{"title":"Research status of hormone replacement therapy on mood and sleep quality in menopausal women.","authors":"Xue-Jian Wang","doi":"10.5498/wjp.v14.i9.1289","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1289","url":null,"abstract":"<p><p>Menopausal syndrome is a common disease of clinical women, which refers to a series of physical and mental symptoms caused by the fluctuation or reduction of sex hormones before and after menopause. Many of these patients have sleep and mood abnormalities that affect their health and quality of life. At present, the understanding of it is gradually improving. This paper mainly analyzes its background and current treatment.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gui-Ping Huang, Li-Ping Mai, Zhi-Jie Zheng, Xi-Pei Wang, Guo-Dong He
{"title":"Sex differences in the association between the muscle quality index and the incidence of depression: A cross-sectional study.","authors":"Gui-Ping Huang, Li-Ping Mai, Zhi-Jie Zheng, Xi-Pei Wang, Guo-Dong He","doi":"10.5498/wjp.v14.i9.1335","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1335","url":null,"abstract":"<p><strong>Background: </strong>Depression presents significant challenges to mental health care. Although physical activity is highly beneficial to mental and physical health, relatively few studies have conducted on the relationship between them.</p><p><strong>Aim: </strong>To investigate the association between muscle quality index (MQI) and incidence of depression.</p><p><strong>Methods: </strong>The data used in this cross-sectional study were obtained from the 2011-2014 National Health and Nutritional Examination Survey, which included information on MQI, depression, and confounding factors. Multivariable logistic regression models were employed, while taking into account the complex multi-stage sampling design. A restricted cubic spline model was utilized to investigate the non-linear relationship between the MQI and depression. Additionally, subgroup analyses were performed to identify influential factors.</p><p><strong>Results: </strong>The prevalence of depression in this population was 8.44%. With the adjusted model, the MQI was associated with depression in females (odds ratio = 0.68, 95% confidence interval: 0.49-0.95) but not in males (odds ratio = 1.08, 95% confidence interval: 0.77-1.52). Restricted cubic spline adjustment of all covariates showed a significant negative non-linear relationship between depression and the MQI in females. The observed trend indicated an 80% decrease in the risk of depression for each unit increase in MQI, until a value of 2.2. Subsequently, when the MQI exceeded 2.2, the prevalence of depression increased by 20% for every unit increase in the MQI. Subgroup analyses further confirmed that the MQI was negatively associated with depression.</p><p><strong>Conclusion: </strong>The MQI was inversely correlated with depression in females but not males, suggesting that females with a higher MQI might decrease the risk of depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Classification of musical hallucinations and the characters along with neural-molecular mechanisms of musical hallucinations associated with psychiatric disorders.","authors":"Xin Lian, Wei Song, Tian-Mei Si, Naomi Zheng Lian","doi":"10.5498/wjp.v14.i9.1386","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1386","url":null,"abstract":"<p><strong>Background: </strong>Musical hallucinations (MH) involve the false perception of music in the absence of external stimuli which links with different etiologies. The pathomechanisms of MH encompass various conditions. The etiological classification of MH is of particular importance and offers valuable insights to understand MH, and further to develop the effective treatment of MH. Over the recent decades, more MH cases have been reported, revealing newly identified medical and psychiatric causes of MH. Functional imaging studies reveal that MH activates a wide array of brain regions. An up-to-date analysis on MH, especially on MH comorbid psychiatric conditions is warranted.</p><p><strong>Aim: </strong>To propose a new classification of MH; to study the age and gender differences of MH in mental disorders; and neuropathology of MH.</p><p><strong>Methods: </strong>Literatures searches were conducted using keywords such as \"music hallucination,\" \"music hallucination and mental illness,\" \"music hallucination and gender difference,\" and \"music hallucination and psychiatric disease\" in the databases of PubMed, Google Scholar, and Web of Science. MH cases were collected and categorized based on their etiologies. The <i>t</i>-test and ANOVA were employed (<i>P</i> < 0.05) to compare the age differences of MH different etiological groups. Function neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were discussed.</p><p><strong>Results: </strong>Among the 357 yielded publications, 294 MH cases were collected. The average age of MH cases was 67.9 years, with a predominance of females (66.8% females <i>vs</i> 33.2% males). MH was classified into eight groups based on their etiological mechanisms. Statistical analysis of MH cases indicates varying associations with psychiatric diagnoses.</p><p><strong>Conclusion: </strong>We carried out a more comprehensive review of MH studies. For the first time according to our knowledge, we demonstrated the psychiatric conditions linked and/or associated with MH from statistical, biological and molecular point of view.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ting Xu, Xi Mei, Zheng Zhao, Yue-Hong Liu, Cheng-Ying Zheng
{"title":"Effectiveness of anti-psychiatric treatment on visual and haptic perceptual disorder for a patient with Alzheimer's disease: A case report.","authors":"Ting Xu, Xi Mei, Zheng Zhao, Yue-Hong Liu, Cheng-Ying Zheng","doi":"10.5498/wjp.v14.i9.1404","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1404","url":null,"abstract":"<p><strong>Background: </strong>Perception is frequently impaired in patients with Alzheimer's disease (AD). Several patients exhibit visual or haptic hallucinations.</p><p><strong>Case summary: </strong>A 71-year-old Chinese man presented with visual and haptic hallucinations he had been experiencing for 2 weeks. The clinical manifestations were the feeling of insects crawling and biting the limbs and geison. He looked for the insects while itching and scratching, which led to skin breakage on the limbs. He was treated with topical and anti-allergic drugs in several dermatology departments without any significant improvement. After admission, the patient was administered risperidone (0.5 mg) and duloxetine (2 mg/day). One week later, the dose of risperidone was increased to 2 mg/day, and that of duloxetine was increased to 60 mg/day. After 2 weeks of treatment, the patient's sensation of insects crawling and biting disappeared, and his mood stabilized.</p><p><strong>Conclusion: </strong>This patient manifested psychiatric behavioral symptoms caused by AD brain atrophy. It was important to re-evaluate the patient's cognitive-psychological status when the patient repeatedly went to the hospital for treatment. Follow-up attention to cognitive function and the consideration of perceptual deficits as early manifestations of AD should be considered.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence.","authors":"Wei-Min He, Xin-Yuan Zhang, Wei-Gen Xie, Dan-Ping Lv, Qun-Di Shen","doi":"10.5498/wjp.v14.i9.1346","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1346","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenic patients are prone to violence, frequent recurrence, and difficult to predict. Emotional and behavioral abnormalities during the onset of the disease, resulting in active myocardial enzyme spectrum.</p><p><strong>Aim: </strong>To explored the expression level of myocardial enzymes in patients with schizophrenia and its predictive value in the occurrence of violence.</p><p><strong>Methods: </strong>A total of 288 patients with schizophrenia in our hospital from February 2023 to January 2024 were selected as the research object, and 100 healthy people were selected as the control group. Participants' information, clinical data, and laboratory examination data were collected. According to Modified Overt Aggression Scale score, patients were further divided into the violent (123 cases) and non-violent group (165 cases).</p><p><strong>Results: </strong>The comparative analysis revealed significant differences in serum myocardial enzyme levels between patients with schizophrenia and healthy individuals. In the schizophrenia group, the violent and non-violent groups also exhibited different levels of serum myocardial enzymes. The levels of myocardial enzymes in the non-violent group were lower than those in the violent group, and the patients in the latter also displayed aggressive behavior in the past.</p><p><strong>Conclusion: </strong>Previous aggressive behavior and the level of myocardial enzymes are of great significance for the diagnosis and prognosis analysis of violent behavior in patients with schizophrenia. By detecting changes in these indicators, we can gain a more comprehensive understanding of a patient's condition and treatment.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of gynecological cancers on women's mental health.","authors":"Giuseppe Marano, Marianna Mazza","doi":"10.5498/wjp.v14.i9.1294","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1294","url":null,"abstract":"<p><p>Gynecological cancers and their treatments are associated with both specific and non-specific long-term physiological effects. Cancer patients face transformations in their lifestyle, body image, role, and social interactions and suffer from physical, psychological, and economic problems. The mental health of cancer patients is of great importance and requires special attention, as growing evidence demonstrates its influence not only on quality of life but also on treatment compliance. Gynecological cancers have peculiar psychological consequences, which are linked to the specificity of the site of the neoplasia. Clinicians should be aware of the importance of protecting the psychophysical health of these patients and the fact that their physical health and quality of life also depend on the quality of their mental health. It is possible to structure targeted and effective prevention interventions and treatments to reduce psychological distress and improve the quality of life of subjects living with gynecological cancers.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xian Zhang, Yang Liu, Hua-Fei Tang, Feng Jiang, Chun-Liang Chen, Ting-Ting Wang, Hui-Zhong Gu, Qiang Zhao, Rui Ma
{"title":"Shugan Jieyu capsule effects on peripheral blood micro-124, micro-132, and brain-derived neurotrophic factor in patients with mild to moderate depression.","authors":"Xian Zhang, Yang Liu, Hua-Fei Tang, Feng Jiang, Chun-Liang Chen, Ting-Ting Wang, Hui-Zhong Gu, Qiang Zhao, Rui Ma","doi":"10.5498/wjp.v14.i9.1354","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1354","url":null,"abstract":"<p><strong>Background: </strong>To assess the effectiveness of Shugan Jieyu capsules on peripheral blood miR-124, miR-132, and brain-derived neurotrophic factor (BDNF) levels in patients with mild to moderate depression following coronary artery intervention [percutaneous coronary intervention (PCI)] for coronary heart disease.</p><p><strong>Aim: </strong>To evaluate the therapeutic efficacy of Shugan Jieyu capsules and their effects on the peripheral blood levels of miR-124, miR-132, and BDNF in patients with mild to moderate depression following PCI for coronary heart disease.</p><p><strong>Methods: </strong>Patients with mild-to-moderate depression of the liver-qi stagnation type after PCI for coronary heart disease at the 305<sup>th</sup> Hospital of the People's Liberation Army were enrolled from June 2022 to November 2023 and randomly assigned to two groups: Experimental (treated with Shugan Jieyu capsules) and control (treated with escitalopram oxalate tablets). This study compared the antidepressant effects of these treatments using 17-item Hamilton Rating Scale for Depression (HAMD-17) scores, metabolic equivalents, low-density lipoprotein cholesterol, BDNF, high-sensitivity C-reactive protein levels, miR-124 and miR-132 levels, distribution of immune-related lymphocyte subsets, and traditional Chinese medicine syndrome scores before and after 6 weeks of treatment.</p><p><strong>Results: </strong>No significant difference was observed in any index between the two groups before treatment (<i>P</i> > 0.05). After treatment, the total efficacy rates were 93.33% and 90.00% in the experimental and control groups, respectively. Experimental group had significantly lower scores for the main and secondary syndromes compared to the control group (<i>P</i> < 0.05). No significant difference was observed in the metabolic equivalents between the two groups before and after treatment (<i>P</i> > 0.05). The levels of low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and miR-132 were significantly lower, whereas those of miR-124, BDNF, CD3+T lymphocytes, CD3+CD4+T helper lymphocytes, and CD3+CD4+/CD3+CD8+ cells were significantly higher in the experimental group compared to the control group (<i>P</i> < 0.05). The incidence of adverse reactions during experimental group was significantly lower than that in control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Shugan Jieyu capsules have good efficacy in patients with mild-to-moderate depression after PCI, and its mechanism may contribute to the regulation of miR-124, miR-132, BDNF levels, and lymphoid immune cells.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on psychological resilience and associated influencing factors in lung cancer patients with bone metastases.","authors":"Chao-Fan Guo, Li-Li Wu, Zhong-Zhong Peng, Hua-Long Lin, Jie-Ni Feng","doi":"10.5498/wjp.v14.i9.1326","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1326","url":null,"abstract":"<p><strong>Background: </strong>Evaluating the psychological resilience of lung cancer (LC) patients helps understand their mental state and guides future treatment. However, there is limited research on the psychological resilience of LC patients with bone metastases.</p><p><strong>Aim: </strong>To explore the psychological resilience of LC patients with bone metastases and identify factors that may influence psychological resilience.</p><p><strong>Methods: </strong>LC patients with bone metastases who met the inclusion criteria were screened from those admitted to the Third Affiliated Hospital of Wenzhou Medical University. The psychological scores of the enrolled patients were collected. They were then grouped based on the mean psychological score: Those with scores lower than the mean value were placed in the low-score group and those with scores equal to or greater than the mean value was placed in the high-score group. The baseline data (age, gender, education level, marital status, residence, monthly income, and religious beliefs), along with self-efficacy and medical coping mode scores, were compared.</p><p><strong>Results: </strong>This study included 142 LC patients with bone metastases admitted to our hospital from June 2022 to December 2023, with an average psychological resilience score of 63.24 ± 9.96 points. After grouping, the low-score group consisted of 69 patients, including 42 males and 27 females, with an average age of 67.38 ± 9.55 years. The high-score group consisted of 73 patients, including 49 males and 24 females, with a mean age of 61.97 ± 5.00 years. <i>χ</i> <sup>2</sup> analysis revealed significant differences between the two groups in education level (<i>χ</i> <sup>2</sup> = 6.604, <i>P</i> = 0.037), residence (<i>χ</i> <sup>2</sup> = 12.950, <i>P</i> = 0.002), monthly income (<i>χ</i> <sup>2</sup> = 9.375, <i>P</i> = 0.009), and medical coping modes (<i>χ</i> <sup>2</sup> = 19.150, <i>P</i> = 0.000)<i>.</i> Independent sample <i>t</i>-test showed that the high-score group had significantly higher self-efficacy scores (<i>t</i> = 3.383, <i>P</i> = 0.001) and lower age than the low-score group (<i>t</i> = 4.256, <i>P</i> < 0.001). Furthermore, multivariate logistic regression hazard analysis confirmed that self-efficacy is an independent protective factor for psychological resilience [odds ratio (OR) = 0.926, <i>P</i> = 0.035, 95% confidence interval (CI): 0.862-0.995], while age (OR = 1.099, <i>P</i> = 0.003, 95%CI: 1.034-1.169) and medical coping modes (avoidance <i>vs</i> confrontation: OR = 3.767, <i>P</i> = 0.012, 95%CI: 1.342-10.570; resignation <i>vs</i> confrontation: OR = 5.687, <i>P</i> = 0.001, 95%CI: 1.974-16.385) were identified as independent risk factors. A predictive model based on self-efficacy, age, and medical coping modes was developed. The receiver operating characteristic analysis showed an area under the curve value of 0.778 (95%CI: 0.701-0.856, <i>P</i> < 0.001), indicating that the model ha","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bang-Shu Zhao, Bi Deng, Qi-Bin Chen, Xiao Li, You Yang, Su Min
{"title":"Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder.","authors":"Bang-Shu Zhao, Bi Deng, Qi-Bin Chen, Xiao Li, You Yang, Su Min","doi":"10.5498/wjp.v14.i9.1375","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1375","url":null,"abstract":"<p><strong>Background: </strong>Electroconvulsive therapy (ECT) is both an effective treatment for patients with major depressive disorder (MDD) and a noxious stimulus. Although some studies have explored the effect of sedation depth on seizure parameters in ECT, there is little research on the noxious stimulation response to ECT. In this study, we used two electroencephalography (EEG)-derived indices, the quantitative consciousness (qCON) index and quantitative nociceptive (qNOX) index, to monitor sedation, hypnosis, and noxious stimulation response in patients with MDD undergoing acute ECT.</p><p><strong>Aim: </strong>To evaluate the effect of anesthesia depth based on the qCON and qNOX indices on seizure parameters.</p><p><strong>Methods: </strong>Patients with MDD (<i>n</i> = 24) underwent acute bilateral temporal ECT under propofol anesthesia. Before ECT, the patients were randomly divided into three groups according to qCON scores (qCON60-70, qCON50-60, and qCON40-50). Continuous qCON monitoring was performed 3 minutes before and during ECT, and the qCON, qNOX, vital signs, EEG seizure parameters, and complications during the recovery period were recorded. The 24-item Hamilton Rating Scale for Depression, Zung's Self-rating Depression Scale, and Montreal Cognitive Assessment scores were evaluated before the first ECT session, after the fourth ECT session, and after the full course of ECT.</p><p><strong>Results: </strong>A total of 193 ECT sessions were performed on 24 participants. The qCON index significantly affected the EEG seizure duration, peak mid-ictal amplitude, and maximum heart rate during ECT (<i>P</i> < 0.05). The qNOX index significantly affected the post-ictal suppression index (<i>P</i> < 0.05). Age, number of ECT sessions, and anesthetic-ECT time intervals also had a significant effect on EEG seizure parameters (<i>P</i> < 0.05). However, there were no significant differences in complications, 24-item Hamilton Rating Scale for Depression scores, Zung's Self-rating Depression Scale scores, or Montreal Cognitive Assessment scores among the three groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Electrical stimulation at a qCON index of 60-70 resulted in better EEG seizure parameters without increasing complications in patients with MDD undergoing bilateral temporal ECT under propofol anesthesia.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gui-Bo Wang, Xue-Feng Zhang, Bing Liang, Jie Lei, Jun Xue
{"title":"Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections.","authors":"Gui-Bo Wang, Xue-Feng Zhang, Bing Liang, Jie Lei, Jun Xue","doi":"10.5498/wjp.v14.i9.1319","DOIUrl":"https://doi.org/10.5498/wjp.v14.i9.1319","url":null,"abstract":"<p><strong>Background: </strong>Pediatric abdominal infection is a common but serious disease that requires timely and effective treatment. In surgical treatment, accurate diagnosis and rational application of antibiotics are the keys to improving treatment effects.</p><p><strong>Aim: </strong>To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic therapy.</p><p><strong>Methods: </strong>A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were grouped. The observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing, and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing; the control group only sent bacterial culture and drug sensitivity testing during the operation.</p><p><strong>Results: </strong>White blood cell count, C-reactive protein, procalcitonin, 3 days after surgery, showed better postoperative index than the control group (<i>P</i> < 0.05). The hospital stay in the observation group was significantly shorter than that in the control group. The hospitalization cost in the observation group was significantly lower than that in the control group, and the difference between the two groups was statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics, improving treatment outcomes and reducing medical costs to some extent.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}