World Journal of Psychiatry最新文献

{"title":"Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of cluster of differentiation 38 as an early biomarker.","authors":"Chun-Rong Wu, Hang-Li Zhu, Yu-Ting Sun, Shi-Hui Shen, Pei-Lin Shi, Yu-Hui Cui, Jian-Guo Tang, Chun-Hui Yang, Shang-Yuan Wang, Xiao-Li Ge, Shu-Ming Pan","doi":"10.5498/wjp.v15.i6.105889","DOIUrl":"10.5498/wjp.v15.i6.105889","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, characterized by cognitive impairment, altered consciousness, and psychiatric symptoms, including anxiety and depression. These psychiatric symptoms often exacerbate the overall prognosis and quality of life of affected patients. However, the underlying metabolic and proteomic features associated with SAE-induced psychiatric symptoms remain poorly understood.</p><p><strong>Aim: </strong>To investigate the clinical manifestations of anxiety and depression in patients with sepsis and SAE and to explore their associated metabolic and proteomic characteristics.</p><p><strong>Methods: </strong>A total of 88 patients were enrolled, comprising 30 healthy controls, 29 patients with sepsis, and 29 with SAE. Anxiety and depression symptoms were evaluated using the Hamilton anxiety rating scale (HAM-A) and Hamilton depression rating scale (HAM-D) in sepsis and SAE. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and quality of life was measured using the 36-Item Short Form Health Survey. Plasma samples were analyzed for metabolomic and proteomic profiling. Metabolic alterations were identified through liquid chromatography-mass spectrometry, while protein expression was assessed using Olink targeted proteomics.</p><p><strong>Results: </strong>Compared to the sepsis group, patients with SAE exhibited significantly higher levels of anxiety (HAM-A: 15.2 ± 4.0 <i>vs</i> 10.4 ± 3.0, <i>P</i> = 0.012) and depression (HAM-D: 16.0 ± 3.5 <i>vs</i> 9.1 ± 2.3, <i>P</i> = 0.003). Cognitive function, as measured by MoCA, was notably impaired in the SAE group (MoCA: 18.5 ± 4.0 <i>vs</i> 24.5 ± 3.2, <i>P</i> = 0.007). Quality of life scores, particularly in physical functioning, emotional well-being, and mental health, were significantly lower in patients with SAE. Metabolomic and proteomic analyses revealed substantial alterations in oxidative stress and nicotinamide adenine dinucleotide (NAD⁺) metabolism pathways, with cluster of differentiation (CD) 38 emerging as a potential biomarker associated with psychiatric symptoms in SAE. Further validation in an independent cohort confirmed the diagnostic relevance of CD38.</p><p><strong>Conclusion: </strong>This study highlights the significant psychological burden of SAE, manifested as anxiety and depression. Multi-omics analysis identified distinct metabolic alterations, particularly in NAD⁺ metabolism, that may contribute to psychiatric symptom development and progression. Furthermore, CD38 was identified as a promising biomarker for the early detection of SAE, providing potential avenues for early intervention and therapeutic targeting.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105889"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of depressive and anxiety symptoms and functional constipation among university students in Eastern China.","authors":"Bo-Chen Jiang, Jing Zhang, Man Yang, Hai-Dong Yang, Xiao-Bin Zhang","doi":"10.5498/wjp.v15.i6.106451","DOIUrl":"10.5498/wjp.v15.i6.106451","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety are prevalent among university students worldwide, often coexisting with functional constipation (FC). Family relationships have been identified as crucial factors affecting mental health, yet the gender-specific associations between these conditions remain underexplored.</p><p><strong>Aim: </strong>To assess prevalence of depressive symptoms, anxiety symptoms, and FC among Chinese university students and explore their associations.</p><p><strong>Methods: </strong>Using a cross-sectional survey design, data were collected from 12721 students at two universities in Jiangsu Province and Shandong Province. Depressive symptoms were assessed using the Patient Health Questionnaire-9, anxiety symptoms using the Generalized Anxiety Disorder-7 scale, and FC using the ROME IV. Gender-stratified analyses and population attributable risk proportions were calculated to evaluate risk factor patterns and population impact.</p><p><strong>Results: </strong>The prevalence of self-reported depressive, anxiety, and comorbid depressive and anxiety symptoms was 16.3%, 24.9%, and 13.3%, respectively, whereas that of FC was 22%. Students with depressive symptoms were 1.811 times more likely to have FC than those without. Female gender, parental relationships, and lower household income were significant risk factors for both mental health conditions. For depressive symptoms, females experienced stronger effects from both parental conflict [odds ratio (OR) = 8.006 <i>vs</i> OR = 7.661 in males] and FC (OR = 1.954 <i>vs</i> OR = 1.628 in males). For anxiety symptoms, conflicted parental relationships had stronger effects in males (OR = 5.946) than females (OR = 4.262). Overall, poor parental relationships contributed to 38.6% of depressive and 33.5% of anxiety symptoms.</p><p><strong>Conclusion: </strong>Family relationships significantly impact student mental health, with gender-specific patterns. Targeted interventions addressing family dynamics could reduce mental health burden in university settings.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106451"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of anxiety and depression among chronic heart failure patients: Factors influencing poor fluid restriction adherence.","authors":"Yun-Tao Luo, Ai-Zhi Ou, Di-Sha Lin, Hong Li, Fang Zhou, Yue-Mei Liu, Xin-Ping Ye, Xu Deng","doi":"10.5498/wjp.v15.i6.103765","DOIUrl":"10.5498/wjp.v15.i6.103765","url":null,"abstract":"<p><strong>Background: </strong>Anxiety and depression are prevalent among patients with chronic heart failure (CHF) and can adversely contribute to treatment adherence and clinical outcomes. Poor fluid restriction adherence is a widespread challenge in the management of CHF. To effectively manage disease progression and alleviate symptoms, it is crucial to identify key influencing factors to facilitate the implementation of targeted interventions.</p><p><strong>Aim: </strong>To investigate the status of anxiety and depression among patients with CHF and determine the factors contributing to poor fluid restriction adherence.</p><p><strong>Methods: </strong>Three hundred CHF patients seeking medical treatment at The First Hospital of Hunan University of Traditional Chinese Medicine between June 2021 and June 2023 were included in the study. Questionnaires, including the Psychosomatic Symptom Scale, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and Fluid Restriction Adherence Questionnaire were administered to patients. Based on their anxiety and depression scores, patients were categorized into anxiety/depression and non-anxiety/depression groups, as well as fluid restriction adherence and fluid restriction non-adherence groups. General patient data were collected, and univariate and logistic regression analyses were conducted to determine the occurrence of depression and anxiety. Logistic regression analysis was used to identify independent factors influencing fluid restriction adherence.</p><p><strong>Results: </strong>Statistically significant differences in age, New York Heart Association (NYHA) grading, marital status, educational attainment, and family support were observed between depressed and non-depressed CHF patients (<i>P</i> < 0.05). Age, NYHA grading, marital status, educational attainment, and family support were identified as factors influencing the development of depression. The anxiety and non-anxiety groups differed statistically in terms of gender, age, NYHA grading, smoking history, alcohol consumption history, monthly income, educational attainment, and family support (<i>P</i> < 0.05). Gender, smoking, alcohol consumption, monthly income, and educational attainment affected anxiety in these patients. The fluid restriction adherence rate was 28.0%, and thirst sensation, anxiety, and depression were identified as independent influencing factors.</p><p><strong>Conclusion: </strong>CHF patients are susceptible to anxiety and depression, with multiple associated influencing factors. Moreover, anxiety and depression are independent factors that can influence fluid restriction adherence in these patients.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"103765"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of electroconvulsive therapy in treating auditory verbal hallucinations in a deaf patient with schizophrenia: A case report.","authors":"Juan Wang, Juan Li, Yan-Ge Wei, Xin-Xin Lu, Zhao-Hui Zhang","doi":"10.5498/wjp.v15.i6.105934","DOIUrl":"10.5498/wjp.v15.i6.105934","url":null,"abstract":"<p><strong>Background: </strong>Auditory verbal hallucinations (AVHs) are believed to be characteristic symptoms of schizophrenia. The prevalence of AVHs in deaf patients with schizophrenia is comparable to that in patients with schizophrenia who have normal hearing ability. AVHs in deaf patients with schizophrenia require treatment.</p><p><strong>Case summary: </strong>A 22-year-old deaf woman with schizophrenia had experienced AVHs for 3 months. Her psychotic symptoms were not alleviated by antipsychotic medication alone. Modified electroconvulsive therapy in combination with antipsychotic drugs effectively alleviated her AVHs and disorganized behavior. During outpatient follow-up for 6 months, her condition have remained stable, and she has been able to take care of herself.</p><p><strong>Conclusion: </strong>Treatment with modified electroconvulsive therapy was found to be safe and might be indicated for deaf patients whose symptoms are not well managed with antipsychotic medication alone. Deaf people might be unable to communicate through spoken language; therefore, to make proper diagnoses and provide appropriate treatment for these patients, psychiatrists must have patience and seek to understand patients' mental state.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105934"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literary case study of psychosis: <i>The Vegetarian</i>.","authors":"Gabor S Ungvari, Stanley N Caroff, Levente Csihi, Gábor Gazdag","doi":"10.5498/wjp.v15.i6.104247","DOIUrl":"10.5498/wjp.v15.i6.104247","url":null,"abstract":"<p><p>In the award-winning and widely-acclaimed fictional novel, <i>The Vegetarian</i>, the author, Han Kang, relates a compelling and dramatic story of inexorable psychotic deterioration from the perspective of a tragically affected young woman and her close family members. Apart from a variety of interpretations of psychosis from historical, social, psychological, and feminist perspectives, the book also presents a detailed and realistic picture of objective psychotic symptoms that reveals insights into historic and nearly forgotten phenomenological concepts. In this literary case study, we analyze the symptoms remarkably described by the author and briefly review the medical literature on the phenomena of catatonia, schizophrenic autism, paragnomen and the praecox-feeling.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"104247"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric symptoms in stroke patients: Clinical features of depression and anxiety.","authors":"Jie-Min Li, Su-Sheng Long, Teng-Xiang Lu, Yi-Chun Jiang, Xiao-Wei Zhang, You-Quan Ren","doi":"10.5498/wjp.v15.i6.103888","DOIUrl":"10.5498/wjp.v15.i6.103888","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke psychiatric complications, particularly depression and anxiety, significantly impact rehabilitation outcomes and quality of life. Despite their prevalence and clinical significance, these conditions often remain underrecognized in routine stroke care. Understanding their clinical features and temporal patterns is crucial for improving patient outcomes.</p><p><strong>Aim: </strong>To investigate the prevalence, temporal evolution, and clinical correlates of depression and anxiety post-stroke and their impact on functional recovery.</p><p><strong>Methods: </strong>In this prospective observational study, 127 patients first-ever ischemic stroke were enrolled between June 2022 and June 2024. Depression and anxiety were assessed using the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale at baseline and follow-up intervals (2 weeks, 1 month, 3 months, and 6 months). Stroke severity was evaluated using the National Institutes of Health Stroke Scale, and functional outcomes were measured using the modified Rankin Scale.</p><p><strong>Results: </strong>Among 120 patients who completed follow-up (94.5% completion rate), 37.5% had depression (mild: 18.3%, moderate: 12.5%, severe: 6.7%) and 41.7% had anxiety at baseline. Depression prevalence showed a biphasic pattern, peaking at 2 weeks (37.5%), declining at 3 months (28.3%), and slightly increasing at 6 months (30.8%). Stroke severity significantly correlated with both depression (odds ratio = 1.18, 95%CI: 1.06-1.31, <i>P</i> = 0.003) and anxiety (odds ratio = 1.15, 95%CI: 1.04-1.27, <i>P</i> = 0.008). Left hemisphere lesions had a stronger association with psychiatric symptoms than right hemisphere lesions (<i>P</i> = 0.035). Patients with psychiatric complications demonstrated poorer functional outcomes at 6 months (median modified Rankin Scale 3 <i>vs</i> 2, <i>P</i> = 0.015) and longer hospital stays (mean difference: 3.2 days, <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Identifying the clinical and neuroanatomical correlates of depression and anxiety will enable effective risk stratification and patient management. Integrating routine psychiatric screening and early intervention is essential in stroke care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"103888"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent non-suicidal self-injury: The moderating influence of social support utilization on depression.","authors":"Jin-Tao Hu, Yang Cao, Lu-Lu Liu, Dan Wang, Ping Zhu, Xia Du, Feng Ji, Rui-Jie Peng, Qing Tian, Feng Zhu","doi":"10.5498/wjp.v15.i6.106017","DOIUrl":"10.5498/wjp.v15.i6.106017","url":null,"abstract":"<p><strong>Background: </strong>Adolescence is a period marked by physiological and psychological imbalances, which pose an increased risk for adolescents with major depressive disorder (MDD) to commit non-suicidal self-injury (NSSI).</p><p><strong>Aim: </strong>To investigate the moderating role of social support utilization in depression and NSSI among adolescents with MDD.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 314 adolescents with MDD (258 with NSSI, 56 without) from a Chinese tertiary psychiatric hospital (2021-2023). Participants completed validated scales, including the self-esteem scale, the Barratt impulsiveness scale, the self-rating depression scale, and the teenager social support rating scale. Logistic regression and hierarchical regression analyses were used to examine predictors of NSSI and the moderating effect of social support utilization.</p><p><strong>Results: </strong>Results showed that the NSSI group had higher depression levels, lower self-esteem, and greater impulsivity. While overall social support was higher in the NSSI group, social support utilization significantly moderated the depression-NSSI relationship. Specifically, higher utilization levels weakened the association between depression and NSSI (<i>β</i> = -0.001, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>These findings suggest that effective utilization of social support, rather than its mere presence, is crucial in reducing NSSI risk among depressed adolescents.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106017"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closer look at the cardiovascular and metabolic predictors of postpartum depression.","authors":"Mihit Kalawatia, Brandon Lucke-Wold, Aabhali Mehrunkar","doi":"10.5498/wjp.v15.i6.106283","DOIUrl":"10.5498/wjp.v15.i6.106283","url":null,"abstract":"<p><p>Postpartum depression (PPD) is a severe mental health disorder affecting 10% to 15% of postpartum women worldwide. Pre-eclampsia is a hypertensive disorder of pregnancy that has been identified as a significant factor for PPD due to its vascular dysfunction, systemic inflammation and neurobiological alterations. The neuroinflammatory mechanisms common to both pre-eclampsia and PPD, that contribute to depressive symptoms include elevated proinflammatory cytokines (interleukin-6, tumor necrosis factor-alpha), activation of the kynurenine pathway, and oxidative stress. To critically evaluate Wu <i>et al</i>'s study, which investigates blood pressure variability (BPV) and gestational body mass index (BMI) as independent predictors of PPD. To integrate recent findings on the metabolic and cardiovascular links between depression, pre-eclampsia, and postpartum mental health outcomes. Pre-pregnancy BMI is found to be a stronger predictor of PPD than gestational weight gain. A vascular-neuropsychiatric connection has been indicated in pre-eclamptic women, indicating a significant correlation between BPV and depressive postpartum symptoms. There is increased susceptibility to depression due to neuroinflammation contributed by blood pressure fluctuations and metabolic dysregulation. The incidence of PPD could be reduced by early identification and intervention for BP fluctuations. Early detection and intervention in high-risk pregnancies should be conducted through public health strategies that prioritize awareness, education, and accessibility to mental health care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106283"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deconstructive meditations and psychotherapy: Transforming the perception of the self.","authors":"Paulina Lamas-Morales, Rinchen Hijar-Aguinaga, Javier Garcia-Campayo","doi":"10.5498/wjp.v15.i6.107505","DOIUrl":"10.5498/wjp.v15.i6.107505","url":null,"abstract":"<p><p>Selfishness, understood as excessive focus on the self, appears to be a predominant feature of contemporary culture. While the degree of self-focus is adaptive for survival and decision-making, self-rigidity has been associated with significant psychological, interpersonal, and social costs. Throughout history, philosophers, religious leaders, and social activists have promoted a \"hypo-egoic\" way of being, characterized by reduced self-fixation and greater openness to others. However, a key question arises: How can one cultivate a more flexible and interdependent perspective on the self? Deconstructive meditations are a group of contemplative practices that aim to dismantle self-rigidity by exploring perception, cognition, and emotion. Their central mechanism is self-inquiry, an experiential process that involves directly observing patterns of the self, questioning the solidity of identity, and developing new ways to relate to experience. From the perspective of contemplative neuroscience, these practices have been shown to reduce self-narrative identification and promote psychological flexibility. Despite their potential, empirical research on deconstructive meditations remains limited and requires further investigation. This article reviews the essential findings on practices, their connection to psychotherapy, and their potential therapeutic applications. Finally, their clinical implications are discussed along with future research directions to validate their impact on mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"107505"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise rehabilitation based on medical care-family integration in older patients with chronic heart failure and psychological problems.","authors":"Can Ao, Shu Hu, Lu Zhan","doi":"10.5498/wjp.v15.i6.105855","DOIUrl":"10.5498/wjp.v15.i6.105855","url":null,"abstract":"<p><strong>Background: </strong>As the aging process has accelerated, psychological problems in older patients with chronic heart failure (CHF) have become increasingly prominent, significantly affecting their quality of life and prognosis. This study explored a sports rehabilitation program based on the concept of medical care-family integration to provide patients with comprehensive and effective rehabilitation interventions and improve their health status.</p><p><strong>Aim: </strong>To explore the effects of medical care-family integration-based exercise rehabilitation in older patients with CHF and psychological problems.</p><p><strong>Methods: </strong>Data from 118 older patients with CHF and psychological problems were retrospectively analyzed. Patients were divided into conventional (<i>n</i> = 56) and exercise rehabilitation groups (<i>n</i> = 62). The results of the 6-min walking distance (6 MWD), N-terminal B-type natriuretic peptide (NT-proBNP), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), Minnesota living with heart failure questionnaire (MLHFQ), generalized anxiety disorder-7 (GAD-7) scale, 9-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were compared before and after intervention.</p><p><strong>Results: </strong>After intervention, there were significant differences in the number of patients with depression and anxiety between the two groups. There was also a significant difference in the distribution of sleep disorders. The PHQ-9 score, GAD-7 score, AIS score, NT-proBNP value, LVEDD value, physical field, emotional field, other fields, and MLHFQ total scores were lower in the exercise rehabilitation group compared to the conventional rehabilitation group, while the 6 MWD and LVEF values were higher compared to the conventional rehabilitation group (<i>P</i> < 0.05). During the intervention period, the readmission rate of the exercise rehabilitation group (1.61%) was significantly lower than that of the conventional rehabilitation group (12.50%) (<i>χ</i> ² = 3.930, <i>P</i> = 0.047).</p><p><strong>Conclusion: </strong>This exercise rehabilitation program with medical care-family integration can improve cardiac function and quality of life, alleviate psychological problems, and reduce readmission rates in older patients with CHF.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105855"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}