors":"Jefferson Chan, Martin J. Schnermann","doi":"10.1016/j.cbpa.2025.102618","DOIUrl":"10.1016/j.cbpa.2025.102618","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102618"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems 从自然和工程光合内共生系统的分子和生化见解
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-04-18 DOI: 10.1016/j.cbpa.2025.102598
Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta
{"title":"Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems","authors":"Jay E. Cournoyer ,&nbsp;Bidhan C. De ,&nbsp;Angad P. Mehta","doi":"10.1016/j.cbpa.2025.102598","DOIUrl":"10.1016/j.cbpa.2025.102598","url":null,"abstract":"<div><div>Mitochondria and chloroplasts evolved through the transformation of bacterial endosymbionts established within the host cells. Studies on these organelles have provided several phylogenetic and biochemical insights related to this remarkable evolutionary transformation. Additionally, comparative studies between naturally existing endosymbionts and present-day organelles have allowed us to identify important common features of endosymbiotic evolution. In this review, we discuss hallmarks of photosynthetic endosymbiotic systems, particularly focusing on some of the fascinating molecular changes that occur in the endosymbiont and the host as the endosymbiont/host chimera evolves and transforms endosymbionts into organelles; these include the following: (i) endosymbiont genome minimization and host/endosymbiont gene transfer, (ii) protein import/export systems, (iii) metabolic crosstalk between the endosymbiont, (iv) alterations to the endosymbiont peptidoglycan, and (v) host-controlled replication of endosymbionts/organelles. We discuss these hallmarks in the context of naturally existing photosynthetic endosymbiotic systems and present-day chloroplasts. Further, we also briefly discuss laboratory efforts to engineer endosymbiosis between photosynthetic bacteria and host cells, the lessons learned from these studies, future directions of these studies, and their implications on evolutionary biology and synthetic biology.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102598"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multifaceted repertoire of cellular reactive metabolites 细胞反应性代谢物的多面曲目
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1016/j.cbpa.2025.102607
Yimon Aye, Christine Winterbourn
{"title":"The multifaceted repertoire of cellular reactive metabolites","authors":"Yimon Aye,&nbsp;Christine Winterbourn","doi":"10.1016/j.cbpa.2025.102607","DOIUrl":"10.1016/j.cbpa.2025.102607","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102607"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Glycobiology (2024) 编辑概述：糖生物学（2024）
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-28 DOI: 10.1016/j.cbpa.2025.102619
Mia L. Huang, Peng Wu
{"title":"Editorial overview: Glycobiology (2024)","authors":"Mia L. Huang,&nbsp;Peng Wu","doi":"10.1016/j.cbpa.2025.102619","DOIUrl":"10.1016/j.cbpa.2025.102619","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102619"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications 化学蛋白质组学近距离标记的最新进展：为体内应用铺平道路
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1016/j.cbpa.2025.102620
Fátima Yuri Tanimura Valor, Tomonori Tamura, Itaru Hamachi
{"title":"Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications","authors":"Fátima Yuri Tanimura Valor,&nbsp;Tomonori Tamura,&nbsp;Itaru Hamachi","doi":"10.1016/j.cbpa.2025.102620","DOIUrl":"10.1016/j.cbpa.2025.102620","url":null,"abstract":"<div><div>The integration of proximity labeling (PL) and advanced mass spectrometry-based proteomics is a robust framework for mapping protein–protein interaction (PPI) networks and local protein inventories in the crowded multimolecular environment of live cells. Over the last decade, numerous PL technologies such as biotin identification (BioID), ascorbate peroxidase (APEX) etc. using engineered enzymes or synthetic photocatalysts have been developed and successfully used in cell-based experiments. However, the application of such technologies beyond cultured cells, (i.e. in more complicated tissues or <em>in vivo</em>) remains challenging. In this review, we summarize the current issues in applying PL methods <em>in vivo</em> and highlight recent studies that could provide breakthroughs to overcome the existing limitations and expand the application of PL to tissues and <em>in vivo</em>.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102620"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural and artificial siderophores: Iron-based applications and beyond 天然和人工铁载体：铁基应用及其他
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1016/j.cbpa.2025.102601
Zih-Jheng Lin, Cheng-Yu Fang, Tsung-Shing Andrew Wang
{"title":"Natural and artificial siderophores: Iron-based applications and beyond","authors":"Zih-Jheng Lin,&nbsp;Cheng-Yu Fang,&nbsp;Tsung-Shing Andrew Wang","doi":"10.1016/j.cbpa.2025.102601","DOIUrl":"10.1016/j.cbpa.2025.102601","url":null,"abstract":"<div><div>Siderophores are iron chelators secreted by microorganisms to scavenge iron from the environment. Natural siderophores have gained remarkable importance because their conjugates can be applied as antibiotics and diagnostic imaging agents. By utilizing the iron uptake system of microorganisms, functional molecules such as antibiotics or imaging agents can be delivered into cells. Notably, artificial siderophores have also been developed to increase stability and broaden metal chelating diversity. Various strategies, including backbone fine-tuning, artificial chelation moieties, and direct metal swapping, can be employed. Therefore, artificial siderophores can bind biorelated metals or radioactive isotopes, expanding their biological and medical applications. The aim of this review is to introduce recent advances in natural and artificial siderophore applications and highlight future challenges in this area of research.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102601"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition 最近的研究进展揭示了金属团在群体感应、抗菌活性和镧系元素获取方面的功能
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-19 DOI: 10.1016/j.cbpa.2025.102604
Ghazal Kamyabi, Erica L. Debley, Elizabeth M. Nolan
{"title":"Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition","authors":"Ghazal Kamyabi,&nbsp;Erica L. Debley,&nbsp;Elizabeth M. Nolan","doi":"10.1016/j.cbpa.2025.102604","DOIUrl":"10.1016/j.cbpa.2025.102604","url":null,"abstract":"<div><div>Metallophores are metal-chelating secondary metabolites that bacteria, fungi, and other organisms produce to acquire essential metal nutrients from their environment. This review highlights some recent discoveries in the field: the role of yersiniabactin in quorum sensing, the capacity of aspergillomarasmine A to inhibit bacterial Ni uptake, and the identification of methylolanthanin, a novel metallophore that enables bacterial lanthanide acquisition.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102604"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale 探测配体诱导的局部稳定性转移：一种在蛋白质组学尺度上识别靶蛋白和结合位点的敏感方法
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-05-31 DOI: 10.1016/j.cbpa.2025.102602
Keyun Wang , Yanan Li , Yanni Ma , Mingliang Ye
{"title":"Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale","authors":"Keyun Wang ,&nbsp;Yanan Li ,&nbsp;Yanni Ma ,&nbsp;Mingliang Ye","doi":"10.1016/j.cbpa.2025.102602","DOIUrl":"10.1016/j.cbpa.2025.102602","url":null,"abstract":"<div><div>Deciphering ligand-induced structural alterations represents a critical frontier in functional proteomics, offering transformative potential for both target identification and mechanistic understanding of ligand actions. Therefore, it is of great interest to develop robust proteomic approaches to uncover the binding relationship between ligands and the targeting proteins. The ligand modification-free approaches have the advantages of bypassing chemical modification and thus are broadly applicable to diverse ligands. Herein, in this review, we will introduce some recent methodology advancements for modification-free approaches in the identification of interactions between ligands and proteins. Especially, we will focus on a newly developed method, peptide-centric local stability assay (PELSA), which was designed to probe the ligand-induced local stability shifts and was demonstrated to have high sensitivity in revealing the binding regions at proteome level. The continued refinement and wider implementation of such technologies are expected to revolutionize fundamental research related with ligand–protein interactions.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102602"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport 编辑概述：转化细胞内递送：大分子运输的创新
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1016/j.cbpa.2025.102599
Jean-Philippe Pellois
{"title":"Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport","authors":"Jean-Philippe Pellois","doi":"10.1016/j.cbpa.2025.102599","DOIUrl":"10.1016/j.cbpa.2025.102599","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102599"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion transport across biological membranes 离子在生物膜上的传输
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-18 DOI: 10.1016/j.cbpa.2025.102606
Robin S. Bon, Matthew J. Langton
{"title":"Ion transport across biological membranes","authors":"Robin S. Bon,&nbsp;Matthew J. Langton","doi":"10.1016/j.cbpa.2025.102606","DOIUrl":"10.1016/j.cbpa.2025.102606","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102606"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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