World Journal of Psychiatry最新文献

{"title":"Effects of positive psychological control intervention on sleep and psychology of officers and soldiers working at sea.","authors":"Yu-Qing Liu, Jian-Liang Sun, Mei Jing, Guo-Xiang Liu, Jie Shi, Xue-Wei Zhu, Fei Wang, Mei-Hua Ye","doi":"10.5498/wjp.v14.i10.1538","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1538","url":null,"abstract":"<p><strong>Background: </strong>The working environment of submarine crews is also very special. They are in a closed, high-temperature, high-noise, high-vibration and narrow working and living space for a long time, and they suffer from physical discomfort caused by seasickness, which will affect the mental health of officers and soldiers. American psychologists have achieved positive results in psychological resilience training for officers and soldiers from the perspective of positive psychology. At present, there are few reports on the correlation between psychological resilience in the field of domestic research on submarine crew psychology, and it is necessary to conduct further research.</p><p><strong>Aim: </strong>To explore the impact of active psychological regulation intervention on officers and soldiers operating in confined spaces at sea.</p><p><strong>Methods: </strong>A total of 121 soldiers working in a confined space of a large ship were randomly divided into an experimental group and a control group. The 50 soldiers in the experimental group were given a training course intervention, while the 71 soldiers in the control group did not receive any intervention measures. The Pittsburgh Sleep Quality Index, Psychological Resilience Scale, military Psychological Stress Self-Assessment Questionnaire, and General Self-Efficacy Scale scores were compared before and 6 months after the intervention.</p><p><strong>Results: </strong>Under the positive psychological control intervention, except for sleep efficiency (<i>P</i> = 0.05), the difference between the remaining dimensions of the Pittsburgh Sleep Quality Index scores and the total scores of the experimental group compared with the control group was statistically significant (<i>P</i> < 0.05); the assessment of the psychological condition showed that, in addition to the Psychological Stress Self-assessment Questionnaire for Military Personnel scores (<i>P</i> = 0.05), the scores of the Mental Toughness Scale (Dispositional Resilience Scale Resilience II) in the experimental group, General Self-Efficacy Scale scores were statistically significant (<i>P</i> < 0.05) compared to pre-intervention.</p><p><strong>Conclusion: </strong>Positive psychological intervention and control can improve the sleep state and psychological state of officers and soldiers working in confined space at sea.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder.","authors":"Mi Wang, Wen-Tao Chen, Hao-Ting Wang, Bang-Shan Liu, Yu-Meng Ju, Qiang-Li Dong, Xiao-Wen Lu, Jin-Rong Sun, Liang Zhang, Hua Guo, Fu-Tao Zhao, Wei-Hui Li, Li Zhang, Ze-Xuan Li, Mei Liao, Yan Zhang, Jin Liu, Ling-Jiang Li","doi":"10.5498/wjp.v14.i10.1474","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1474","url":null,"abstract":"<p><strong>Background: </strong>Symptoms of depression and comorbid anxiety are known risk factors for cognitive impairment in major depressive disorder (MDD). Understanding their relationships is crucial for developing targeted interventions to mitigate cognitive impairments in MDD patients. We expect that the severity of sleep disturbances and other depressive symptoms will be positively correlated with the degree of cognitive impairments. We also hypothesize that anxiety symptoms, especially psychic anxiety, is a key factor in predicting cognitive performance in MDD patients and may indirectly contribute to cognitive impairment by affecting sleep disturbances and other potential factors.</p><p><strong>Aim: </strong>To determine which dimension of the depressive and anxiety symptoms predicts cognitive impairment during a depressive episode.</p><p><strong>Methods: </strong>A comprehensive neurocognitive test battery assessed executive function, attention, processing speed, and memory in 162 medication-free MDD patients and 142 matched healthy controls. The 24-item Hamilton Depression Rating Scale was used to assess depressive symptoms, and the 14-item Hamilton Anxiety Scale was used to assess anxiety symptoms. Linear regression analyses and mediation analyses were conducted to evaluate the impact of depressive and anxiety symptoms, as well as their interactions, on cognitive impairments.</p><p><strong>Results: </strong>Among the depressive symptoms, sleep disturbances were associated with poorer executive function (<i>P</i> = 0.004), lower processing speed (<i>P</i> = 0.047), and memory impairments (<i>P</i> < 0.001), and psychomotor retardation (PR) was associated with lower processing speed in patients with MDD (<i>P</i> = 0.019). Notably, PR was found to mediate the impact of sleep disturbances on the processing speed. Regarding anxiety symptoms, psychic anxiety, rather than somatic anxiety, was associated with cognitive impairments in all aspects. Sleep disturbances mediated the effect of psychic anxiety on executive function [β = -0.013, BC CI (-0.027, -0.001)] and memory [β = -0.149, BC CI (-0.237, -0.063)], while PR mediated its effect on processing speed (β = -0.023, BC CI (-0.045, -0.004)].</p><p><strong>Conclusion: </strong>Sleep disturbances may be a key predictor of poorer executive function, lower processing speed, and memory loss, while PR is crucial for lower processing speed during a depressive episode. Psychic anxiety contributes to all aspects of cognitive impairments, mediated by sleep disturbances and PR.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interoception mediates the association between social support and sociability in patients with major depressive disorder.","authors":"Wen-Liang Wang, Ji-Kang Liu, Yi-Fan Sun, Xiao-Hong Liu, Yu-Hang Ma, Xue-Zheng Gao, Li-Min Chen, Zhen-He Zhou, Hong-Liang Zhou","doi":"10.5498/wjp.v14.i10.1484","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1484","url":null,"abstract":"<p><strong>Background: </strong>Interoception dysfunction has an important impact on the onset and development of major depressive disorder (MDD). Social support serves as a protective factor against MDD, and sociability also plays a significant role in this condition. These interconnected constructs-social support and sociability-play pivotal roles in MDD. However, no research on the mechanisms underlying the associations between social support and sociability, particularly the potential role of interoception, have been reported.</p><p><strong>Aim: </strong>To investigate the mediating effect of interoception between social support and social ability and to explore the independent role of social support in sociability.</p><p><strong>Methods: </strong>The participants included 292 patients with MDD and 257 healthy controls (HCs). The patient health questionnaire 9, the multidimensional assessment of interoception awareness, version 2 (MAIA-2), the social support rating scale (SSRS), and the Texas social behavior inventory (TSBI) were used to assess depression, interoception, social support, and sociability, respectively. A mediation analysis model for the eight dimensions of interoception (noticing, not distracting, not worrying, attention regulation, emotional awareness, self-regulation, body listening, and trust), social support, and sociability were established to evaluate the mediating effects.</p><p><strong>Results: </strong>A partial correlation analysis of eight dimensions of the MAIA-2, SSRS, and TSBI scores, with demographic data as control variables, revealed pairwise correlations between the SSRS score and both the MAIA-2 score and TSBI score. In the major depression (MD) group, the SSRS score had a positive direct effect on the TSBI score, while the scores for body listening, emotional awareness, self-regulation, and trust in the MAIA-2C had indirect effects on the TSBI score. In the HC group, the SSRS score had a positive direct effect on the TSBI score, and the scores for attention regulation, emotional awareness, self-regulation, and trust in the MAIA-2C had indirect effects on the TSBI score. The proportion of mediators in the MD group was lower than that in the HC group.</p><p><strong>Conclusion: </strong>Interoceptive awareness is a mediating factor in the association between social support and sociability in both HCs and depressed patients. Training in interoceptive awareness might not only help improve emotional regulation in depressed patients but also enhance their social skills and support networks.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain networks in newborns and infants with and without sensorineural hearing loss: A functional near-infrared spectroscopy study.","authors":"Juan Tan, Qian-Mei Hou, Fen Zhang, Xu Duan, Yan-Long Zhang, Yu-Jun Lee, Hao Yan","doi":"10.5498/wjp.v14.i10.1547","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1547","url":null,"abstract":"<p><strong>Background: </strong>Understanding the impact of early sensory deficits on brain development is essential for understanding developmental processes and developing potential interventions. While previous studies have looked into the impact of prenatal experiences on language development, there is a lack of research on how these experiences affect early language and brain function development in individuals with sensorineural hearing loss (SNHL).</p><p><strong>Aim: </strong>To investigate SNHL effects on early brain development and connectivity in 4-month-olds <i>vs</i> healthy newborns and controls.</p><p><strong>Methods: </strong>The research involved analyzing the functional brain networks of 65 infants, categorized into three groups: 28 healthy newborns, 22 4-month-old participants with SNHL, and 15 age-matched healthy participants. The resting-state functional connectivity was measured and compared between the groups using functional near-infrared spectroscopy and graph theory to assess the brain network properties.</p><p><strong>Results: </strong>Significant differences were found in resting-state functional connectivity between participants with SNHL and age-matched controls, indicating a developmental lag in brain connectivity for those with SNHL. Surprisingly, SNHL participants showed better connectivity development compared to healthy newborns, with connectivity strengths of 0.13 ± 0.04 for SNHL, 0.16 ± 0.08 for controls, and 0.098 ± 0.04 for newborns. Graph theory analysis revealed enhanced global brain network properties for the SNHL group, suggesting higher communication efficiency at 4 months. No significant differences were noted in network properties between 4-month-old SNHL participants and neonates. A unique pattern of central hubs was observed in the SNHL group, with 2 hubs in the left hemisphere compared to 6 in controls.</p><p><strong>Conclusion: </strong>4-month-old infants with SNHL have a distinct brain network pattern with efficient long-distance information transmission but less effective local communication compared to age-matched controls.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression.","authors":"Yi Cheng, Li-Jing Lv, Yu Cui, Xiao-Mei Han, Yan Zhang, Cai-Xia Hu","doi":"10.5498/wjp.v14.i10.1437","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1437","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is a common form of hair loss that can be influenced by psychological factors.</p><p><strong>Aim: </strong>To investigate the impact of mental stress on neurotrophic factors in patients with AGA and correlate the findings with the progression of AGA.</p><p><strong>Methods: </strong>A total of 120 patients with AGA were analyzed in this study, which were divided into a non-stress group (<i>n</i> = 30) and a stress group (<i>n</i> = 90) on the basis of the presence or absence of psychological stress confirmed by Depression Anxiety Stress Scale-21 scale. The baseline demographic characteristics, serum cortisol levels, hair growth parameters, neurotrophic factors, and AGA progression scores between the non-stress and stress groups were compared. Correlation analyses were conducted to assess the relationships among stress, neurotrophic factors, hair loss progression, and AGA progression.</p><p><strong>Results: </strong>This study revealed significantly higher cortisol levels throughout the day in the stress group than in the non-stress group. The stress group exhibited lower levels of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor and higher expression levels of neurotrophin (NT)-3 and NT-4 than the non-stress group. Hair parameters indicated lower hair diameter, decreased hair density, and more severe AGA grading in the stress group, whereas follicle count and terminal/vellus hair ratio showed no significant differences between the two groups. After 1 year of treatment with 5% minoxidil, efficacy was observed to be lower but AGA progression was notably more pronounced in the stress group than in the non-stress group. Disease progression was positively correlated with high stress and NT-4 levels.</p><p><strong>Conclusion: </strong>This study provides compelling evidence of the influence of mental stress on neurotrophic factors and its correlation with the progression of AGA. The findings underscore the need for a comprehensive approach to the management of AGA that considers the physiological and psychosocial aspects. Further research is warranted to validate the findings and explore targeted therapeutic interventions for individuals with stress-related AGA.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum neutrophil gelatinase-associated lipocalin levels and cognitive impairment, anxiety, and depressive symptoms in acute ischemic stroke.","authors":"You-Quan Gu, Xuan Zhou, Li-He Yao, Qiang Wang, Chao-Ning Zhou, Zhao-Dong Liu","doi":"10.5498/wjp.v14.i10.1467","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1467","url":null,"abstract":"<p><strong>Background: </strong>Acute ischemic stroke (AIS) is a significant global health issue with increasing incidence owing to aging populations and rising cardiovascular risk factors. In addition to physical impairments, AIS frequently leads to neuropsychiatric complications, such as cognitive impairment, anxiety, and depressive symptoms, which adversely affect patients' quality of life and rehabilitation. Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a potential biomarker for various conditions, including AIS. This study investigated the association between serum NGAL levels at admission and neuropsychiatric complications in patients with AIS.</p><p><strong>Aim: </strong>To investigate the relationship between serum NGAL levels at admission and neuropsychiatric complications in patients with AIS.</p><p><strong>Methods: </strong>Between January 2022 and December 2023, 150 patients with AIS were enrolled. Serum NGAL levels were measured at admission using an enzyme-linked immunosorbent assay. Cognitive function was assessed using the Mini-Mental State Examination, while anxiety and depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale at discharge. The relationship between serum NGAL levels and cognitive impairment, anxiety, and depressive symptoms was analyzed using multivariate logistic regression, adjusted for potential confounders of age, sex, body mass index, smoking status, hypertension, diabetes mellitus, dyslipidemia, previous stroke, and stroke severity.</p><p><strong>Results: </strong>The mean age of the participants was 65.4 ± 10.2 years, and 58% were males. Prevalence rates of cognitive impairment, anxiety, and depressive symptoms at discharge were 34.7%, 28.0%, and 32.0%, respectively. Serum NGAL levels were significantly higher in patients with cognitive impairment (median: 5.6 ng/mL <i>vs</i> 3.2 ng/mL, <i>P</i> < 0.001), anxiety (median: 5.1 ng/mL <i>vs</i> 3.5 ng/mL, <i>P</i> = 0.002), and depressive symptoms (median: 5.4 ng/mL <i>vs</i> 3.3 ng/mL, <i>P</i> < 0.001), compared to those without these conditions. Multivariate logistic regression analysis showed that higher serum NGAL levels at admission were independently associated with cognitive impairment [odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.18-1.71, <i>P</i> < 0.001], anxiety (OR = 1.28, 95%CI: 1.09-1.51, <i>P</i> = 0.003), and depressive symptoms (OR = 1.39, 95%CI: 1.16-1.67, <i>P</i> < 0.001) after adjusting for potential confounders.</p><p><strong>Conclusion: </strong>Elevated serum NGAL levels were independently associated with cognitive impairment, anxiety, and depressive symptoms in patients with AIS; and may function as potential biomarkers for patients at risk.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for postpartum depression after cesarean section in women with early-onset preeclampsia.","authors":"Ran Wang, Xin Liang, Xing-Yan Su","doi":"10.5498/wjp.v14.i10.1448","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1448","url":null,"abstract":"<p><strong>Background: </strong>Early-onset preeclampsia significantly increases maternal and fetal morbidity and mortality. Many pregnant women with early onset preeclampsia choose cesarean section as their delivery method. Although extensive research has explored the association between postpartum depression (PPD) and cesarean section, few studies have investigated the risk factors after cesarean section in women with early-onset preeclampsia.</p><p><strong>Aim: </strong>To examine these risk factors through a retrospective, observational analysis of 287 women who underwent a cesarean section for early preeclampsia between June 2014 and March 2024.</p><p><strong>Methods: </strong>Participants were assessed in person during the 32^nd week of pregnancy, 2 days post-cesarean, and 6 weeks postpartum. According to the Edinburgh Postnatal Depression Scale (EPDS), participants who underwent cesarean section were divided into PPD (<i>n</i> = 60) and non-PPD groups (<i>n</i> = 227). Furthermore, PPD was diagnosed at 6 weeks postpartum according to depressive symptoms (EPDS score ≥ 11). The demographic and clinical features of PPD were screened. Multivariate logistic regression analysis was used to identify PPD risk factors.</p><p><strong>Results: </strong>The prevalence of PPD was 20.9% (60/287) among the 287 women who underwent cesarean section for early-onset preeclampsia. Multivariate logistic regression analyses revealed that advanced age (age > 40 years) [odds ratio (OR) = 1.93, 95%CI: 1.31-2.82], previous preeclampsia (OR = 7.15, 95%CI: 5.81-8.85), pre-pregnancy obesity (OR = 2.42, 95%CI: 1.62-3.63), gestational diabetes mellitus (OR = 3.52, 95%CI: 2.51-4.92), preexisting hypertension (OR = 1.35, 95%CI: 1.03-1.89), PPD symptoms (EPDS ≥ 11) at 2 days postpartum (OR = 6.15, 95%CI: 1.32-28.35), high prenatal self-rating anxiety scale score (OR = 1.13, 95%CI: 1.06-1.18), and pain at 6 weeks postpartum (OR = 2.16, 95%CI: 1.28-3.66) were independently associated with PPD.</p><p><strong>Conclusion: </strong>Risk factors for PPD after cesarean section in women with early-onset preeclampsia include advanced age (age > 40 years), pre-pregnancy obesity, previous preeclampsia, gestational diabetes mellitus, preexisting hypertension, PPD symptoms (EPDS ≥ 11) at 2 days postpartum, prenatal anxiety, and pain at 6 weeks postpartum. The early identification of these factors and interventions can mitigate the risk of PPD.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between <i>5-HTR1A</i> gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis.","authors":"Huai-Neng Wu, Shuang-Yue Zhu, Li-Na Zhang, Bian-Hong Shen, Lian-Lian Xu","doi":"10.5498/wjp.v14.i10.1573","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1573","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a substantial global health concern, and its treatment is complicated by the variability in individual response to antidepressants.</p><p><strong>Aim: </strong>To consolidate research and clarify the impact of genetic variation on MDD treatment outcomes.</p><p><strong>Methods: </strong>Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search across PubMed, EMBASE, Web of Science, and the Cochrane Library was conducted without date restrictions, utilizing key terms related to MDD, serotonin 1A receptor polymorphism (5-HTR1A), C-1019G polymorphism, and antidepressant response. Studies meeting inclusion criteria were thoroughly screened, and quality assessed using the Newcastle-Ottawa Scale. Statistical analyses, including <i>χ</i> ² and <i>I²</i> values, were used to evaluate heterogeneity and fixed-effect or random-effect models were applied accordingly.</p><p><strong>Results: </strong>The initial search yielded 1216 articles, with 11 studies meeting criteria for inclusion. Analysis of various genetic models showed no significant association between the 5-HTR1A C-1019G polymorphism and antidepressant efficacy. The heterogeneity was low to moderate, and no publication bias was detected through funnel plot symmetry and Egger's and Begg's tests.</p><p><strong>Conclusion: </strong>This meta-analysis does not support a significant association between the 5-HTR1A C-1019G polymorphism and the efficacy of antidepressant treatment in MDD. The findings call for further research with larger cohorts to substantiate these results and enhance the understanding of antidepressant pharmacogenetics.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in postoperative depression and anxiety and their relationship with recovery from femoral head necrosis: A longitudinal study.","authors":"Guo-Zheng Fang, Jie Lin, Lie-Hu Cao, Tong-Sheng Liu, Yu-Hong Ma, Lu Yang","doi":"10.5498/wjp.v14.i10.1506","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1506","url":null,"abstract":"<p><strong>Background: </strong>Femoral head necrosis (FHN) can significantly affect patients' psychological well-being and functional outcomes. However, the long-term relationship between postoperative depression, anxiety, and functional recovery in patients with FHN remains unclear.</p><p><strong>Aim: </strong>To investigate the dynamic changes in postoperative depression and anxiety and their relationship with functional recovery in patients with FHN for 3 years.</p><p><strong>Methods: </strong>Ninety-three patients with FHN who underwent surgical treatment in March 2020 to 2023 were enrolled in this longitudinal study. Depression and anxiety status were assessed using the hospital anxiety and depression scale (HADS) at baseline, 6 months, 1, 2, and 3 years postoperatively. Functional recovery was evaluated using the Harris hip score (HHS). The dynamic changes in HADS and HHS were analyzed using repeated measures ANOVA; the relationship between depression/anxiety status and functional recovery was examined using Pearson's correlation analysis.</p><p><strong>Results: </strong>The mean HADS-depression (HADS-D) and HADS-anxiety (HADS-A) scores significantly improved over time (<i>P</i> < 0.001). The prevalence of depression and anxiety decreased from 36.6% and 41.9% at baseline to 10.8% and 12.9%, respectively, at 3 years postoperatively. The mean HHS increased significantly from 52.3 ± 10.5 at baseline to 88.1 ± 7.2 at 3 years postoperatively (<i>P</i> < 0.001). Significant negative correlations were found between HADS-D/HADS-A scores and HHS at all time points (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The severity of depression and anxiety negatively correlated with functional recovery, highlighting the importance of psychological interventions in the management of patients with FHN.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone replacement therapy for menopausal mood swings and sleep quality: The current evidence.","authors":"Sanja Borozan, Abul Bashar M Kamrul-Hasan, Joseph M Pappachan","doi":"10.5498/wjp.v14.i10.1605","DOIUrl":"https://doi.org/10.5498/wjp.v14.i10.1605","url":null,"abstract":"<p><p>Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women's health, leading to decreased well-being, psychological distress, and impaired quality of life. Common menopausal symptoms include hot flashes, sleep and mood changes, fatigue, weight gain, and urogenital disturbances. Clinicians often neglect mood swings and disrupted sleep, although those can significantly limit the productivity of women and impair their cognitive function and mental health. Evidence-based management should include a personalized, holistic approach to alleviate symptoms and careful consideration of the risks <i>vs</i> benefits of hormone replacement therapy (HRT), with due consideration of personal preferences. A research paper in the recent issue of the <i>World Journal of Psychiatry</i> by Liu <i>et al</i> investigated the role of HRT in altering mood changes and impaired sleep quality in menopausal women, which helps us to understand the benefits of this treatment approach.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}