World Journal of Psychiatry最新文献

{"title":"Determinants of generalized anxiety and construction of a predictive model in patients with chronic obstructive pulmonary disease.","authors":"Yi-Pu Zhao, Wei-Hua Liu, Qun-Cheng Zhang","doi":"10.5498/wjp.v15.i2.98447","DOIUrl":"10.5498/wjp.v15.i2.98447","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic obstructive pulmonary disease (COPD) frequently experience exacerbations requiring multiple hospitalizations over prolonged disease courses, which predispose them to generalized anxiety disorder (GAD). This comorbidity exacerbates breathing difficulties, activity limitations, and social isolation. While previous studies predominantly employed the GAD 7-item scale for screening, this approach is somewhat subjective. The current literature on predictive models for GAD risk in patients with COPD is limited.</p><p><strong>Aim: </strong>To construct and validate a GAD risk prediction model to aid healthcare professionals in preventing the onset of GAD.</p><p><strong>Methods: </strong>This retrospective analysis encompassed patients with COPD treated at our institution from July 2021 to February 2024. The patients were categorized into a modeling (MO) group and a validation (VA) group in a 7:3 ratio on the basis of the occurrence of GAD. Univariate and multivariate logistic regression analyses were utilized to construct the risk prediction model, which was visualized using forest plots. The model's performance was evaluated using Hosmer-Lemeshow (H-L) goodness-of-fit test and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>A total of 271 subjects were included, with 190 in the MO group and 81 in the VA group. GAD was identified in 67 patients with COPD, resulting in a prevalence rate of 24.72% (67/271), with 49 cases (18.08%) in the MO group and 18 cases (22.22%) in the VA group. Significant differences were observed between patients with and without GAD in terms of educational level, average household income, smoking history, smoking index, number of exacerbations in the past year, cardiovascular comorbidities, disease knowledge, and personality traits (<i>P <</i> 0.05). Multivariate logistic regression analysis revealed that lower education levels, household income < 3000 China yuan, smoking history, smoking index ≥ 400 cigarettes/year, ≥ two exacerbations in the past year, cardiovascular comorbidities, complete lack of disease information, and introverted personality were significant risk factors for GAD in the MO group (<i>P <</i> 0.05). ROC analysis indicated that the area under the curve for predicting GAD in the MO and VA groups was 0.978 and 0.960. The H-L test yielded <i>χ</i> <sup>2</sup> values of 6.511 and 5.179, with <i>P</i> = 0.275 and 0.274. Calibration curves demonstrated good agreement between predicted and actual GAD occurrence risks.</p><p><strong>Conclusion: </strong>The developed predictive model includes eight independent risk factors: Educational level, household income, smoking history, smoking index, number of exacerbations in the past year, presence of cardiovascular comorbidities, level of disease knowledge, and personality traits. This model effectively predicts the onset of GAD in patients with COPD, enabling early identification ","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"98447"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium channel mutation <i>SCN1A</i> T875M, D188V and associated dysfunction with drug resistant epilepsy.","authors":"Pradeep Kumar Dabla, Swapan Gupta, Swati Singh, Aroop Viswas, Manisha Yadav, Subash Chandra Sonkar, Bidhan Chandra Koner","doi":"10.5498/wjp.v15.i2.100738","DOIUrl":"10.5498/wjp.v15.i2.100738","url":null,"abstract":"<p><strong>Background: </strong>The NaV1.1 sodium channel alpha subunit, encoded by <i>SCN1A</i>, is crucial for initiating and propagating action potentials in neurons. <i>SCN1A</i> gene has long been an established target in the etiology and therapy of epilepsy. However, very few studies have investigated the relevance of genetic variations in epilepsy and anti-epileptic drug resistance.</p><p><strong>Aim: </strong>To investigate associations between polymorphisms, rs121917953 T/A and rs121918623 C/T, and drug resistance in epilepsy patients in the north Indian population.</p><p><strong>Methods: </strong>A total of 100 age- and sex-matched epilepsy patients (50 drug responsive and 50 drug resistant subjects) were recruited and <i>SCN1A</i> rs121918623 C/T* and rs121917953 T/A* polymorphisms were analyzed by the allele specific-PCR technique. <i>χ</i> ² and Fisher's exact test were used to estimate differences between the distribution of <i>SCN1A</i> rs121918623 and rs121917953 gene polymorphisms among various groups. The association between distinct rs121917953 genotypes and drug resistance was analyzed using logistic regression analysis.</p><p><strong>Results: </strong>For the <i>SCN1A</i> rs121917953 T/A* (D188V) polymorphism, a significantly higher proportion of individuals with AT genotype were observed in the drug-resistant group as compared to the drug-responsive group. Additionally, a higher risk association was exhibited by AT genotype for drug resistance with an odds ratio of 3.51 and <i>P</i> value = 0.017. For the <i>SCN1A</i> rs121918623 C/T* (T875M) polymorphism, no significant difference in genotype distribution was observed between the drug-resistant and drug-sensitive groups.</p><p><strong>Conclusion: </strong>Our findings indicate that the <i>SCN1A</i> polymorphism D188V is associated with a higher risk of drug resistance for the AT variant as compared to the homozygous TT wild-type. Further research is needed at the functional level and in larger cohorts to determine the potential of these genes as a therapeutic target in epilepsy subjects.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100738"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative effects of stress-sensitivity factors on depressive symptoms and suicide risk: A prospective study.","authors":"Xue-Mei Qin, Meng-Qi Xu, Ya-Qi Qin, Fang-Zhou Shao, Mo-Han Ma, Wen-Wen Ou, Guan-Yi Lv, Qian-Qian Zhang, Wen-Tao Chen, Xiao-Tian Zhao, Ao-Qian Deng, Jin-Tao Xiong, Ling-Si Zeng, Yi-Lin Peng, Mei Huang, Shu-Yin Xu, Mei Liao, Li Zhang, Ling-Jiang Li, Yu-Meng Ju, Jin Liu, Bang-Shan Liu, Yan Zhang","doi":"10.5498/wjp.v15.i2.99996","DOIUrl":"10.5498/wjp.v15.i2.99996","url":null,"abstract":"<p><strong>Background: </strong>Sensitivity to stress is essential in the onset, clinical symptoms, course, and prognosis of major depressive disorder (MDD). Meanwhile, it was unclear how variously classified but connected stress-sensitivity variables affect MDD. We hypothesize that high-level trait- and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of MDD.</p><p><strong>Aim: </strong>To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up results.</p><p><strong>Methods: </strong>In this prospective study, 281 MDD patients were enrolled from a tertiary care setting. High-level stress-sensitivity factors were classified as trait anxiety, state anxiety, perceived stress, and neuroticism, with a total score in the top quartile of the research cohort. The cumulative effects of stress-sensitivity factors on cognitive dysfunction, disability and functional impairment, suicide risk, and depressive and anxiety symptoms were examined using an analysis of variance with linear trend analysis. Correlations were investigated further using multiple regression analysis.</p><p><strong>Results: </strong>Regarding high-level stress-sensitivity factors, 53.40% of patients had at least one at baseline, and 29.61% had two or more. Four high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline (all <i>P</i> < 0.001). Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms (partial <i>η</i> ² = 0.153; standardized <i>β</i> = 0.195; <i>P</i> < 0.05). The follow-up outcomes were significantly impacted only by the high-level trait-related components, mainly when it came to depressive symptoms and suicide risk, which were predicted by trait anxiety and neuroticism, respectively (partial <i>η</i> ² = 0.204 and 0.156; standardized <i>β</i> = 0.247 and 0.392; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>To enhance outcomes of MDD and lower the suicide risk, screening for stress-sensitivity factors and considering multifaceted measures, mainly focusing on trait-related ones, should be addressed clinically.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99996"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing social function in the treatment of depression: A call for holistic approaches.","authors":"Muhammed Fatih Tabara","doi":"10.5498/wjp.v15.i2.102658","DOIUrl":"10.5498/wjp.v15.i2.102658","url":null,"abstract":"<p><p>This article discusses the importance of addressing social functioning impairment in patients with residual depressive symptoms, as highlighted in the study by Liao <i>et al</i>. The authors showed that social dysfunction persists in many patients despite symptom remission. This observation calls for a shift in depression treatment strategies, with an emphasis on integrating social functioning as a key treatment goal. This article suggests targeted interventions that focus on both symptomatic relief and the restoration of social function.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"102658"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 222-nm ultraviolet disinfection combined with psychological care on the emotional and hospital infection of critical patients.","authors":"Li-Juan Wang, Mei-Juan Wang, Lan Jing, Ran Su, Qiu-Ju Jian, Zhi-Yun Zhang, Mei-Lian Xie","doi":"10.5498/wjp.v15.i2.99449","DOIUrl":"10.5498/wjp.v15.i2.99449","url":null,"abstract":"<p><strong>Background: </strong>Empathetic psychological care improves mood and enhances the quality of life in critically ill patients.</p><p><strong>Aim: </strong>To study the impact of combining 222-nm ultraviolet (UV) disinfection with empathetic psychological care on emotional states, nosocomial infection rates, and quality of life in critically ill patients.</p><p><strong>Methods: </strong>A total of 202 critically ill patients admitted to Beijing Ditan Hospital (December 2023 to May 2024) were randomly assigned to control (Ctrl, <i>n</i> = 101) or observation groups (Obs, <i>n</i> = 101). The Ctrl group received 222-nm UV disinfection and routine care, while the Obs group received 222-nm UV disinfection with empathetic psychological care. Emotional states [Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS)], hospital infection rates, quality of life (36-Item Short Form Health Survey), and patient satisfaction were evaluated.</p><p><strong>Results: </strong>At baseline, there were no significant differences in SAS and SDS scores between the groups (<i>P</i> > 0.05). Following care, both groups demonstrated reductions in SAS and SDS scores, with the Obs group exhibiting a significantly greater reduction (<i>P</i> < 0.05). The Obs group also experienced a significantly lower overall hospital infection rate (<i>P</i> < 0.05). Similarly, while baseline 36-Item Short Form Health Survey scores did not differ significantly between the groups (<i>P</i> > 0.05), post-care scores improved in both groups, with a greater improvement observed in the Obs group (<i>P</i> < 0.05). Additionally, the Obs group reported higher patient satisfaction ratings (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The combination of 222-nm UV disinfection and empathetic psychological care improves emotional states, reduces hospital infection rates, enhances the quality of life, and increases patient satisfaction among critically ill patients.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99449"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the prevalence and risk factors of burnout syndrome among healthcare workers: A cross-sectional study.","authors":"Nur Adam Mohamed, Yusuf Abdirisak Mohamed, Rahma Yusuf Haji Mohamud, Adan Ali Gabow","doi":"10.5498/wjp.v15.i2.98496","DOIUrl":"10.5498/wjp.v15.i2.98496","url":null,"abstract":"<p><strong>Background: </strong>Burnout syndrome is a significant issue among healthcare professionals worldwide, marked by depersonalization, emotional exhaustion, and a reduced sense of personal achievement. This psychological and physical burden profoundly affects healthcare professionals' quality of care and overall well-being. In Somalia, where the healthcare system faces numerous challenges, the escalating demand for medical services and inadequate resources, coupled with overwhelming workloads, long hours, and high-stress levels, make healthcare providers particularly vulnerable to burnout syndrome. This, in turn, affects both the mental health of healthcare personnel and the quality of care they provide.</p><p><strong>Aim: </strong>To examine the prevalence and determinants of burnout syndrome among healthcare practitioners in Mogadishu, Somalia.</p><p><strong>Methods: </strong>This cross-sectional prospective study was performed among 246 healthcare providers employed at a tertiary care hospital in Mogadishu, Somalia, who were recruited <i>via</i> random sampling. Data were collected using questionnaires that covered sociodemographic, psychological, work-related characteristics, and burnout syndrome. Bivariate and multivariate logistic regression analyses were performed to identify the variables that correlated with burnout syndrome. The results were presented using adjusted odds ratios (AORs), 95%CIs, and <i>P</i> values, with a cutoff of 0.05 for identifying significant associations.</p><p><strong>Results: </strong>Among the participants, 24% (95%CI: 18.8%-29.8%) exhibited symptoms of burnout syndrome. Factors associated with burnout included female gender (AOR = 6.60; 95%CI: 2.29-19.04), being married (AOR = 3.07; 95%CI: 1.14-8.28), being divorced or widowed (AOR = 5.84; 95%CI: 1.35-25.35), working more than 7 night shifts (AOR = 3.19; 95%CI: 1.30-7.82), having less than 5 years of job experience (AOR = 5.28; 95%CI: 1.29-21.65), experiencing poor sleep quality (AOR = 5.29; 95%CI: 1.88-14.89), and exhibiting depressive (AOR = 4.46; 95%CI: 1.59-12.53) and anxiety symptoms (AOR = 7.34; 95%CI: 2.49-21.60).</p><p><strong>Conclusion: </strong>This study found that nearly one in four healthcare professionals suffers from burnout syndrome. Improving sleep quality, monitoring, and providing mental health support could enhance their well-being and patient care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"98496"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of virtual reality on reducing restrictive practices in psychiatric wards.","authors":"Akpoveta Eguono Deborah, Uchenna Esther Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i2.101287","DOIUrl":"10.5498/wjp.v15.i2.101287","url":null,"abstract":"<p><p>This manuscript critically evaluates the randomized controlled trial (RCT) conducted by Phiri <i>et al</i>, which assessed the effectiveness of virtual reality (VR) training for psychiatric staff in reducing restrictive practices (RPs). Specifically, this RCT investigated the impact of VR on the handling of aggressive patients by psychiatric staff compared to traditional training methods. Despite significant reductions in perceived discrimination in the VR group, there were no major improvements in self-efficacy or anxiety levels. The system usability scale rated the VR platform highly, but it did not consistently outperform traditional training methods. Indeed, the study shows the potential for VR to reduce RPs, although fluctuations in RP rates suggest that external factors, such as staff turnover, influenced the outcomes. This manuscript evaluates the study's methodology, results, and broader implications for mental health training. Additionally, it highlights the need for more comprehensive research to establish VR as a standard tool for psychiatric staff education, focusing on patient care outcomes and real-world applicability. Finally, this study explores future research directions, technological improvements, and the potential impact of policies that could enhance the integration of VR in clinical training.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101287"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between psychological, family social support, and home nursing quality for an implanted venous access port.","authors":"Heng-Ya Jia, Li-Qun Yan, Xiao-Bei Liu, Jie Cao","doi":"10.5498/wjp.v15.i2.99252","DOIUrl":"10.5498/wjp.v15.i2.99252","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients with an implanted venous access port (IVAP) often manage their care at home during chemotherapy intervals, including maintaining the device, monitoring complications, and following medication instructions. Home care ensures continued support after discharge. However, due to factors such as age, gender, culture, psychological status, and family support, the quality of home care varies significantly. Understanding these factors can help provide targeted guidance to improve the care of cancer patients.</p><p><strong>Aim: </strong>To explore IVAP chemotherapy on home care quality and its association with mental health and family support for cancer patients.</p><p><strong>Methods: </strong>This investigative study was based on a medical records system. It investigated the relationship between psychological status, family support, and home care quality in 180 patients with cancer undergoing IVAP chemotherapy. Psychological status was assessed using the State Anxiety Inventory (S-AI); family support was assessed using the Perceived Social Support Scale (PSSS), and home care quality was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Pearson's correlation and Structural Equation Modeling were used to analyze the interplay between these factors.</p><p><strong>Results: </strong>The average S-AI score was 47.52 ± 14.47, PSSS was 52.48 ± 12.64, and EORTC QLQ-C30 was 70.09 ± 17.32. A substantial inverse relationship was observed between the EORTC QLQ-C30 and S-AI scores (<i>r</i> = -0.712). A significant positive correlation was found between the EORTC QLQ-C30 and the PSSS, with a correlation coefficient of (<i>r</i> = 0.744). The multiple linear regression analysis indicated that family social support, psychological status, and average monthly family income were the main factors influencing the variation in the quality of home care, explaining 71.9% of the variation. The Structural Equation Modeling results indicated that psychological status acted as a partial mediator in the association between family social support and home care quality of life, explaining 32.78% of the mediation effect.</p><p><strong>Conclusion: </strong>Psychological status and family social support positively impacted cancer patients' home care quality, with psychology partially mediating this effect.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99252"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.","authors":"Lan-Ying Wang, Qi-Qin Wang, Jia-Nan Xu, Si-Yuan Wang, Yao Shi","doi":"10.5498/wjp.v15.i2.100062","DOIUrl":"10.5498/wjp.v15.i2.100062","url":null,"abstract":"<p><strong>Background: </strong>Despite laparoscopic total hysterectomy provided more benefits to patients and has become one of the most commonly used surgical methods for total hysterectomy. However, vaginal cuff dehiscence is a serious complication after laparoscopic total hysterectomy and so far, there are limited studies on vaginal cuff dehiscence after a total hysterectomy.</p><p><strong>Aim: </strong>To investigate the factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.</p><p><strong>Methods: </strong>This study retrospectively, univariately, and multivariately analyzed the clinical data of patients who experienced vaginal cuff dehiscence after laparoscopic hysterectomy in Yuyao People's Hospital from January 2015 to December 2021. Logistic regression was utilized to analyze the high-risk factors of vaginal cuff dehiscence.</p><p><strong>Results: </strong>Among 1459 cases with laparoscopic hysterectomy, 9 reported vaginal cuff dehiscence postoperatively, with an incidence of 0.617%. Univariate logistic regression analysis revealed that preoperative hemoglobin value [odds ratio (OR) = 5.12, <i>P</i> = 0.016], vaginal cuff suture method (OR = 0.26, <i>P</i> = 0.048), and postoperative first sexual lifetime (OR = 15.86, <i>P</i> = 0.002) were associated with vaginal cuff dehiscence following laparoscopic hysterectomy. Multivariate logistic regression analysis revealed that preoperative hemoglobin value of < 90 g/L (OR = 5.17, <i>P</i> = 0.015) and time interval between postoperative first sexual life and operation of < 3 months (OR = 54.00, <i>P</i> = 0.004) are independent risk factors for vaginal cuff dehiscence after laparoscopic hysterectomy.</p><p><strong>Conclusion: </strong>Postoperative hemoglobin and the time interval between postoperative first sexual life and operation were the independent factors of developing vaginal cuff dehiscence after laparoscopic hysterectomy.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100062"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023.","authors":"Biao Huang, Wei-Ning Chen, Chun-Mei Peng, Xiu-Li Shen, Jin Xue, Chun-Chuan Yan, Fa-Ming Zhong","doi":"10.5498/wjp.v15.i2.102344","DOIUrl":"10.5498/wjp.v15.i2.102344","url":null,"abstract":"<p><strong>Background: </strong>Depression significantly threatens human health. Purinergic receptors are reported to be associated with depression. However, there is no bibliometric research in this field have been published.</p><p><strong>Aim: </strong>To provide some reference for the further research in the field of purinergic receptors and depression utilizing bibliometric analysis.</p><p><strong>Methods: </strong>Relevant researches were retrieved from the Web of Science Core Collection database. The period of the search was from January 1, 2003 to December 31, 2023. The CiteSpace (6.2.R7) and VOSviewer (1.6.19) were applied to identify the main contributors of countries, authors, institutions, references and journals. Besides, we evaluate keywords to assess the hotspots and trends over the previous 2 decades.</p><p><strong>Results: </strong>Totally, 247 articles were identified, showing an increasing trend over time. The most productive country, institution, and journal in this field are China, Harvard University, and Biological Psychiatry, respectively. Liang SD and Rodrigues, Ana Lucia S were the most prolific authors. Burnstock G ranked first among the cited authors. The cooperation among countries and disciplines is crucial. The P2X7 receptor provides promising prospects for treating depression and further studies are warranted to validate the scope and significance of depression therapeutic strategies.</p><p><strong>Conclusion: </strong>This study provides an overview of the worldwide research status and future trends in purinergic receptors and depression. P2X7 receptor is considered an appropriate target for the treatment of depression, as well as neurological diseases. It is implied that based on purinergic system, the future prospects for interventions aimed at depression treatment are promising, showing the way for both augmentation strategies and new drug treatments in the context of the pharmacology of depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"102344"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}