World Journal of Psychiatry最新文献

{"title":"Interplay between insomnia, anxiety, and depression.","authors":"Güzel Nur Yıldız, Bahar Çiftçi","doi":"10.5498/wjp.v15.i6.104796","DOIUrl":"10.5498/wjp.v15.i6.104796","url":null,"abstract":"<p><p>Insomnia, anxiety, and depression have become critical mental health issues exacerbated by the coronavirus disease 2019 pandemic, highlighting the importance of understanding their interrelationships. This article evaluates the study by Li <i>et al</i>, which investigates the links between insomnia, anxiety, and depression while examining the mediating role of cognitive failures and the moderating effect of neuroticism. The study employed a cross-sectional design with 1011 participants, using validated scales to measure insomnia severity, neuroticism, cognitive failures, and mental health indicators. Li <i>et al</i> found that approximately 40% of participants exhibited symptoms of anxiety, depression, and insomnia, with most cases being mild. The results demonstrated that cognitive failures play a mediating role in the relationship between insomnia and both anxiety and depression. Furthermore, neuroticism moderated the relationship between insomnia and cognitive failures, with a stronger effect observed in individuals with lower levels of neuroticism. These findings underscore the importance of considering personality traits and cognitive processes in understanding mental health outcomes. This study emphasizes the critical need for interventions aimed at reducing cognitive failures and enhancing emotional stability to mitigate the impact of insomnia on mental health. Strategies to improve sleep quality, boost cognitive resilience, and regulate emotional responses could significantly enhance individuals' mental well-being. Moreover, integrating personality assessments into mental health services could facilitate more effective and personalized interventions. This article provides an original perspective on the effects of the coronavirus disease 2019 pandemic on global mental health. The content of the article addresses the complex relationships between sleep disorders, cognitive function losses, and neuroticism in light of data compiled from existing literature and current research. In addition, how these relationships have deepened during the pandemic and the effectiveness of proposed treatment methods for these phenomena are discussed in comparison with previous studies. The arguments in the article offer new perspectives and suggestions aimed at filling gaps in the literature, and make an important contribution to both clinical practice and public health policies. Li <i>et al</i>'s study provides a comprehensive framework for understanding the connections between insomnia, cognitive failures, and neuroticism, as well as their influence on anxiety and depression. The findings offer valuable implications for public health strategies, emphasizing the necessity of holistic approaches to address post-pandemic mental health challenges.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"104796"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive and negative risk-taking behaviors in adolescents: Distinct characteristics, interrelationships, and influencing factors.","authors":"Jun-Jie Zhang, En-Na Wang","doi":"10.5498/wjp.v15.i6.106944","DOIUrl":"10.5498/wjp.v15.i6.106944","url":null,"abstract":"<p><p>Adolescence is a crucial period marked by significant developmental changes, during which risk-taking behaviors can be both a normative part of development and a potential source of concern. However, prior research has focused predominantly on the adverse aspects of risk-taking (<i>i.e.</i>, negative risk-taking), overlooked the positive counterpart (<i>i.e.</i>, positive risk-taking), and lacked a detailed examination of both. This study aims to elucidate the distinct characteristics and interrelationships of positive and negative risk-taking behaviors among adolescents and to identify the key factors that influence these behaviors. Through a comprehensive synthesis of theoretical and empirical literature, we explore the multifaceted nature of risk-taking, highlighting its complex influencing factors, including individual traits, family dynamics, peer influence, school environment, and broader community contexts. By identifying the shared and unique factors contributing to positive and negative risk-taking behaviors, we can enable adolescents to navigate this complex stage of life and design targeted interventions. Future research directions include the application of person-centered approaches, the implementation of longitudinal tracking and the interactive effects of influencing factors, among other aspects.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106944"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future anxiety and belongingness in young and older adults: An empirical study.","authors":"Elif Sarac, Esra Yıldız","doi":"10.5498/wjp.v15.i6.106227","DOIUrl":"10.5498/wjp.v15.i6.106227","url":null,"abstract":"<p><strong>Background: </strong>Human beings, by nature, have many expectations that create a feeling of anxiety about the future, but they are endured and long-ranged. They expect to have relationships with others and need to perceive an emotional interest, an interpersonal bond, and sustainment to continue living. Perceiving this link is required for feelings of belongingness, which decreases future anxiety.</p><p><strong>Aim: </strong>To investigate the future anxiety and belongingness of young and older adults and determine their relationships.</p><p><strong>Methods: </strong>The study was conducted with 404 volunteer participants. Data were collected using the demographic characteristics from the \"Dark Future Scale\" and \"General Belongingness Scale\".</p><p><strong>Results: </strong>The mean age of older adults was 66.76 ± 3.74, while that of younger adults was 36.72 ± 10.12. The average score for \"future anxiety\" was 18.81 ± 7.59, and for \"general belongingness\", it was 63.31 ± 1.40. Findings indicated a reverse correlation between future anxiety and belongingness. A significant difference in belonging scores was observed between young and older adults (<i>P</i> = 0.016, which is < 0.05), whereas no significant difference was found regarding future anxiety scores (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Participants had a moderate level of \"future anxiety\" and higher \"belongingness\". Lower belongingness scores correlated with increased future anxiety. Older adults reported a lower sense of belonging than younger individuals.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106227"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer's disease.","authors":"Ya-Ni Zheng, Yan Wang, Ling Chen, Li-Zhang Xu, Lei Zhang, Jia-Lu Wang, Juan Liu, Qi-Lei Zhang, Qiong-Lan Yuan","doi":"10.5498/wjp.v15.i6.105751","DOIUrl":"10.5498/wjp.v15.i6.105751","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder currently lacking effective therapeutic interventions. Pathological hallmarks of AD include intracellular neurofibrillary tangles (NFTs) and extracellular amyloid beta (Aβ) plaques. Neuroplastin 65 (NP65), highly expressed in the brain, has been previously shown to mitigate cognitive impairments and decrease Aβ plaques in the AD mouse model, suggesting that NP65 is involved in AD neuropathology. However, direct evidence linking NP65 expression to AD pathogenesis in human brain remains absent.</p><p><strong>Aim: </strong>To quantify NP65 isoform expression gradients across distinct neuroanatomical regions in the healthy brain and investigate the alterations of NP65 expression in the AD brain.</p><p><strong>Methods: </strong>Immunohistochemical, immunofluorescent and western blot analyses were used to investigate NP65 expression in 19 postmortem brains (AD = 10, controls = 9). Double immunostaining with 6E10 and or phosphorylated-microtubule-associated protein tau (AT-8, a marker for NFT) markers was performed to assess NP65 colocalization with Aβ plaques and NFTs.</p><p><strong>Results: </strong>In controls, NP65 was highly expressed in a wide-range of brain areas. AD cases showed significantly increased NP65 immunoreactivity across multiple brain regions, including the frontal and temporal cortex, hippocampus, and cerebellum, compared to controls. Western blot analysis consistently confirmed significantly elevated NP65 expression in the hippocampus of AD patients relative to controls. Double immunostaining demonstrated partial colocalization of NP65 with NFTs and Aβ plaques in AD brain tissue.</p><p><strong>Conclusion: </strong>Our findings demonstrate a significant increase of NP65 protein, which colocalizes with NFTs and Aβ plaques in AD brains, providing direct evidence supporting a critical role of NP65 expression in the neuropathological mechanisms of this disease.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105751"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized pelvic floor rehabilitation training on psychological and functional recovery in postpartum women with generalized anxiety disorder.","authors":"Cong-Ying Zhao, Shu-Qing Han, Xian-Chai Peng, Zhen-Hong Liu","doi":"10.5498/wjp.v15.i6.103738","DOIUrl":"10.5498/wjp.v15.i6.103738","url":null,"abstract":"<p><strong>Background: </strong>Postpartum women are at an increased risk of generalized anxiety disorder (GAD), which can negatively affect both mental health and physical recovery. Pelvic floor dysfunction, common in this population, can exacerbate psychological distress. Although pelvic floor rehabilitation is effective in physical recovery, its potential to improve psychological outcomes, especially in women with GAD, remains underexplored.</p><p><strong>Aim: </strong>To evaluate the effectiveness of an individualized pelvic floor rehabilitation program in improving anxiety, pelvic floor function, and quality of life in postpartum women with GAD.</p><p><strong>Methods: </strong>A retrospective study was performed to analyze 80 postpartum women with GAD who completed a 12-week individualized pelvic floor rehabilitation program (January 2020-December 2024), combining supervised pelvic floor muscle training and psychological support. Primary outcomes were changes in GAD-7 and Hamilton anxiety rating scale (HAM-A) scores and pelvic floor function measured by surface electromyography (sEMG). Secondary outcomes included World Health Organization quality of life-BREF, pelvic floor symptom severity, and impact on daily activities (pelvic floor impact questionnaire). Assessments were conducted at baseline and 6 and 12 weeks during the intervention period.</p><p><strong>Results: </strong>Significant improvements were observed in anxiety measures, with mean GAD-7 scores decreasing from 14.8 ± 3.2 at baseline to 8.2 ± 2.9 at week 12 (<i>P</i> < 0.001) and HAM-A scores decreasing from 22.6 ± 4.5 to 12.4 ± 3.8 (<i>P</i> < 0.001). Pelvic floor function showed substantial enhancement, with sEMG amplitude increasing from 22.4 ± 5.6 µV to 35.9 ± 6.8 µV (<i>P</i> < 0.001). Quality of life improved across all domains, with the most significant improvements in psychological (28.5% increase) and physical health (25.8% increase). Program adherence was 91.5% for the supervised sessions, and no serious adverse events were reported.</p><p><strong>Conclusion: </strong>Individualized pelvic floor rehabilitation training effectively improves both psychological and functional outcomes in postpartum women with GAD. The high adherence and significant outcomes make this integrated approach feasible and effective.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"103738"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice.","authors":"Wen-Yue Chang, Qiao-Zhen Qin, Xiao-Tong Li, Jia-Jing Wang, Yue Chen, Hua-Qiang Ruan, Yan-Nv Qu, Xiao-Xia Jiang, Hui-Xia He","doi":"10.5498/wjp.v15.i6.104809","DOIUrl":"10.5498/wjp.v15.i6.104809","url":null,"abstract":"<p><strong>Background: </strong>Hypobaric hypoxia exposure (HHE) often causes neuropsychiatric disorders. Due to its complex mechanism, efficient strategies for alleviating HHE-induced anxiety- and depression-like behaviors remain limited.</p><p><strong>Aim: </strong>To characterize alterations in the oral and gut microbiota following HHE and to explore a potential microbiota-based intervention to mitigate associated psychiatric symptoms.</p><p><strong>Methods: </strong>C57BL/6J mice were exposed to simulated high-altitude hypoxia (5000 m) for 1, 3, 5, or 7 days. Behavioral assessments, including the open field test, elevated plus maze, and forced swim test, were conducted to evaluate anxiety- and depression-like behaviors. Oral and fecal microbiota were analyzed using 16S rRNA sequencing to assess changes in microbial composition and diversity. Immunofluorescence staining was performed to examine c-Fos expression in brain nuclei. A probiotic formulation containing <i>Lactobacillus rhamnosus</i> (<i>L. rhamnosus</i>) DSM17648, <i>Lactobacillus acidophilus</i> DDS-1, and <i>L. rhamnosus</i> UALR-06 was administered to mice subjected to one day of HHE (HH1) to evaluate its therapeutic efficacy.</p><p><strong>Results: </strong>Behavioral tests revealed that HHE caused anxiety- and depression-like behaviors, which were most pronounced after 1 day of exposure. The IF data revealed significantly increased expression of c-Fos in various brain nuclei after HHE, including the anterior cingulate cortex, paraventricular thalamic nucleus, lateral habenula nucleus, paraventricular hypothalamic nucleus, lateral hypothalamus, and periaqueductal gray. The 16S rRNA sequencing results demonstrated a sharp decline in the abundance of <i>Lactobacillus</i> in the oral microbiota of mice exposed to HH1 and a marked decrease in the abundance of <i>Lactobacillus</i> and <i>Bifidobacterium</i> in the fecal microbiota of mice exposed to three days of HHE. Finally, oral administration and gavage of <i>Lactobacillus</i> significantly alleviated anxiety- and depression-like behaviors in HH1 mice.</p><p><strong>Conclusion: </strong>HHE caused significant variations in the oral and fecal microbiota of mice. <i>Lactobacillus</i> supplementation alleviated anxiety- and depression-like behaviors in mice. Improving oral flora may relieve HHE-induced psychiatric disorders.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"104809"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses.","authors":"Kang-Ning Li, Shi-Xiong Tang, You-Fu Tao, Hai-Ruo He, Mo-Han Ma, Qian-Qian Zhang, Mei Huang, Wen-Tao Chen, Hui Liang, Ao-Qian Deng, Si-Rui Gao, Fan-Yu Meng, Yi-Lin Peng, Yu-Meng Ju, Wen-Wen Ou, Su Shu, Yan Zhang","doi":"10.5498/wjp.v15.i6.105555","DOIUrl":"10.5498/wjp.v15.i6.105555","url":null,"abstract":"<p><strong>Background: </strong>Rumination is a critical psychological factor contributing to the relapse of major depressive episodes (MDEs) and a core residual symptom in remitted MDEs. Investigating its neural correlations is essential for developing strategies to prevent MDE relapse. Despite its clinical importance, the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.</p><p><strong>Aim: </strong>To investigate the brain network mechanism underlying rumination in patients with remitted MDEs using functional magnetic resonance imaging (fMRI).</p><p><strong>Methods: </strong>We conducted an fMRI-based rumination-distraction task to induce rumination and distraction states in 51 patients with remitted MDEs. Functional connectivity (FC) was analyzed using the network-based statistic (NBS) approach, and eight topological metrics were calculated to compare the network topological properties between the two states. Correlation analyses were further performed to identify the relationships between individual rumination levels and the significantly altered brain network metrics.</p><p><strong>Results: </strong>The NBS analysis revealed that the altered FCs between the rumination and distraction states were located primarily in the frontoparietal, default mode, and cerebellar networks. No significant correlation was detected between these altered FCs and individual rumination levels. Among the eight topological metrics, the clustering coefficient, shortest path length, and local efficiency were significantly lower during rumination and positively correlated with individual rumination levels. In contrast, global efficiency was greater in the rumination state than in the distraction state and was negatively correlated with individual rumination levels.</p><p><strong>Conclusion: </strong>Our work revealed the altered FC and topological properties during rumination in remitted MDE patients, offering valuable insights into the neural mechanisms of rumination from a brain network perspective.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105555"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional psychiatry for hypertensive older adults.","authors":"Takahiko Nagamine","doi":"10.5498/wjp.v15.i6.106262","DOIUrl":"10.5498/wjp.v15.i6.106262","url":null,"abstract":"<p><p>Hypertension, a prevalent condition among older adults, has been identified as a risk factor for cognitive decline. Nutritional status is a pivotal factor in preserving cognitive function in hypertensive older adults. Nutritional psychiatry underscores the significance of anti-inflammatory diets in promoting mental and cognitive health. This article examined the mechanisms by which body mass index, serum hemoglobin, serum albumin, and alkaline phosphatase levels predict cognitive function in hypertensive older adults. Nutrition emerges as a modifiable factor that can be targeted to maintain cognitive function in these patients.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106262"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived stress, risk factors and prognostic monitoring loci for the development of depression.","authors":"Xuan Li, Wei Zhao, Yu-Han Wei, Xiao-Shuang Zhang, Yong Zhu, Xu-Hao Li","doi":"10.5498/wjp.v15.i6.105222","DOIUrl":"10.5498/wjp.v15.i6.105222","url":null,"abstract":"<p><p>This article examines stress and its potential role in the development of depression. By reviewing existing literature, the article explores the possible role of stress in diagnosing and monitoring depression and highlights the importance of managing personal stress in the treatment of depression. The article also discusses the many ways that stress and depression are connected, and suggests ideas for subsequent investigations. This includes developing more exact ways to measure biomarkers, exploring treatments that are not based on drugs, and looking at the effect that society has on depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105222"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for anxiety and depression in patients with atopic dermatitis and their impact on prognosis.","authors":"Kun Liu, Wei Gao, Hong-Guang Lu, Zhao-Gui Chen","doi":"10.5498/wjp.v15.i6.104738","DOIUrl":"10.5498/wjp.v15.i6.104738","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by visible lesions that can lead to anxiety and depression. These psychological impacts may severely affect the physical and mental health and the overall quality of life of the affected individuals.</p><p><strong>Aim: </strong>To identify the risk factors for anxiety and depression among patients with AD and to assess their influence on prognosis.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 273 patients with AD who visited Shanghai Jinshan Tinglin Hospital between July 2021 and June 2023. Data were collected using standardized instruments, including the general information questionnaire, hospital anxiety and depression scale, scoring AD index, and dermatology life quality index.</p><p><strong>Results: </strong>Among the evaluated patients, 24.5% had symptoms of anxiety, and 19.8% had symptoms of depression. Independent risk factors for anxiety included lower education level [odds ratio (OR) = 0.338, 95% confidence interval (CI): 0.183-0.625], increased number of medical visits (OR = 2.300, 95%CI: 1.234-4.255), sleep disorders (OR = 2.013, 95%CI: 1.032-3.923), and allergic rhinitis (OR = 2.052, 95%CI: 1.097-3.839). Factors for depression included more severe pruritus (OR = 6.837, 95%CI: 1.330-35.132), higher number of medical visits (OR = 2.979, 95%CI: 1.430-6.205), sleep disorders (OR = 2.245, 95%CI: 1.033-5.024), and asthma (OR = 2.208, 95%CI: 1.003-4.859). Dermatology life quality index scores correlated positively with anxiety, depression, scoring AD index, sleep disorders, number of visits, and intensity of pruritus (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>In patients with AD, anxiety and depression are associated with educational level, frequency of medical visits, sleep disorders, allergic rhinitis, pruritus, and asthma, all of which exacerbate symptoms and reduce quality of life.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"104738"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}