Acta medica Eurasica最新文献

{"title":"THE ROLE OF MAST CELLS IN CARCINOGENESIS (LITERATURE REVIEW)","authors":"","doi":"10.47026/2413-4864-2023-1-147-159","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-147-159","url":null,"abstract":"Mast cells are an important link in the immune system. They are involved in many pathological processes such as stress, inflammation, autoimmune processes and carcinogenesis. The purpose of the review is to summarize the data on the role of mast cells in carcinogenesis. Materials and methods. Review of available literature sources published in Elibrary and PubMed. Results. Tumor growth in the body is accompanied by immune system dysfunction and mast cell response. Mast cells are able to stimulate tumour growth through the secretion of proteases, angiogenic and growth factors, and at the same time have a tumour suppressive effect. The response of the mast cell population depends on the type of tissue from which the tumor is developing, the speed and stage of the process, the localization of the mast cells, and the combination of pro- and anti-tumor factors. During tumour development and growth, total degranulation of mast cells occurs. In addition, mast cells in normal and tumor tissue differ in structure. This article provides information on the role of mast cells in carcinogenesis. Conclusion. Thus, mast cells on the one hand positively affect tumor growth through the synthesis of proteases, growth and angiogenic factors, and on the other hand, act as inhibitors of malignant growth. The response of mastocytes directly depends on the tissue in which tumour develops, on its type and degree of malignancy, the stage of pathological process, localization of mast cells and the degree of their activation, as well as the total balance of pro- and antitumour effects.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128624061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN ULTRASOUND IMAGING TECHNOLOGIES IN THE DIAGNOSIS OF PAPILLARY THYROID CANCER","authors":"A. Sencha, L. A. Timofeeva, M. Tukhbatullin, M. N. Nasrullayev, Sergey S. Alekseev","doi":"10.47026/2413-4864-2022-4-58-64","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-58-64","url":null,"abstract":"The aim of the study was to determine the opportunities of multiparametric ultrasound in the early detection of papillary thyroid cancer. Examination results of 258 patients with papillary thyroid cancer at the stage of preoperative preparation were analyzed. All patients underwent multiparametric ultrasound examination in grey-scale mode, in color Doppler mapping mode, in compression elastography mode and shear wave elastography, ultrasound with contrast enhancement. In papillary thyroid cancer, \"cold\" tones prevailed. the velocity of the shear wave was 4.61±1.33 m/s (95% CI), Young's modulus was 63.3±14.7 kPa (95% CI), the elasticity index (strain ratio) was 4.89±1.65 (95% CI) c.u. When assessing the qualitative parameters of ultrasound with contrast enhancement, it was noted that in papillary thyroid cancer, heterogeneous accumulation of ultrasound contrast agent prevailed (54.5%), there was a more pronounced intensive accumulation of ultrasound contrast agent (63.6%). when measuring TPI, the EC indicator was 20.64±4.37 s, PI – 31.08±1.65 dB, PI (DT/2) – 64.00±10.27 s. Thus, the study showed that the complex use of multiparametric ultrasound examination techniques (B-mode, color Doppler mapping, compression elastography, shear wave elastography, ultrasound with contrast enhancement) is highly informative and should be used in the differential diagnosis of papillary thyroid cancer in the preoperative assessment.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128099245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN INCREASE IN THE AMOUNT OF TISSUE AND CYTOLOGICAL MATERIAL WHEN PERFORMING VACUUM FINE NEEDLE ASPIRATION BIOPSY UNDER THE CONTROL OF ULTRASOUND NAVIGATION IN FOCAL THYROID PATHOLOGY","authors":"A. Borsukov, A. Tagil","doi":"10.47026/2413-4864-2022-4-1-11","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-1-11","url":null,"abstract":"Thyroid diseases rank the second among endocrine pathology, at this, thyroid cancer is the most common among endocrine tumors. Ultrasound examination has contributed to more frequent detection of thyroid pathology and remains an effective method for the differential diagnosis of focal thyroid pathology, and the use of multiparametric ultrasound makes it possible to identify a malignant process at its early stage of development. Despite the introduction of multiparametric ultrasound, fine needle aspiration biopsy remains the \"gold\" standard in the differential diagnosis of benign and malignant changes in the thyroid gland. However, a large range of informative value, sensitivity and obtaining a false negative result when using this method promoted the search of solutions for modifying biopsy performing with an increase in the amount of cytological material and reducing the risks of complications. the purpose of the study is to determine the effectiveness of using v-FNAB compared to the FNAB performed with a LUER syringe. on the basis of diagnostic and minimally invasive technologies department at Clinical Hospital No. 1 of the town of Smolensk in the period from April to December 2021, 48 vacuum fine needle aspiration biopsies were performed without using modifications, and from January to April 2022, 51 vacuum fine needle aspiration biopsies were performed using a modified technique. All the results obtained were correlated with the results of 273 fine needle aspiration biopsies using a 20 ml 3LUER syringe performed in the period from 2019 to 2021. Sampling of cytological material when performing vacuum fine needle aspiration biopsy is much easier, since when using a vacuum, a negative pressure vacuum in the syringe is formed with the help of the apparatus and is maintained at a constant level. in addition, when performing a vacuum fine needle aspiration biopsy with a modified syringe, there was a decrease in the amount of cytological material lost, which in the original version was absorbed into the tissue membrane. This is especially important in hypervascular focal formations, as a result, the number of Bethesda 3 conclusions decreases from 16.6% to 5.9%. Thus, v-FNAB facilitates performing the manipulation due to no need to perform aspiration using a syringe piston, thereby reducing the number of uncontrolled needle movements during sampling the cytological material, which affects the diagnostic value of the examination. Due to the high level of negative pressure when performing v-FNAB, the amount of cytological material obtained increases, which also affects obtaining an informative conclusion. the ability to select the level of negative pressure in the syringe depending on the data of multiparametric ultrasound examination makes it possible to individualize the procedure.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115293082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERDISCIPLINARY DENTAL TREATMENT FOR CONGENITAL ABSENCE OF MAXILLARY LATERAL INCISORS","authors":"L. I. Nikitina, Anna S. Gromova","doi":"10.47026/2413-4864-2022-4-47-57","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-47-57","url":null,"abstract":"The interdisciplinary approach to dental treatment is associated with an increasing number of severe dental anomalies. One of the most common dental anomalies according to modern research is congenital absence of teeth. This pathology requires individual approach and complex treatment using digital dentistry. Dental practice experience of the authors shows that interdisciplinary approach in treatment of patients with congenital absence of maxillary lateral incisors should include the work of oral surgeon, orthodontist, prosthodontist, periodontist and dental technician. the aim of the research was to increase effectiveness and aesthetic results of the treatment of patients with congenital congenital absence of maxillary lateral incisors using dental implants, orthodontic treatment and digital prosthetics. Materials and methods. 84 patients with congenital absence of maxillary lateral incisors were treated with orthodontic and dental implants in the area of the missing teeth from 1998 to 2022. a total of 32 patients (10 men and 22 women,16 to 35 years old) underwent the complete treatment with previous orthodontic treatment, braces on the top or bottom teeth and dental implants in 1.2 and 2.2. Sixty-four implants of different systems – Astra Tech, Nobel Biocare, Straumann, Mis, Conmet, STI-OL, STAS, RADIX and others were placed. Patients were evaluated at all stages of treatment. Patients were followed up for more than 20 years. Results. the number of successful cases of rehabilitation of patients with congenital absence of teeth was 93.75%. Total failure rate was in the first follow-up year (1999) and was eliminated. Conclusions. Use of the interdisciplinary approach, special dental implant planning software, template-assisted guided surgery, metal-free prosthetic restorations according to CAD/CAM technology in treatment of patients with congenital absence of maxillary lateral incisors allows to achieve effective functional and esthetic of the dentoalveolar structure.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115392660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ON THE ISSUE OF LIVER BIOPSY IN PATIENTS WITH METABOLICALLY ASSOCIATED FATTY LIVER DISEASE","authors":"D. Venidiktova, A. Borsukov","doi":"10.47026/2413-4864-2022-4-12-26","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-12-26","url":null,"abstract":"The aim of the work was to evaluate the possibility of replacing liver biopsy with other methods of examination in patients with metabolically associated fatty liver disease. All patients were examined according to a single diagnostic algorithm consisting of four stages: physical, laboratory, instrumental (using non-invasive bioimpedansometry, multiparametric ultrasound examination, dual-energy X-ray absorptiometry in the \"Whole body\" mode, computer and magnetic resonance imaging), histological (evaluation of liver micropreparations on the SAF scale). the patients were divided into three groups, taking into account the results of histological examination of biopsies on the SAF scale: group 1 – patients with hepatic steatosis without signs of inflammation, fibrosis (n = 56, 53.9%); group 2 – patients with steatohepatitis and clinically insignificant hepatic fibrosis F0-F1 (n = 30, 28.8%); group 3 – patients with steatohepatitis and clinically significant liver fibrosis F2-F3 (n = 16, 15.4%). the correlation of findings obtained by the histological examination of liver biopsies and the data of ultrasound quantitative liver steatometry is high – r = 0.95 (for liver steatosis S1), r = 0.84 (for liver steatosis S2), r = 0.91 (for liver steatosis S3); ultrasonic shear wave elastography – r = 0.84 (for clinically insignificant liver fibrosis F0-F1), r = 0.88 (for clinically significant liver fibrosis F2-F3). the data obtained using dual-energy X-ray absorptiometry in the \"Whole Body\" mode quantitatively reflect the state of the patient's metabolic status, they can be evaluated in dynamics due to low radiation load. Thus, the diagnostic complex consisting of assessing the level of hepatic transaminases, multiparametric ultrasound examination and dual-energy X-ray absorptiometry in the \"Whole body\" mode is optimal to examine the patients who have contraindications to liver biopsy or completely refuse to pass this study. in case of the patient's consent, absence of contraindications, as well as in the presence of a number of diffuse liver diseases, histological examination is recommended to identify and to assess in detail the dystrophic, inflammatory, sclerotic, regenerative processes.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128381445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHARMACOKINETIC AND PHARMACODYNAMIC FEATURES OF THE RESPONSE TO WARFARIN THERAPY ON THE EXAMPLE OF EXCESSIVE HYPOCOAGULATION DEVELOPMENT IN A PATIENT OF THE CHUVASH POPULATION WITH A PROSTHETIC HEART VALVE","authors":"K. S. Georgieva, S. Pavlova, S. M. Bogdanova","doi":"10.47026/2413-4864-2022-4-97-102","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-97-102","url":null,"abstract":"Atrial fibrillation remains a significant public health problem worldwide to this day, and in combination with valvular heart disease it worsens the patient's prognosis. in patients with prosthetic heart valves, the use of anticoagulants is a prerequisite to prevent thromboembolic complications. Indirect anticoagulants, in particular, Warfarin, remain the front-line therapy. This article presents a clinical case of hypersensitivity to Warfarin in a patient of the Chuvash population with an implanted mitral valve. in the postoperative period, difficulties were identified to control the target international normalized ratio. the article examines the factors that could contribute to an increase in sensitivity to Warfarin in this patient. Current literature data on polymorphisms of the CYP2C9 and VKORC1 genes that predetermine hypersensitivity to Warfarin and their prevalence are presented. the clinical case demonstrates the prospects for introducing pharmacogenetic testing as a tool that increases the effectiveness and safety of pharmacotherapy in certain ethnic groups.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"327 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125783364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE NUMBER OF MAST CELLS AND MACROPHAGES IN CHRONIC GINGIVAL INFLAMMATION IN YOUNG PEOPLE","authors":"E. Speranskaya, Albina F. Saleeva, N. N. Golubtsova","doi":"10.47026/2413-4864-2022-4-65-72","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-65-72","url":null,"abstract":"The aim of this work was to study the number of mast cells and macrophages of the gingival lamina propria in young people in chronic inflammation. as a result of the study, new data were obtained on the distribution of mast cells and macrophages in the gum without inflammation. It is for the first time that the effect of microbial inflammation and laser therapy on resident cells of the connective gingival tissue is studied, those cells are part of the oral mucosal immune system, depending on the age. Gingival biopsy material obtained according to dental indications in patients aged 20–40 years was used in the work. CD68+ macrophages were detected by immunohistochemical method, the number and secretory activity of gingival mast cells were evaluated by staining with toluidine blue. The results of the conducted examinations showed that in parodontitis, the number of macrophages and degranulating mast cells in the connective tissue of the gingival lamina propria increases. the use of a diode laser in chronic parodontitis has an effect on the increase in the number of macrophages and gingival mast cells, but not on the degranulation process of mast cells.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114777572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF NEUROGLIAL RELATIONSHIPS IN SOME FORMS OF NEURODEGENERATIVE DISEASES","authors":"V. A. Kozlov, L. N. Voronov, N. V. Smirnova, P. B. Karyshev, Anatasia A. Stepanova, S. V. Plyukhin, Elena Yu. Lyalina","doi":"10.47026/2413-4864-2022-4-27-36","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-27-36","url":null,"abstract":"The aim of the study was to compare the measurable quantitative indicators of neurons and neuroglia in the gyrus precentralis region in relatively healthy individuals who died from nonviolent death and not as an outcome of the disease with similar indicators in those who died as a result of lifetime neurodegenerative diseases. Material and methods. 47 cases of nonviolent death were examined: 6 persons were relatively healthy individuals without a history of neurological diseases (average age – 67.0±7.7 years), in 2 persons– parkinsonism was diagnosed in vivo (G20.X, average age 77.0±7.1 years), in 23 persons – G93.4 (unspecified encephalopathy, 51.6±14.1 years), in 13 persons – G31.2 (degeneration of the nervous system caused by alcohol, 55.5±8.4 years). There were 32 men and 15 women. Sex differences were not taken into account in statistical processing. Results. in relatively healthy patients, the median number of neurons (N) is 26.0 (percentiles 10¸90 – 22,0¸29,0 ), coefficient of variation (CV) – 11.0, area of neurons, microns 2 (SN) – 265.3 (234.2¸352.5), CV = 16.6; neuroglia (NG) – 80.0 (75 ¸88), CV = 6.0; neuroglial index (NGI) – 3.1 (2.6¸3.8), CV = 3.2, neuroglial area, microns2 (SNG) – 15.3 (9.9¸25.9, KV = 38.2. In the deceased G20.X – N = 2.0 (1.0¸5.0), p = 0.0116, CV = 54.0, SN = 88.8 (53.6¸117.6), p = 0.0124, CV = 31.1; NG = 32.0 (21.0¸37.0), p = 0.4179, CV = 21.0, SNG = 12.3 (8.1¸20.0), p = 0.0006, CV = 36.1; NGI = 12.2 (6.8¸28.0), p = 0.000, CV = 57.0. In G93.4 – N = 3.0 (1.0¸4.0), p = 0.0065, CV = 35.0, SN = 177.6 (47.9¸299.6), p = 0.0007, CV = 52.4; NG = 83.0 (68.0¸94.0), p = 0.1618, CV = 10, SNG = 14.6 (9.9¸21.0), p = 0.0007, CV = 31.6; NGI = 28.7 (19.3¸83.0), p = 0.0000, CV = 56.0. In G31.2 – N = 15.0 (11.0¸20.0), p = 0.6767, CV = 21.0, SN = 59.7 (37.9¸77.8), p = 0.0000, CV = 28.1; NG = 62.0 (49.0¸77.0), p = 0.0477, CV = 16.0, SNG = 14.6 (9.2¸21.7), p = 0.0122, CV = 33.4; NGI = 3.8 (2.7¸7.0), p = 0.0003, CV = 38.2. Conclusions: 1) in parkinsonism, a significant decrease in the number and area of neurons and neuroglia was revealed; 2) in G93.4, neurons are more involved in the pathological process than glial cells; 3) in G31.2, there is an equally large decrease in the number of neurons and glial cells, but the area of neurons decreases more significantly than in glial cells.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123302623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF GREEN TEA POLYPHENOLS ON THE CHANGE IN THE MITOCHONDRIAL FUNCTION OF HIPPOCAMPAL CELLS IN A DEFICIENCY IN THE ACTIVITY OF MITOCHONDRIAL COMPLEX IV","authors":"D. I. Pozdnyakov","doi":"10.47026/2413-4864-2022-4-80-87","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-80-87","url":null,"abstract":"The aim of the study was to evaluate the effect of green tea polyphenols on changes in the mitochondrial function in conditions of cerebrospecific blockade of mitochondrial complex IV activity. Materials and methods. Male Wistar rats were used in the work, in which the deficiency of mitochondrial complex IV activity was reproduced by direct injection of a 3M sodium azide solution into the hippocampal tissue. Green tea polyphenols and the reference drug ethylmethylhydroxypyridine succinate were administered at the dose of 100 mg/ kg, orally, for 30 days. Subsequently, changes in cognitive deficits in the Y-shaped maze test, the activity of succinate dehydrogenase and cytochrome-c-oxidase in hippocampal tissue were evaluated in rats. Results and their discussion. It was found that in animals without pharmacological support, when sodium azide was administered, there was a decrease in the activity of succinate dehydrogenase and cytochrome-c-oxidase by 29.2% (p < 0.05) and 78.8% (p < 0.05) with a deterioration in the rats' cognitive abilities by 47.6% (p < 0.05). the use of the reference drug and green tea polyphenols increased the activity of succinate dehydrogenase by 30.5% (p < 0.05) and 24.1% (p < 0.05), as well as that of cytochrome c oxidase by 20.9% (p < 0.05) and 56.0% (p < 0.05), respectively. the cognitive deficit in animals which received ethylmethylhydroxypyridine succinate and green tea polyphenols was significantly lower than that in untreated animals. Conclusions. Against the background of sodium azide introduction into the hippocampal tissue of animals, the development of cognitive deficits with a decrease in the activity of succinate dehydrogenase and cytochrome c oxidase is observed. a course administration of green tea polyphenols and a reference drug increased the activity of succinate dehydrogenase and cytochrome-c-oxidase, which contributed to the restoration of cognitive abilities in animals.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130904749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEUKEMOID REACTION AS A MARKER OF ACUTE SURGICAL PATHOLOGY (A CLINICAL CASE)","authors":"N. Timofeeva, I. S. Stomenskaya, O. Kostrova, O. V. Zimina","doi":"10.47026/2413-4864-2022-4-103-107","DOIUrl":"https://doi.org/10.47026/2413-4864-2022-4-103-107","url":null,"abstract":"The most accessible method for diagnosing various pathological processes is a complete blood cell count. It can reveal, in particular, such changes in the white hematopoietic lineage as leukocytosis and leukopenia. the causes of leukocytosis are very diverse. the most dangerous among them are leukemias and leukemoid reactions. in doubtful cases, additional methods of clinical examination are counting the differential white blood cell count and determining inflammation markers. Leukemoid reactions can develop against the background of sepsis, peritonitis, oncological diseases and severe infectious processes. This article presents a clinical case of leukemoid reaction in acute surgical pathology. the high point of the event was intestinal necrosis, which was manifested by corresponding symptoms and signs and a change in the complete blood cell count. the correctness of the diagnosis was proved by rapid normalization of the patient's white blood parameters after the surgical intervention.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123010797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}