Opportunities in exploring chemical biology tools for better strategies against Candida albicans

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2025-04-04 DOI:10.1016/j.cbpa.2025.102595

Lanxin Li, Yuan Qiao

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Abstract

The growing global prevalence of drug-resistant fungal infections and the scarcity of effective clinical antifungal drugs necessitate an urgent need for new treatments and strategies. In the quest for novel antifungal and anti-virulence compounds and alternative drug targets in fungi, we recognize the significant value of chemical biology tools in guiding these endeavors. Focusing on Candida albicans, the major fungal pathogen in humans, this review explores recent antifungal research efforts that utilize chemical biology tools—such as chemical probes and toolkits—that offer valuable biological insights into the cellular processes of C. albicans. In addition, we discuss the wealth of compounds in the host gut microbiota that naturally influence C. albicans invasive growth in the gut habitat, presenting promising yet underexplored opportunities for developing novel antifungal and anti-virulence strategies. Chemical biology tools are uniquely positioned to unlock the potential of gut microbiota-derived molecules and metabolites in combating C. albicans infections.

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探索化学生物学工具的机会，以更好地对抗白色念珠菌

全球耐药真菌感染的日益流行和有效的临床抗真菌药物的缺乏迫切需要新的治疗方法和策略。在寻找新的抗真菌和抗毒化合物和真菌替代药物靶点的过程中，我们认识到化学生物学工具在指导这些努力中的重要价值。针对人类主要的真菌病原体白色念珠菌，本文综述了近年来利用化学生物学工具（如化学探针和工具箱）进行抗真菌研究的成果，这些研究为白色念珠菌的细胞过程提供了有价值的生物学见解。此外，我们讨论了宿主肠道微生物群中丰富的化合物，这些化合物自然影响白色念珠菌在肠道栖息地的侵袭性生长，为开发新的抗真菌和抗毒策略提供了有希望但尚未开发的机会。化学生物学工具具有独特的定位，可以释放肠道微生物衍生分子和代谢物在对抗白色念珠菌感染方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.