World Journal of Psychiatry最新文献

{"title":"Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment.","authors":"Wei Liang, Lan Wang, Mei Song, Hao Geng, Xin-Yang Jing, Wei Li, Ya-Xin Huo, An-Qi Huang, Xue-Yi Wang, Cui-Xia An","doi":"10.5498/wjp.v15.i5.103256","DOIUrl":"10.5498/wjp.v15.i5.103256","url":null,"abstract":"<p><strong>Background: </strong>Mild behavioral impairment (MBI) refers to the neurobehavioral symptoms observed in older adults that may be potential risk factors for neurodegenerative diseases. While a significant number studies have explored the association between cerebrospinal fluid and MBI, only a few have examined the connection between plasma biomarkers and MBI.</p><p><strong>Aim: </strong>To examine the prevalence of MBI in healthy older adults (HOAs) and individuals with mild cognitive impairment (MCI), as well as the association between MBI and plasma biomarkers of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>We enrolled a total of 241 subjects, which included 136 HOAs and 105 MCIs, from the Yuhua District of Shijiazhuang City, Hebei Province, China. The MBI symptom checklist (MBI-C) was utilized for the assessment and diagnosis of MBI, and a score of MBI-C ≥ 6.5 was considered indicative of the condition. Fasting venous blood samples were collected from 70 patients, 32 HOAs and 38 MCIs, and levels of amyloid β-protein (Aβ) 40, Aβ42, and hyperphosphorylated tau (p-Tau217) in these samples were measured using an enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The prevalence of MBI in the HOAs and MCI groups was 4.4% and 15.3%, respectively (<i>χ</i> ² = 7.262, <i>P</i> = 0.007), with particularly notable decreases in motivation and increases in impulse dyscontrol (the highest detection rate) and social inappropriateness (<i>P</i> < 0.05). The total MBI score correlated with Aβ42 and p-Tau217 (<i>r</i> = -0.385, <i>P</i> = 0.019; <i>r</i> = -0.330, <i>P</i> = 0.041), but not with Aβ40 or the Aβ42/40 ratio. Among the subdomains, impulse dyscontrol was correlated with Aβ42 (<i>r</i> = -0.401, <i>P</i> = 0.025).</p><p><strong>Conclusion: </strong>Both MCI and HOAs have exhibited a higher prevalence of MBI, with changes in impulse control behavior being the most common. MBI not only presents as an independent risk factor for cognitive decline but is also linked with AD-related peripheral biomarkers.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103256"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating burnout syndrome among healthcare workers: Prevalence and risk factors.","authors":"Xue-Jian Wang","doi":"10.5498/wjp.v15.i5.104880","DOIUrl":"10.5498/wjp.v15.i5.104880","url":null,"abstract":"<p><p>In this editorial we comment on the article by Mohamed <i>et al</i> published in the recent issue of <i>World Journal of Psychiatry</i>. Globally, health care workers are facing a major problem called burnout syndrome, which is characterized by emotional alienation, burnout, and decreased personal fulfillment. This physical and mental stress has a significant impact on the quality of care and health of medical personnel. This study delves into the challenges facing Somalia's healthcare system, such as lack of resources, heavy workloads, long working hours, and high-pressure environments that make healthcare personnel particularly vulnerable to burnout. This situation further affects their mental health and the quality of care services. Research shows that about 25% of healthcare professionals are affected by burnout syndrome. By improving the quality of sleep, strengthening monitoring, and providing mental health support, the health status of medical personnel and patient care can be effectively improved. The findings highlight the need for interventions including improved sleep quality, enhanced mental health monitoring and support, appropriate workload management, a supportive work climate, and effective time management strategies in the workplace to enhance health staff well-being and the quality of patient care. These measures are critical to addressing the current challenges of the healthcare system, improving patient care and prioritizing the well-being of frontline healthcare staff.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"104880"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-related potentials reveal hypnotherapy's impact on attention bias in social anxiety disorder.","authors":"Han Zhang, Mi Zhang, Ni Li, Wen-Zhuo Wei, Lin-Xi Yang, Yong-Yi Li, Zhen-Yue Zu, Li-Jun Ma, Hui-Xue Wang, Kai Wang, Xiao-Ming Li","doi":"10.5498/wjp.v15.i5.102552","DOIUrl":"10.5498/wjp.v15.i5.102552","url":null,"abstract":"<p><strong>Background: </strong>Exploring hypnotherapy's potential to modulate attention bias offers promising avenues for treating social anxiety disorder (SAD).</p><p><strong>Aim: </strong>To determine if hypnotherapy can alleviate social anxiety by influencing attention bias, specifically identifying the aspects of attention processes affected by hypnosis.</p><p><strong>Methods: </strong>In this study, 69 SAD participants were divided into three groups based on their Liebowitz Social Anxiety Scale scores: Experimental group, control group, and baseline group. The experimental group (<i>n</i> = 23) underwent six weekly hypnosis sessions, while the control (<i>n</i> = 23) and baseline groups (<i>n</i> = 23) received no treatment. To evaluate alterations in SAD severity and attention bias towards threatening stimuli following hypnotherapy, we employed a combination of self-report questionnaires, an odd-one-out task, and electroencephalography recordings.</p><p><strong>Results: </strong>The experimental group showed significant reductions in P1, N170, N2pc, and late positive potential (LPP) brain wave activities during attention sensitivity and disengagement conditions. This indicates that hypnotherapy modulates early-stage face processing and later-stage emotional evaluation of threat-related stimuli in SAD patients.</p><p><strong>Conclusion: </strong>Our findings highlight P1, N170, N2pc, and LPP as key neural markers in SAD treatment. By identifying these neural markers influenced by hypnotherapy, we offer insight into the mechanisms by which this treatment modality impacts attentional processes, potentially easing SAD symptoms.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102552"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-brain connection in schizophrenia: A narrative review.","authors":"Asma Iqbal, Syed Faqeer Hussain Bokhari, Muneeb Ur Rehman, Syed Muhammad Faizan Sattar, Danyal Bakht, Wahidullah Dost, Abdul Basit","doi":"10.5498/wjp.v15.i5.103751","DOIUrl":"10.5498/wjp.v15.i5.103751","url":null,"abstract":"<p><p>Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive, emotional, and behavioral impairments. The microbiota-gut-brain axis is crucial in its pathophysiology, mediating communication between the gut and brain through neural, immune, endocrine, and metabolic pathways. Dysbiosis, or an imbalance in gut microbiota, is linked to neuroinflammation, systemic inflammation, and neurotransmitter disruptions, all of which contribute to the symptoms of schizophrenia. Gut microbiota-derived metabolites, such as short-chain fatty acids, influence brain function, including immune responses and neurotransmitter synthesis. These findings suggest that microbial imbalances exacerbate schizophrenia, providing a novel perspective on the disorder's underlying mechanisms. Emerging microbiota-targeted therapies-such as probiotics, prebiotics, dietary interventions, and fecal microbiota transplantation-show promise as adjunctive treatments, aiming to restore microbial balance and improve clinical outcomes. While further research is needed, targeting the microbiota-gut-brain axis offers an innovative approach to schizophrenia management, with the potential to enhance patient outcomes and quality of life.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103751"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving cancer patients' prognosis by incorporating mindfulness intervention into the treatment strategy.","authors":"Ning Lu, Kuo-Cherh Huang","doi":"10.5498/wjp.v15.i5.102977","DOIUrl":"10.5498/wjp.v15.i5.102977","url":null,"abstract":"<p><p>This letter discusses the study by Liu <i>et al</i> recently published in <i>World Journal of Psychiatry</i>, which examines the benefits of combining epirubicin (EPI) with mindfulness interventions for patients with urinary system tumors and depression. The study included 110 patients and compared an experimental group receiving EPI and a mindfulness intervention strategy with a control group treated with mitomycin and standard care. Results showed that the experimental group had significant improvements in immune function, tumor markers, depression severity, quality of life, cancer-related fatigue, and nursing satisfaction. Despite acknowledging the study limitations such as a relatively small sample size and a short duration, the study highlights the efficacy of integrating mindfulness interventions into cancer treatment strategies to enhance patient outcomes and address psychological distress.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102977"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural network communication differences in drug-naive depressed adolescents with non-suicidal self-injury and suicide attempts.","authors":"Shuai Wang, Jiao-Long Qin, Lian-Lian Yang, Ying-Ying Ji, Hai-Xia Huang, Xiao-Shan Gao, Zi-Mo Zhou, Zhen-Ru Guo, Ye Wu, Lin Tian, Huang-Jing Ni, Zhen-He Zhou","doi":"10.5498/wjp.v15.i5.102706","DOIUrl":"10.5498/wjp.v15.i5.102706","url":null,"abstract":"<p><strong>Background: </strong>Depression, non-suicidal self-injury (NSSI), and suicide attempts (SA) often co-occur during adolescence and are associated with long-term adverse health outcomes. Unfortunately, neural mechanisms underlying self-injury and SA are poorly understood in depressed adolescents but likely relate to the structural abnormalities in brain regions.</p><p><strong>Aim: </strong>To investigate structural network communication within large-scale brain networks in adolescents with depression.</p><p><strong>Methods: </strong>We constructed five distinct network communication models to evaluate structural network efficiency at the whole-brain level in adolescents with depression. Diffusion magnetic resonance imaging data were acquired from 32 healthy controls and 85 depressed adolescents, including 17 depressed adolescents without SA or NSSI (major depressive disorder group), 27 depressed adolescents with NSSI but no SA (NSSI group), and 41 depressed adolescents with SA and NSSI (NSSI + SA group).</p><p><strong>Results: </strong>Significant differences in structural network communication were observed across the four groups, involving spatially widespread brain regions, particularly encompassing cortico-cortical connections (<i>e.g.</i>, dorsal posterior cingulate gyrus and the right ventral posterior cingulate gyrus; connections based on precentral gyrus) and cortico-subcortical circuits (<i>e.g.</i>, the nucleus accumbens-frontal circuit). In addition, we examined whether compromised communication efficiency was linked to clinical symptoms in the depressed adolescents. We observed significant correlations between network communication efficiencies and clinical scale scores derived from depressed adolescents with NSSI and SA.</p><p><strong>Conclusion: </strong>This study provides evidence of structural network communication differences in depressed adolescents with NSSI and SA, highlighting impaired neuroanatomical communication efficiency as a potential contributor to their symptoms. These findings offer new insights into the pathophysiological mechanisms underlying the comorbidity of NSSI and SA in adolescent depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102706"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting parents in autism care.","authors":"Mihit Kalawatia, Brandon Lucke-Wold, Aabhali Mehrunkar","doi":"10.5498/wjp.v15.i5.103575","DOIUrl":"10.5498/wjp.v15.i5.103575","url":null,"abstract":"<p><p>Autism spectrum disorder is a developmental disorder impacting a child's social interactions, behaviors, and communication skills. One of the crucial aspects of autism care, which is often overlooked, is the parent's mental health status while trying to improve and overcome challenges faced by their child. A study by Lu <i>et al</i> examined the effectiveness of remote family psychological support courses on the mental health status of parents having children with autism spectrum disorder. It was found that the integration of these remote psychological courses with conventional care had a positive impact on the parents by reducing their stress levels, leading to an increase in their competence, and hence they could engage effectively in child therapy. However, a long-term study is necessary to assess whether these interventions have a sustained effect. The study emphasizes the need for developing such culturally sensitive intervention models on a global scale, making them accessible to all and improving autism care support.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103575"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of influencing factors on the nutritional status of non-dialysis elderly patients with chronic kidney disease and depression.","authors":"Zi-Yu Song, Ni Li, Hong-Bao Liu","doi":"10.5498/wjp.v15.i5.102539","DOIUrl":"10.5498/wjp.v15.i5.102539","url":null,"abstract":"<p><strong>Background: </strong>The assessment of nutritional status in non-dialysis elderly patients with chronic kidney disease (CKD) and comorbid depression is clinically important. Determining key determinants of nutritional status in this population significantly improves nutritional management strategies and assists these patients overcome the disease.</p><p><strong>Aim: </strong>To investigate the factors influencing the nutritional status of non-dialysis elderly patients with CKD and comorbid depression.</p><p><strong>Methods: </strong>This study retrospectively collected the clinical data of 182 non-dialysis elderly patients with CKD and comorbid depression admitted at Tangdu Hospital, Air Force Medical University, from January 2022 to June 2023. The participants were categorized based on the presence of malnutrition into the nutritionally normal group (<i>n</i> = 97) and the malnutrition group (<i>n</i> = 85). The clinical data of the two groups were subjected to unifactorial and multifactorial regression to analyze the factors influencing malnutrition among the participants. Data included sex, age, body mass index (BMI), percentage body fat, basal metabolic rate (BMR), blood urea nitrogen (BUN), creatinine (Cr), albumin (Alb), hemoglobin (Hb), pre-albumin (PA), patient-generated subjective global assessment, and Patient Health Questionnaire-9 (PHQ-9) score to identify depressive symptoms. After admitting the patients to the hospital, 5 mL of peripheral serum was withdrawn, the centrifuge was operated at 3500 rpm/minute with a centrifugal radius of 10 cm for 10 minutes, serum was collected, and serum Alb, Hb, PA, BUN, and Cr levels were detected using a fully automatic biochemical analyzer. The results were assessed using Statistical Package for the Social Sciences version 21.0 for conducting technical analyses. Metric data are presented as the mean ± standard error of the mean and replaced using the <i>t</i>-test. Count data are expressed as case counts and percentages and were replaced using the <i>χ</i> ² test. Effective factors were modeled using logistic return modeling.</p><p><strong>Results: </strong>BMI, BMR, and serum Alb, Hb, PA, and Cr levels were lower in the nutritionally normal group than in the malnutrition group. Furthermore, BUN levels, PHQ-9 scores, and the percentage of anxiety symptoms were greater in the nutritionally normal group than in the normal nutrition group, with statistically significant differences (<i>P</i> < 0.05). Multiple factorial interpretations revealed anxiety and serum Alb, Hb, and PA levels as factors influencing the nutritional status of non-dialysis elderly patients with CKD and depression (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Serum Alb, Hb, PA levels, and anxiety symptoms are all factors influencing malnutrition in non-dialysis elderly patients with CKD and depression; hence, clinical interventions can be targeted to patients with the above characteristics.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102539"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and psychological influence of lateral rectus approach for treating pelvic fracture with lumbosacral plexus injury.","authors":"Xiao-Dong Yang, Yu-Ting Lu, Zhen Lai, Jun-Jie Wang, Huan-Chang Jiang, Cheng Gu, Shi-Cai Fan","doi":"10.5498/wjp.v15.i5.101844","DOIUrl":"10.5498/wjp.v15.i5.101844","url":null,"abstract":"<p><strong>Background: </strong>The surgical treatment of pelvic fractures is challenging, particularly after lumbosacral plexus injuries. Such impairments affect a patient's physiological function and can cause significant mental health problems. In recent years, the new transrectus lateral approach has favorably treated pelvic fractures and possibly preserved patients' physiological and psychological conditions. Therefore, investigating its clinical efficacy for treating pelvic fractures plus lumbosacral plexus injuries is of great clinical significance.</p><p><strong>Aim: </strong>To investigate the clinical effect of the transrectus lateral approach on pelvic fractures complicated by lumbosacral plexus injuries as well as anxiety and depression.</p><p><strong>Methods: </strong>Data of 136 patients with pelvic fractures complicated by lumbosacral plexus injuries treated by the transrectus lateral approach (January 2011 to May 2024) were retrospectively analyzed. The patients' general data were collected via questionnaire. The Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess anxiety and depression, respectively. We adopted a numerical rating scale (NRS) to evaluate pain degree, the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, and Medical Research Council (MRC) Scale for Muscle Strength to evaluate treatment efficacy and complications.</p><p><strong>Results: </strong>The 136 included patients (92 male, 44 female) were a mean 48.02 ± 15.72 years old. The mean SAS score was 66.36 ± 5.15 preoperatively <i>vs</i> 42.15 ± 4.36 postoperatively, while the mean SDS score was 65.61 ± 5.02 preoperatively <i>vs</i> 43.83 ± 4.54 postoperatively, showing statistically significant differences (<i>P</i> < 0.05). The mean NRS and PSQI scores were significantly lower pre- <i>vs</i> postoperatively (<i>P</i> < 0.05). Postoperatively, 67 patients with fresh pelvic fractures plus nerve injuries achieved an MRC of M5, 22 achieved an M1-M4, and four achieved an M0. Postoperative motor function improved by a mean 4.20 grades (scale, 0-5). Among the patients with old pelvic fractures and nerve injuries, 19 achieved an M5, 16 achieved an M1-M4, and eight achieved an M0. Motor function improved significantly by a mean 3.30 grades (scale, 0-5; <i>P</i> < 0.05). No serious postoperative complications occurred.</p><p><strong>Conclusion: </strong>The transrectus lateral approach to treating pelvic fractures plus lumbosacral plexus injuries can safely alleviate anxiety and depression, relieve pain, improve sleep quality, reduce intraoperative blood loss, and improve postoperative recovery.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"101844"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of poor prognosis in long-term survivors of differentiated thyroid cancer with psychiatric disorders.","authors":"Jin-Liang Jia, Ji-Hua Han, Rui Pang, Wen Bi, Bo Liu, Kun Yang","doi":"10.5498/wjp.v15.i5.103628","DOIUrl":"10.5498/wjp.v15.i5.103628","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Thyroid malignancies, while accounting for a small proportion of cancer diagnoses globally, have demonstrated a consistent upward trend in occurrence across diverse populations, with gender-specific analyses revealing a disproportionate burden among women. Despite the characteristically indolent nature of most thyroid carcinomas and their associated high survival rates, emerging evidence points to significant unmet needs regarding psychosocial adaptation and neuropsychiatric sequelae in this growing survivor population. The spectrum of mental health conditions, ranging from affective and anxiety disorders to cognitive impairments, presents substantial barriers to functional recovery and may potentially influence disease trajectories through complex psychoneuroimmunological pathways. Clinical observations consistently report elevated rates of mood disturbances and executive function deficits persisting throughout the cancer continuum, from active treatment into extended follow-up periods. These findings highlight a critical knowledge gap in understanding the dynamic interplay between thyroid cancer biology, its therapeutic interventions, and the development of treatment-resistant psychiatric manifestations that complicate long-term patient care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To analyse the factors influencing the poor prognosis of patients surviving long-term differentiated thyroid cancer with psychiatric disorders and to construct a prediction model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Forty-eight patients with mental disorders combined with differentiated thyroid cancer who were treated in our hospital during the period of March 2018 to March 2023 were retrospectively selected as the study subjects (thyroid cancer group), and 30 cases each of patients with mental disorders combined with benign thyroid nodules (benign nodules group) and patients with mental disorders alone (mental disorders group), who were treated during the same time period, were selected as controls. The patients with differentiated thyroid cancer were further divided into a poor prognosis group (10 cases) and a good prognosis group (38 cases). The study outcome was poor prognosis as shown by whole body bone imaging within 2 years after thyroid cancer surgery. Factors influencing poor prognosis in survivors of differentiated thyroid cancer were analyzed by univariate and multivariate logistic regression analyses, receiver operating characteristic (ROC) curve analysis was used to assess the predictive efficacy of these factors for poor prognosis, and the DeLong test was used to determine whether there was a statistically significant difference in the area under the curve (AUC) of the model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;One-way logistic regression analysis showed that tumour diameter [odds ratio (OR) = 19.190, &lt;i&gt;P&lt;/i&gt; = 0.002], T-stage (OR = 7.692, &lt;i&gt;P&lt;/i&gt; = 0.018), extra-glandular infiltration (OR = 37.000, &lt;i&gt;P&lt;/i&gt; = 0.003), degree of differentia","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103628"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}