刺激反应性合成离子载体的治疗应用

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2025-03-03 DOI:10.1016/j.cbpa.2025.102582

Sandip Chattopadhayay, Pinaki Talukdar

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引用次数: 0

摘要

大自然赋予不同结构和功能复杂的跨膜转运体在外界刺激下通过开启或关闭离子流来输送离子，维持细胞的健康功能。利用合成类似物模拟天然转运体的这种刺激反应行为是目前科学界持续关注的问题。本文简要介绍了近年来合成响应性离子载体系统的研究进展。这包括pH、光、氧化还原、酶和多刺激控制的离子载体系统，这些系统具有从抗菌活性到抗癌活性等不同生物医学应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Stimuli-responsive synthetic ionophores for therapeutic applications

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Stimuli-responsive synthetic ionophores for therapeutic applications

Nature endowed different structurally and functionally complex transmembrane transporters to flux the ions to maintain the healthy functions of the cells by turning on or turning off the ion flow in the presence of external stimuli. Mimicking this stimuli-responsive behavior of natural transporters using synthetic analogs is currently an ongoing interest in the scientific community. This short review highlights the recent development of synthetic responsive ionophore systems. This includes pH, light, redox, enzyme, and multi-stimuli-controlled ionophores systems that have the potential to be utilized in different biomedical applications ranging from antibacterial activity to anticancer activity.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.