World Journal of Psychiatry最新文献

{"title":"Neuropsychiatric symptoms in the context of hemodynamic disruption during septic shock.","authors":"Hai-Ning Li, Jia-Lin Wang, Wei Chen","doi":"10.5498/wjp.v15.i7.105992","DOIUrl":"10.5498/wjp.v15.i7.105992","url":null,"abstract":"<p><strong>Background: </strong>Septic shock represents one of the most severe critical illness types, characterized by significant hemodynamic disorders and neuropsychiatric symptoms. This study aimed to investigate the association mechanism between hemodynamic indicators and neuropsychiatric symptoms in patients with septic shock, revealing potential pathophysiological connections.</p><p><strong>Aim: </strong>To investigate the link between hemodynamic parameters and neuropsychiatric symptoms in septic shock.</p><p><strong>Methods: </strong>A retrospective case-control study involving 132 patients with septic shock. Multiple assessment tools were employed, including the Confusion Assessment Method, Hospital Anxiety and Depression Scale, Posttraumatic Stress Disorder Scale, and Mini-Mental State Examination, systematically evaluating patients' neuropsychiatric symptoms and hemodynamic indicators.</p><p><strong>Results: </strong>Patient mean age was 52.4 ± 12.3 years, with 68.5% males. Multivariate analysis revealed significant correlations between neuropsychiatric symptom severity and mean arterial pressure < 65 mmHg [odds ratio (OR) = 2.7], lactate levels > 4 mmol/L (OR = 3.1), and elevated interleukin-6 inflammatory factors (OR = 2.4). Neuropsychiatric symptom incidence rates were: Delirium 37.1%; anxiety 28.8%; depression 24.2%; and posttraumatic stress disorder 19.7%.</p><p><strong>Conclusion: </strong>Hemodynamic disorders in patients with septic shock are closely associated with neuropsychiatric symptoms, influencing central nervous system function through complex inflammatory and neurotransmitter pathways.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"105992"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of psychological care on anxiety and depression in older adult patients with coronary heart disease complicated by arrhythmia.","authors":"Su Yang, Xiu-Mei Gao, Su-Juan Li, Xue Yang","doi":"10.5498/wjp.v15.i7.106762","DOIUrl":"10.5498/wjp.v15.i7.106762","url":null,"abstract":"<p><strong>Background: </strong>Coronary heart disease (CHD) has shown a consistent upward trend in global incidence in recent years. Notably, older adults with CHD complicated by arrhythmia exhibit significantly higher susceptibility to psychological distress compared with the general CHD population. This increased vulnerability has garnered growing clinical and research interest in the potential therapeutic benefits of structured psychological interventions for alleviating comorbid depressive and anxiety symptoms in this high-risk demographic.</p><p><strong>Aim: </strong>To evaluate the efficacy of psychological care in reducing anxiety and depressive symptoms among older adult patients with CHD and comorbid arrhythmia.</p><p><strong>Methods: </strong>This retrospective analysis included 100 patients with CHD and arrhythmia admitted to the First Affiliated Hospital of Jinzhou Medical University from June 2024 to December 2024. Of these, 49 patients in the control group received routine care, whereas 51 patients in the observation group received psychological care in addition to routine care. Therapeutic outcomes were compared between the two groups. Psychological distress was assessed before and after providing nursing care. A treatment compliance scale developed by the hospital was used to assess adherence. Complication rates were also compared. Quality of life was evaluated using the Short Form-36 Health Survey after providing nursing care. Patient satisfaction with nursing care was assessed using a self-designed questionnaire.</p><p><strong>Results: </strong>The observation group demonstrated a higher overall treatment effectiveness compared with the control group (<i>P</i> < 0.05). After nursing care, both groups showed reduced scores on the Self-Rating Anxiety Scale and Self-Rating Depression Scale compared with baseline (<i>P</i> < 0.05), with significantly greater improvements in the observation group (<i>P</i> < 0.05). Treatment compliance was higher and complication rates were lower in the observation group (<i>P</i> < 0.05). Additionally, the observation group demonstrated better quality of life after 1 month of care and higher satisfaction with nursing services (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Psychological care for patients with CHD and comorbid arrhythmia effectively enhanced therapeutic outcomes, reduced anxiety and depression, improved treatment compliance and quality of life, and lowered the risk of complications. These findings support the broader implementation of psychological care for patients with CHD in clinical practice.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106762"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic inequality and mental health in older adults: Exploring new dimensions of economic well-being.","authors":"Jaewon Lee, Jennifer Allen","doi":"10.5498/wjp.v15.i7.107489","DOIUrl":"10.5498/wjp.v15.i7.107489","url":null,"abstract":"<p><p>Economic inequality is a persistent global issue with profound implications for mental health, particularly among older adults. Previous studies have largely focused on objective economic well-being indicators such as income, employment status, and poverty. While these factors are crucial, emerging evidence suggests that welfare benefits and subjective economic well-being components of what can be deemed augmented economic well-being, may play equally significant roles in shaping psychological health among aging populations. This research explores how disparities in these aspects contribute to psychological distress in older adults. We highlight the role of financial security, government assistance programs, and personal economic satisfaction. We propose policy interventions to mitigate adverse effects and emphasize the need for a holistic approach to economic well-being to improve mental health outcomes in older adults. This study reveals that subjective financial security and access to welfare benefits often surpass income as predictors of mental health. These insights underscore the importance of broadening economic frameworks in aging research and developing integrated policies to enhance financial and psychological well-being.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107489"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of cognitive impairment in arterial hypertension.","authors":"Stanislav Nikolaevich Kotlyarov","doi":"10.5498/wjp.v15.i7.106597","DOIUrl":"10.5498/wjp.v15.i7.106597","url":null,"abstract":"<p><p>Cognitive impairment in elderly patients with arterial hypertension is an urgent medical and social problem. This is especially important given the high prevalence of arterial hypertension. In this regard, the mechanisms of cognitive impairment are of growing interest in order to find new preventive and therapeutic strategies. In general, the main mechanisms determining the association between hypertension and cognitive impairment include imbalances in cerebral blood flow perfusion, immune and metabolic disorders, blood-brain barrier dysfunction, and brain structure abnormalities. Metabolic disorders, including insulin resistance in the brain, are of growing interest as mechanisms of cognitive impairment. Comorbid diseases and target organ damage, which are common in arterial hypertension, also play an important role.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106597"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoepigenetics in schizophrenia: Predicting drug response.","authors":"Sariye Aybüke Yıldırım, Irmak Dal, Selin Özkan-Kotiloğlu, Bora Baskak, Dilek Kaya-Akyüzlü","doi":"10.5498/wjp.v15.i7.107597","DOIUrl":"10.5498/wjp.v15.i7.107597","url":null,"abstract":"<p><p>Individual differences in treatment response in schizophrenia pose a significant challenge in the management of the disease, due to several biological as well as psychosocial factors, including genetic and epigenetic mechanisms. Pharmacoepigenetics investigates how epigenetic mechanisms affect the variability in effectiveness of treatments and adverse side effects. Antipsychotics such as clozapine (atypical) and haloperidol (typical) directly induce epigenetic changes by altering DNA methyltransferases and histone acetyltransferases, while indirectly affecting neuroinflammatory and stress response pathways. Personalized medicine using epigenetic markers (DNA methylation, non-coding RNAs including microRNAs and long non-coding RNAs) holds great promise for improving the drug response and reducing the side effects of antipsychotic treatment. These developments could revolutionize the treatment of schizophrenia by addressing the complexities involved in responding to treatment. However, ethical and technical barriers to implementing strategies based on epigenetic regulation in clinical practice are fundamental challenges that need to be carefully addressed in this field. This review examined the epigenetic mechanisms involved in the efficacy of antipsychotic drugs.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107597"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between death anxiety and coping with death competence among Chinese oncology nurses: A chain mediation model.","authors":"Ying Wen, Qun-Xiang Zhang, Yang Liu, Xiao-Hua He, You-Wen Gong","doi":"10.5498/wjp.v15.i7.107416","DOIUrl":"10.5498/wjp.v15.i7.107416","url":null,"abstract":"<p><strong>Background: </strong>Death anxiety (DA) is a prevalent psychological challenge among oncology nurses that affects their emotional well-being and professional competence in coping with death-related situations. Death-related attitudes and resilience are critical factors that may mediate the relationship between DA and coping with death competence (CDC). However, few studies have examined the chain-mediating effect of these factors among Chinese oncology nurses. This study aimed to investigate the association between DA and CDC among Chinese oncology nurses, with a focus on the mediating roles of death attitude and resilience.</p><p><strong>Aim: </strong>To investigate the association between DA and CDC among Chinese oncology nurses.</p><p><strong>Methods: </strong>A national cross-sectional survey was conducted among Chinese oncology nurses using an electronic questionnaire distributed in Wenjuanxing, China. In total, 615 valid responses were obtained. The participants completed the Templer death anxiety scale, death attitude profile-revised, Connor-Davidson resilience scale, and coping with death scale. A chain mediation analysis was performed using the PROCESS macro in SPSS to examine the relationships between these variables.</p><p><strong>Results: </strong>The findings indicated that DA had a significant direct effect on CDC [effect = 0.201, 95% confidence interval (CI): 0.112-0.322]. In addition to this direct effect, three significant indirect pathways were observed: (1) Death attitude (effect = 0.118, 95%CI: 0.056-0.163); (2) Resilience (effect = 0.108, 95%CI: 0.032-0.176); and (3) A sequential mediation pathway involving both death attitude and resilience (effect = 0.071, 95%CI: 0.042-0.123). The total indirect effects of the three mediation paths accounted for 29.7% of the relationship between DA and CDC.</p><p><strong>Conclusion: </strong>Using a chain mediation model, this study explored the mechanisms linking DA, death attitude, resilience, and CDC among Chinese oncology nurses. These findings highlighted the crucial role of death attitude and resilience in mediating the relationship between DA and CDC. Interventions aimed at fostering adaptive attitudes toward death and enhancing resilience may improve nurses' ability to cope with death-related stressors, ultimately benefiting their psychological well-being and professional competence.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107416"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and etiology of poststroke depression: A review.","authors":"Meng-Chan Lin, Si-Sheng Huang","doi":"10.5498/wjp.v15.i7.107598","DOIUrl":"10.5498/wjp.v15.i7.107598","url":null,"abstract":"<p><p>Following an acute stroke, patients often encounter a range of impairments affecting their physical, cognitive, verbal, and social capabilities. Poststroke depression (PSD) has been identified as a significant consequence of stroke and serves as a crucial predictor of patient outcomes. The diagnosis of PSD presents a challenge, as the physical manifestations following a stroke can overlap with certain depressive symptoms, leading to a potential underdiagnosis of this condition. This review employs a narrative approach to synthesize diverse findings within this domain. PSD is categorized as an organic mood disorder, and a more accurate diagnosis may be achieved by considering the location of the stroke, the patient's specific symptoms, and the timeline of depressive symptom onset. Notably, if depressive symptoms emerge at more than one year poststroke, the likelihood of PSD diminishes. The etiology of PSD is currently understood to stem from a combination of physiological and psychosocial factors, as well as their interactions. Several mechanisms associated with PSD have been identified, including inflammation, dysregulation of the hypothalamic-pituitary-adrenal axis, oxidative stress, autophagy, apoptosis, abnormal neurotrophic responses, glutamate-mediated excitotoxicity, dysfunction within brain networks, reduced monoamine levels, locations of brain lesions, and psychosocial influences. This review also outlines potential directions for future research.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107598"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interconnected struggles: How insomnia, anxiety, and depression impact mental health.","authors":"Wen-Jie Yang, Yong-Juan Xin","doi":"10.5498/wjp.v15.i7.105086","DOIUrl":"10.5498/wjp.v15.i7.105086","url":null,"abstract":"<p><p>Insomnia, anxiety, and depression have emerged as significant public mental health concerns, particularly during the coronavirus disease 2019 (COVID-19) pandemic. Early recognition and intervention, addressing COVID-19's health effects before diverse symptoms appear, will expedite recovery and significantly enhance public mental health. Li <i>et al</i> conducted a cross-sectional online survey to assess neuroticism, cognitive function, insomnia, and emotional disorders in adult participants, examining how these factors correlate with mental health. The study revealed that a substantial number of participants reported experiencing varying degrees of anxiety, depression, and insomnia, most of which were classified as mild. Neuroticism was found closely associated with cognitive failure and poor mental health. Furthermore, moderated mediation analysis indicated that cognitive failure mediated the relationship between insomnia and anxiety and depression, whereas neuroticism moderated the pathway. These findings suggest that improving the subjective cognitive function and emotional stability can significantly improve mental health. However, this study has several limitations, including a limited sample size, cross-sectional design, and a focus on behavioral-level data. Future research should broaden its scope to include multiple hospitals at various levels to enhance the representativeness of the study population, adopt longitudinal designs, and integrate advanced technologies such as neuroimaging to explore the neural mechanisms underlying these conditions.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"105086"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the incidence and risk factors of postoperative delirium in organ transplant patients.","authors":"Shan-Sheng Hou, Jun Liu, Peng-Fei Qiao, Dong-Ge Yang, Liang-Fei Huang, Fei Liu, Yue Liu, Ting-Ting Jia, Hong-Liang Wang","doi":"10.5498/wjp.v15.i7.104812","DOIUrl":"10.5498/wjp.v15.i7.104812","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium (POD) is a concerning complication of organ transplantation. With organ transplantation offering hope to patients with end-stage organ disease, understanding the incidence and risk factors of POD is crucial, as it can significantly affect patients' prognosis and healthcare costs.</p><p><strong>Aim: </strong>To systematically evaluate the incidence and risk factors of POD following organ transplantation to facilitate clinical prevention and optimize patient management and prognosis.</p><p><strong>Methods: </strong>Multiple databases such as PubMed and their reference lists were comprehensively searched using a combination of keywords related to organ transplantation and POD. Relevant observational studies on patients who had undergone solid organ transplantation and randomized controlled trials containing relevant analyses were included. Duplicated, data-deficient, non-English, and non-original data studies were excluded. Data were extracted independently by two researchers and then cross-checked. The Newcastle-Ottawa scale was used to evaluate the quality of the included studies. RevMan 5.3 was employed for data analysis. The pooled incidence of POD was calculated according to the data type, and the fixed or random effect model was employed to analyze risk factors based on heterogeneity. Subsequently, sensitivity analysis and publication bias assessments were performed.</p><p><strong>Results: </strong>A total of 39 relevant literatures were included. The overall incidence of POD in the organ transplant group was 20% [95% confidence interval (CI): 18%-22%]; liver transplant group, 22% (95%CI: 17%-26%); lung transplant group, 34% (95%CI: 23%-45%); and kidney transplant group, 6% (95%CI: 2%-10%). Primary graft dysfunction increased the POD risk, with a pooled odds ratio (OR) (95%CI) of 1.78 (1.09-2.91). A history of hepatic encephalopathy increased the POD risk, with a pooled OR (95%CI) of 3.19 (2.30-4.43). The higher the Acute Physiology and Chronic Health Evaluation II score, the greater the POD risk, with a pooled OR (95%CI) of 1.52 (1.09-2.12). A history of alcohol abuse increased the POD risk, with a pooled OR (95%CI) of 2.84 (1.74-4.65). Thus, the higher the model for end-stage liver disease score, the greater the POD risk, with a pooled OR (95%CI) of 2.49 (1.14-5.43). POD was more likely to develop in patients with preoperative infections, with a pooled OR (95%CI) of 2.78 (1.56-4.97). The use of diuretics increased the POD risk, with a pooled OR (95%CI) of 2.36 (1.38-4.04).</p><p><strong>Conclusion: </strong>In this study, the overall incidence of POD in patients who underwent organ transplantation is 20%. The incidence varies among different types of organ transplantation, and multiple factors can increase the POD risk.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"104812"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Permissive hypercapnia combined with goal-directed fluid therapy improve postoperative mental health in elderly patients undergoing laparoscopic surgery.","authors":"Li Yuan, Xiao-Min Zhang, Na Liu, Jun-Qi Shi, Xiao-Jie Sun, Guo-Li Li, Jin-Liang Teng","doi":"10.5498/wjp.v15.i7.106023","DOIUrl":"10.5498/wjp.v15.i7.106023","url":null,"abstract":"<p><strong>Background: </strong>An investigation is undertaken to assess the effects of permissive hypercapnia (PH) combined with goal-directed fluid therapy (GDFT) on postoperative recovery and psychological well-being among elderly patients undergoing laparoscopic surgical procedures.</p><p><strong>Aim: </strong>To ascertain whether the combination of PH and GDFT improves clinical recovery indicators, reduces postoperative complications, and alleviates anxiety, depression, and inflammatory responses in this specific patient population.</p><p><strong>Methods: </strong>A total of 120 elderly patients who underwent laparoscopic surgery in our hospital from July 2023 to June 2024 were randomly allocated into two groups: A control group (<i>n</i> = 60) and a study group (<i>n</i> = 60). In the control group, conventional anesthesia ventilation and fluid management protocols were administered, while in the study group, PH (with intraoperative PaCO₂ maintained between 45-55 mmHg) was combined with GDFT. Postoperative recovery indicators, including the time to first flatus, time to ambulation, and length of hospital stay, were compared between the groups. Additionally, complication rates, anxiety-depression scores assessed <i>via</i> the Hospital Anxiety and Depression scale, and levels of inflammatory factors were analyzed to evaluate the outcomes.</p><p><strong>Results: </strong>When compared with the control group, the study group demonstrated significantly shorter time to first flatus [(48.3 ± 6.2) hours <i>vs</i> (62.5 ± 7.8) hours], time to ambulation [(28.4 ± 4.2) hours <i>vs</i> (38.6 ± 5.1) hours], and length of hospital stay [(5.2 ± 1.1) days <i>vs</i> (7.4 ± 1.3) days] (<i>P</i> < 0.05). A significantly lower postoperative complication rate was observed in the study group (8.3% <i>vs</i> 21.7%, <i>P</i> < 0.05). Additionally, at 3 days postoperatively, significantly lower anxiety scores [(5.2 ± 1.4) <i>vs</i> (7.8 ± 1.6)] and depression scores [(4.8 ± 1.2) <i>vs</i> (7.1 ± 1.5)] were recorded in the study group compared to the control group (<i>P</i> < 0.05); Furthermore, at 24 hours postoperatively, serum levels of interleukin-6, tumor necrosis factor α, and C-reactive protein were found to be significantly lower in the study group than in the control group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Postoperative recovery is significantly expedited, postoperative complications are markedly reduced, anxiety-depression status is substantially improved, and inflammatory response is notably diminished in elderly patients undergoing laparoscopic surgery when PH is combined with GDFT, thereby making it worthy of clinical application.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106023"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}