World Journal of Psychiatry最新文献

{"title":"From operating room to recovery: Evidence and gaps in cardiac surgical nursing integrative psychological support.","authors":"Xing Li, Li-Ping Xiong, Ying Zhang, Ting-Ting Zhao, Cai-Yun Zhang","doi":"10.5498/wjp.v15.i7.107103","DOIUrl":"10.5498/wjp.v15.i7.107103","url":null,"abstract":"<p><p>This review explored the application and effectiveness of and research gaps in integrative psychological support in patients undergoing cardiac surgery during the perioperative period. These patients often encounter psychological issues such as anxiety and depression, which affect their postoperative recovery and quality of life. Previous research indicated that preoperative psychological assessments and interventions significantly enhance patients' psychological states and postoperative outcomes. Interventions, including preoperative education, mindfulness-based stress reduction, and cognitive training, have proven effective in reducing the incidence of postoperative delirium and anxiety. Intraoperative environment optimization (<i>e.g.</i>, music therapy) and postoperative psychological support (<i>e.g.</i>, family visits and psychological interventions in intensive care unit psychological interventions) positively influence patient recovery. Furthermore, theory-based nursing interventions and digital health tools (<i>e.g.</i>, remote monitoring applications) offer new directions for psychological support. However, challenges, including fragmented psychological support, insufficient cross-stage integration, and inadequate training, remain in current nursing practices. Future research should focus on developing standardized psychological support pathways, enhancing multidisciplinary collaboration, and verifying the long-term effects of digital therapeutics.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107103"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-skin-brain axis in people suffering from sepsis with acute skin failure.","authors":"Takahiko Nagamine","doi":"10.5498/wjp.v15.i7.106062","DOIUrl":"10.5498/wjp.v15.i7.106062","url":null,"abstract":"<p><p>Sepsis, a life-threatening condition, can lead to acute skin failure characterized by extensive skin damage. This is often due to decreased blood flow, inflammation, and increased susceptibility to infection. Acute skin failure in people with sepsis is often associated with sleep disturbances, anxiety, and poor mood. Inflammatory markers and lactate levels correlate with these psychiatric symptoms, suggesting a link between skin and brain function. The skin and the central nervous system (CNS) have bidirectional communication. The CNS is also in close contact with the digestive tract. The gut, skin, and brain influence each other's functions through nervous, hormonal, and immune pathways, forming a gut-skin-brain axis. Understanding the interaction among the gut, skin, and CNS is critical to the diagnosis and treatment of various skin and neurological disorders. By recognizing individual variations in gut microbiota, immune responses, and neural pathways, treatments can be tailored to specific patient needs, enhancing efficacy and minimizing side effects. The gut plays a large role in mental health. Understanding the gut skin brain axis, will lead to improved mental health outcomes.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106062"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of work-family facilitation on work engagement among physical education teachers.","authors":"Zi-Qi Wang, Si-Yu Hong, Zi-Xuan Jia, Sha-Sha Ma, Qing-Lu Wang, Wen-Jun Wang","doi":"10.5498/wjp.v15.i7.106613","DOIUrl":"10.5498/wjp.v15.i7.106613","url":null,"abstract":"<p><strong>Background: </strong>Enhancing work engagement among physical education (PE) teachers is crucial for building a strong sports nation and fostering educational advancement. However, PE teachers frequently experience conflicts between work and family roles, significantly impacting their professional involvement. The concept of work-family facilitation, highlighting mutual facilitation between work and family domains, has considerable theoretical and practical significance but remains underexplored in this context. This study integrates ecosystem theory, spillover theory, social exchange theory, and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement. Specifically, it investigates the roles of psychological resilience and job satisfaction in this relationship, providing a novel theoretical perspective and empirical evidence.</p><p><strong>Aim: </strong>To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.</p><p><strong>Methods: </strong>A cross-sectional questionnaire survey was conducted among 436 PE teachers. Structural equation modeling was used to examine relationships among variables and assess mediating effects.</p><p><strong>Results: </strong>Work-family facilitation positively correlated with psychological resilience, job satisfaction, and work engagement (<i>r</i> = 0.323-0.705, <i>P</i> < 0.001). Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement, demonstrating a significant chain mediation effect.</p><p><strong>Conclusion: </strong>This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction, thereby significantly boosting work engagement among PE teachers. These findings underline the importance of targeted interventions to enhance work-family resources, psychological resilience, and job satisfaction, contributing to theoretical advancements and practical implications for educational management.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106613"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anxiety, depression, self-perceived burden, and psychological resilience in patients with chronic renal failure on maintenance hemodialysis.","authors":"Yin-Yin Ye, Liang-Fei Tao, Yan-Lang Yang, Yu-Wei Wang, Xiao-Ming Yang, Hai-Hong Xu","doi":"10.5498/wjp.v15.i7.103850","DOIUrl":"10.5498/wjp.v15.i7.103850","url":null,"abstract":"<p><strong>Background: </strong>Research examining the relationships among anxiety, depression, self-perceived burden (SPB), and psychological resilience (PR), along with the determinants of PR, in patients with chronic renal failure (CRF) receiving maintenance hemodialysis (MHD) is limited.</p><p><strong>Aim: </strong>To investigate the correlation between anxiety, depression, SPB, and PR in patients with CRF on MHD.</p><p><strong>Methods: </strong>This study included 225 patients with CRF on MHD who were admitted between June 2021 and June 2024. The anxiety level was evaluated using the Self-Rating Anxiety Scale (SAS); the depression status was assessed using the Self-Rating Depression Scale (SDS); the SPB was measured using the SPB Scale (SPBS); and the PR was determined using the Connor-Davidson Resilience Scale (CD-RISC). The correlations among the SAS, SDS, SPB, and CD-RISC were analyzed using Pearson's correlation coefficients. Univariate and multivariate analyses were performed to identify the factors that influence the PR of patients with CRF on MHD.</p><p><strong>Results: </strong>The SAS, SDS, SPB, and CD-RISC scores of the 225 patients were 45.25 ± 15.36, 54.81 ± 14.68, 32.31 ± 11.52, and 66.48 ± 9.18, respectively. Significant negative correlations were observed between SAS, SDS, SPB, and CD-RISC. Furthermore, longer dialysis vintage (<i>P</i> = 0.015), the absence of religious beliefs (<i>P</i> = 0.020), lower monthly income (<i>P</i> = 0.008), higher SAS score (<i>P</i> = 0.013), and higher SDS score (<i>P</i> = 0.006) were all independent factors that adversely affected the PR of patients with CRF on MHD.</p><p><strong>Conclusion: </strong>Patients with CRF on MHD present with varying degrees of anxiety, depression, and SPB, all of which exhibit a significant negative correlation with their PR. Moreover, longer dialysis vintage, the absence of religious beliefs, lower monthly income, higher SAS score, and higher SDS score were factors that negatively affected the PR of patients with CRF on MHD.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"103850"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of anxiety and depression with ankle function in chronic ankle instability patients and analysis of risk factors.","authors":"Zu-Po Yu","doi":"10.5498/wjp.v15.i7.103185","DOIUrl":"10.5498/wjp.v15.i7.103185","url":null,"abstract":"<p><strong>Background: </strong>Psychological comorbidities, such as anxiety and depression, in patients with chronic ankle instability (CAI) may impede ankle function improvement, although the precise nature of this association warrants further investigation.</p><p><strong>Aim: </strong>To analyze the correlation of anxiety and depression with ankle function in patients with CAI and discussing the risk factors.</p><p><strong>Methods: </strong>This study included 116 patients with CAI, who were admitted to our hospital from July 2022 to July 2024. Anxiety and depression states of patients were assessed with the self-rating anxiety scale (SAS) and self-rating depression scale (SDS), respectively, and their ankle joint function was assessed with the ankle-hindfoot function score of the American Orthopedic Foot and Ankle Society. Further, the ankle function of patients with CAI with different anxiety and depression states was discussed. Furthermore, the Pearson correlation coefficient was used to analyze the correlation of anxiety and depression with ankle joint function in such patients. Univariate and multivariate analyses were conducted to investigate the factors affecting ankle joint function in patients with CAI.</p><p><strong>Results: </strong>Among the 116 patients with CAI, 97, 13, 5, and 1 cases demonstrated none, mild, moderate, and severe anxiety, whereas 95, 15, 6, and 0 cases showed none, mild, moderate, and severe depression, respectively. The average ankle joint function score was 74.82 ± 6.93 points. The ankle joint function in patients with CAI presented a significant downward tendency as the degree of anxiety and depression increased. Correlation analysis revealed that both the SAS and SDS scores of patients with CAI were significantly negatively correlated with the ankle joint function score. Univariate and multivariate analyses indicated that the risk factors affecting patients' ankle joint function included early functional rehabilitation, visual analog scale, and SDS.</p><p><strong>Conclusion: </strong>A substantial number of patients with CAI suffer from anxiety and depression, and these negative emotions, to a certain extent, harm the smooth rehabilitation of ankle joint function.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"103185"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anxiety scores and academic performance among adolescent schoolchildren in Northern Sudan: A cross-sectional study.","authors":"Hiba Elhag, Ahmed A Hassan, Hatim Y Alharbi, Ishag Adam","doi":"10.5498/wjp.v15.i7.107446","DOIUrl":"10.5498/wjp.v15.i7.107446","url":null,"abstract":"<p><strong>Background: </strong>The impact of mental health, including anxiety, on academic performance has been studied in several countries, but few data exist for Sudan.</p><p><strong>Aim: </strong>To investigate the correlation between anxiety scores and academic performance among adolescent schoolchildren in Northern Sudan.</p><p><strong>Methods: </strong>This cross-sectional study was carried out during the 2021-2022 academic year among schoolchildren from randomly selected schools in Almatamah locality, River Nile State, Northern Sudan. A questionnaire was used to collect the participants' sociodemographic data. Anxiety levels were assessed using the questionnaire tools of the General Anxiety Disorder 7-item scale. Students' academic performance scores were obtained from school records. Multivariate linear regression was performed.</p><p><strong>Results: </strong>A total of 328 students participated in this study, comprising 156 boys (47.6%) and 172 girls (52.4%). The median [interquartile range (IQR)] age of the students was 14.9 years (13.9-15.6 years). The median (IQR) of the students' academic scores was 27.6% (22.2%-48.1%). The median (IQR) of the students' anxiety scores was 0 (0-3). In univariate linear analysis, anxiety scores were positively associated with academic performance scores (coefficient = 1.19, <i>P</i> value < 0.001). In multivariate linear analysis, after controlling for age, sex, parental education, occupation, and body mass index-Z-score, anxiety scores were positively associated with academic performance scores (coefficient = 0.60, <i>P</i> value < 0.001).</p><p><strong>Conclusion: </strong>The current study revealed a positive correlation between anxiety scores and students' academic performance scores. However, the association between mental health disorders, including anxiety, and academic performance is a complex issue. Therefore, further studies are recommended.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107446"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of repetitive transcranial magnetic stimulation on electroencephalogram and memory function in patients with mild cognitive impairment.","authors":"Hai-Xia Fu","doi":"10.5498/wjp.v15.i7.106761","DOIUrl":"10.5498/wjp.v15.i7.106761","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) is a high-risk precursor to Alzheimer's disease characterized by declining memory or other progressive cognitive functions without compromising daily living abilities.</p><p><strong>Aim: </strong>To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with MCI.</p><p><strong>Methods: </strong>This retrospective analysis involved 180 patients with MCI who were admitted to The First Hospital of Shanxi Medical University from January 2021 to June 2023. Participants were allocated into the research (<i>n</i> = 98, receiving rTMS) and control groups (<i>n</i> = 82, receiving sham stimulation). Memory tests, cognitive function assessments, event-related potential-P300 tests, and electroencephalogram (EEG) examinations were conducted pre-treatment and post-treatment. Further, memory quotient (MQ), cognitive function scores, and EEG grading results were compared, along with adverse reaction incidences.</p><p><strong>Results: </strong>Pre-treatment MQ scores, long-term and short-term memory, as well as immediate memory scores, demonstrated no notable differences between the groups. Post-treatment, the research group exhibited significant increases in MQ scores, long-term memory, and short-term memory compared to baseline (<i>P</i> < 0.05), with these improvements being statistically superior to those in the control group. However, immediate memory scores exhibited no significant change (<i>P</i> > 0.05). Further, the research group demonstrated statistically better post-treatment scores on the Revised Wechsler Memory Scale than the control group. Furthermore, post-treatment P300 latency and amplitude improved significantly in the research group, surpassing the control group. EEG grading in the research group improved, and the incidence of adverse reactions was significantly lower than in the control group.</p><p><strong>Conclusion: </strong>Patients with MCI receiving rTMS therapy demonstrated improved memory and cognitive functions and EEG grading and exhibited high safety with fewer adverse reactions.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106761"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between depressive-like behavior and gut microbiota in mice with hypothyroidism.","authors":"Han-Jie Guo, Xiao-Qing Ma, Yan-Ting Li, Zhao-Han Zhou, Wei Tao, Yu-Hao Jiang, Xiao-Long Li, Xi-Liang Zhang","doi":"10.5498/wjp.v15.i7.104921","DOIUrl":"10.5498/wjp.v15.i7.104921","url":null,"abstract":"<p><strong>Background: </strong>The association between hypothyroidism and depression is well established, but the underlying mechanisms remain unclear.</p><p><strong>Aim: </strong>To explore the potential role of the gut microbiota in depressive-like behaviors in a mouse model of hypothyroidism, with a focus on bacterial composition.</p><p><strong>Methods: </strong>Hypothyroidism was induced in mice using propylthiouracil. Depressive-like behaviors were assessed using the sucrose preference test (SPT), forced swimming test (FST), tail suspension test (TST), and open field test (OFT). Inflammatory cytokines, including interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α, and IL-10, were quantified, together with colon histopathology scores, brain-derived neurotrophic factor, nuclear factor κB, inhibitor of nuclear factor κB, and tight junction proteins (occludin, claudin-1, zonula occludens-1). Gut microbial composition was determined by 16S rRNA gene sequencing of fecal samples.</p><p><strong>Results: </strong>Propylthiouracil-treated mice exhibited pronounced depressive-like behaviors, intestinal barrier dysfunction, elevated peripheral and central inflammation, and gut microbiota dysbiosis. Pearson correlation analysis showed that <i>Bilophila</i> and <i>Psychrobacter</i> abundance positively correlated with sucrose preference in the SPT and locomotor activity in the OFT, and negatively correlated with immobility times in the FST and TST. <i>Gordonibacter</i> abundance was positively correlated with locomotion in the OFT and negatively correlated with immobility in the FST and TST. Prevotellaceae_UCG_001 was inversely correlated with immobility in the FST and TST. <i>Streptococcus</i> was positively associated with sucrose preference in the SPT.</p><p><strong>Conclusion: </strong>The observed associations between specific bacterial taxa and behavioral indices support a potential connection between gut microbiota composition and depressive symptoms in mice with hypothyroidism.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"104921"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for posttraumatic stress disorder in patients with multiple injuries and its relationship with anxiety and depression.","authors":"Zhi-Hao Zhou, Jin Mao, Da Cao","doi":"10.5498/wjp.v15.i7.105742","DOIUrl":"10.5498/wjp.v15.i7.105742","url":null,"abstract":"<p><strong>Background: </strong>Patients with multiple injuries endure not just physical trauma and suffering but are also at risk of psychological conditions such as posttraumatic stress disorder (PTSD), anxiety, and depression. The co-occurrence of PTSD in these patients may cause prolonged physical and mental health complications, thereby further increasing their healthcare expenses.</p><p><strong>Aim: </strong>To determine the association between the high-risk factors of PTSD and anxiety as well as depression among patients with multiple injuries.</p><p><strong>Methods: </strong>This study selected 110 patients with multiple injuries who were admitted to our hospital from November 2022 to November 2024. The number and percentage of patients developing PTSD were tallied. Univariate and multivariate analyses were conducted to investigate the high-risk factors of PTSD in these patients. Subsequently, the associations between these factors and the anxiety and depression levels of patients were analyzed.</p><p><strong>Results: </strong>Of the 110 patients, 33 suffered from PTSD, representing an incidence rate of 30.0%. The univariate analysis identified age, personality, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), economic status, negative life events, and smoking history to be significantly associated with PTSD in patients with multiple injuries. Further, the multivariate analysis revealed age, HAMA, HAMD, monthly income, and negative life events as prominent high-risk factors for PTSD in such patients. Regarding the relationships between these factors and HAMA and HAMD, age exhibited a significant positive correlation (<i>r</i> = 0.398, <i>P</i> < 0.001; <i>r</i> = 0.387, <i>P</i> < 0.001), monthly income showed a significant negative correlation (<i>r</i> = -0.437, <i>P</i> < 0.001; <i>r</i> = -0.319, <i>P</i> < 0.001), and negative life events demonstrated a significant positive correlation (<i>r</i> = 0.505, <i>P</i> < 0.001; <i>r</i> = 0.365, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>These results indicate age, HAMA, HAMD, monthly income, negative life events, <i>etc.</i> as high-risk factors for PTSD in patients with multiple injuries, among which age, monthly income, and negative life events are closely associated with anxiety and depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"105742"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Pediococcus acidilactici</i> CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial.","authors":"Du-Xing Li, Qi-Ming Hu, Chen-Chen Xu, Hong-Yu Yang, Ji-Kang Liu, Yi-Fan Sun, Gang Wang, Jun Wang, Zhen-He Zhou","doi":"10.5498/wjp.v15.i7.105249","DOIUrl":"10.5498/wjp.v15.i7.105249","url":null,"abstract":"<p><strong>Background: </strong>Anhedonia, a hallmark symptom of major depressive disorder (MDD), is often resistant to common antidepressants. Preliminary evidence indicates that <i>Pediococcus acidilactici</i> (<i>P. acidilactici</i>) CCFM6432 may offer potential benefits in ameliorating this symptomatology in patients with MDD.</p><p><strong>Aim: </strong>To further assess the efficacy of <i>P. acidilactici</i> CCFM6432 in alleviating anhedonia in patients with MDD, using a combination of objective and subjective assessment tools.</p><p><strong>Methods: </strong>Adult patients with MDD exhibiting anhedonic symptoms were enrolled and randomly assigned to two treatment groups: One receiving standard antidepressant therapy plus <i>P. acidilactici</i> CCFM6432, and the other receiving standard antidepressant treatment along with a placebo, for 30 days. Assessments were conducted at baseline and post-intervention using the Hamilton Depression Rating Scale (HAMD), Temporal Experience of Pleasure Scale (TEPS), and synchronous electroencephalography (EEG) during a \"Doors Guessing Task.\" Changes in both clinical outcomes and EEG biomarkers, specifically the stimulus-preceding negativity (SPN) and feedback-related negativity amplitudes, were analyzed.</p><p><strong>Results: </strong>Of the 92 screened participants, 71 were enrolled and 55 completed the study (CCFM6432 group: <i>n</i> = 27; Placebo group: <i>n</i> = 28). No baseline differences were noted between the groups in terms of demographics, clinical assessments, or EEG metrics. A mixed-design analysis of variance revealed that the CCFM6432 group showed significantly greater improvements in both HAMD and TEPS scores compared to the Placebo group. Moreover, the CCFM6432 group demonstrated a significant increase in SPN amplitudes, which were inversely correlated with the improvements observed in HAMD scores. No such changes were observed in the Placebo group.</p><p><strong>Conclusion: </strong>Adjunctive administration of <i>P. acidilactici</i> CCFM6432 not only augments the therapeutic efficacy of antidepressants but also significantly ameliorates the symptoms of anhedonia in MDD.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"105249"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}