World Journal of Psychiatry最新文献

{"title":"Retraction note to: Shugan Jieyu capsule effects on peripheral blood micro-124, micro-132, and brain-derived neurotrophic factor in patients with mild to moderate depression.","authors":"Xian Zhang, Yang Liu, Hua-Fei Tang, Feng Jiang, Chun-Liang Chen, Ting-Ting Wang, Hui-Zhong Gu, Qiang Zhao, Rui Ma","doi":"10.5498/wjp.v15.i2.103118","DOIUrl":"10.5498/wjp.v15.i2.103118","url":null,"abstract":"<p><p>[This retracts the article on p. 1354 in vol. 14, PMID: 39319232.].</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"103118"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of insomnia on anxiety and depression: Mediation of cognitive failures and moderated mediation of neuroticism.","authors":"Yue Li, Jia-Long Yu, Shu-Yi Wang, Lu-Xin Xie, Jia-Long Hong, Sha Liu","doi":"10.5498/wjp.v15.i2.101026","DOIUrl":"10.5498/wjp.v15.i2.101026","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 pandemic has had an ongoing impact on the public's mental health that requires long-term attention. Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.</p><p><strong>Aim: </strong>To investigate the prevalence of anxiety, depression, and insomnia and explore the relationship among neuroticism, cognitive failures, and mental health.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants. The neuroticism, subjective cognitive function, and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version, cognitive failures questionnaire, generalized anxiety disorder-7, patient health questionnaire-9, and insomnia severity index. Pearson's correlation analysis, independent samples <i>t</i>-tests, one-way analysis of variance, and structural equation model were used to examine the relationship between mental health indicators.</p><p><strong>Results: </strong>A total of 1011 valid questionnaires were collected, of which 343 were completed by male (33.93%) respondents and 668 were completed by female (66.07%) respondents. The rates of anxiety, depression, and insomnia were 41.3%, 44.6%, and 36.3%, respectively, most cases of which were mild. Among the mental health indicators, there were significant differences by age and between those with siblings and those who were only children. Neuroticism and cognitive failures were significantly positively correlated with mental health indicators. Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression, with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.</p><p><strong>Conclusion: </strong>Cognitive failures and neuroticism play important roles in mental health. Therefore, enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101026"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer's disease patients.","authors":"Xue-Lian Wang, Yi-Ran Zhao, Ying Yu, Zhi-Fang Mao, Su-Xian Tan, Shan-Shan Yu","doi":"10.5498/wjp.v15.i2.99008","DOIUrl":"10.5498/wjp.v15.i2.99008","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential in providing nutritional guidance for patients with Alzheimer's disease (AD) remains relatively unexplored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024. Based on data from previous similar studies, the patients were randomly assigned to either a routine diet (RD) group (&lt;i&gt;n&lt;/i&gt; = 48) or a personalized nutrition (PN) group (&lt;i&gt;n&lt;/i&gt; = 48). The RD group received conventional dietary guidance, while the PN group received individualized diet intervention measures based on human BCA. The intervention period lasted for 12 weeks. Bone mineral density (BMD), body mass index (BMI), muscle mass, mineral content, osteocalcin, 25-hydroxyvitamin D, procollagen type I N-terminal propeptide (PINP), beta C-terminal telopeptide of type I collagen (β-CTX), and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No significant differences were observed between groups in terms of age, sex, height, BMI, or other baseline data (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). In both groups, BMI did not show significant changes after the intervention (&lt;i&gt;P&lt;/i&gt; &gt; 0.05), whereas muscle mass and mineral content were significantly increased (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). After the intervention, BMI in the PN group did not differ significantly from that of the RD group, but muscle mass and mineral content were significantly higher in the PN group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). After the intervention, a higher proportion of patients in the PN group had a T score &gt; -1 compared to the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The mini-mental state examination (MMSE) score was similar in both groups before the intervention. However, 12 weeks after the intervention, the MMSE score in the PN group was significantly higher than that in the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In both groups, the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Before the intervention, the levels of osteocalcin, serum calcium, PINP, β-CTX, and 25-hydroxyvitamin D were not significantly different between the two groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). After 12 weeks of intervention, the PN group exhibited higher levels of osteocalcin, serum calcium, and 25-hydroxyvitamin D, as well as lower levels of PINP and β-CTX, compared to the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In both groups, osteocalcin, serum calcium, and 25-hydroxyvitamin D levels were significantly higher, while PINP and β-CTX levels were significantly lower after 12 weeks of intervention compared to baseline (&lt;i&gt;P&lt;/i&gt; ","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99008"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work-family behavioral role conflict and daytime sleepiness on suicide risk among Chinese nurses: A cross-sectional study.","authors":"Qing-Wen Gan, Yi-Ling Yuan, Yuan-Ping Li, Yi-Wen Du, Li-Lan Zheng","doi":"10.5498/wjp.v15.i2.100859","DOIUrl":"10.5498/wjp.v15.i2.100859","url":null,"abstract":"<p><strong>Background: </strong>Work-family conflicts and daytime sleepiness are related to the risk of suicide. At present, no study has investigated the relationship between nurses' work-family behavioral role conflict and suicide risk. Moreover, it has not been confirmed whether, considering the effect of daytime sleepiness on suicide risk, daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.</p><p><strong>Aim: </strong>To explore the pathway relationships among nurses' work-family behavioral role conflict, daytime sleepiness, and suicide risk.</p><p><strong>Methods: </strong>Convenience and purposive sampling methods were used to select 750 nurses from six provinces, including Jiangxi, Sichuan, and Shanxi. The work-family behavioral role conflict scale, the Chinese adult daytime sleepiness scale, and the suicide behavior questionnaire were used for the survey. The data were statistically analyzed <i>via</i> SPSS 25.0 software, Pearson correlation analysis was used to explore the correlations between the variables, the PROCESS 4.0 program was used for the mediation effect analysis, and the mediation effect model was tested <i>via</i> the bootstrap method.</p><p><strong>Results: </strong>Nurses' work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk (<i>r</i> = 734, 0.717). Work-family behavioral role conflict positively predicted suicide risk (<i>β</i> = 0.118), and daytime sleepiness positively predicted suicide risk (<i>β</i> = 0.152). Daytime sleepiness partially mediated the role of nurses' work-family behavioral role conflict and suicide risk, with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.</p><p><strong>Conclusion: </strong>The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses' work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100859"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of self-esteem in the relationship between parental disapproval of the child and alexithymic personality.","authors":"Elif Yöyen, Ali Rıfat Kılıç","doi":"10.5498/wjp.v15.i2.100135","DOIUrl":"10.5498/wjp.v15.i2.100135","url":null,"abstract":"<p><strong>Background: </strong>Alexithymia is defined as difficulties in identifying, expressing, and understanding emotions. An unapproving environment during childhood is defined as the child not receiving emotional approval from their parents, being punished, or having their emotions devalued. The formation of self-esteem is shaped by the influence of parental behavior during childhood. The communication that the child establishes with their parents contributes to their increased self-esteem and sense of importance. The absence of this may play a role in developmental psychopathology.</p><p><strong>Aim: </strong>To examine the mediating role of self-esteem in the relationship between a disapproving environment in childhood and alexithymia.</p><p><strong>Methods: </strong>The research in the relational screening model was conducted with 404 participants. Demographic Information Form, Disapproving Environment Scale in Childhood, Toronto Alexithymia Scale, and Rosenberg Self-Esteem Scale were used as data collection tools. Hayes' bootstrapping technique was used in the analysis of the data obtained from the research.</p><p><strong>Results: </strong>As a result of the analyses, parental disapproval positively predicted the level of alexithymia (<i>r_mother</i> = 0.51, <i>r_father</i> = 0.52, <i>P</i> < 0.05) and negatively predicted self-esteem (<i>r_mother</i> = -0.75, <i>r_father</i> = -0.67, <i>P</i> < 0.05). Additionally, self-esteem negatively predicted alexithymia (<i>r</i> = -0.58, <i>P</i> < 0.05). It was observed that self-esteem had a partial mediating effect on the relationship between parental disapproval and alexithymia. Family types were analyzed separately as chaotic, approving, perfect, and typical. Of these, the chaotic family type positively predicted alexithymia (<i>r</i> = 0.33, <i>P</i> < 0.05) and negatively predicted self-esteem (<i>r</i> = -0.60, <i>P</i> < 0.05). The approving family type negatively predicted alexithymia (<i>r</i> = -0.43, <i>P</i> < 0.05) and positively predicted self-esteem (<i>r</i> = 0.61, <i>P</i> < 0.05). The perfect family type negatively predicted alexithymia (<i>r</i> = -0.27, <i>P</i> < 0.05) and positively predicted self-esteem (<i>r</i> = -0.45, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The type of family in which the child grows up in and parental disapproval during childhood affected the child's self-esteem and caused alexithymic personality traits.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100135"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-suicidal self-injury risk among left-behind children and adolescents in China: A systematic review and meta-analysis.","authors":"Qi Zheng, Xin-Chao Chen, Ying-Jian Deng, Ya-Juan Ji, Qi Liu, Chen-Yun Zhang, Tian-Tian Zhang, Ling-Jiang Li","doi":"10.5498/wjp.v15.i2.101595","DOIUrl":"10.5498/wjp.v15.i2.101595","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence has shown an increased risk of non-suicidal self-injury (NSSI) in left-behind children and adolescents (LBCAs). However, a systematic summary of studies comparing the risk of NSSI between LBCAs and non-LBCAs in China is lacking.</p><p><strong>Aim: </strong>To investigate the risk of NSSI among LBCAs in China.</p><p><strong>Methods: </strong>We performed a systematic search of Embase, PubMed, and Web of Science from initiation to October 25, 2024, for all relevant studies of NSSI and LBCAs. The effect sizes were reported as odds ratios (ORs) with 95% confidence intervals (CI). Sensitivity analyses were conducted to further confirm the stability of the findings.</p><p><strong>Results: </strong>A total of 10 studies with 165276 children and adolescents were included in this study. LBCAs had significantly higher rates of NSSI compared with non-LBCAs (OR = 1.33, 95%CI: 1.19-1.49), with high heterogeneity observed (<i>I</i> ² = 77%, <i>P</i> < 0.001). Further sensitivity analyses were consistent with the primary analysis (OR = 1.29, 95%CI: 1.21-1.39, <i>I</i> ² = 0%).</p><p><strong>Conclusion: </strong>LBCAs are found to be at an increased risk of NSSI compared with children and adolescents of non-migrants. More attention and intervention are urgently needed for LBCAs, especially those living in developing countries.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101595"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin.","authors":"Jian Dai, Xiao-Tong Lin, Lu-Lu Shen, Xi-Wen Zhang, Zi-Wen Ding, Jing Wang, Xi-Wang Fan, Wei-Dong Ning","doi":"10.5498/wjp.v15.i2.101818","DOIUrl":"10.5498/wjp.v15.i2.101818","url":null,"abstract":"<p><strong>Background: </strong>Depression is a significant psychiatric disorder with particularly high prevalence among adolescents. This mental health condition can have severe consequences, including academic failure, social withdrawal, and suicidal behavior. Given the increasing rate of depression in this age group, understanding the underlying biological mechanisms is essential for early detection and intervention. Recent studies have suggested that immune markers play a role in the pathophysiology of depression, prompting further investigation of their potential association with depressive symptoms in adolescents.</p><p><strong>Aim: </strong>To investigate the relationship between immune markers (monocytes, lymphocytes, and direct bilirubin) and the incidence and severity of depression among adolescents.</p><p><strong>Methods: </strong>This cross-sectional study recruited 145 adolescent patients with depression [male (M)/female (F) = 38/107] from Jiangbin Hospital in Guangxi, Zhuang and 163 healthy controls (M/F = 77/86) from routine health check-ups. Blood samples were collected after an overnight fast. Depression severity was measured using the Zung Self-Rating Depression Scale. The inclusion criteria were age 12-24 years, diagnosis of depressive disorder (ICD-10), and no recent antidepressant use. The exclusion criteria included psychiatric comorbidities and serious somatic diseases. Key statistical methods included group comparisons and correlation analyses.</p><p><strong>Results: </strong>There was a higher prevalence of females in the depression group (<i>P</i> < 0.001). Significant age differences were observed between the groups (<i>Z</i> = 9.43, <i>P</i> < 0.001). The depression group had higher monocyte (<i>Z</i> = 3.43, <i>P</i> < 0.001) and lymphocyte (<i>t</i> = 2.29, <i>P</i> < 0.05) counts, and higher serum direct bilirubin levels (<i>Z</i> = 4.72, <i>P</i> < 0.001). Monocyte count varied significantly according to depression severity, with lower counts in the mild group (<i>Z</i> = -2.90, <i>P</i> < 0.05). A negative correlation between age and lymphocyte counts was observed (<i>ρ</i> = -0.22, <i>P</i> < 0.01). Logistic regression analysis showed that serum direct bilirubin levels significantly predicted depression.</p><p><strong>Conclusion: </strong>The potential role of elevated levels of immune markers in the early detection of depression in adolescents has been highlighted. Therefore, it is necessary to explore further the relationships between these immune markers and depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101818"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression levels of the general public increases during the COVID-19 pandemic in China: A web-based cross-sectional survey.","authors":"Qin-Ming Qiu, Yu Xiao","doi":"10.5498/wjp.v15.i2.97971","DOIUrl":"10.5498/wjp.v15.i2.97971","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) outbreak lasted several months, having started in December 2019. This study aimed to report the impacts of various factors on the depression levels of the general public and ascertain how emotional measures could be affected by psychosocial factors during the COVID-19 pandemic.</p><p><strong>Aim: </strong>To investigate the depression levels of the general public in China during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A total of 2001 self-reported questionnaires about Beck Depression Inventory (BDI) were collected on August 22, 2022 <i>via</i> the website. Each questionnaire included four levels of depression and other demographic information. The BDI scores and incidences of different depression levels were compared between various groups of respondents. <i>χ</i> ² analysis and the two-tailed <i>t</i>-test were used to assess categorical and continuous data, respectively. Multiple linear regressions and logistic regressions were employed for correlation analysis.</p><p><strong>Results: </strong>The averaged BDI score in this study was higher than that for the non-epidemic periods, as reported in previous studies. Even higher BDI scores and incidences of moderate and severe depression were recorded for people who were quarantined for suspected COVID-19 infection, compared to the respondents who were not quarantined. The participants who did not take protective measures were associated with higher BDI scores than those who made efforts to keep themselves relatively safer. Similarly, the people who did not return to work had higher BDI scores compared to those managed to. A significant association existed between the depression levels of the subgroups and each of the factors, except gender and location of residence. However, quarantine was the most relative predictor for depression levels, followed by failure to take preventive measures and losing a partner, either through divorce or death.</p><p><strong>Conclusion: </strong>Based on these data, psychological interventions for the various subpopulations in the general public can be implemented during and after the COVID-19 pandemic. Other countries can also use the data as a reference.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"97971"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and treatment of bipolar disorder in Phelan-McDermid syndrome: A case report and review of literature.","authors":"Yu-Yong Sun, Yong Xia, Qian-Na Zhi, Xiao-Yan Liu","doi":"10.5498/wjp.v15.i2.101948","DOIUrl":"10.5498/wjp.v15.i2.101948","url":null,"abstract":"<p><strong>Background: </strong>Phelan-McDermid syndrome (PMS) is a rare genetic disorder characterized by intellectual disability, delayed language development, autism spectrum disorders, motor tone abnormalities, and a high risk of psychiatric symptoms, including bipolar disorder.</p><p><strong>Case summary: </strong>This report presented an 18-year clinical history of a 36-year-old woman with PMS, marked by intellectual disabilities, social withdrawal, and stereotyped behaviors. Diagnosed with bipolar disorder at the age of 18 years old, she encountered significant treatment challenges, including severe adverse reactions to antipsychotic medications in 2022, which led to speech and functional regression. Through rehabilitation and comprehensive therapy, her condition gradually improved. In 2024, after further treatment, her symptoms stabilized, highlighting the complexities and successes of long-term management.</p><p><strong>Conclusion: </strong>Effective management of PMS requires a thorough clinical history, genetic testing, and long-term supportive care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101948"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation <i>via</i> the CaMKII-CREB-BDNF pathway in schizophrenia.","authors":"Feng Li, Xing Ren, Jia-Xiu Liu, Tian-Dao Wang, Bi Wang, Xiao-Bin Wei","doi":"10.5498/wjp.v15.i2.100214","DOIUrl":"10.5498/wjp.v15.i2.100214","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SZ), a chronic and widespread brain disorder, presents with complex etiology and pathogenesis that remain inadequately understood. Despite the absence of a universally recognized endophenotype, peripheral blood mononuclear cells (PBMCs) serve as a robust model for investigating intracellular alterations linked to SZ.</p><p><strong>Aim: </strong>To preliminarily investigate potential pathogenic mechanisms and identify novel biomarkers for SZ.</p><p><strong>Methods: </strong>PBMCs from SZ patients were subjected to integrative transcriptomic and proteomic analyses to uncover differentially expressed genes (DEGs) and differentially expressed proteins while mapping putative disease-associated signaling pathways. Key findings were validated using western blot (WB) and real-time fluorescence quantitative PCR (RT-qPCR). RNAi-lentivirus was employed to transfect rat hippocampal CA1 neurons in vitro, with subsequent verification of target gene expression <i>via</i> RT-qPCR. The levels of neuronal conduction proteins, including calmodulin-dependent protein kinase II (caMKII), CREB, and BDNF, were assessed through WB. Apoptosis was quantified by flow cytometry, while cell proliferation and viability were evaluated using the Cell Counting Kit-8 assay.</p><p><strong>Results: </strong>The integration of transcriptomic and proteomic analyses identified 6079 co-expressed genes, among which 25 DEGs were significantly altered between the SZ group and healthy controls. Notably, haptoglobin (<i>HP</i>), lactotransferrin (<i>LTF</i>), and <i>SERPING1</i> exhibited marked upregulation. KEGG pathway enrichment analysis implicated neuroactive ligand-receptor interaction pathways in disease pathogenesis. Clinical sample validation demonstrated elevated protein and mRNA levels of <i>HP</i>, <i>LTF</i>, and <i>SERPING1</i> in the SZ group compared to controls. WB analysis of all clinical samples further corroborated the significant upregulation of <i>SERPING1</i>. In hippocampal CA1 neurons transfected with lentivirus, reduced <i>SERPING1</i> expression was accompanied by increased levels of CaMKII, CREB, and BDNF, enhanced cell viability, and reduced apoptosis.</p><p><strong>Conclusion: </strong><i>SERPING1</i> may suppress neural cell proliferation in SZ patients <i>via</i> modulation of the CaMKII-CREB-BDNF signaling pathway.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100214"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}