Current Opinion in Chemical Biology最新文献_第2页

Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale 探测配体诱导的局部稳定性转移：一种在蛋白质组学尺度上识别靶蛋白和结合位点的敏感方法

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-05-31 DOI: 10.1016/j.cbpa.2025.102602

Keyun Wang , Yanan Li , Yanni Ma , Mingliang Ye

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引用次数: 0

Natural and artificial siderophores: Iron-based applications and beyond 天然和人工铁载体：铁基应用及其他

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-05-23 DOI: 10.1016/j.cbpa.2025.102601

Zih-Jheng Lin, Cheng-Yu Fang, Tsung-Shing Andrew Wang

引用次数: 0

Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity 在探测选定的细胞器阳离子的水平和通量以及细胞器的机械敏感性方面的最新进展

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-05-03 DOI: 10.1016/j.cbpa.2025.102600

Taufiq Rahman , Sandip Patel

{"title":"Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity","authors":"Taufiq Rahman , Sandip Patel","doi":"10.1016/j.cbpa.2025.102600","DOIUrl":"10.1016/j.cbpa.2025.102600","url":null,"abstract":"<div><div>Electrochemical gradients exist not only across the plasma membrane (PM) but also across membranes of organelles. Various endomembrane-localised ion channels and transporters have been identified, the activity of which is critical for organellar (and also cellular) ionic homeostasis that underpins diverse cellular processes. Aberrant organellar ion flux underlies several diseases, identifying organellar channels and transporters as potential drug targets. Therefore, the need for probing the functions of these proteins in situ cannot be overemphasised. The acidic interior of a few organelles as well as the dynamic nature of most organelles historically presented challenges for reliable estimation of luminal ionic concentrations. But there have been significant methodological and technical advancements by now, allowing measurement of levels of specific ions within these organelles as well as their flux across endomembranes with increasing precision. Evidence also continues to amass reporting mechanosensitivity of the endomembranes and its physiological significance. Here we highlight some recent developments in tools and techniques for measuring the levels and movement of some selected organellar cations as well as organellar mechanosensitivity.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102600"},"PeriodicalIF":6.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport 编辑概述：转化细胞内递送：大分子运输的创新

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-28 DOI: 10.1016/j.cbpa.2025.102599

Jean-Philippe Pellois

引用次数: 0

Editorial: Unusual enzyme reactions in natural products biosynthesis 社论：天然产物生物合成中不寻常的酶反应

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-26 DOI: 10.1016/j.cbpa.2025.102597

Taifo Mahmud, Ikuro Abe

引用次数: 0

Chemical strategies for targeting lipid pathways in bacterial pathogens 针对细菌病原体脂质途径的化学策略

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-19 DOI: 10.1016/j.cbpa.2025.102596

Alyssa M. Carter , Emily C. Woods , Matthew Bogyo

引用次数: 0

Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems 从自然和工程光合内共生系统的分子和生化见解

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-18 DOI: 10.1016/j.cbpa.2025.102598

Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta

{"title":"Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems","authors":"Jay E. Cournoyer , Bidhan C. De , Angad P. Mehta","doi":"10.1016/j.cbpa.2025.102598","DOIUrl":"10.1016/j.cbpa.2025.102598","url":null,"abstract":"<div><div>Mitochondria and chloroplasts evolved through the transformation of bacterial endosymbionts established within the host cells. Studies on these organelles have provided several phylogenetic and biochemical insights related to this remarkable evolutionary transformation. Additionally, comparative studies between naturally existing endosymbionts and present-day organelles have allowed us to identify important common features of endosymbiotic evolution. In this review, we discuss hallmarks of photosynthetic endosymbiotic systems, particularly focusing on some of the fascinating molecular changes that occur in the endosymbiont and the host as the endosymbiont/host chimera evolves and transforms endosymbionts into organelles; these include the following: (i) endosymbiont genome minimization and host/endosymbiont gene transfer, (ii) protein import/export systems, (iii) metabolic crosstalk between the endosymbiont, (iv) alterations to the endosymbiont peptidoglycan, and (v) host-controlled replication of endosymbionts/organelles. We discuss these hallmarks in the context of naturally existing photosynthetic endosymbiotic systems and present-day chloroplasts. Further, we also briefly discuss laboratory efforts to engineer endosymbiosis between photosynthetic bacteria and host cells, the lessons learned from these studies, future directions of these studies, and their implications on evolutionary biology and synthetic biology.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102598"},"PeriodicalIF":6.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opportunities in exploring chemical biology tools for better strategies against Candida albicans 探索化学生物学工具的机会，以更好地对抗白色念珠菌

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-04-04 DOI: 10.1016/j.cbpa.2025.102595

Lanxin Li, Yuan Qiao

引用次数: 0

Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141 “细菌二萜合成酶：机械酶学和工程生物合成的新机遇”的更正[当前观点化学生物，16 (2012)132-141

IF 6.9 2区生物学

Current Opinion in Chemical Biology Pub Date : 2025-03-26 DOI: 10.1016/j.cbpa.2025.102594

Michael J. Smanski , Ryan M. Peterson , Sheng-Xiong Huang , Ben Shen

引用次数: 0

Recent advances in de novo designed metallopeptides as tailored enzyme mimics 重新设计金属肽作为定制酶模拟物的最新进展。