Acta medica Eurasica最新文献

{"title":"THE EFFECT OF SILICON NANOPARTICLES AND WATER-SOLUBLE SILICATES ON THE LIVER (COMPARISON OF OUR OWN RESEARCH RESULTS WITH THE LITERATURE DATA)","authors":"Evgeniia A. Grigoreva, V. Gordova, V. Sergeeva","doi":"10.47026/2413-4864-2022-4-108-120","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-108-120","url":null,"abstract":"This literature review combines data on the effect of silicon compounds on the body – silicon nanoparticles and water-soluble silicates, obtained by domestic and foreign researchers over the past decade. a widespread use of amorphous silicon dioxide in modern industry, as well as revision of regulatory documents on silicon content in drinking water in the Russian Federation give this aspect special relevance. Increased attention is paid to comparing our own results of long-term experiments on silicon intake with drinking water by laboratory animals and the literature data. It has been shown that morphological changes in the liver caused by exposure to water-soluble silicates and nanoparticles are similar. Thus, questions about the biological inertness of silicon, monitoring the use of silicon in industry, and adjustment of its maximum permissible concentration in drinking water require further study.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122447052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND SOCIAL CHARACTERISTICS AND FEATURES OF BIOCHEMICAL INDICATORS IN PERSONS WITH MENTAL DISORDERS WHO HAVE COMMITTED VIOLENT CRIMES","authors":"O. Makushkina, V. Golenkova","doi":"10.47026/2413-4864-2022-4-37-46","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-37-46","url":null,"abstract":"The relevance of the study is conditioned by the need to develop effective methods to prevent public danger arising from persons suffering from mental disorders, with identification of factors that influence aggressive behavior formation in order to improve measures to prevent crimes related to violence. the purpose of this work was to study the socio-demographic, clinical and psychopathological features and biochemical parameters in persons with mental disorders who committed violent crimes. the scientific novelty is determined by the importance of establishing the features of the complex influence of clinical, biological and social factors on the tendency to heteroaggression, the lack of scientifically substantiated data on the role of neurotransmitter and hormonal systems in aggressive behavior formation in patients with severe forms of mental pathology. Materials and methods. the research sample consisted of 100 respondents aged 18 to 60 years with a verified diagnosis of a severe mental disorder and the fact of criminal prosecution for violent crimes. the clinical features of the patients were evaluated using a clinical-psychopathological method with identification of the leading characteristics in psychopathological symptoms and syndromes. Standardized assessment of clinical characteristics was provided by the use of the psychometric methodology \"Positive and Negative Syndrome Scale\" (PANSS), the methodology \"Structured Assessment of Unsafe Behavior Risk\" (SOROP). for laboratory testing, blood and urine samples were used to determine the levels of serotonin, dopamine, cortisol, testosterone, free T3 (free T3), estradiol. Results. the most common clinical and social characteristics of persons with severe mental disorders and persistent aggressive criminal behavior were identified and described. in the majority of respondents, the indicators of the neurotransmitter system (serotonin, dopamine levels) were found to differ significantly from the reference values. a negative correlation was determined between serotonin excretion and the sum of points according to SOROP technique, as well as the subscale of aggression, which is part of the indicators in PANSS technique. Conclusions. the obtained data contribute to understanding the nature of heteroaggression in persons with mental disorders, indicating the need for further studying the relationship of social, clinical and biological parameters, determining their role in aggressive behavior formation in this contingent of patients.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122485160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL TREATMENT OF INFECTIOUS ENDOCARDITIS","authors":"A. Shonbin, D. Bystrov, Boris O. Afonin, Roman O. Sorokin","doi":"10.47026/2413-4864-2022-4-73-79","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-73-79","url":null,"abstract":"Infectious endocarditis is one of extremely dangerous diseases. Despite the opportunities of modern medicine, hospital mortality in infectious endocarditis remains high. Most patients are operated on for urgent and emergency indications. the article presents 11 years of experience in surgical treatment of infectious endocarditis at the State Budgetary Healthcare Institution JSC \"PGKB named after E.E. Volosevich\" in the town of Arkhangelsk. the study included 169 patients with infectious endocarditis, verified based on the presence of criteria corresponding to the modified Duke criteria. Infectious endocarditis of native valves (group I) was compared to prosthetic endocarditis (group II). the operative risk according to the EuroScore I, II and STS scales was significantly higher in the group of patients with prosthetic infectious endocarditis (p < 0.001). Para-valve destructive changes were more common (p = 0.05) in the group of prosthetic infectious endocarditis. There were no statistically significant differences in the localization of infectious endocarditis (p > 0.05), however, multiple valve lesions were more often observed in infectious endocarditis of native valves (p = 0.05). a complicated postoperative period was detected in 41.9% of patients of group I and in 71.4% of group II (p = 0.05). Hospital mortality in group I was 3.4%, in group II – 9.5% (p < 0.001). the main cause of death in the postoperative period was acute cardiovascular insufficiency. Despite the fact that hospital mortality in the surgical treatment of active infectious endocarditis continues to be high, surgical intervention in active infectious endocarditis is the only effective method of treatment.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127062759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE CORRELATIONAL RELATIONSHIP BETWEEN THE RESULTS OF ULTRASOUND ELASTOGRAPHY AND THE VALUES OF THE MEASURED DIFFUSION COEFFICIENT IN ASSESSING UTERINE AND ADNEXAL STRUCTURES IN REPRODUCTIVE AGE WOMEN","authors":"V. Diomidova, O. V. Zakharova, Marina A. Safonova, O. Valeeva","doi":"10.47026/2413-4864-2022-3-1-11","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-1-11","url":null,"abstract":"The purpose of the study. To study the correlational relationship between the results obtained by examining the uterus and ovaries in healthy women of reproductive age using shear wave ultrasound elastography with elastometry and magnetic resonance imaging (MRI) and assessment of the measured diffusion coefficient (MDC) of diffusion-weighted images (DWI). Materials and methods. The study group consisted of 45 healthy women of reproductive age (the average age was 32.9±3.1 years). All of them underwent ultrasound examination with the technology of two-dimensional shear wave elastography with elastometry (Aixplorer, Supersonic Imagine, France) according to the method developed and implemented by us. The MRI of uterine and ovarian structures was performed using the DWI protocol (Excelart Vantage Atlas magnetic resonance tomograph, Toshiba, Japan, 1.5 T), the myometrium and the uterine mucosa in the body and cervix, ovaries were evaluated. In the automatic mode, the MDC of unaltered structures in the uterine body and cervix and their appendages was calculated in the area of interest on ADC-maps. The degree of correlational relationship between the results of ultrasound elastography with elastometry and magnetic resonance tomography with an estimate of the measured diffusion coefficient was calculated. Results. Correlation analysis of the relationship between rigidity and the MDC of uterine and adnexal structures showed a direct inverse relationship between these values and a high degree of connection by Cheddock scale (p = 0.000000). At this, lesser MDC values (mm2 /s) of similar structures of the organs under study corresponded to large quantitative values of the Young's elasticity modulus (kPa) of all uterine and ovarian structures. Conclusion. The obtained data make it possible to optimize the diagnostic algorithm and to supplement the standard protocols for ultrasound and magnetic resonance imaging studies of gynecological organs using two-dimensional shear wave elastography with elastometry and magnetic resonance tomography with an assessment of the measured diffusion coefficient of diffusion-weighted images.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126222501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ACTUAL STATUS OF TOXOCAROSIS INCIDENCE IN THE CHUVASH REPUBLIC","authors":"L. N. Voronov, N. V. Smirnova, Lidiya Yu. Agafoshkina, V. A. Kozlov","doi":"10.47026/2413-4864-2022-3-63-70","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-63-70","url":null,"abstract":"Toxocarosis is helminthosis caused by representatives of Nematoda type, manifested by nonspecific symptoms (from allergic manifestations to involvement of the lungs, eyes, the brain and other organs), depending on the localization of the larva in the human body. Currently, in the Russian Federation there is a tendency to increase the incidence, which makes it necessary to analyze the actual situation for this helminthosis. The aim of the study is to assess current epidemiological situation on the incidence of toxocarosis in the Chuvash Republic in the period from 2008 to 2021. The paper analyzes statistical data on the incidence of toxocarosis in the Chuvash Republic (Russia) from 2008 to 2021. During the period under study, the incidence of toxocarosis ranged from 0.91 to 6.74 per 100 thousand of population and made 4.09±0.44 per 100 thousand of population, and a decrease in this indicator was also noted in the republic over the past 13 years. However, the incidence of toxocarosis in Chuvashia remains at a level exceeding that of the average in Russia. A high incidence of toxocarosis was found to be confined to forest-growing areas (the Volga oak-forest-steppe, the South-eastern steppe and the South-western steppe regions), in which the soil-forming materials are mainly clays and loams.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131945901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF MULTIPARAMETRIC ULTRASOUND TECHNIQUES IN THE DIFFERENTIAL DIAGNOSIS OF THYROID CANCER","authors":"L. A. Timofeeva, M. N. Nasrullayev, T. N. Aleshina, Daria G. Zhirnova","doi":"10.47026/2413-4864-2022-3-47-53","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-47-53","url":null,"abstract":"The aim of the study is to determine the value of multiparametric ultrasound examination in the differential diagnosis of thyroid cancer. The results of a multiparametric ultrasound examination performed in 219 patients with thyroid cancer at the stage of preoperative assessment are analyzed. There were 123 patients with papillary thyroid cancer, 96 patients with follicular thyroid cancer. All patients underwent multiparametric ultrasound examination in grey-scale mode, color Doppler mapping mode and elastography mode: compression elastography and shear wave elastography. In papillary thyroid cancer, two–color staining was found in 13.4% of cases, three–color staining – in 19.3%, four-color staining – in 28.7%, five-color staining – in 26.4%, six–color staining – in 12.2%. The pattern was dominated by \"cold\" tones. The velocity of the shear wave was 4.61±1.33 m/s (95% CI), Young's modulus was 63.3±14.7 kPa (95% CI), the elasticity index (strain ratio) was 4.89±1.65 (95% CI) c.u. The color scheme of follicular thyroid cancer was characterized by patchiness, the presence of both rigid and elastic areas. In 2 cases (14.3%) there was two-color staining, in 4 (28.6%) – three-color staining, in 8 (57.1%) – four-color and five-color staining. The velocity of the shear wave was 4,53±1,25 m/s (95% CI), Young's modulus was 62,1±12,1 kPa (95% CI), the elasticity index (strain ratio) was 3,76±0,76 (95% CI) c.u. Thus, the study showed that the complex use of multiparametric ultrasound examination techniques (B-mode, color Doppler mapping, compression elastography, shear wave elastography) is highly informative and should be used in the differential diagnosis of thyroid cancer in the preoperative assessment. Thus, the performed examination showed that the complex application of multiparametric ultrasound techniques (V, mode, CDM, CEG, ESP) is highly informative and should be used in the differential diagnosis of thyroid cancer in the preoperative period.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116600764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFORMATIVE VALUE OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF RECTAL TUMOR INVOLVEMENT AGAINST THE BACKGROUND OF COMBINED TREATMENT","authors":"D. Ivanova, Marina A. Safonova","doi":"10.47026/2413-4864-2022-3-12-19","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-12-19","url":null,"abstract":"The aim of the study is to prove the informative value of magnetic resonance imaging in the diagnosis of rectal tumor involvement against the background of combined treatment for the patients (chemotherapy + radiation therapy) on the basis of the AI \"Republican Oncological Dispensary\", Cheboksary. All patients underwent magnetic resonance imaging on Elekta Synergy linear accelerator with a multi-leaf collimator, an integrated XVI X-ray volumetric imaging system and iViewGT portal imaging system, Mosaiq information and control system. Statistical processing was performed using standard methods of medical statistics using the SPSS Statistics package (version 17.0), arithmetic mean (M), standard deviation from the general mean age, mean value errors (m), Student's t-test were also calculated. Magnetic resonance imaging diagnostics made it possible to identify and dynamically control the change in the tumor involvement of the rectum against the background of the treatment: a change in the localization of the tumor in different parts of the rectum, a change in localization depending on the distance from the anal margin, a change in the thickness of the tumor wall, a change in the size and number of lymph nodes. Extramural venous invasion (EMVI), marginal resection boundary (CRM) of the tumor and invasion into surrounding tissues after surgical intervention were evaluated. This article examines the incidence of rectal cancer depending on age, gender, complaints, oncological history, risk factors contributing to the development of this pathology, as well as the presence of concomitant diseases that aggravate treatment. According to the results of the study, rectal cancer is revealed to be most often found in people aged 60–70, while men are most susceptible to the disease. According to histomorphological data, adenocarcinoma prevailed in 94 persons. Rectal cancer before and after chemoradiotherapy, according to magnetic resonance imaging (MRI) findings, prevailed in the rectal lower ampulla (before chemoradiotherapy – in 51 persons, after chemoradiotherapy – in 48), while the malignant neoplasm was at the distance of 21-30 mm from the anal margin in 27 persons, with the average wall thickness of 21.5 mm according to MRI findings before chemoradiotherapy and 13.9 mm after chemoradiotherapy. The difference in the average wall thickness according to the findings of two MRI studies was 7.61 mm (33.3%), which indicates the effectiveness of chemoradiotherapy.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126570224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF FIREARMS AVAILABILITY ON THE FREQUENCY OF HOMICIDES AND SUICIDES","authors":"Nina D. Antonova, A. Golenkov","doi":"10.47026/2413-4864-2022-3-85-98","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-85-98","url":null,"abstract":"The mortality of the population from external causes ranks third after circulatory diseases and oncological pathology. The purpose of the review is to study the prevalence of firearms in the regions of the world and its impact on the frequency of homicides and suicides (intentional external causes of death) in various socio-demographic groups of the population. The issue of allowing firearms is solved in different ways – from a ban on its storage, carrying and use among the population to free sale and wide circulation in a particular country. In general, there is a growing trend in the number of people owning firearms, including the Russian Federation and its subjects. Availability of firearms at home, as well as free access to their use (among police officers, military personnel, etc.) increases the risk of suicide in these population groups several times with lethal outcomes in 85–91% of cases. Although the murder rate has been declining in recent years in the world and Russia, the share of violent crimes involving firearms is increasing. The number of mass murders committed by young people (schoolchildren, students, military personnel, recently conscripted into the army), whose victims are primarily their peers, is growing. Both murders and suicides are many (3-9) times more likely to be committed by males of mature (able-bodied) age. People having previous criminal records for illegal acquisition, transfer, sale, possession of firearms and other misdeeds often turn out to be murderers, and persons with mental pathology – self-murderers. At this, murders with subsequent suicide are most often committed with the use of firearms. Legislative restrictions on trafficking in firearms contribute primarily to reducing mass murders, as well as to reducing its use as instruments of murder and suicide.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124457931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFFICULTIES IN DIFFERENTIAL DIAGNOSIS OF THYROID NODULAR PATHOLOGY. A CASE REPORT","authors":"V. G. Stepanov, L. A. Timofeeva, M. N. Nasrullayev, M. A. Yusova","doi":"10.47026/2413-4864-2022-3-79-84","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-79-84","url":null,"abstract":"This paper presents a clinical case of follicular thyroid cancer, the importance of multiparametric ultrasound in the early detection of thyroid cancer is shown. To diagnose follicular thyroid cancer, multiparametric ultrasound examination was performed in B-mode, color Doppler mapping mode, sonoelastography and in contrast enhancement mode. Based on the results, indications for fine needle aspiration puncture biopsy were determined and further management tactics for the patient with follicular thyroid cancer were determined. Thus, a timely diagnosis and a correct chosen tactics for treating follicular thyroid cancer resulted in a favorable disease outcome.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"2673 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123632961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THYROID ELASTOGRAPHY IN CHILDREN","authors":"M. Pykov, N. Kuzmina, N. Rostovtsev","doi":"10.47026/2413-4864-2022-3-36-46","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-3-36-46","url":null,"abstract":"The aim of the research was to study the stiffness of an unchanged thyroid gland using shear wave elastography with elastometry in children in different gender and age groups. 175 children with normal hormonal status aged from 3 to 17 were examined, 80 of them were girls and 95 boys. All children underwent ultrasound examination of the thyroid gland in the \"supine\" position of the examinees, supplemented by two-dimensional shear wave elastography on Aixplorer apparatus (Supersonic Imagine, France) using a linear sensor in the frequency range of 5-18 MHz. Five measurements of Young's modulus value of the right and left lobes of the thyroid gland were carried out. Using Multi Q-box software, the following values of Young's modulus (E) for each fraction were automatically determined: the mean (Emean), the maximum (Emax), the minimum (Emin), the standard deviation (SD). The study established a statistically significant increase in thyroid stiffness values in children with increasing age, statistically significant differences in the stiffness of thyroid right and left lobes (p = 0.003), the absence of gender differences in thyroid stiffness (median Emean in boys – 7.40 kPa, in girls – 6.80 kPa; p = 0.170). The technique of shear wave elastography that is offered by the authors can become an additional diagnostic tool in assessing the condition of the thyroid gland in children. The established values of thyroid tissue stiffness in children of different age groups can be recommended to be used for the purpose of timely diagnosis of thyroid pathology.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116530536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}