IF 23.5 1区化学

Chem Pub Date : 2026-03-20 DOI: 10.1016/j.chempr.2026.102957

Indrajit Paul, Attila Csomos, Krzysztof A. Konieczny, Roberto Chavez, Zoltán Mucsi, Levente Cseri, Balázs József Rózsa, Miguel A. Garcia-Garibay

{"title":"Three-dimensional imaging via quantum chain amplification in a crystalline two-photon adiabatic photocage","authors":"Indrajit Paul, Attila Csomos, Krzysztof A. Konieczny, Roberto Chavez, Zoltán Mucsi, Levente Cseri, Balázs József Rózsa, Miguel A. Garcia-Garibay","doi":"10.1016/j.chempr.2026.102957","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102957","url":null,"abstract":"We report here a Dewar-benzene-1,2-dicarboxylic-acid monoester with a 7-hydroxycoumarin (7H) fluorescent cage (DB-7HC) that leverages two-photon excitation (TPE) to trigger an adiabatic triplet-state reaction that initiates a quantum chain capable of releasing up to 400 molecules of 7HC per excitation event. The chemical enhancement afforded by a TPE microscope enables precise, chemically amplified uncaging, which together with sensitive fluorescence detection results in high three-dimensional (3D) spatial resolution. Using a femtosecond pulse laser operating in the 690- to 770-nm range, this system allows for deep bulk activation with minimal scattering, with 7HC acting as a TPE antenna and triplet sensitizer and, once released, as a fluorescent reporter for real-time imaging. The high quantum yield and solid-state reactivity of the Dewar-benzene-1,2-dicarboxylic-acid monoester motif make it a promising probe for 3D microfabrication, patterning, optogenetics, and targeted drug delivery, with a demonstrated 1- to 5-μm spatial resolution.","PeriodicalId":268,"journal":{"name":"Chem","volume":"13 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superlattice electrocatalysis matching microbial metabolism for sustainable CO2-to-bioproduct conversion 超晶格电催化与微生物代谢相匹配，实现二氧化碳到生物产品的可持续转化

IF 23.5 1区化学

Chem Pub Date : 2026-03-19 DOI: 10.1016/j.chempr.2026.102955

Miao Liu, Yanfeng Shi, Hao Shi, Peilin Huang, Lupeng Wang, Zhujun Fu, Tianming Wu, Yuanhong Xu

{"title":"Superlattice electrocatalysis matching microbial metabolism for sustainable CO2-to-bioproduct conversion","authors":"Miao Liu, Yanfeng Shi, Hao Shi, Peilin Huang, Lupeng Wang, Zhujun Fu, Tianming Wu, Yuanhong Xu","doi":"10.1016/j.chempr.2026.102955","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102955","url":null,"abstract":"The integrated electrochemical-microbial system (iEMS) is a promising strategy for converting CO<sub>2</sub> into high-value bioproducts. However, the mismatch in the carbon species and flux between electrocatalysis and microbial metabolism hinders its overall efficiency. Herein, we develop a scalable Ag/Cu metal superlattice (MSL@Ag/Cu) electrocatalyst with a periodic electric-potential gradient, which enables the selective and stable production of microbe-biased ethanol substrate and maintains carbon flux for the iEMS. The directional Ag/Cu configuration causes a spatial confinement effect, which enriches and holds the key intermediates for sustainable C–C coupling. MSL@Ag/Cu achieves a high Faradaic efficiency of ethanol (>61.1%) and maintains this efficiency for over 220 h at 200 mA cm<sup>−2</sup> in an industrial electrolyzer. This long-term ethanol yield (160 mmol L<sup>−1</sup>) with indispensable carbon flux of <em>Saccharomyces cerevisiae</em> enables the breakthrough conversion of CO<sub>2</sub> to bioproducts. Techno-economic analysis indicates that the iEMS generates a profit of $15.5 million per year, which is 15-fold that of traditional electrocatalytic synthesis.","PeriodicalId":268,"journal":{"name":"Chem","volume":"33 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supradynamics: Motion in cavitand complexes 超动力学：空腔和复合物中的运动

IF 23.5 1区化学

Chem Pub Date : 2026-03-18 DOI: 10.1016/j.chempr.2026.102954

Ya Gao, Pablo Ballester, Gantulga Norjmaa, Fahmi Himo, Julius Rebek, Yang Yu

引用次数: 0

1,2-Boryl/hydrogen transposition via reversible C–H sampling 1,2-硼基/氢的可逆C-H转位

IF 23.5 1区化学

Chem Pub Date : 2026-03-17 DOI: 10.1016/j.chempr.2026.102961

Longhuan Xie, Peijie Luo, Tao Lu, Weipeng Zheng, Yinyan Su, Jianbo Wang, Xiaotian Qi, Yan Xu

{"title":"1,2-Boryl/hydrogen transposition via reversible C–H sampling","authors":"Longhuan Xie, Peijie Luo, Tao Lu, Weipeng Zheng, Yinyan Su, Jianbo Wang, Xiaotian Qi, Yan Xu","doi":"10.1016/j.chempr.2026.102961","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102961","url":null,"abstract":"Boryl groups are central to modern synthetic chemistry, in particular because of their facile installation from various functional groups (FGs) and versatile transformations into diverse chemical bonds. Although the introduction and interconversion of boryl groups are well established, the direct repositioning of an existing boryl group along a carbon backbone—without any other pre-installed FGs—remains underexplored. Herein, we disclose a direct 1,2-boryl translocation reaction with common C(<em>sp</em><sup>3</sup>)–H bonds in alkyl boronic esters. Driven by the synergy between hydrogen atom abstraction (HAA) and donation (HAD) catalysis, this reaction features reversible radical generation at multiple C–H sites yet ensures selective transformation via the kinetically favored 1,2-radical boryl migration. No directing groups (DGs) or stoichiometric reagents are needed, and the mechanism is supported by both experimental and computational evidence. By integrating on-demand boryl repositioning with boryl’s established synthetic versatility, this method further offers strategic opportunities for planning streamlined syntheses.","PeriodicalId":268,"journal":{"name":"Chem","volume":"27 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid-state NMR provides location-specific information on the chemical environment inside MOF pores 固态核磁共振提供了MOF孔内化学环境的特定位置信息

IF 23.5 1区化学

Chem Pub Date : 2026-03-17 DOI: 10.1016/j.chempr.2026.102949

Hao Deng, Marco Bengsch, Christophe Farès, Zihang Qiu, Mir Henglin, Constanze N. Neumann

引用次数: 0

In situ insights from non-equilibrium solution combustion synthesis: From semiconducting thin films to metallic nanostructures 非平衡溶液燃烧合成的原位洞察：从半导体薄膜到金属纳米结构

IF 23.5 1区化学

Chem Pub Date : 2026-03-16 DOI: 10.1016/j.chempr.2026.102943

Thomas W. Colburn, Abigail Carbone, Justus Just, Sarah Bindon, Ryan Wainer, Robert D. Miller, Reinhold H. Dauskardt

{"title":"In situ insights from non-equilibrium solution combustion synthesis: From semiconducting thin films to metallic nanostructures","authors":"Thomas W. Colburn, Abigail Carbone, Justus Just, Sarah Bindon, Ryan Wainer, Robert D. Miller, Reinhold H. Dauskardt","doi":"10.1016/j.chempr.2026.102943","DOIUrl":"https://doi.org/10.1016/j.chempr.2026.102943","url":null,"abstract":"Solution combustion synthesis (SCS) is a rapid and scalable synthetic pathway for producing metallic and oxide nanoparticles and thin films, resulting from the exothermic combustion between a metal cation, chelating organic fuel, and an oxidant. However, understanding the divergence in SCS between thin-film and unconfined bulk combustion, as well as <em>in situ</em> experiments probing the reaction progression, remains limited. Here, we leverage X-ray absorption spectroscopy (XAS), along with other X-ray- and electron-based characterizations, to explore the interplay between precursor chemistry and combustion geometry (thin film versus bulk powder) in yielding a range of nickel-based oxide, metallic, and complex carbide/metallic structures, with generalizability to other transition metals. We develop a fundamental understanding of the effect of precursor stoichiometries on the reaction products attainable using SCS. Using shallow-angle <em>in situ</em> XAS, we then measure the kinetics and activation energies for thin-film conversion via combustion synthesis.","PeriodicalId":268,"journal":{"name":"Chem","volume":"20 1","pages":"102943"},"PeriodicalIF":23.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread hypermodified β-helical peptides in common bacteria 普遍存在于普通细菌中的超修饰β-螺旋肽

IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2026-02-04 DOI: 10.1016/j.chempr.2025.102877

Lida Vadakumchery , Christoph M. Meier , Clarissa C. Forneris , Lucas Paoli , Alicia Courvoisier-Clément , Agneya Bhushan , Alessandro Lotti , Chandrashekhar Padhi , Shinichi Sunagawa , Alvar D. Gossert , Jörn Piel

{"title":"Widespread hypermodified β-helical peptides in common bacteria","authors":"Lida Vadakumchery , Christoph M. Meier , Clarissa C. Forneris , Lucas Paoli , Alicia Courvoisier-Clément , Agneya Bhushan , Alessandro Lotti , Chandrashekhar Padhi , Shinichi Sunagawa , Alvar D. Gossert , Jörn Piel","doi":"10.1016/j.chempr.2025.102877","DOIUrl":"10.1016/j.chempr.2025.102877","url":null,"abstract":"<div><div>Polytheonamides are extraordinarily complex and potent ribosomal peptide cytotoxins featuring up to 50 mostly non-canonical post-translational modifications, including 18 <span>d</span>-amino acids. They act by forming minimalistic, unimolecular transmembrane ion channels that adopt a β-helical structure. Only a few related natural products are known, and they occur mostly in uncultivated, poorly studied bacteria. Here, we report the genomic discovery of a large, cryptic peptide family, termed origamins, that occurs in phylogenetically diverse, well-known bacteria, including <em>Escherichia coli</em>. Characterization of several pathways revealed striking similarities to polytheonamides, indicating convergent evolution of the complex maturation pattern. These include up to 44 modifications, a β-helical structure, and cytotoxic activity. A high prevalence in human-associated bacteria, including symbionts and pathogens, suggests widespread roles in host-microbiome interactions.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 3","pages":"Article 102877"},"PeriodicalIF":19.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147428979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular train-style nanorobots for targeted deep penetration and multi-directional collaborative treatment of colorectal cancer 用于大肠癌靶向深度穿透和多方向协同治疗的模块化列车式纳米机器人

IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2025-10-01 DOI: 10.1016/j.chempr.2025.102750

Jiamin Ye , Yueyue Fan , Gaoli Niu , Yong Kang , Jiacheng Shi , Ruiyan Li , Yiwen Yang , Xiaoyuan Ji

{"title":"Modular train-style nanorobots for targeted deep penetration and multi-directional collaborative treatment of colorectal cancer","authors":"Jiamin Ye , Yueyue Fan , Gaoli Niu , Yong Kang , Jiacheng Shi , Ruiyan Li , Yiwen Yang , Xiaoyuan Ji","doi":"10.1016/j.chempr.2025.102750","DOIUrl":"10.1016/j.chempr.2025.102750","url":null,"abstract":"<div><div>Colorectal cancer (CRC) remains a major global health challenge due to insufficient tumor penetration and immunosuppressive microenvironments. Herein, we propose a modular train-style nanorobot (TPP-Exo@LOX-Pd-Cu<sub>7</sub>S<sub>4</sub>) as a targeted synergistic therapeutic platform for CRC. The exosome “head” enables neutrophil-like tumor homing, while the Cu<sub>7</sub>S<sub>4</sub> “tail” generates thermophoretic propulsion for deep tumor penetration. Under near-infrared region II (NIR-II) laser irradiation, the Pd-Cu<sub>7</sub>S<sub>4</sub> Schottky heterojunction drives highly efficient catalytic cascades, disrupting redox homeostasis and inducing metabolic stress by converting O₂ to ·O₂<sup>−</sup>, H₂O₂ to ·OH, GSH to GSSG, NADH to NAD<sup>+</sup>, and lactate to pyruvate. The nanorobot directly targets mitochondria to reprogram tumor metabolism and trigger cuproptosis. Meanwhile, lactate oxidase (LOX), encapsulated within the engineered exosomes, depletes excess lactate to relieve immunosuppression and boost antitumor immunity. In CRC models, these nanorobots exhibit strong barrier penetration, precise targeting, and deep tumor infiltration, offering a multifunctional and metabolically disruptive therapeutic approach.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 3","pages":"Article 102750"},"PeriodicalIF":19.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zeolite framework flexibility: A new dimension for zeolite catalysts 沸石骨架灵活性：沸石催化剂的新维度

IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2026-02-14 DOI: 10.1016/j.chempr.2025.102888

Chunzheng Wang , Eddy Dib , Hailing Guo , Svetlana Mintova

{"title":"Zeolite framework flexibility: A new dimension for zeolite catalysts","authors":"Chunzheng Wang , Eddy Dib , Hailing Guo , Svetlana Mintova","doi":"10.1016/j.chempr.2025.102888","DOIUrl":"10.1016/j.chempr.2025.102888","url":null,"abstract":"<div><div>Zeolites, traditionally defined as crystalline porous aluminosilicates, are among the most effective catalysts in chemical industry. Although, zeolites are often considered as rigid materials, emerging evidence reveals underexplored features related to the flexibility of zeolite frameworks. This dynamic property, along with structural defects, allows zeolites to process molecules larger than their nominal pore apertures under specific stimuli. This perspective examines two key aspects of zeolite flexibility: (1) inferring framework flexibility based on reactivity trends and (2) utilizing this flexibility to improve catalytic performance. Tailoring zeolite flexibility is increasingly recognized as a critical parameter for optimizing catalytic performance. Several examples highlighting the impact of zeolite flexibility on molecular diffusion, adsorption, and reaction processes are presented here. The discussion underscores the critical role of advanced characterization and molecular simulations in guiding the design and synthesis of flexible zeolite catalysts, paving the way for more efficient and sustainable catalytic processes.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"12 3","pages":"Article 102888"},"PeriodicalIF":19.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146205573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aluminum redox catalysis has a ring to it 铝氧化还原催化有一个环

IF 19.6 1区化学

Chem Pub Date : 2026-03-12 Epub Date: 2026-02-20 DOI: 10.1016/j.chempr.2025.102909

Matthew J. Evans , Cameron Jones

引用次数: 0

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