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Current Opinion in Chemical Biology最新文献

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Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity 在探测选定的细胞器阳离子的水平和通量以及细胞器的机械敏感性方面的最新进展
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-05-03 DOI: 10.1016/j.cbpa.2025.102600
Taufiq Rahman , Sandip Patel
{"title":"Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity","authors":"Taufiq Rahman ,&nbsp;Sandip Patel","doi":"10.1016/j.cbpa.2025.102600","DOIUrl":"10.1016/j.cbpa.2025.102600","url":null,"abstract":"<div><div>Electrochemical gradients exist not only across the plasma membrane (PM) but also across membranes of organelles. Various endomembrane-localised ion channels and transporters have been identified, the activity of which is critical for organellar (and also cellular) ionic homeostasis that underpins diverse cellular processes. Aberrant organellar ion flux underlies several diseases, identifying organellar channels and transporters as potential drug targets. Therefore, the need for probing the functions of these proteins in situ cannot be overemphasised. The acidic interior of a few organelles as well as the dynamic nature of most organelles historically presented challenges for reliable estimation of luminal ionic concentrations. But there have been significant methodological and technical advancements by now, allowing measurement of levels of specific ions within these organelles as well as their flux across endomembranes with increasing precision. Evidence also continues to amass reporting mechanosensitivity of the endomembranes and its physiological significance. Here we highlight some recent developments in tools and techniques for measuring the levels and movement of some selected organellar cations as well as organellar mechanosensitivity.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102600"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical tools to study and modulate glycan-mediated host-bacteria interactions 研究和调节聚糖介导的宿主-细菌相互作用的化学工具
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1016/j.cbpa.2025.102603
Divya Bhargava , Aniqa Chowdhury , Danielle H. Dube
{"title":"Chemical tools to study and modulate glycan-mediated host-bacteria interactions","authors":"Divya Bhargava ,&nbsp;Aniqa Chowdhury ,&nbsp;Danielle H. Dube","doi":"10.1016/j.cbpa.2025.102603","DOIUrl":"10.1016/j.cbpa.2025.102603","url":null,"abstract":"<div><div>Glycans cover the surfaces of all cells, where they are poised to mediate a two-way discourse between bacteria and host cells. In some instances, glycan-mediated interactions foster a symbiotic state, and in others, they tip the balance toward disease. Chemical biology approaches have begun to reveal the roles of glycans in host-bacteria interactions and provide novel pathways to modulate these interactions. Here, we highlight recent advances in the development and application of chemical biology tools to delineate the roles of glycans in bacterial adhesion, bacterial evasion of the host immune system, host recognition of bacterial cells, and endogenous mechanisms to maintain symbiosis. Further, we present glycan-based strategies to disrupt host-pathogen interactions and to promote the growth of beneficial bacteria.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102603"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical synthesis and biological functions of carbohydrates 碳水化合物的化学合成及生物功能
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1016/j.cbpa.2025.102617
You Yang, Biao Yu
{"title":"Chemical synthesis and biological functions of carbohydrates","authors":"You Yang,&nbsp;Biao Yu","doi":"10.1016/j.cbpa.2025.102617","DOIUrl":"10.1016/j.cbpa.2025.102617","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102617"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Unusual enzyme reactions in natural products biosynthesis 社论：天然产物生物合成中不寻常的酶反应
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-04-26 DOI: 10.1016/j.cbpa.2025.102597
Taifo Mahmud, Ikuro Abe
{"title":"Editorial: Unusual enzyme reactions in natural products biosynthesis","authors":"Taifo Mahmud,&nbsp;Ikuro Abe","doi":"10.1016/j.cbpa.2025.102597","DOIUrl":"10.1016/j.cbpa.2025.102597","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102597"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating and understanding new-to-nature chemistry 创造和理解新的自然化学
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-07-17 DOI: 10.1016/j.cbpa.2025.102621
Sonja Billerbeck, Virginia W. Cornish
{"title":"Creating and understanding new-to-nature chemistry","authors":"Sonja Billerbeck,&nbsp;Virginia W. Cornish","doi":"10.1016/j.cbpa.2025.102621","DOIUrl":"10.1016/j.cbpa.2025.102621","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102621"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in chemical proteomics for protein profiling and targeted degradation 化学蛋白质组学在蛋白质分析和靶向降解方面的最新进展
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1016/j.cbpa.2025.102605
Peng-Kai Liu , Zicong Wang , Lingjun Li
{"title":"Recent advances in chemical proteomics for protein profiling and targeted degradation","authors":"Peng-Kai Liu ,&nbsp;Zicong Wang ,&nbsp;Lingjun Li","doi":"10.1016/j.cbpa.2025.102605","DOIUrl":"10.1016/j.cbpa.2025.102605","url":null,"abstract":"<div><div>Chemical proteomics has emerged as a powerful approach to decipher protein function, interactions, and targeted degradation pathways in complex biological systems. Recent advances in chemical labeling strategies, including activity-based protein profiling (ABPP), proximity labeling (PL), and proteolysis-targeting chimeras (PROTACs), have facilitated a deeper understanding of protein function and interaction networks. First, ABPP employs covalent probes to selectively label active enzymes, uncovering functional proteomics and drug–target interactions. Innovations such as PhosID-ABPP and streamlined cysteine ABPP have improved site-specific quantification and throughput, enabling proteome-wide analysis of enzyme activity and small-molecule interactions. Second, PL enables the characterization of transient protein–protein interactions using enzymatic or chemically triggered approaches. Advances including TurboID and TransitID enhanced the spatiotemporal resolution of PL. Third, PROTACs expand the scope of targeted protein degradation by leveraging the ubiquitin–proteasome system. Collectively, we highlight recent advancements in integrating mass spectrometry (MS) with these methodologies in the field of chemical proteomics.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"87 ","pages":"Article 102605"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in de novo designed metallopeptides as tailored enzyme mimics 重新设计金属肽作为定制酶模拟物的最新进展。
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.cbpa.2025.102586
Salvatore La Gatta, Vincent L. Pecoraro
{"title":"Recent advances in de novo designed metallopeptides as tailored enzyme mimics","authors":"Salvatore La Gatta,&nbsp;Vincent L. Pecoraro","doi":"10.1016/j.cbpa.2025.102586","DOIUrl":"10.1016/j.cbpa.2025.102586","url":null,"abstract":"<div><div>Advances in <em>de novo</em> design of metallopeptides have paved the way for customized metalloenzyme mimics with impressive catalytic capabilities. Over the last few years, incorporation of transition metals into simplified peptide scaffolds has allowed for catalytic efficiencies similar to or greater than those found in natural metalloenzymes. Artificial <em>de novo</em> peptide scaffolds highlight how precise modifications to metal coordination environments can improve scaffold stability and catalytic efficiency for a wide range of applications towards redox, non redox, synthetic, and energy conversion chemistry. These insights deepen our understanding of enzyme evolution and set a solid foundation for new directions in biocatalysis.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102586"},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical strategies for targeting lipid pathways in bacterial pathogens 针对细菌病原体脂质途径的化学策略
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI: 10.1016/j.cbpa.2025.102596
Alyssa M. Carter , Emily C. Woods , Matthew Bogyo
{"title":"Chemical strategies for targeting lipid pathways in bacterial pathogens","authors":"Alyssa M. Carter ,&nbsp;Emily C. Woods ,&nbsp;Matthew Bogyo","doi":"10.1016/j.cbpa.2025.102596","DOIUrl":"10.1016/j.cbpa.2025.102596","url":null,"abstract":"<div><div>Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has been limited development of antibiotics with new mechanisms of action, highlighting our need to identify processes that can be targeted by next generation therapeutics. Recent advancements in our understanding of the roles that lipids play in key bacterial processes suggest that these biomolecules are a potentially valuable site for disruption by therapeutic agents. Specifically, the success of a pathogen depends on its ability to make fatty acids <em>de novo</em> or scavenge lipids from its host. This review focuses on recent advances using chemical biology tools for defining and disrupting lipid pathways in bacteria.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102596"},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes 非细胞毒性催化酶功能模拟物，包括氰化物中毒解毒剂
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1016/j.cbpa.2025.102584
Sigridur G. Suman
{"title":"Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes","authors":"Sigridur G. Suman","doi":"10.1016/j.cbpa.2025.102584","DOIUrl":"10.1016/j.cbpa.2025.102584","url":null,"abstract":"<div><div>Functional mimics of enzymes have a long history with bioinorganic chemists. Early motivation for creating these mimics was strongly based on the study of the enzyme reaction mechanisms. In more recent times, interest in functional mimics has expanded to catalytic metallodrugs, where the mimics are deliberately designed for specific catalytic reactions intended for therapeutic purposes. <em>In vivo,</em> noncytotoxic catalysis targets reactions designed to activate prodrugs. Natural or <em>de novo</em> proteins were developed for artificial enzyme catalysis of Diels–Alder reactions, or as artificial oxygenase mimics. Novel sulfur-rich catalytic superoxide dismutase (SOD) mimics were discovered as antioxidants. Detoxification of elevated levels of cyanide where the natural rhodanese enzyme becomes inefficient in turnover rates and bioavailability is particularly attractive for sulfur-rich molybdenum clusters. This brief overview includes metal catalysts performing abiotic reactions <em>in vivo</em> disguised by attachment to cell surfaces, as artificial enzymes, and interesting new sulfur-rich complexes performing SOD reactions or neutralizing cyanide.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102584"},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities in exploring chemical biology tools for better strategies against Candida albicans 探索化学生物学工具的机会，以更好地对抗白色念珠菌
IF 6.9 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2025-06-01 Epub Date: 2025-04-04 DOI: 10.1016/j.cbpa.2025.102595
Lanxin Li, Yuan Qiao
{"title":"Opportunities in exploring chemical biology tools for better strategies against Candida albicans","authors":"Lanxin Li,&nbsp;Yuan Qiao","doi":"10.1016/j.cbpa.2025.102595","DOIUrl":"10.1016/j.cbpa.2025.102595","url":null,"abstract":"<div><div>The growing global prevalence of drug-resistant fungal infections and the scarcity of effective clinical antifungal drugs necessitate an urgent need for new treatments and strategies. In the quest for novel antifungal and anti-virulence compounds and alternative drug targets in fungi, we recognize the significant value of chemical biology tools in guiding these endeavors. Focusing on <em>Candida albicans</em>, the major fungal pathogen in humans, this review explores recent antifungal research efforts that utilize chemical biology tools—such as chemical probes and toolkits—that offer valuable biological insights into the cellular processes of <em>C. albicans</em>. In addition, we discuss the wealth of compounds in the host gut microbiota that naturally influence <em>C. albicans</em> invasive growth in the gut habitat, presenting promising yet underexplored opportunities for developing novel antifungal and anti-virulence strategies. Chemical biology tools are uniquely positioned to unlock the potential of gut microbiota-derived molecules and metabolites in combating <em>C. albicans</em> infections.</div></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":"86 ","pages":"Article 102595"},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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