World Journal of Psychiatry最新文献

{"title":"Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia: Implications for early intervention.","authors":"Uchenna E Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i1.102131","DOIUrl":"https://doi.org/10.5498/wjp.v15.i1.102131","url":null,"abstract":"<p><p>This manuscript explores the recent study by Cui <i>et al</i> which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor (BDNF) levels in first-episode schizophrenia patients. The study revealed that higher levels of interleukin-6 and tumor necrosis factor-α correlated with reduced BDNF levels and poorer cognitive performance. Schizophrenia is a severe psychiatric disorder impacting approximately 1% of the global population, characterized by positive symptoms (hallucinations and delusions), negative symptoms (diminished motivation and cognitive impairments) and disorganized thoughts and behaviors. Emerging research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic targeting. The findings from Cui <i>et al</i>'s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive outcomes. Effective treatment approaches involve a combination of pharmacological and non-pharmacological interventions tailored to individual patient needs. Hence, monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of life. Consequently, this manuscript highlights the need for an integrated approach to schizophrenia management, considering both clinical symptoms and underlying neurobiological changes.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 1","pages":"102131"},"PeriodicalIF":3.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021.","authors":"Ya-Xin Xu, Xiao-Xuan Niu, Wen-Chang Jia, Jing Wen, Xue-Lin Cheng, Yan Han, Ming-Hui Peng, Jing Zhou, Yao Liu, Sun-Fang Jiang, Xiao-Pan Li","doi":"10.5498/wjp.v15.i1.101750","DOIUrl":"https://doi.org/10.5498/wjp.v15.i1.101750","url":null,"abstract":"<p><strong>Background: </strong>The burden of mental disorders (MD) in the Western Pacific Region (WPR) remains a critical public health concern, with substantial variations across demographics and countries.</p><p><strong>Aim: </strong>To analyze the burden of MD in the WPR from 1990 to 2021, along with associated risk factors, to reveal changing trends and emerging challenges.</p><p><strong>Methods: </strong>We used data from the Global Burden of Disease 2021, analyzing prevalence, incidence, and disability-adjusted life years (DALYs) of MD from 1990 to 2021. Statistical methods included age-standardisation and uncertainty analysis to address variations in population structure and data completeness.</p><p><strong>Results: </strong>Between 1990 and 2021, the prevalence of MD rose from 174.40 million cases [95% uncertainty interval (UI): 160.17-189.84] to 234.90 million cases (95%UI: 219.04-252.50), with corresponding DALYs increasing from 22.8 million (95%UI: 17.22-28.79) to 32.07 million (95%UI: 24.50-40.68). During this period, the burden of MD shifted towards older age groups. Depressive and anxiety disorders were predominant, with females showing higher DALYs for depressive and anxiety disorders, and males more affected by conduct disorders, attention-deficit hyperactivity disorder, and autism spectrum disorders. Australia, New Zealand, and Malaysia reported the highest burdens, whereas Vietnam, China, and Brunei Darussalam reported the lowest. Additionally, childhood sexual abuse and bullying, and intimate partner violence emerged as significant risk factors.</p><p><strong>Conclusion: </strong>This study highlights the significant burden of MD in the WPR, with variations by age, gender, and nation. The coronavirus disease 2019 pandemic has exacerbated the situation, emphasizing the need for a coordinated response.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 1","pages":"101750"},"PeriodicalIF":3.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of adolescent non-suicidal self-injury subgroups identified through latent profile analysis.","authors":"Wei Yang, Kun Lian, Yu-Qi Cheng, Xiu-Feng Xu, Xin-Cen Duan, Xu You","doi":"10.5498/wjp.v14.i12.1936","DOIUrl":"10.5498/wjp.v14.i12.1936","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is common among adolescents and frequently co-occurs with depression. Understanding the distinct patterns of NSSI behaviors, along with their associated risk and protective factors, is crucial for developing effective interventions.</p><p><strong>Aim: </strong>To classify NSSI behaviors and examine interactions between risk and resilience factors in Chinese adolescents.</p><p><strong>Methods: </strong>A cross-sectional study involving 3967 Chinese students (51.7% female, mean age 13.58 ± 2.24 years) who completed questionnaires on parenting styles, bullying, childhood maltreatment, depression, resilience, and NSSI. Latent profile analysis (LPA) was used to identify NSSI subtypes, and network analysis explored interactions between risk and resilience factors.</p><p><strong>Results: </strong>Three NSSI subtypes were identified: NSSI with depression (18.8%), NSSI without depression (12.3%), and neither (68.9%). Bullying was the central risk factor across subtypes, while emotional control and family support were key protective factors. Statistical analyses showed significant differences between groups (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>This study identified three NSSI subtypes among Chinese adolescents. Bullying emerged as a central risk factor, while emotional control and family support were key protective factors. Targeting these areas may help reduce NSSI behaviors in this population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1936-1946"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis.","authors":"Yin-Kai Zhao, Meng Li, Ting-Ting Shi, Miao-Miao Feng, Lu-Lu Hu","doi":"10.5498/wjp.v14.i12.1956","DOIUrl":"10.5498/wjp.v14.i12.1956","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in childhood. There is growing evidence that both preterm birth and maternal education levels substantially affect the likelihood of ADHD in children. However, there are limited systematic reviews and meta-analyses examining these associations.</p><p><strong>Aim: </strong>To systematically review and conduct a meta-analysis on the association of preterm birth and maternal education level on the risk of ADHD in children.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search across MEDLINE (PubMed), Web of Science, Embase, and the Cochrane Library, including studies published up to June 17, 2024. Data synthesis was performed using random-effect models, and the quality of studies was assessed using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>This study included twelve studies, which revealed a significant association between premature delivery and an increased risk of ADHD in children [odds ratio (OR) = 2.76, 95% confidence interval (CI): 2.52-3.04, <i>P</i> < 0.001, <i>I²</i> = 1.9%). Conversely, higher maternal education levels were significantly associated with a reduced risk of ADHD in children (OR = 0.59, 95%CI: 0.48-0.73, <i>P</i> < 0.001, <i>I²</i> = 47.1%). Subgroup analysis further indicated that maternal education levels significantly influenced ADHD risk, particularly in studies conducted in China (OR = 0.59, 95%CI: 0.46-0.75, <i>P</i> < 0.001, <i>I²</i> = 81.2%), while no significant association was observed in studies from other regions (OR = 1.25, 95%CI: 0.66-2.40, <i>P</i> = 0.495, <i>I²</i> = 92.3%). The sensitivity analysis confirmed the robustness of our findings, showing no significant publication bias.</p><p><strong>Conclusion: </strong>This study found that preterm birth significantly increases the risk of ADHD in children, while a higher maternal education level serves as a protective factor against ADHD. To reduce the incidence of ADHD in children, public health policies should focus on early intervention for preterm infants and improving maternal education levels.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1956-1970"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients.","authors":"Li-Jun Cui, Li-Li Cai, Wan-Qiu Na, Rui-Long Jia, Jie-Lin Zhu, Xin Pan","doi":"10.5498/wjp.v14.i12.1804","DOIUrl":"10.5498/wjp.v14.i12.1804","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of cognitive impairment in schizophrenia (SCZ) remains unclear. Accumulating studies showed that inflammatory-immune dysregulation and altered brain derived neurotrophic factor (BDNF) levels play a crucial role in the psychopathology of SCZ. However, their association with cognitive dysfunction in first-episode SCZ patients has not been thoroughly investigated.</p><p><strong>Aim: </strong>To explore the interaction effects between cognitive function and inflammatory cytokines and BDNF in first-episode SCZ.</p><p><strong>Methods: </strong>The current study is a cross-sectional case-control investigation that recruited 84 patients with first-episode SCZ (SCZ group) and 80 healthy controls (HCs group) at the Huzhou Third Municipal Hospital between August 2021 and September 2023. ELISA was employed to measure the serum levels of interleukin (IL)-1β, IL-4, IL-6, IL-10, and BDNF. The Chinese brief cognitive test (C-BCT) and the positive and negative syndrome scales were measured the severity of cognitive impairment and psychiatric symptoms.</p><p><strong>Results: </strong>Compared to the HC group, the SCZ group exhibited elevated IL-1β and IL-6 levels, decreased BDNF levels, and reduced C-BCT scores (all <i>P</i> < 0.001). In SCZ, BDNF was negatively correlated with IL-6 (<i>r</i> = -0.324, <i>P</i> < 0.05). Information processing speed was negatively correlated with IL-6 (<i>r</i> = -0.315, <i>P</i> < 0.05) and positively with BDNF (<i>r</i> = 0.290, <i>P</i> < 0.05); attention, working memory, comprehensive ability, and executive function were negatively correlated with IL-1β and IL-6 (all <i>P</i> < 0.05) and positively with BDNF (all <i>P</i> < 0.05). Multiple regression analysis showed IL-6 influenced C-BCT dimensions (<i>β</i> = -0.218 to -0.327<i>,</i> all <i>P</i> < 0.05); attention and executive ability were influenced by IL-1β (<i>β</i> = -0.199 to -0.261<i>,</i> all <i>P</i> < 0.05<i>)</i>; comprehensive executive ability was influenced by BDNF (<i>β</i> = 0.209, <i>P</i> < 0.05<i>)</i>.</p><p><strong>Conclusion: </strong>Our findings suggested that interrelationships between immune dysfunction and neurotrophic deficiency might underlie the pathological mechanisms of cognitive impairments in first-episode SCZ patients.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1804-1814"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music therapy combined with motivational interviewing.","authors":"De-Fang Meng, Jun Bao, Tao-Zhi Cai, Ying-Jie Ji, Yan Yang","doi":"10.5498/wjp.v14.i12.1886","DOIUrl":"10.5498/wjp.v14.i12.1886","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) is one of the main treatment methods for myocardial infarction (MI). Despite its positive effects, patients often experience different degrees of anxiety and depression after the intervention. Therefore, effectively changing the emotional state of patients with MI during PCI remains a focus of clinical research.</p><p><strong>Aim: </strong>To assess the effect of music therapy and motivational interviewing in young and middle-aged patients with anxiety and depression after PCI.</p><p><strong>Methods: </strong>We collected data from January 2022 to December 2023 from 86 young and middle-aged patients with MI after PCI. They were divided into observation and control groups according to the random throwing method. The observation group consisted of 43 patients undergoing music therapy and motivational interviewing, and the control group (43 cases) underwent music therapy and conventional communication. The two groups were then compared on mood status [Chinese Brief Mood Status Scale (POMS)], coping methods [Medical Coping Methods Questionnaire (MCMQ) Chinese version], and healthy lifestyle behaviors [Heart Health Self-Efficacy and Self-Management (HH-SESM) scale].</p><p><strong>Results: </strong>Two weeks post-intervention, the observation group had lower POMS scores, improved MCMQ scores, and higher HH-SESM scores than the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The combined intervention of music therapy and motivational interviewing for young and middle-aged patients with anxiety and depression after MI can effectively regulate their mood, reduce anxiety and depression symptoms, and stimulate patients to actively face their condition. It also encourages the formation of healthy behavioral habits.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1886-1891"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of comprehensive intervention model based on drug-psychology-society-skills on medication compliance and cognitive ability of chronic schizophrenia patients.","authors":"Hai-Jun Wang, Wei Chen, Xiao-Lin Yan, Qian-Ying Huang, Wei-Dong Xu","doi":"10.5498/wjp.v14.i12.1947","DOIUrl":"10.5498/wjp.v14.i12.1947","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Overall, 98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study (50 patients) and control groups (48 patients). For 3 months, the control group was treated with conventional drugs, and the research group with a comprehensive intervention model of drug-psychology-society-skills. Data were obtained for the mini mental assessment scale (MMSE), Montreal cognitive assessment scale (MoCA), positive and negative symptom scale, insight and treatment attitude scale, cognitive ability scale and social skills [personal and social function scale (PSP)]. The adverse reactions were observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After the intervention, the MMSE and MoCA scores improved in both groups. MoCA scores in the study group (26.58 ± 3.21) were significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) higher than those in the control group (24.68 ± 3.02), MMSE scores were not significantly higher. Post-intervention, positive and negative symptom scores improved in both groups, and the positive and negative symptom scores in the study group [(12.01 ± 2.58) and (32.51 ± 2.11)] were significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) different than those in the control group [(14.54 ± 2.33) and (33.74 ± 2.55)]. Post-intervention, insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group (7.97 ± 3.02), the study group (13.56 ± 6.35) had significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) higher scores. Post-intervention, the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group (38.44 ± 6.23), the score of the study group was significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) increased (43.51 ± 6.01). Post-intervention, the PSP score of the study group (78.38 ± 6.63) was significantly (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) higher than that of the control group (74.52 ± 7.01). During the intervention period, the incidence of adverse reactions in the study group was 6.25%, not significantly different from that in the control group (8.33%). During the intervention, both groups experienced adverse reactions, with no significant difference between groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia, which improves their cognitive ability and reduces their positive and negative symptoms. Simultaneously, it improves the self-knowledge of patients, improves their attitude toward treatment, effectivel","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1947-1955"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of bright-light therapy on depression and anxiety of a patient with Alzheimer's disease combined with sleep disorder: A case report.","authors":"Xi Mei, Chen-Jun Zou, Cheng-Ying Zheng, Jun Hu, Dong-Sheng Zhou","doi":"10.5498/wjp.v14.i12.1982","DOIUrl":"10.5498/wjp.v14.i12.1982","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a common type of dementia due to neuronal impairment. In addition, psychobehavioral symptoms including severe sleep disorders, depression and anxiety can occur in most patients with AD.</p><p><strong>Case summary: </strong>We report a case of a 68-year-old woman with a 2-year history of AD. She initially presented with memory loss, progressively more severe, leading to a depressive and anxious status. The clinical symptoms also included severe sleep disturbances. Considering the age and health state of the patient, a non-pharmacological treatment of bright light therapy was used to improve her sleep quality. The treatment was provided for 30 minutes twice a day, during 8:30 am to 9:00 am and 16:30 pm to 17:00 pm. After 4 weeks of therapy, the sleep quality notably improved, with a marked decrease in daytime sleep, increase in nighttime sleep, and disappearance of nocturnal activity. The depression and anxiety were also suppressed significantly.</p><p><strong>Conclusion: </strong>This case report suggested that bright light therapy can have a positive effect on sleep quality in elderly patients with AD and can be used as an effective and safe non-pharmacological treatment.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1982-1987"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminishing restrictive practices in psychiatric wards <i>via</i> virtual reality training: Old wine in a new bottle?","authors":"Yan Zeng, Jun-Wen Zhang, Jian Yang","doi":"10.5498/wjp.v14.i12.1783","DOIUrl":"10.5498/wjp.v14.i12.1783","url":null,"abstract":"<p><p>This editorial examines the application of virtual reality (VR) training to mitigate restrictive practices (RPs) within psychiatric facilities. RPs include physical restraints, seclusion, and chemical restraints, used to ensure patient safety but with varying usage rates across regions. In recent years, there has been a growing focus on the adverse effects of RPs on both healthcare workers and patients, leading to calls for its reduction. Previous research has shown the efficiency of VR training in RP reduction. This editorial will analyze the limitations of VR training in prior research aimed at reducing RP, emphasizing that the essence of RPs is a medical safety issue, calling for careful differentiation of the causes of RPs, and avoiding the use of AR technology as a \"new bottle\" for \"old wine\" to improve the quality and reproducibility of future research in this field.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1783-1787"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between gestational body mass index, blood pressure variability, and postpartum depression in pregnant women with pre-eclampsia.","authors":"Fang-Fang Wu, Hong Xu","doi":"10.5498/wjp.v14.i12.1868","DOIUrl":"10.5498/wjp.v14.i12.1868","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pre-eclampsia has long been proven to be an independent risk factor for postpartum depression (PPD). Excessive increase in body mass index (BMI) during pregnancy is an important factor inducing pre-eclampsia. Increased blood pressure is the main symptom of patients with pre-eclampsia. However, whether there is a correlation between BMI and blood pressure variability during pregnancy and PPD occurrence in pregnant women with pre-eclampsia remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the relationship between BMI, blood pressure variability, and PPD in pregnant women with pre-eclampsia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using a cross-sectional survey research, 201 pregnant women with pre-eclampsia who were treated and delivered in Suzhou Ninth People's Hospital from May 2016 to June 2024 were selected as this study's subjects. At 42 days after delivery, the subjects were re-examined in the hospital's outpatient department. The Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate whether PPD symptoms, divided the subjects into two groups: The PPD and non-PPD groups. We analyzed clinical data, changes in BMI during pregnancy, and blood pressure variability in the two groups. The Pearson method was used to test the correlation between BMI increase, blood pressure variability during pregnancy, and EPDS score in patients with pre-eclampsia. Logistic regression analysis was performed to explore whether increased BMI and blood pressure variability during pregnancy are influencing factors for PPD occurrence in patients with pre-eclampsia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 201 pre-eclamptic women who underwent an outpatient review 42 days after delivery, 37 had PPD symptoms based on the EPDS scale evaluation, resulting in an incidence rate of 18.41% (37/201). The differences between the PPD and non-PPD groups in terms of age, educational level, place of residence, reproductive history, gestational age, mode of delivery, newborn gender, and newborn birth weight were not statistically significant (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). The gestational BMI increase, 24-hour systolic blood pressure (SBP) variability, and 24-hour diastolic blood pressure (DBP) variability in the PPD group were significantly higher than those in the non-PPD group; the differences were statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Pearson correlation analysis showed that BMI increase, SBP variability, and DBP variability during pregnancy correlated positively with the EPDS score of pregnant women with pre-eclampsia (&lt;i&gt;r&lt;/i&gt; = 0.349, 0.336, and 0.241; &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Logistic regression analysis showed that a high increase in BMI during pregnancy [odds ratio (OR) = 4.614, 95% confidence interval (CI): 1.749-12.170, &lt;i&gt;P&lt;/i&gt; = 0.002], large variability in 24-hour SBP (OR = 2.910, 95%CI: 1.322-6.404, &lt;i&gt;P&lt;/i&gt; = 0.008), and large variability in 24-hour DBP (OR = 2.347, 95%CI: 1.138-4.831, &lt;i&gt;P&lt;/i&gt; = 0.021) were factors affecting PPD occurren","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 12","pages":"1868-1875"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}