World Journal of Psychiatry最新文献

{"title":"Neural correlates of attentional switching dysfunction in major depressive disorder: Evidence from an event-related potential study with a dual-task paradigm.","authors":"Ya-Wen Wu, Xin-Yu Wang, Yi-Fan Sun, Luo-An Wu, Wei Li, Yu Li, Xue-Zheng Gao, Xiao-Hong Liu, Zhen-He Zhou, Hong-Liang Zhou","doi":"10.5498/wjp.v15.i12.111513","DOIUrl":"10.5498/wjp.v15.i12.111513","url":null,"abstract":"<p><strong>Background: </strong>Research has consistently demonstrated that patients with major depressive disorder (MDD) exhibit attentional switching dysfunction, and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits. However, the neuroelectrophysiological mechanism underlying this deficit has not been clarified.</p><p><strong>Aim: </strong>To investigate the event-related potential (ERP) characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.</p><p><strong>Methods: </strong>The participants included 29 MDD patients and 29 healthy controls (HCs). The ERPs of the participants were measured while they performed the dual-task paradigm. The behavioral and ERP N100, P200, P300, and late positive potential (LPP) data were analyzed.</p><p><strong>Results: </strong>This study revealed greater accuracy in HCs and slower reaction times (RTs) in MDD patients. Angry facial pictures led to lower accuracy. The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony. With respect to ERP characteristics, happy facial pictures and neutral facial pictures evoked higher amplitudes. The N100, P200, P300, and LPP amplitudes at Pz were the highest. MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.</p><p><strong>Conclusion: </strong>In conclusion, MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm, which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD. These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"111513"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety disorders following percutaneous coronary intervention for acute myocardial infarction: A comprehensive review of clinical manifestations and interventions.","authors":"Xin Tang, Gan Liu, Yun-Jie Zeng","doi":"10.5498/wjp.v15.i12.110290","DOIUrl":"10.5498/wjp.v15.i12.110290","url":null,"abstract":"<p><p>Anxiety disorders following percutaneous coronary intervention for acute myocardial infarction affect approximately 20%-40% of patients, with a significantly greater prevalence in females (OR = 1.8). These disorders manifest through physiological symptoms, cognitive distortions, behavioral avoidance, and cardiac-specific concerns and typically emerge within 1-2 weeks post-procedure. Key risk factors include female sex, younger age (< 55 years), psychiatric history, procedural complexity, and poor social support. Anxiety negatively affects cardiovascular outcomes when left untreated, leading to higher readmission rates (HR = 1.47) and recurrent cardiovascular events (HR = 1.31), as well as lower medication adherence and quality of life. Screening is optimally conducted 7-10 days post-procedure via validated tools such as the Hospital Anxiety and Depression Scale, Anxiety. Heart-specific cognitive behavioral therapy (SMD = -0.72), selective serotonin reuptake inhibitors (especially sertraline), and integrated cardiac rehabilitation programs that incorporate both psychological and physical elements are among the beneficial interventions that have been supported by evidence. These all-encompassing strategies show long-term improvements in cardiovascular outcomes, functional ability, and healthcare expenses in addition to immediate benefits in lowering anxiety. Digital initiatives have the potential to increase access, especially in underprivileged areas. Early identification of high-risk patients and implementation of timely, targeted interventions represent crucial strategies for improving both psychological and cardiovascular outcomes in this vulnerable population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"110290"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anxiety-depression disorders and brain structural connectivity abnormalities after subarachnoid hemorrhage.","authors":"Lei Qin, Kai Wang, Li-Ping Jiang, Zhang Xiao, Song Luo","doi":"10.5498/wjp.v15.i12.111754","DOIUrl":"10.5498/wjp.v15.i12.111754","url":null,"abstract":"<p><strong>Background: </strong>Subarachnoid hemorrhage (SAH) is associated with high incidence of anxiety and depression disorders (27%-54% and 20%-42%, respectively), significantly affecting patient quality of life. However, the pathophysiological mechanisms underlying post-SAH emotional disorders remain poorly understood, limiting targeted therapeutic interventions.</p><p><strong>Aim: </strong>To identify potential biomarkers and therapeutic targets through comprehensive analysis of behavioral, neuroimaging, and inflammatory parameters in a rat SAH model.</p><p><strong>Methods: </strong>We established a rat SAH model using cisternal injection of autologous blood and conducted comprehensive assessments including behavioral tests (elevated plus maze, forced swimming test, sucrose preference test), diffusion tensor imaging (DTI), and inflammatory factor detection. Seventy-two male SD rats were randomly divided into sham and SAH groups, with evaluations performed at multiple time points (1 hour to 72 hours post-hemorrhage). DTI parameters including fractional anisotropy (FA) and apparent diffusion coefficient were measured in limbic-prefrontal circuits. Serum and cerebrospinal fluid inflammatory markers [interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α] were quantified using enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>SAH rats exhibited significant anxiety-like and depression-like behaviors at 12 hours, which further deteriorated at 24 hours (open arm time: 30.3 ± 4.7 seconds <i>vs</i> 82.1 ± 8.3 seconds in controls, <i>P</i> < 0.01; immobility time: 136.5 ± 12.7 seconds <i>vs</i> 78.3 ± 9.2 seconds in controls, <i>P</i> < 0.01). DTI analysis revealed progressive white matter microstructural damage, with hippocampus-prefrontal FA values decreasing by 21.8% and amygdala-prefrontal FA values by 20.3% at 24 hours (<i>P</i> < 0.001). Apparent diffusion coefficient values significantly decreased at 12 hours, indicating cellular edema. Inflammatory markers showed marked elevation, with stronger correlations between cerebrospinal fluid IL-1β and behavioral changes (<i>r</i> = 0.72-0.81, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>This study demonstrates that post-SAH emotional disorders result from a temporal cascade involving early neuroinflammation and progressive limbic-prefrontal circuit microstructural damage.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"111754"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between anxiety/depression, self-efficacy, and social support in patients with gastric cancer and analysis of risk factors.","authors":"Zhong-Yan Zhang, Xue-Jiao Yong, Shen Jiang","doi":"10.5498/wjp.v15.i12.109328","DOIUrl":"10.5498/wjp.v15.i12.109328","url":null,"abstract":"<p><strong>Background: </strong>Patients with gastric cancer (GC) frequently experience notable psychological distress, which often manifests as anxiety and depression. Identifying key contributing factors is essential for developing effective interventions to improve mental health outcomes.</p><p><strong>Aim: </strong>To investigate the relationships between anxiety/depression, self-efficacy, and social support in patients with GC and identified significant risk factors.</p><p><strong>Methods: </strong>We enrolled 124 patients with GC undergoing treatment at Chongqing University Cancer Hospital between May 2021 and May 2024. Information regarding the patients' anxiety and depression evaluated by the hospital anxiety and depression scale (HADS), [including a subscale for anxiety (HADS-A) and a separate subscale for depression (HADS-D)] self-efficacy, measured by the general self-efficacy scale (GSES), and social support, assessed by the perceived social support scale (PSSS), was gathered. Relationships among HADS, GSES, and PSSS scores were determined through Pearson correlation analysis. Risk factors for anxiety and depression among patients with GC were identified using univariate and multivariate analyses, specifically binary logistic regression.</p><p><strong>Results: </strong>The obtained data demonstrated mild psychological distress (mean HADS-A: 8.74 ± 3.70; mean HADS-D: 10.26 ± 3.84), suboptimal self-efficacy levels (GSES: 17.81 ± 5.45), and moderate social support (PSSS: 56.27 ± 11.28). Correlational analysis revealed significant inverse relationships between psychological distress (anxiety and depression) and both social support and self-efficacy (<i>P</i> < 0.01), with self-efficacy showing a strong positive association with social support (<i>P</i> < 0.01). Univariate analysis revealed that gender, age, clinical stage, tumor size, GSES, and PSSS were closely associated with anxiety and depression in patients with GC. Multivariate logistic regression identified three independent predictors of these mood disturbances: Advanced age (≥ 60), large tumor size (≥ 3 cm), and diminished GSES scores (< 18).</p><p><strong>Conclusion: </strong>Our findings suggest that patients with GC generally experience mild anxiety and depression, which are closely related to low self-efficacy and insufficient social support. Age, tumor size, and low self-efficacy are independent predictors of anxiety and depression. In clinical practice, psychosocial interventions should be integrated, with a focus on high-risk populations, to improve patients' mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"109328"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study.","authors":"Fu-Gang Mao, Ya-Ling Tang, Xiao-Yuan Wang, Xing Jin, Jing-Yuan Fan","doi":"10.5498/wjp.v15.i12.109437","DOIUrl":"10.5498/wjp.v15.i12.109437","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Depression is a highly prevalent and clinically significant psychiatric comorbidity in patients with heart failure (HF), exerting multidimensional effects that extend beyond emotional symptoms to influence physiological outcomes and disease progression. Emerging evidence in psychocardiology highlights the bidirectional interplay between mood disorders and cardiovascular dysfunction through neuroendocrine, autonomic, and behavioral pathways. This study aims to explore the real-world effect of depression severity - measured by the Patient Health Questionnaire-9 (PHQ-9) - on left ventricular systolic function and one-year cardiovascular readmission in patients with HF, providing insights into its prognostic relevance within a psychocardiological framework.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the impact of depression severity on medication adherence, ventricular function, and readmission in patients with HF.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 160 patients hospitalized for HF between January 2020 and December 2023 were included in this real-world retrospective cohort study. Depression severity was assessed by using the PHQ-9, with scores ≥ 10 indicating moderate-to-severe depression. Cardiac function was evaluated through transthoracic echocardiography to determine left ventricular ejection fraction (LVEF). Medication adherence was assessed at three and six months postdischarge by employing the four-item Morisky Medication Adherence Scale (MMAS-4) and categorized as high (score = 0), moderate (1-2), or low (3-4). Data on antidepressant or anxiolytic prescriptions and psychological interventions during hospitalization were collected. Patients were followed up for one year to capture cardiovascular-related readmissions. Kaplan-Meier analysis was employed to estimate event-free survival, and Cox regression identified independent predictors of readmission.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Patients with moderate-to-severe depression (PHQ-9 ≥ 10) presented with significantly lower LVEF at baseline, higher N-terminal pro-B-type natriuretic peptide levels, and more severe HF symptoms than other patients. They also demonstrated poorer medication adherence postdischarge, with a higher proportion classified as low adherence on the MMAS-4 scale, and were less likely to receive β-blockers or angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker at discharge than other patients. At three and six months postdischarge, PHQ-9 and MMAS-4 scores were inversely correlated with LVEF, suggesting a behavioral pathway linking depression to impaired cardiac recovery. During the one-year follow-up period, 30.0% of patients experienced cardiovascular-related readmissions, predominantly due to worsening HF (54.1%). In multivariable Cox regression analysis, high PHQ-9 scores, reduced LVEF, old age, elevated N-terminal pro-B-type natriuretic peptide levels, New York Heart Association class IV, and absence of β-blocker","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"109437"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute poisoning and psychological trauma: Bridging emergency care to long-term mental health rehabilitation.","authors":"Cai-Xia Lin, Xia-Rong Liu, Kun-Bin Lin","doi":"10.5498/wjp.v15.i12.111516","DOIUrl":"10.5498/wjp.v15.i12.111516","url":null,"abstract":"<p><p>This review addresses the critical intersection between acute poisoning and the associated psychological trauma, highlighting the need to bridge the gap between emergency care and long-term mental health rehabilitation. The global incidence of acute poisoning varies, showing different demographic patterns in psychological trauma post-poisoning, with suicide attempts accounting for approximately 76% of cases in some cohorts. Additionally, an estimated 385 million unintentional pesticide poisonings occur annually worldwide. A comprehensive understanding of the biological and neurobiological mechanisms involved-along with accurate diagnostic strategies and treatment methods-is essential. Multidisciplinary and integrated care approaches associated with a reduction in all-cause mortality (odds ratio: 0.52) and significant symptom burden relief, along with technological and therapeutic innovations, are essential for improving patient outcomes. Finally, this review outlines policy and research recommendations to enhance integrated care systems for the better management of acute poisoning and its associated psychological trauma.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"111516"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted exercise interventions on stress, anxiety, depression, and sleep disorders in PhD students.","authors":"Fei-Long Wu, Qun Yang, Juan Jiang, Jing Yu, Yin-Chuan Jin","doi":"10.5498/wjp.v15.i12.109558","DOIUrl":"10.5498/wjp.v15.i12.109558","url":null,"abstract":"<p><strong>Background: </strong>Doctoral students often encounter mental health challenges, including stress, anxiety, depression, and sleep disorders. It is important to explore effective intervention methods to enhance their overall physical and mental well-being. It is anticipated that targeted exercise will lead to a significant reduction in stress, anxiety, and depression levels as well as an improvement in sleep quality.</p><p><strong>Aim: </strong>To assess the feasibility and potential benefits of both intervention models in enhancing the sleep quality of doctoral students while alleviating stress, anxiety, and depression.</p><p><strong>Methods: </strong>A retrospective analysis of health data from 64 doctoral students across three universities in Shenyang during the 2024-2025 academic year was conducted. The participants were divided into a targeted exercise group and a Tai Chi group. The study employed the Epworth Sleepiness Scale, Insomnia Severity Index, Pittsburgh Sleep Quality Index, Perceived Stress Scale-10, Generalized Anxiety Disorder Scale-7, and Patient Health Questionnaire-9 to evaluate the impact of the two interventions on reducing stress, anxiety, depression, and sleep disorders.</p><p><strong>Results: </strong>The primary results of the study indicated that targeted exercise interventions are significantly effective in alleviating symptoms of anxiety, stress, and depression, as well as in improving sleep quality. Compared to Tai Chi interventions, this approach demonstrates greater durability of effects. Although the efficacy of targeted interventions may gradually diminish over time, the overall research findings suggest that targeted exercise remains a more effective therapeutic approach than Tai Chi interventions.</p><p><strong>Conclusion: </strong>The impact of targeted exercise on stress, anxiety, depression, and sleep disorders was greater than that of Tai Chi, confirming the potential benefits for psychological health intervention for doctoral students.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"109558"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic abuse as a female battering form: A cross-sectional study among physicians and nurses.","authors":"Elif Sarac, Deniz Odabas","doi":"10.5498/wjp.v15.i12.111334","DOIUrl":"10.5498/wjp.v15.i12.111334","url":null,"abstract":"<p><strong>Background: </strong>Economic violence is a type of domestic violence in which an intimate partner attempts to oppress, restrict, or direct a female by exercising control over her financial resources.</p><p><strong>Aim: </strong>To explore the impact of economic abuse on individual work performance and clarify the effective factors on financial exploitation among physicians and nurses.</p><p><strong>Methods: </strong>The study has a cross-sectional design, and 305 married, female physicians and nurses working in a university hospital were included. Data was collected with demographic characteristics forms, \"Revised Scale of Economic Abuse\" and \"Individual Work Performance Questionnaire\". Pearson correlation, comparative analyses, and internal consistency reliability tests were used.</p><p><strong>Results: </strong>The average age was 39.04 ± 9.41. Among the respondents 69.2% were nurses and 63.9% held a bachelor's degree. The mean score for the Revised Scale of Economic Abuse was 2.80 ± 4.73 while it was 3.86 ± 0.60 for the Individual Work Performance Questionnaire.</p><p><strong>Conclusion: </strong>Our study revealed no relationship between economic abuse and individual work performance, confirming that nurses are exposed to more economic abuse and exploitation than physicians and exhibit higher work performance.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"111334"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cognitive behavioral therapy on cancer-related fatigue and psychological status in ovarian cancer patients: A meta-analysis.","authors":"Fei Zhao, Yan Bo, Xue-Lian Su","doi":"10.5498/wjp.v15.i12.112479","DOIUrl":"10.5498/wjp.v15.i12.112479","url":null,"abstract":"<p><strong>Background: </strong>Substantial clinical evidence supports the efficacy of cognitive behavioral therapy (CBT) for various diseases, particularly in oncology. However, the true impact of CBT interventions on cancer-related fatigue and mental health in patients with ovarian cancer remains unknown.</p><p><strong>Aim: </strong>To evaluate the effects of CBT on fatigue, anxiety, depression and quality of life in patients with ovarian cancer.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) on CBT for patients with ovarian cancer were searched in the PubMed, EMBASE, Web of Science and Cochrane Library databases. According to the preferred reporting items for systematic reviews and meta-analyses statement, we formulated the inclusion and exclusion criteria, strictly screened the literatures, extracted data and performed a meta-analysis.</p><p><strong>Results: </strong>Six RCTs with 332 ovarian cancer patients were included. Compared with the control group, cancer fatigue [mean difference (MD) = -0.98, 95% confidence interval (CI): -1.47 to -0.50], anxiety [standardized mean difference (SMD) = -0.64, 95%CI: -0.91 to -0.36] and depression levels (SMD = -0.41, 95%CI: -0.76 to -0.06) of the patients in the experimental group reduced after CBT intervention. Quality of life (MD = 1.28, 95%CI: 0.65 to 1.90) and sleep quality (MD = -0.49, 95%CI: -0.66 to -0.33) of the patients improved, and the differences between the groups were statistically significant (<i>P</i> < 0.01). The quality evaluation results suggested that the quality of the included RCTs was low. The meta-regression results showed that patient age and nurse guidance affected treatment outcomes, especially anxiety, whereas the specific method of CBT had a non-significant effect.</p><p><strong>Conclusion: </strong>CBT effectively improves mental status and cancer-related fatigue in patients with ovarian cancer undergoing chemotherapy. Future research should prioritize adequately powered RCTs with standardized outcome measures and longitudinal designs to establish sustained efficacy.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"112479"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep.","authors":"Esra Kabadayi Sahin","doi":"10.5498/wjp.v15.i12.113893","DOIUrl":"10.5498/wjp.v15.i12.113893","url":null,"abstract":"<p><p>Sleep is a critical yet often underestimated physiological parameter in psychiatric disorders. In their article, Gokcay <i>et al</i> examined sleep quality in bipolar disorder patients treated with lithium or valproic acid, showing lithium's advantage in habitual sleep efficiency and reduced disturbances. While this study provides valuable data in a chronic and clinically challenging cohort, reliance solely on self-reported sleep measures remains a limitation. Polysomnography, although the gold standard, is not always practical; therefore, actigraphy and wearable technologies represent feasible alternatives to capture objective sleep patterns. This letter emphasizes the importance of integrating objective, scalable technologies and pharmacological monitoring into longitudinal designs to clarify whether improvements in sleep translate into better clinical outcomes and reduced relapse risk in bipolar disorder.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 12","pages":"113893"},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}