Acta medica Eurasica最新文献

{"title":"INFORMATIVE VALUE OF RADIOLOGICAL METHODS FOR DIAGNOSING SUBACROMIAL IMPINGEMENT SYNDROME","authors":"E. A. Andronnikov, V. Diomidova, Nikolai S. Nikolaev, R. N. Drandrov, N. V. Gogulina","doi":"10.47026/2413-4864-2023-2-101-113","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-2-101-113","url":null,"abstract":"Up to 30% of the adult population suffers from impingement syndrome with severe pain. Detection of the disease in the early stages is difficult. Early diagnosis of the initial signs of degenerative changes in the subacromial space saves the patient from surgery and additional risk of postoperative complications. The aim of the study is to evaluate the informative value of radiation methods for diagnosing subacromial impingement syndrome based on the analysis of papers published by domestic and foreign authors, depending on etiopathogenetic factors and anatomical structure of the shoulder joint. Materials and methods. The authors analyzed Russian and foreign publications on anatomical, etiological, pathogenetic, clinical, diagnostic features of subacromial conflict syndrome from databases: e-library (https://www.elibrary.ru), Oxford Medicine Online (https://academic.oup.com /), PubMed (https://pubmed.ncbi.nlm.nih.gov/) and others. The applied research methods were analysis and synthesis, axiomatic method and abstraction. Results. The development of subacromial impingement syndrome was revealed to be due to the structural features of the shoulder joint, which differs from other joints in anatomical and functional complexity. At this, changes in the rotator cuff of the shoulder joint develop under the influence of various etiopathogenetic factors, which can be both external (a decrease in subacromial space, an increase in the volume of the coracoacromial arch, instability, overload of the shoulder joint) and internal (changes in vascularization, pathology of collagen fibers' microstructure, degeneration of the tendons in the rotator cuff, etc.) Currently there is no unified approach to the algorithm of radiation diagnosing the early signs of impingement syndrome and injuries to the rotator cuff of the shoulder joint. Although radiography is a simple and informative method to assess the condition of the shoulder joint, its sensitivity at an early stage of impingement syndrome is insufficient. Magnetic resonance imaging is highly informative and sensitive in the diagnosis of injuries to the rotator cuff of the shoulder joint, however, it has a number of limitations, such as the presence of some contraindications, its high cost, protracted examination time, etc. Ultrasound examination is currently considered the preferred method in the diagnosis of impingement syndrome due to its high informative value, speed of execution and the possibility of its repeatability. Conclusions. The analysis of the informative value of radiation diagnostics methods showed that in identifying the early signs of subacromial impingement syndrome, taking into account etiopathogenetic factors and the anatomical structure of the shoulder joint, the ultrasound method is optimal and preferable; for more complex and controversial cases, according to certain indications, they are the methods of X-ray computer and magnetic resonance imaging. In the absence of the possibility of usin","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134398330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE BIOLOGICAL ROLE OF SELENIUM (LITERATURE REVIEW)","authors":"N. V. Bubnova, N. Timofeeva, O. Kostrova, G. Struchko, A. A. Kotelkina, Ekaterina S. Samakina","doi":"10.47026/2413-4864-2023-2-114-123","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-2-114-123","url":null,"abstract":"Micro- and macroelements play a significant role in the unimpaired functioning of all organs and systems. Important essential trace elements include selenium, which plays a crucial role in many physiological processes, including immune responses. The purpose is to generalize available data on the effect of selenium on the functioning of various organs and systems of the human body. Materials and methods. This literature review presents data on the effect of selenium on the body, published in domestic and foreign literature sources. Results. Selenium belongs to essential trace elements; it is a part of various proteins and enzymes that have cytoprotective, antitumor, antimutagenic effects. In addition, selenium participates in the functioning of the body's endocrine, reproductive, immune and antioxidant systems, although it was previously considered one of the most toxic trace elements. Many studies have been devoted to the analysis of selenium's effect on the processes of carcinogenesis and prevention of the development of tumor processes of various localization. Selenium-containing enzymes play one of the leading roles in anti-carcinogenic action, as they take part in the antioxidant defense of the body, regulate apoptosis and cell proliferation, protect desoxyribonucleic acid from damage, affect the metabolism and detoxification of carcinogens. Conclusions. The study of selenium's antitumor effect is of the greatest interest at present, since the number of patients with oncopathology is increasing every year.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113997174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATING THE EFFECTIVENESS OF APEXIFICATION METHOD IN PEDIATRIC DENTAL PRACTICE WHEN TREATING APICAL PERIODONTITIS","authors":"G. R. Ruvinskaya, E. Silantyeva, Adelina M. Azaridi","doi":"10.47026/2413-4864-2023-2-42-52","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-2-42-52","url":null,"abstract":"Apexification is the process of forming a calcified barrier (bridge) of osteocement in the root canal with necrotic pulp in permanent teeth with unformed roots. The result of apexification is closing the apex at the level where root formation was interrupted as a result of necrosis in the pulp and the germ zone of the root. The purpose of the present study was to carry out comparative assessment of the effectiveness of treating permanent teeth with unformed roots by apexification using calcium hydroxide or mineral trioxide aggregate based on the analysis of clinical cases of apical periodontitis. Materials and methods. The study involved 40 clinical cases of apical periodontitis: group I – treatment by apexification method with a long–term use of calcium hydroxide; group II – \"rapid\" insertion of a plug made of a mineral trioxide aggregate. Study results. According to the obtained calculations of the root length and the width of the apical opening before and after treatment, diagrams were constructed that reflect subsequent formation of the root, narrowing of the apical part of the root, which corresponds to the concept of apexification. All the data obtained were confirmed by the method of variational statistics with determining the median values. Conclusions. In the course of the work, a high efficiency of using this method was revealed and it was shown that, on average, in 1-1.5 years, there were optimal changes in the length of the root and width of the apical foramen, restoration of periapical tissues.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121878616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN THE HISTAMINE STATUS OF THE INTERNAL ORGANS OF LABORATORY ANIMALS DEPENDING ON THE SILICON CONCENTRATION IN DRINKING WATER","authors":"","doi":"10.47026/2413-4864-2023-1-83-92","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-83-92","url":null,"abstract":"The results of a study of the histamine status of the internal organs of Djungarian hamsters when silicon was taken with drinking water are presented. The aim of the study was to assess the histamine status of the liver, spleen and testicles of Djungarian hamsters when silicon was ingested with drinking water for three months at various concentrations. Material and methods. The hamsters were kept in the vivarium on a standard diet with free access to drinking water for three months. Hamsters of the control group (n = 3) received bottled drinking water, hamsters of the experimental groups received the same bottled water with the addition of sodium metasilicate 9-hydrate at a concentration of 10 mg/l in terms of silicon (the first experimental group, n = 3) and 20 mg/l in terms of silicon (the second experimental group, n = 3). To detect and quantify histamine in organs and tissues in cryostat sections of the liver, spleen and testicles, the fluorescent-histochemical Cross method was used. A general blood test and a blood test for glucose and cholesterol were also performed. Results and their discussion. A general blood test of hamsters that received drinking water with different concentrations of silicon did not reflect the effect of microelement intaked into the organism, while, depending on the concentration of silicon in water, the average blood glucose level tended to increase, and the cholesterol level tended to decrease. The obtained results do not contradict our previous studies in that direction. It has been shown that the concentration of silicon in drinking water from 10 mg/l hardly noticeably affects the histamine status of such organs as the liver, spleen and testes: only the intensity of histamine luminescence in macrophages of the red pulp increases statistically significantly. When silicon enters the body with drinking water at a concentration of 20 mg/l, the histamine status of organs changes more noticeably, the cells surrounding the central veins and the interstitial histamine-containing testes cells are “involved” into the reaction, which is visually reflected in the luminescent morphology of the investigated organs. Conclusions. The intake of silicon at a concentration of 10 mg/l and 20 mg/l for three months affects the histamine status of the liver, spleen and testes of Djungarian hamsters, while the indicators of the general blood test do not change.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115564688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESULTS OF A COMPARATIVE PHRMACOECONOMICS ANALYSIS OF STRATEGIES FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE IN CHILDREN WITH HEMATOLOGICAL MALIGNANCES: A SINGLE CENTER EXPERIENCE","authors":"","doi":"10.47026/2413-4864-2023-1-1-10","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-1-10","url":null,"abstract":"The discussion around the cost of allogeneic hematopoietic stem cell transplantation and follow-up of patients, methods of calculation and cost structure, despite the breadth of application of hematopoietic stem cell transplantation in oncohematological practice, remains an unresolved problem. The discussion is complicated using various modifications of therapeutic options regarding the preparation of the patient for surgery and the prevention of complications. The purpose of this article is a comparative assessment of the clinical and economic efficiency of the two most used technological platforms – TCRαβ/CD19 depletion and ‘’in vivo’’ depletion with high doses of cyclophosphamide, having studied the features of each of these methods in the real practice of one center. Materials and Methods. For evaluation, two “match paired” groups of children were selected, who underwent transplantation according to one of the methods for hemoblastosis in the period from May 2013 to January 2021 at the National Medical Research Center for Pediatric Hematology, oncology and immunology named after Dmitry Rogachev\" of the Ministry of Health of Russia. Based on the obtained indicators of clinical effectiveness (significance of differences was made using the nonparametric Mann-Whitney test), pharmacoeconomic modeling was carried out on the basis of the Markov model, the cost structure was determined and the pharmacoeconomic analysis \"cost-effectiveness\" was performed, incremental analysis \"cost-effectiveness\" ”, as well as the calculation of indicators of the cost of the operation after 5 years, taking into account discounting. The results of overall and event-free survival, as well as survival without the development of graft-versus-host disease and relapse were used as endpoints. The costs are divided into 2 time periods: stage 1 – up to 30 days after HSCT and stage 2 – from 31 days after HSCT and up to 1 year. Costs are divided into direct and indirect. For indirect costs, the average figures of the available socio-economic data are taken. Results of the study: The total costs for the two stages were comparable for both platforms: TCRa/b/CD19 deletions – 6702.094 thousand rubles; PtCy – 7325.661 thousand rubles. The costs are unevenly distributed over the stages: the 1st stage is more expensive for the TCR platform, the second for PtCy. In cost-effectiveness analysis, each unit of efficiency (1% survival per 1 year of curation will cost more for the PtCy platform. Given the WHO recommended discount factor of 3% per year, over 5 years, the annual cost for the TCR method should decrease to 5933.316 thousand rubles, and for the PtСy platform up to 6,485.355 thousand rubles without considering macroeconomic indicators. Each additional unit of efficiency (1% survival rate) of TCR will cost: survival rate of 207 855.67 rubles, for survival without GVHD and recurrence of 51 963.92 rubles. Conclusions. Pharmacoeconomically less costly for a period of 1 year of curation","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"407 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115994943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOLOGICAL COMPATIBILITY AND PROLIFERATIVE POTENTIAL OF FIBROBLASTS SEEDED ON BIOCOMPOSITE FORMED USING LASER RADIATION AND SOLDERS","authors":"","doi":"10.47026/2413-4864-2023-1-93-100","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-93-100","url":null,"abstract":"The aim of the work was to determine the viability, proliferative potential and adhesive properties of fibroblasts seeded on the surface and in the volume of a biocomposite formed using laser radiation and solders in in vitro experiments. Materials and methods. For the study, Wistar rat fibroblasts obtained at the National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei were used. The biocomposite was formed using laser radiation and solders. The viability of cells on the surface of the biocomposite was assessed using the multiparametric RTCA iCELLigence cell culture analysis system (USA). The cytotoxicity of the biocomposite was determined in combination with triphenyltetrazolium bromide (MTT test, Merck Sigma-Aldrich, Switzerland). The proliferative potential and adhesive properties of fibroblasts were studied using a FEI Helios NanoLab 650 scanning electron microscope. Results and conclusions. The viability of cells on the surface and in the volume of a biocomposite formed using laser radiation and solder was proved using an electrophysical system for analyzing cell cultures. The absence of cytotoxicity of the biocomposite under the action of triphenyltetrazolium bromide in the spectrophotometric MTT test was demonstrated. It was found that during incubation of rat fibroblasts in the volume of the biocomposite, cell death is not observed, but, on the contrary, their proliferative potential is stimulated by increasing adhesion, which contributes to the formation of a dense cell layer. Conclusions. Biocomposite as a whole, as well as its individual elements, creates a favorable environment for the growth of fibroblast culture and can be used to restore the integrity of blood vessels using laser radiation and solder.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116609403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIOLOGICAL ROLE OF THIOREDOXIN-MEDIATED INTRACELLULAR SIGNALING DURING PHYSIOLOGICAL AGING (LITERATURE REVIEW)","authors":"O. S. Tasakova, N. N. Golubtsova, A. Gunin","doi":"10.47026/2413-4864-2023-1-139-146","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-139-146","url":null,"abstract":"Thioredoxin is a low molecular weight protein found in all organisms. It is associated with the regulation of numerous cellular processes such as gene expression, antioxidant response, apoptosis, and proliferation. In humans, thioredoxin is represented by two functionally different forms, Trx1 and Trx2. The review contains the results of studies on the biological role of thioredoxin, with special attention paid to its role in the regulation of the physiological aging process. The aim of the study was to study the available literature sources that publish materials on the biological role of thioredoxin, paying special attention to its significance in the regulation of the physiological aging process. Materials and methods. To achieve the goal of the study, methods of analysis, generalization, comparison and systematization of these publications of domestic and foreign authors were used. Results. The main function of the thioredoxin-dependent system is antioxidant activity. Trx and glutathione (GSH) play a central role in counteracting oxidative stress. In addition to its antioxidant properties, Trx, unlike other antioxidant enzymes, plays an important role in maintaining the redox state of cells and in regulating redox signaling. There is a lot of evidence in the literature that shows the stimulating effect of thioredoxin on tissue proliferation. The Trx system is hypothesized to promote the development and spread of cancer through various mechanisms, including inhibition of apoptosis, promotion of cell growth, and maintenance of angiogenesis. There is also evidence of an important role of the thioredoxin system in aging. Conclusions. Thus, there are data on the participation of the thioredoxin system in the processes of aging, carcinogenesis, regulation of proliferation, and apoptosis. However, the role of thioredoxin in age-related changes in organs has not been studied enough, so additional studies are needed.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115130003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHODS OF VISUALIZATION OF MAST CELLS (LITERATURE REVIEW)","authors":"","doi":"10.47026/2413-4864-2023-1-160-170","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-160-170","url":null,"abstract":"Mast cells play an important role in many processes occurring in the human body. These include inflammation, allergic reactions, parasitic infections, carcinogenesis and others. Therefore, the detection of mast cells plays an important role in the diagnosis of pathological conditions. The purpose of the study is to summarize data on imaging methods of mast cells. Materials and methods. Review of available literature sources published in Elibrary and PubMed. Results. There are several major groups of methods for finding mast cells: histochemical, enzyme-linked histochemical and immunohistochemical. All are based on the ability to detect specific substances contained in mast cell granules. Histochemical methods include Unno, alcian blue and safranin staining of mast cells and others. The most modern method is mast cell visualisation using immunohistochemical reactions based on antigen-antibody reactions. Conclusion. This review presents the most common methods of mast cell staining, differing in difficulty of performance, specificity in relation to mast cells and staining cost.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130432261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF THE IMMUNE STATUS IN PATIENTS WITH DECOMPENSATION OF LIVER CIRRHOSIS","authors":"","doi":"10.47026/2413-4864-2023-1-53-62","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-53-62","url":null,"abstract":"Liver cirrhosis continues to be an acute problem of modern medicine due to the high rates of its prevalence and mortality. The high mortality rate is caused by the development of the number of life–threatening complications in decompensated forms of liver cirrhosis – hepatorenal syndrome, infections and varicose bleeding. Hepatorenal syndrome and infections are the result of immunological shifts occurring during decompensation of liver cirrhosis. Currently available literature data do not allow us to create a complete picture of the functional state of various links of adaptive immunity with decompensated liver cirrhosis. The aim of the research was to study the characteristic features of adaptive immunity in patients with decompensated liver cirrhosis. Material and methods. The prospective cohort study included 136 patients with decompensated liver cirrhosis, who received inpatient treatment in the hepatological department of the multidisciplinary hospital. The cohort of examined patients was divided into two groups, one of which included patients with liver cirrhosis of viral origin (n = 78), the other – patients with alcoholic liver cirrhosis (n = 58). In addition to the generally accepted standard methods, the patient examination program included immunological tests: identification of T- and B-lymphocytes, immunoregulatory and activated subpopulations of T-lymphocytes by the method of immunophenotyping peripheral blood mononuclear cells using monoclonal antibodies. The serum levels of immunoglobulins IgM, IgG, IgA, circulating immune complexes were determined by immunoturbidimetric method. Results. The study of indicators of the humoral link of adaptive immunity revealed an increase in the number of B cells, an increase in IgM, IgG, IgA and circulating immune complexes in patients with decompensated liver cirrhosis. The cellular link of adaptive immunity was characterized by an increase in the relative content of T helper cells, activated T cells against the background of a decrease in the number of immature T cells and T regulatory cells. Conclusions. The distinctive features of adaptive immunity in patients with decompensated liver cirrhosis are simultaneous activation of both humoral and cellular components, which, apparently, supports the systemic inflammatory process and the associated progressive liver fibrosis.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129029467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEASUREMENT OF THE AREA OF EROSIVE LESIONS IN PATIENTS WITH LICHIPLANUS OF THE MOUTH USING THE AUTHOR'S COMPUTER PROGRAM","authors":"","doi":"10.47026/2413-4864-2023-1-31-37","DOIUrl":"https://doi.org/10.47026/2413-4864-2023-1-31-37","url":null,"abstract":"Oral lichen planus is an inflammatory disease of the skin and oral mucosa, the etiology of which has not been fully elucidated, has a certain potential for malignancy and is often torpid to ongoing therapy. To evaluate the effectiveness and control of the therapy, we used a photo protocol using the author's computer program \"OralPath – monitoring of pathological foci\" (hereinafter referred to as the program). The aim of the study was to measure the area and fix localizations of erosions on the oral mucosa in patients with oral lichen planus using the author's computer program. Materials and methods. The areas of single and multiple erosions were recorded and measured in 89 patients with erosive form of oral lichen planus (47 men, 42 women), whose average age was 48,8±8,9 years. An analysis of groups for the normality of data distribution (Kolmogorov-Smirnov criterion, Shapiro-Vilka) was carried out. The groups were described using mean and standard deviation, and a 95% confidence interval was used to estimate the accuracy of the mean. Results of the study. The vast majority of erosions in oral lichen planus were of a single nature, and occurred in 80,9% of cases (n = 72). The area of erosions on the cheek mucosa was the largest in comparison with other localizations. With single lesions it was 1,92±0,7 cm2, with multiple lesions it was 2,6±0,63 cm2. The area of tongue erosions was 0,71±0,26 cm2 for single lesions and 1.08±0.19 cm2 for multiple lesions, respectively. Findings. The use of the computer program \"OralPath – monitoring of pathological foci\" in the practice of a dentist makes it possible to record observations of patients' conditions, evaluate the dynamics of changes in pathological foci, and, if necessary, correct the treatment process, as well as motivate patients.","PeriodicalId":249759,"journal":{"name":"Acta medica Eurasica","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125167082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}