Acta medica Eurasica最新文献

{"title":"RADIATION DIAGNOSIS OF SEROUS CARCIONEOMA OF THE OVARY OF ENORMOUS SIZE IN A PATIENT OF POSTMENOPAUSAL AGE (CLINICAL CASE)","authors":"","doi":"10.47026/2413-4864-2023-1-108-117","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-108-117","url":null,"abstract":"Topicality. Among the tumors of the female genital organs, ovarian cancer is considered one of the most common. Due to the lack of a specific clinical picture at an early stage, in more than half of cases there is a delayed detection of ovarian cancer. In view of this, an urgent problem in oncogynecology remains the timely diagnosis of ovarian cancer. The purpose of the work is to demonstrate the complexity and untimely diagnosis of ovarian cancer on the example of the presented clinical case of primary radiation diagnosis of serous ovarian carcinoma of enormous size in a postmenopausal patient. Outcomes. The article reflects some experience of domestic and foreign researchers, where the reasons that explain the late diagnosis of ovarian cancer are studied. A case from clinical practice with an analysis of the development of the clinical picture of the disease, the tactics of patient management is presented. This clinical example is an example of a belated diagnosis of ovarian cancer in a postmenopausal patient. Unfortunately, in this situation, at the time of the initial diagnosis of ovarian cancer, the tumor already had a huge size, probably because of this, the clinical picture of the disease and the objective assessment of the patient's condition were regarded erroneously. Conclusion. The analysis of this clinical example convincingly indicates that only the implementation of a complete algorithm for the complex use of anamnestic, laboratory (including tumor markers), instrumental (primarily radiation diagnostic methods, such as ultrasound, computed tomography) and other diagnostic methods is the basis for the timely diagnosis of ovarian cancer.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115898339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSSIBILITIES OF DIFFERENTIAL DIAGNOSIS OF DIABETIC AND ATHEROSCLEROTIC ANGIONEPHROSCLEROSIS BASED ON ECHOCONTRASTY OF THE KIDNEYS AND ULTRASOUND EXAMINATION OF THE MAIN VESSELS OF THE NECK","authors":"A. Borsukov, Olga O. Gorbatenko","doi":"10.47026/2413-4864-2023-1-19-30","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-19-30","url":null,"abstract":"Relevance. Currently, atherosclerosis is one of the leading causes of mortality and disability of the population. Since diabetic angionephrosclerosis in patients with DM develops for a long time and mainly in patients of the age group of the population, a differential diagnosis between diabetic and atherosclerotic angionephrosclerosis is necessary, which is reflected in the patent for the invention (patent RU No. 2785489). Aim of the research. To evaluate the effectiveness of a new method of differential diagnosis of diabetic and atherosclerotic angionephrosclerosis based on echocontrasty of the kidneys and ultrasound examination of the vessels of the neck. Materials and methods. In the period from 2019 to 2022, 86 people were examined, who underwent a comprehensive clinical laboratory and multiparametric ultrasound examination with subsequent assessment of the diagnosis of angioedema according to the original technique (Patent No. 2785489). All patients underwent a comprehensive diagnosis, including: collection of complaints and anamnesis, lipidogram, laboratory biochemical examination (capillary blood glucose mmol / L, glycated hemoglobin (HbA1c, %), multiparametric ultrasound examination of the kidneys in B-mode with further Doppler assessment of the state of hemodynamics in the renal vessels, ultrasound of the intima-media complex carotid artery. Results and discussions. As a result of the study, the patients were divided into 2 groups: group 1 (n = 44) – patients with glucose levels ≥ 6.1 mmol/l; group 2 (n = 42) – patients with glucose levels ≤6.1 mmol/l. As a result of complex clinical and laboratory and multiparametric ultrasound examination, combined with contrast-enhanced ultrasound examination of the kidneys, the differential diagnosis of atherosclerotic and diabetic angionephrosclerosis was evaluated according to the proposed method. Diabetic angionephrosclerosis was detected in 31.81% of group 1 patients, and atherosclerotic angionephrosclerosis was detected in 11.3% of patients. In group 2, 69.04% had atherosclerotic angionephrosclerosis, diabetic angionephrosclerosis was not detected in any of their studied group 2 patients. Conclusions. 1. Thus, using the method of differential diagnosis of diabetic and atherosclerotic angionephrosclerosis (patent RU No. 2785489), it allows to separate diabetic and atherosclerotic angionephrosclerosis, as well as to correct diagnostic and therapeutic tactics of patient management with the possibility of preventing early vascular complications. 2. The proposed method of differential diagnosis of diabetic and atherosclerotic angionephrosclerosis allows monitoring the effectiveness of treatment of most diabetic and atherosclerotic angionephropathy.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127519041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEDICAL AND STATISTICAL CHARACTERISTICS OF PATIENTS WITH ODONTOGENIC PHLEGMONS (BASED ON THE MATERIALS OF THE REPUBLIC OF UZBEKISTAN)","authors":"B.N. Zhuraev, S. Ksembaev, A. K. Salakhov, Matluba A. Kholmatova","doi":"10.47026/2413-4864-2023-1-47-52","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-47-52","url":null,"abstract":"In the clinic of purulent maxillofacial surgery, one of the most acute problems is odontogenic phlegmons arising from the spread of pathogenic origin from the focus of chronic infection of the so-called \"causal\" tooth, which is associated with the severity of the purulent process itself, the rapidity of its spread to neighboring cellular spaces, a high risk of severe complications and frequent death]. The problem under consideration has not only medical, but also important socio-economic significance. The aim of the work was to study the prevalence of odontogenic phlegmon in the Republic of Uzbekistan to identify the main trends in the development and course of this pathology. Materials and methods. 845 case histories of patients with odontogenic phlegmon hospitalized in the hospital of maxillofacial surgery of the Department of adult maxillofacial surgery of the Tashkent State Dental Institute in the period from 2019 to 2021 were studied. Statistical processing of the research results was carried out using Microsoft Excel 10 application programs and the STATISTICA for Windows 6.0 statistical package (Statsoft, USA) by the method of variational statistics using the Student's parametric criterion. We also used a statistical research method – Pearson Chi-squared. Results of the study. There was an increase in the number of patients with odontogenic phlegmon, among whom residents of the districts of the Republic of Uzbekistan prevailed and were most often found among people of working age. The odontogenic \"cause\" in most cases were the molars of the lower jaw. The structure of morbidity was dominated by odontogenic phlegmons of one cellular space. Most of the hospitalized patients, bypassing the pre-hospital stage, went to the hospital on their own. Findings. Given the increase in the number of patients with odontogenic phlegmon, the issues of their prevention and effective treatment remain relevant.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121798257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POLYMORPHISM OF GENES RESPONSIBLE FOR NEUROHUMORAL MECHANISMS OF DEVELOPMENT OF CHRONIC HEART FAILURE WITH PRESERVED EJECTION FRACTION IN PERSONS WITH TYPE 2 DIABETES MELLITUS","authors":"T. Sveklina, S. N. Kolyubaeva, S. Shustov, A. Kuchmin, V. A. Kozlov, M. B. Nagorny","doi":"10.47026/2413-4864-2023-1-73-82","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-73-82","url":null,"abstract":"The search for genetic markers of chronic heart failure (CHF), comorbid with type II diabetes mellitus, is an urgent task. The study aim was to identify genetic polymorphisms associated with impaired neurohumoral regulation in patients with CHF with preserved and low ejection fraction and type II diabetes mellitus. Material and methods. Polymorphisms of genes responsible for neurohumoral mechanisms of CHF development were studied in 167 patients (69.9±10.1 years) with type II diabetes mellitus, hypertension, CHF with preserved or low ejection fraction, and healthy volunteers. Results and discussion. The angiotensin gene, angiotensin-converting enzyme, angiotensin 1 and 2 receptors polymorphisms are not involved in the CHF formation in patients with type II diabetes mellitus. In the control group, rs1403543 GA polymorphism was found in 90.48% of the examined, in patients with CHF with preserved ejection fraction and type II diabetes mellitus, GA and AA variants were found in 20% of cases, in the CHF group with a low ejection fraction AA polymorphism was found in 53.85% of the examined. It is possible they do not participate in the formation of CHF in patients with type II diabetes mellitus, or have a protective effect. The gene GNB: 825 C > T rs5443 polymorphism was detected from 53.33 to 61.9% of the examined in all groups. rs1799998 polymorphism is not associated with the development of CHF. The rs2070744 polymorphism is associated with the development of CHF with a preserved ejection fraction, but not CHF with a low ejection fraction, in patients with type II diabetes mellitus. The gene NOS3: 894 G > T rs1799983 in heterozygous and homozygous variants polymorphism was more common in patients with CHF with preserved ejection fraction (statistically insignificant). Conclusions. CHF with a preserved ejection fraction and CHF with a low ejection fraction in patients with type II diabetes mellitus are associated with different polymorphisms and have different pathogenesis. The gene AGTR2 polymorphism rs1403543 in patients with type II diabetes mellitus and CHF with preserved ejection fraction occurs less frequently than in the control group. The gene GNB polymorphism rs5443 in patients with CHF with a preserved ejection fraction and CHF with a low ejection fraction occurs much less frequently than in the control group. The gene NOS3 polymorphism rs2070744 in patients with CHF with a preserved ejection fraction occurs significantly more often than in the control group and in patients with CHF with a low ejection fraction.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125870575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF PYRIMIDINE AND CAVINTON DERIVATIVES ON THE CHANGE BIOELECTRIC POTENTIAL IN THE CONDITIONS OF FOCAL CEREBRAL ISCHEMIA OF THE RAT BRAIN","authors":"","doi":"10.47026/2413-4864-2023-1-101-107","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-101-107","url":null,"abstract":"Acute disorders of cerebral hemodynamics lead to the development of socially and demographically significant diseases, as a result of which they are one of the main health problems requiring a rational pharmacological approach. In the pathogenesis of pathologies of cerebral circulation, in addition to a decrease in blood flow, an important role is played by a violation of the bioelectric activity of brain tissues, which is evidenced by changes in the frequency and amplitude of oscillations on the encephalogram. Pyrimidine derivatives have proven themselves as potential cerebroprotectors, as a result of which we considered them as means capable of correcting electroencephalogram disorders in ischemic brain tissues. In this regard, the purpose of this work was to study the effect of pyrimidine and cavinton derivatives on the change in bioelectric potential under conditions of focal central ischemia in rats. Materials and methods. The study was conducted on 40 male rats of the Wistar line (m = 220–220 g). Focal cerebral ischemia of rats was reproduced by occlusion of the left middle cerebral artery. The animals were divided into 4 equal groups, all groups, except the first, were simulated pathology under chloral hydrate anesthesia (350 mg/kg). The first group – falsely operated rats, the second – individuals of negative control. The reference drug cavinton (3.2 mg/kg) and the pi-rimidine derivative PIR-10 (50 mg/kg) were administered to the third and fourth groups within 3 days after surgery. The electrical activity of the rat brain (delta-, theta-, alpha-, high-frequency beta-range in the frontal and parietal lobes of the left hemisphere) was evaluated after 3 days by electroencephalography (EEG) using the Neuron-Spectrum 1 encephalograph (Neurosoft, Russia). Statistical processing was carried out using the STATISTICA 8.0 application software package (StatSoft, Inc., USA). Results of the study. In the rats of the negative control group, there was a marked deterioration in bioelectric potential, which was noted in an increase in theta and delta rhythms and a decrease in alpha and high-frequency beta rhythms. The introduction of the compound PIR-10 to animals contributed to a decrease in delta rhythm by 39,8% (p < 0,05) (FP1-A1) and 56,3% (p < 0,05) (C3-A1), theta rhythm – by 23,9% (p < 0,05) (FP1-A1) and 39,4% (p < 0,05) (C3-A1), the amplitude of the alpha rhythm increased by 75,3% (p < 0,05) (C3-A1), the high-frequency beta rhythm by 25,9% (p<0,05) (FP1-A1) and 41,4% (p < 0,05) (C3-A1). Findings. The experimental derivative of pyrimidine PIR-10, equally with cavinton, contributed to the restoration of bioelectric rhythm in the form of a decrease in the amplitude of delta and theta rhythms and an increase in the amplitude of alpha and high-frequency beta rhythms in the frontal and parietal regions of the left hemisphere of the rat brain.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114709119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASPECTS OF ETIOLOGY, DIAGNOSIS AND TREATMENT OF PREERUPTIVE INTRACORONAL RESORPTION IN CHILDREN (LITERATURE REVIEW)","authors":"T. Kostyakova, K. Losev, M. Verendeeva, O. V. Kuzina","doi":"10.47026/2413-4864-2023-1-129-138","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-129-138","url":null,"abstract":"The purpose of this work was to study the literature on research papers by domestic and foreign authors describing pre-eruption intracoronal resorption. The review discusses issues that indicate the presence of a resorption process in permanent teeth before their eruption. This lesion of the hard tissues of the teeth is rare, and the etiology of this process is not fully understood. The processes of tooth resorption can be observed outside on the root surface or inside the pulp chamber, and if a permanent tooth is involved in this process, this indicates the development of pathological resorption. Along with dental caries and periodontal disease in childhood, processes of resorption of coronal dentin tissue in unerupted permanent teeth can be observed. Some authors describe internal resorption, ectopic positioning, external resorption, and origin from developmental pits on the occlusal surface as etiological factors for preeruptive intracoronal resorption, but other authors suggest that the etiology of this lesion remains poorly understood. The main diagnostic method is an x-ray examination, in which preeruptive intracoronal resorption is accidentally detected and other research methods are additionally used. Histological examination reveals osteoclasts, multinucleated giant cells, macrophages, and serrated edges in this lesion, which may possibly enter the developing tooth from the surrounding bone or through breaks in the dental follicle or enamel epithelium. With a small lesion and if the tooth is close to eruption, periodic X-ray control is necessary, and after eruption, when occlusal access is reached, the defect is restored in order to minimize the attachment of the carious process.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129586380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ULTRASOUND DIAGNOSIS OF SUBACROMIAL FIBROSIS IN PATIENTS WITH ROTATOR CUFF IMPINGEMENT SYNDROME","authors":"E. A. Andronnikov, V. Diomidova, R. N. Drandrov, Nikolai S. Nikolaev","doi":"10.47026/2413-4864-2023-1-11-18","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-11-18","url":null,"abstract":"Rotator cuff impingement syndrome (SURM) of the shoulder is considered one of the most common causes of pain in the shoulder joint in people of working age, mostly males. Due to the absence of characteristic signs of this pathology of the shoulder joint at the initial stage of the disease, fibrotic changes in the subacromial space (FI SAP) are detected late. The aim of the study was to evaluate the effectiveness of ultrasound navigation in the diagnosis and verification of fibrous changes in the subacromial space in patients with rotator cuff entrapment syndrome. Materials and methods. An analysis was made of 86 patients with cuff impingement syndrome, in whom fibrotic changes in the subacromial space are was initially detected according to ultrasound data. In group N1 (n1 = 42), the study data were analyzed without a minimally invasive intra-articular treatment procedure at the stage of conservative treatment, and in group N2 (n2 = 44) – with ultrasonic navigation of the subacromial space during a minimally invasive intra-articular treatment procedure. The comparison group (N3; n3 = 25) represented individuals without shoulder joint pathology. All patients underwent an ultrasound examination of the shoulder joint (Philips Sparq ultrasound scanner, linear high-density multifrequency transducer 5–13 MHz). Verification of the results of ultrasound of the shoulder joint is confirmed by the data of other methods of radiation imaging. Results. Ultrasound examination of the shoulder joint using dynamic functional tests before the start of therapeutic manipulations in patients with fibrotic changes in the subacromial space (in groups N1 and N2) visualization of the thickening of the supraspinatus tendon in combination with a decrease in the thickness of the subacromial space correlated with limitation of movement of the upper limb in the shoulder joint (p < 0,001). Comparative results in the study groups showed that the use of ultrasound diagnostics and navigation technologies during a minimally invasive intra-articular treatment procedure for fibrotic changes in the subacromial space provides an improvement in clinical manifestations. Conclusions. The possibility of ultrasonic visualization of the supacromial space in normal conditions without pathological changes in the shoulder joint and with fibrous changes in the subacromial space allows us to recommend the proposed method of ultrasound examination of the shoulder joint to be included in the treatment and diagnostic algorithm for the syndrome of incarceration of the rotator cuff of the shoulder. Ultrasound navigation as an effective method for diagnosing and verifying subacromial fibrosis in patients with rotator cuff entrapment syndrome.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117172454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DYNAMICS OF INTESTINAL CONTENT FLUCTUATIONS ANASTOMOSED SMALL INTESTINE LOOPS AS MARKER IN DIAGNOSIS OF DUMPING SYNDROME OF DIFFERENT SEVERITY IN GASTRIC CANCER PATIENTS AFTER GASTRECTOMY","authors":"Yuvenaliy A. Igonin, Dmitry O. Dolgov, O. Y. Dolgov","doi":"10.47026/2413-4864-2023-1-63-72","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-63-72","url":null,"abstract":"The aim: to study the effectiveness of the method of daily fibroesophagoejunoscopy in determining the number of pellets of intestinal contents in the newly created anatomical-physiological complex and related functional disorders, accompanied by the manifestation of clinical symptoms of dumping syndrome of varying severity. Materials and methods. The method of fibrogastroscopic examination was by 190 patients with gastric tract after gastrectomy carried out. All patients were diagnosed with dumping syndrome of varying severity. The study showed that the severity of clinical manifestations of dumping syndrome depends on the number of intestinal contents in the newly created anatomical-physiological complex depending on the time of day. For proof of body, observing the stage, 30 patients underwent a modified esophagogastroscopic examination method, which was proposed by us – daily fibroeophagoeunoscopy, as well as histological and histochemical studies to detect inflammatory changes in anastomosed loops of the small intestine. To determine the dependence of clinical manifestations of dumping syndrome on the number of intestinal pellets, all patients underwent intracavitary intestinal laser therapy with helium-neon laser ULF-01. Results. When analyzing and comparing the data obtained during daily fibroesoeunoscopy with the clinical manifestations of dumping syndrome of varying severity, it was found, that at different periods of the day the intensity of intestinal casting in anastomosed loops of the small intestine and clinical manifestations of the disease differ significantly. It was established, that in the morning hours, at all degrees of severity of dumping syndrome, there was a minimum number of pellets of intestinal contents in the newly created anatomical complex and, accordingly, there were minimal clinical manifestations of the disease. The study also showed that the increase in clinical symptoms in patients with dumping syndrome is clearly precisely in the daytime manifested. Conclusions. The findings suggest that daily fibroesophagoeunoscopy is a pathognomonic method for diagnosing dumping syndrome in gastric cancer patients after gastrectomy. The method made it possible to establish that the severity of clinical manifestations depends on the number of casts of intestinal content and the time of its exposure in the newly created anatomical complex. The clinical symptoms of dumping syndrome are most in the daytime pronounced. The method also made it possible to determine that the most effective time for laser therapy is the morning period.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132919949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS WITH SYSTEMIC MANIFESTATIONS WITH INTERLEUKIN INHIBITORS-1 (CLINICAL CASE)","authors":"N. Zhuravleva, Angelina V. Aksionova, S. Yakupova, T. Smirnova, Taisiya V. Prokopyeva, Anastasia V. Arkhipova, Evgenia A. Gurianova","doi":"10.47026/2413-4864-2023-1-118-128","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-118-128","url":null,"abstract":"The purpose of this study is to evaluate the effectiveness of the treatment of juvenile idiopathic arthritis with systemic manifestations with interleukin-1 (IL-1) inhibitors. Material and methods. A prospective analysis of the course of systemic juvenile idiopathic arthritis was performed in a 15-year-old patient; she was examined using laboratory and instrumental methods before and after therapy with the interleukin-1 (IL-1) inhibitor canakinumab. Laboratory examination included general and biochemical blood tests, determination of rheumatoid factor, C-reactive protein, lactate dehydrogenase, procalcitonin, antinuclear antibodies, anti-citrullinated peptide (ACCP) antibody titer, antistreptolysin-O titer. The patient underwent ECG, echocardiography (EchoCG), ultrasound examination of the pleural cavities, abdominal organs, kidneys, knee joints, radiography of the chest cavity organs and radiography of the hand, computed tomography of the chest and abdominal cavities. Results. Examination of the patient revealed: synovitis of the knee joints, bilateral pleurisy and pericarditis, positive markers of the inflammatory process, characteristic of juvenile idiopathic arthritis with systemic manifestations. The patient was diagnosed with leukocytosis up to 20.3×109/l with a stab shift of leukocytes up to 18%, an increase in the erythrocyte sedimentation rate of 55 mm/h, an increase in C-reactive protein up to 288 mg/l, lactate dehydrogenase up to 500 units/l, in the analyzes urine revealed moderate hematuria and proteinuria. X-ray examination revealed structural changes in the knee and interphalangeal joints. We observed the effectiveness of canakinumab therapy. During therapy with canakinumab, after the second injection, positive dynamics was noted: leukocytes 5.1 × 109/l, ESR 6 mm/h, CRP 12 mg/l, relief of symptoms of the disease. Conclusions. During therapy with canakinumab, the patient showed positive clinical and laboratory dynamics of the disease. The study demonstrated the effectiveness of interleukin-1 (IL-1) inhibitors, canakinumab, in achieving remission of the disease.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123821460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF PULMONARY DENERVATION ON QUALITY OF LIFE AFTER COMPLEX MITRAL VALVE SURGERY","authors":"Dmitry V. Egorov, N. A. Trofimov, Aleksandr V. Nikolskiy, A. L. Rodionov, D. S. Ivanov","doi":"10.47026/2413-4864-2023-1-38-46","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-38-46","url":null,"abstract":"Relevance. In recent years, concepts for assessing the quality of life have been developed. According to the WHO definition, quality of life is a person's perception of his position in life, culture and value system, it is associated with his goals, expectations, standards and concerns. Approximately three people out of every thousand have pulmonary hypertension for various reasons. This can lead to decreased exercise tolerance, quality of life, increased hospital admissions, and early death. An objective assessment of the quality of life of such patients will help achieve better clinical outcomes for patients and develop new treatments. Purpose of the study is to assessment of changes in the quality of life of patients with mitral valve disease associated with atrial fibrillation and high pulmonary hypertension (systolic blood pressure over 40 mmHg) during the first 24 months after radiofrequency denervation of the pulmonary arteries according to the SF-36 and MLHFQ questionnaires. Materials and Methods. The general population of patients (n = 202) with mitral heart disease, concomitant atrial fibrillation and high pulmonary hypertension was divided into several groups according to the complexity of surgical treatment: patients of the 1st group (n = 62) underwent only surgical correction of the mitral valve pathology (repair or replacement); patients of the 2nd group (n = 89) – surgical correction of the mitral valve pathology, as well as the Maze IV procedure using the AtriCure© bipolar ablator; patients of the 3rd group (n = 51) received complex surgical treatment by correcting mitral valvular pathology, performing the Maze IV procedure, as well as using radiofrequency denervation of the pulmonary arteries. The quality of life was assessed over several periods: initially, 6 months later, 1 and 2 years after surgical treatment. The scores were also converted to physical health component scores and mental health component scores. Results. The initial data of patients from different subgroups according to the criteria of the SF-36 questionnaire were comparable with each other. The indicators of the physical component and the psychological component of SF-36 characterize the 3rd group of patients with a lower level of quality of life in terms of the physical component, although no significant intergroup differences were found. Quality of life indicators after 6 months show positive changes in patients of all study groups without significant intergroup differences. Based on the results of 12 months, the greatest dynamics of the parameters of the questionnaire in terms of physical and mental components was observed in the 3rd group of patients. After 24 months, there is a significant advantage in changes in the indicators of patients of the 3rd group for all categories of the questionnaire. The target level after 6 months in the 3rd group was 100%, in the 2nd and 1st – 85.3% and 40.7%, respectively, maintaining differences up to 24 months. Conclusio","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115330465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}