Natural and artificial siderophores: Iron-based applications and beyond

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zih-Jheng Lin, Cheng-Yu Fang, Tsung-Shing Andrew Wang
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引用次数: 0

Abstract

Siderophores are iron chelators secreted by microorganisms to scavenge iron from the environment. Natural siderophores have gained remarkable importance because their conjugates can be applied as antibiotics and diagnostic imaging agents. By utilizing the iron uptake system of microorganisms, functional molecules such as antibiotics or imaging agents can be delivered into cells. Notably, artificial siderophores have also been developed to increase stability and broaden metal chelating diversity. Various strategies, including backbone fine-tuning, artificial chelation moieties, and direct metal swapping, can be employed. Therefore, artificial siderophores can bind biorelated metals or radioactive isotopes, expanding their biological and medical applications. The aim of this review is to introduce recent advances in natural and artificial siderophore applications and highlight future challenges in this area of research.
天然和人工铁载体:铁基应用及其他
铁载体是由微生物分泌的铁螯合剂,用于清除环境中的铁。天然铁载体具有显著的重要性,因为它们的偶联物可以用作抗生素和诊断显像剂。利用微生物的铁摄取系统,可以将抗生素或显像剂等功能分子输送到细胞中。值得注意的是,人工铁载体也被开发出来,以提高稳定性和扩大金属螯合的多样性。可以采用各种策略,包括骨干微调、人工螯合部分和直接金属交换。因此,人工铁载体可以结合生物相关金属或放射性同位素,扩大其生物和医学应用。本文综述了天然和人工铁载体应用的最新进展,并强调了该研究领域未来的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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