World Journal of Psychiatry最新文献

{"title":"Study on the correlation between abdominal infection and psychological stress in children based on nucleic acid detection.","authors":"Gui-Bo Wang, Xue-Feng Zhang, Bing Liang, Jie Lei, Jun Xue","doi":"10.5498/wjp.v14.i11.1728","DOIUrl":"10.5498/wjp.v14.i11.1728","url":null,"abstract":"<p><strong>Background: </strong>Diagnosing and treating abdominal infection in children remains a challenge. Nucleic acid detection, as a rapid and accurate diagnosis tool, has great significance in this field.</p><p><strong>Aim: </strong>To investigate the diagnosis and treatment of abdominal infection by nucleic acid detection and its possible correlation with psychological stress in children.</p><p><strong>Methods: </strong>A total of 50 pediatric patients diagnosed with abdominal infections between September 2020 and July 2021 were included in this study. Intra-abdominal pus samples were collected for pathogen culture, drug susceptibility testing, and broad-spectrum bacterial nucleic acid testing. Psychological stress, anxiety, depression, and coping styles were assessed using the coping with a disease (CODI) scale.</p><p><strong>Results: </strong>Based on susceptibility testing, a regimen of cefazoxime, piperacillin/tazobactam, and metronidazole or ornidazole achieved 100% effectiveness in treating appendicitis. Psychological assessments revealed a positive correlation between pressure level and both anxiety (<i>r</i> = 0.324, <i>P</i> = 0.001) and depressive disorders (<i>r</i> = 0.325, <i>P</i> < 0.001). Acceptance and distancing as coping strategies were negatively correlated with anxiety and depression, while negative emotional responses were strongly associated with increased anxiety (<i>r</i> = 0.574, <i>P</i> < 0.001) and depression (<i>r</i> = 0.511, <i>P</i> = 0.001). Coping strategies such as illusion and escape showed no significant correlation with emotional outcomes.</p><p><strong>Conclusion: </strong>Nucleic acid testing helps in the diagnosis of abdominal infections in children, and also focuses on children's mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1728-1734"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation enhanced by neuronavigation in the treatment of depressive disorder and schizophrenia.","authors":"Xian-Yang Wang, Yuan-Bei Zhang, Rong-Xue Mu, Long-Biao Cui, Hua-Ning Wang","doi":"10.5498/wjp.v14.i11.1618","DOIUrl":"10.5498/wjp.v14.i11.1618","url":null,"abstract":"<p><p>This editorial assesses the advancements in neuronavigation enhanced repetitive transcranial magnetic stimulation for depressive disorder and schizophrenia treatment. Conventional repetitive transcranial magnetic stimulation faces challenges due to the intricacies of brain anatomy and patient variability. Neuronavigation offers innovative solutions by integrating neuroimaging with three-dimensional localization to pinpoint brain regions and refine therapeutic targeting. This systematic review of recent literature underscores the enhanced efficacy of neuronavigation in improving treatment outcomes for these disorders. This editorial highlights the pivotal role of neuronavigation in advancing psychiatric care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1618-1622"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the complexities of adolescent depression: A call for action.","authors":"Yuan Zhang, Ming-Yan Hei, Min-Zhong Wang, Jian-Guo Zhang, Shu Wang","doi":"10.5498/wjp.v14.i11.1772","DOIUrl":"10.5498/wjp.v14.i11.1772","url":null,"abstract":"<p><p>The adolescent years are a period of profound change, both physically and psychologically. For many, these years are marked by excitement and exploration, but for others, they are fraught with challenges that can lead to significant mental health issues. Depression, in particular, has become an increasingly prevalent concern among adolescents worldwide, and its multifaceted etiology requires a comprehensive approach to understanding and intervention. A recent study on the relationships among negative life events, dysfunctional attitudes, social support, and depressive symptoms in Chinese adolescents offers valuable insights into the complex interplay between various factors contributing to adolescent depression. The authors explore a moderated mediation model to better understand how these factors interact with and contribute to the onset of depression. This article aims to delve into the key findings of the study, highlight its implications for clinical practice, and encourage further research in this critical area.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1772-1778"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation linking illness perception, negative emotions, and the post-operative recovery effect in patients with perianal disease.","authors":"Shu-Xiang Hou, Feng-Jun Dai, Xian-Xue Wang, Shao-Wen Wang, Ting Tian","doi":"10.5498/wjp.v14.i11.1718","DOIUrl":"10.5498/wjp.v14.i11.1718","url":null,"abstract":"<p><strong>Background: </strong>Improvements in the standard of living have led to increased attention to perianal disease. Although surgical treatments are effective, the outcomes of post-operative recovery (POR) are influenced by various factors, including individual differences among patients, the characteristics of the disease itself, and the psychological state of the patient. Understanding these factors can help healthcare providers develop more personalized and effective post-operative care plans for patients with perianal disease.</p><p><strong>Aim: </strong>To investigate the effect of illness perception (IP) and negative emotions on POR outcomes in patients with perianal disease.</p><p><strong>Methods: </strong>A total of 146 patients with perianal disease admitted to the First People's Hospital of Changde City from March to December 2023 were recruited. We employed a general information questionnaire, the Brief Illness Perception Questionnaire (B-IPQ), and the Hospital Anxiety and Depression Scale (HADS). We used the 15-item Quality of Recovery Score (QoR-15) to measure patients' recovery effects. Finally, we conducted Pearson's correlation analysis to examine the relationship between pre-operative IP and anxiety and depression levels with POR quality.</p><p><strong>Results: </strong>Fifty-three (36.3%) had poor knowledge of their disease. Thirty (20.5%) were suspected of having anxiety and 99 (67.8%) exhibited symptoms. Forty (27.4%) were suspected of having depression and 102 (69.9%) displayed symptoms. The B-IPQ, HADS-A, HADS-D, and QoR-15 scores were 46.82 ± 9.97, 12.99 ± 3.60, 12.58 ± 3.36, and 96.77 ± 9.85, respectively. There was a negative correlation between pre-operative IP, anxiety, and depression with POR quality. The influence of age and disease course on post-operative rehabilitation effect are both negative. The impact of B-IPQ, HADS-A, and HADS-D on POR was negative. Collectively, these variables accounted for 72.6% of the variance in POR.</p><p><strong>Conclusion: </strong>The quality of POR in patients with perianal disease is medium and is related to age, disease course, IP, anxiety, and depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1718-1727"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared spectroscopy in schizophrenia: A bibliometric perspective.","authors":"Xin-Xing Fei, Shi-Qi Wang, Ji-Yang Li, Zhang-Yu Xu, Jian-Xiong Wang, Ya-Qian Gao, Yue Hu","doi":"10.5498/wjp.v14.i11.1755","DOIUrl":"10.5498/wjp.v14.i11.1755","url":null,"abstract":"<p><strong>Background: </strong>Compared with current methods used to assess schizophrenia, near-infrared spectroscopy (NIRS) has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and providing direct and objective assessment information.</p><p><strong>Aim: </strong>To explore the research field of NIRS in schizophrenia from the perspective of bibliometrics.</p><p><strong>Methods: </strong>The Web of Science Core Collection was used as the search tool, and the last search date was April 21, 2024. Bibliometric indicators, such as the numbers of publications and citations, were recorded. Bibliometrix and VOS viewer were used for visualization analysis.</p><p><strong>Results: </strong>A total of 355 articles from 105 journals were included in the analysis. The overall trend of the number of research publications increased. <i>Schizophrenia Research</i> was identified as an influential journal in the field. Kasai K was one of the most influential and productive authors in this area of research. The University of Tokyo and Japan had the highest scientific output for an institution and a country, respectively. The top ten keywords were \"schizophrenia\", \"activation\", \"near-infrared spectroscopy\", \"verbal fluency task\", \"cortex\", \"brain, performance\", \"working-memory\", \"brain activation\", and \"prefrontal cortex\".</p><p><strong>Conclusion: </strong>Our study reveals the evolution of knowledge and emerging trends in the field of NIRS in schizophrenia. the research focus is shifting from underlying disease characteristics to more in-depth studies of brain function and physiological mechanisms.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1755-1765"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the mechanism of exercise against depression.","authors":"Ya-Lin Zhao, Shu-Ya Sun, Hao-Cheng Qin, Yu-Lian Zhu, Zhi-Wen Luo, Yuan Qian, Shuo Chen","doi":"10.5498/wjp.v14.i11.1611","DOIUrl":"10.5498/wjp.v14.i11.1611","url":null,"abstract":"<p><p>The substantial global health burden of depression encourages the development of innovative and broadly effective interventions. This paper aimed to examine recent advancements by which exercise works as an antidepressant and recommends optimal types and quantity of exercise as supplemental therapies in treating depression. Sedentary behavior and low physical activity significantly influence the onset of depression. Being an effective treatment option, exercise can significantly reduce depression risk. Exercise exerts antidepressant effects as it modulates neurotransmitters, neuroplasticity, the immune system, and hormone levels. Effective exercise forms include yoga, strength training, and walking/jogging. Tailored exercise regimens that consider individual preferences and tolerability can improve outcomes. Regular exercise enhances general well-being and reduces depressive symptoms. Additional research is needed to understand the complex basis of exercise's effects on depression. Exercise is a cost-effective and accessible intervention for depression management that needs additional exploration. Thus, customized exercise programs, as per each patient's needs, are essential for their successful implementation clinically.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1611-1617"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who can benefit more from its twelve-week treatment: A prospective cohort study of blonanserin for patients with schizophrenia.","authors":"Bao-Yan Xu, Kun Jin, Hai-Shan Wu, Xue-Jun Liu, Xi-Jin Wang, Hong Sang, Ke-Qing Li, Mei-Juan Sun, Hua-Qing Meng, Huai-Li Deng, Zhi-Yuan Xun, Xiao-Dong Yang, Lin Zhang, Guan-Jun Li, Rui-Ling Zhang, Duan-Fang Cai, Jia-Hong Liu, Gui-Jun Zhao, Long-Fa Liu, Gang Wang, Chang-Lie Zhao, Bin Guo, Sheng-Chun Jin, Ling-Yun Huang, Fu-De Yang, Jian-Min Zheng, Gui-Lai Zhan, Mao-Sheng Fang, Xiang-Jun Meng, Guang-Ya Zhang, Hai-Min Li, Xiang-Lai Liu, Ju-Hong Li, Bin Wu, Hai-Yun Li, Jin-Dong Chen","doi":"10.5498/wjp.v14.i11.1735","DOIUrl":"10.5498/wjp.v14.i11.1735","url":null,"abstract":"<p><strong>Background: </strong>Blonanserin (BNS) is a well-tolerated and effective drug for treating schizophrenia.</p><p><strong>Aim: </strong>To investigate which types of patients would obtain the most benefit from BNS treatment.</p><p><strong>Methods: </strong>A total of 3306 participants were evaluated in a 12-week, prospective, multicenter, open-label post-marketing surveillance study of BNS. Brief psychiatric rating scale (BPRS) scores were calculated to evaluate the effectiveness of BNS, and its safety was assessed with the incidence of adverse drug reactions. Linear regression was used to screen the influencing factors for the reduction of BPRS total score, and logistic regression was used to identify patients with a better response to BNS.</p><p><strong>Results: </strong>The baseline BPRS total score (48.8 ± 15.03) decreased to 27.7 ± 10.08 at 12 weeks (<i>P</i> < 0.001). Extrapyramidal symptoms (14.6%) were found to be the most frequent adverse drug reactions. The acute phase, baseline BPRS total score, current episode duration, number of previous episodes, dose of concomitant antipsychotics, and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment initiation. Specifically, patients in the acute phase with baseline BPRS total score ≥ 45, current episode duration < 3 months, and ≤ 3 previous episodes derived greater benefit from 12-week treatment with BNS.</p><p><strong>Conclusion: </strong>Patients in the acute phase with more severe symptoms, shorter current episode duration, fewer previous episodes, and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1735-1745"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of proton magnetic resonance spectroscopy in metabolic alterations of prefrontal white and gray matter in depression adolescents.","authors":"Ying Zou, Yu-Qin Wu, Yao-Jing Han, Xiao-Ming He, Jiang Zhao","doi":"10.5498/wjp.v14.i11.1652","DOIUrl":"10.5498/wjp.v14.i11.1652","url":null,"abstract":"<p><strong>Background: </strong>Cases of depression among adolescents are gradually increasing. The study of the physiological basis of cognitive function from a biochemical perspective has therefore been garnering increasing attention. Depression has been hypothesized to be associated with the brain biochemical metabolism of the anterior cingulate gyrus, frontal lobe white matter, and the thalamus.</p><p><strong>Aim: </strong>To explore the application of proton magnetic resonance spectroscopy (¹H-MRS) in the metabolic alterations in the prefrontal white matter (PWM) and gray matter (GM) in adolescents with depression.</p><p><strong>Methods: </strong>¹H-MRS was performed for semi-quantitative analysis of the biochemical metabolites N-acetylaspartate (NAA), choline (Cho) complexes, creatine (Cr), and myo-inositol (mI) in bilateral PWM, anterior cingulate GM, and thalami of 31 adolescent patients with depression (research group) and 35 healthy adolescents (control group), and the NAA/Cr, Cho/Cr, and mI/Cr ratios were calculated. Meanwhile, Hamilton Depression Scale (HAMD) and Wechsler Memory Scale were used to assess the degree of depression and memory function in all adolescents. The correlation of brain metabolite levels with scale scores was also analyzed.</p><p><strong>Results: </strong>The research group had markedly higher HAMD-24 scores and lower memory quotient (MQ) compared with the control group (<i>P</i> < 0.05). Adolescents with depression were found to have lower bilateral PWM NAA/Cr and Cho/Cr ratios compared with healthy adolescents (<i>P</i> < 0.05). The mI/Cr ratios were found to be similar in both groups (<i>P</i> > 0.05). The bilateral anterior cingulate GM NAA/Cr, Cho/Cr, and mI/Cr also did not demonstrate marked differences (<i>P</i> > 0.05). No statistical inter-group difference was determined in NAA/Cr of the bilateral thalami (<i>P</i> > 0.05), while bilateral thalamic Cho/Cr and mI/Cr were reduced in teenagers with depression compared with healthy adolescents (<i>P</i> < 0.05). A significant negative correlation was observed between the HAMD-24 scores in adolescents with depression with bilateral PWM NAA/Cr and Cho/Cr and were inversely linked to bilateral thalamic Cho/Cr and mI/Cr (<i>P</i> < 0.05). In adolescents with depressions, MQ positively correlated with right PWH NAA/Cr, left PWH Cho/Cr, and bilateral thalamic Cho/Cr and mI/Cr.</p><p><strong>Conclusion: </strong>PWM and thalamic metabolic abnormalities might influence teen depression, and the reduction in bilateral PWM NAA/Cr and Cho/Cr could be related to the neuropathology of adolescents with depression suffering from memory impairment. There exists a possibility of dysfunction of nerve cell membrane phospholipids in the thalami of adolescent patients with depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1652-1660"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation among anxiety and depression, fear of disease progression, and social support in coronary heart disease.","authors":"Yan Xu, Han-Xiang Ma, Shan-Shui Liu, Qian Gong","doi":"10.5498/wjp.v14.i11.1708","DOIUrl":"10.5498/wjp.v14.i11.1708","url":null,"abstract":"<p><strong>Background: </strong>The mental well-being of individuals with coronary heart disease (CHD) during the intensive care unit (ICU) transition period is a multifaceted and significant concern. In this phase, the individuals might encounter psychological challenges like anxiety and depression, which can impede their recuperation and potentially have lasting effects on their health.</p><p><strong>Aim: </strong>To investigate the correlation among psychological factors in CHD patients in the ICU transition period.</p><p><strong>Methods: </strong>A questionnaire survey was conducted with 119 patients admitted to the ICU after coronary artery bypass grafting between March and December 2023. Variations in Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD), Fear of Progression Questionnaire-Short Form (Fop-Q-SF), and Social Support Rating Scale (SSRS) were collected and analyzed among diverse populations. We used Pearson's correlation analysis to examine the correlation. Multiple linear regression analysis was used to explore whether these indicators influenced depression and anxiety in the patients.</p><p><strong>Results: </strong>The total scores for anxiety, depression, fear of disease progression, and social support were (7.50 ± 1.41) points, (8.38 ± 1.62) points, (35.19 ± 8.14) points, and (36.34 ± 7.08) points, respectively (<i>P</i> < 0.05). Multivariate regression analysis showed that both the level of disease progression and social support affected the level of postoperative depression and anxiety in patients.</p><p><strong>Conclusion: </strong>The anxiety and depression levels were positively related to each dimension of phobia disease progression and negatively related to each dimension of social support among patients with CHD.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1708-1717"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major depressive disorder is associated with mitochondrial <i>ND6</i> T14502C mutation in two Han Chinese families.","authors":"Pan Jing, Hai-Hang Yu, Ting-Ting Wu, Bi-Hua Yu, Ming Liang, Ting-Ting Xia, Xue-Wen Xu, Ting Xu, Ling-Jiang Liu, Xiao-Bin Zhang","doi":"10.5498/wjp.v14.i11.1746","DOIUrl":"10.5498/wjp.v14.i11.1746","url":null,"abstract":"<p><strong>Background: </strong>Globally, the World Health Organization ranks major depressive disorder (MDD) as the leading cause of disability. However, MDD molecular etiology is still poorly understood.</p><p><strong>Aim: </strong>To explore the possible association between mitochondrial <i>ND6</i> T14502C mutation and MDD.</p><p><strong>Methods: </strong>Clinical data were collected from two pedigrees, and detailed mitochondrial genomes were obtained for the two proband members. The assessment of the resulting variants included an evaluation of their evolutionary conservation, allelic frequencies, as well as their structural and functional consequences. Detailed mitochondrial whole genome analysis, phylogenetic, and haplotype analysis were performed on the probands.</p><p><strong>Results: </strong>Herein, we reported the clinical, genetic, and molecular profiling of two Chinese families afflicted with MDD. These Chinese families exhibited not only a range of onset and severity ages in their depression but also extremely low penetrances to MDD. Sequence analyses of mitochondrial genomes from these pedigrees have resulted in the identification of a homoplasmic T14502C (I58V) mutation. The polymorphism is located at a highly conserved isoleucine at position 58 of <i>ND6</i> and distinct mitochondrial DNA (mtDNA) polymorphisms originating from haplogroups M10 and H2.</p><p><strong>Conclusion: </strong>Identifying the T14502C mutation in two individuals with no genetic relation who exhibit symptoms of depression provides compelling evidence that this mutation may be implicated in MDD development. Nonetheless, the two Chinese pedigrees that carried the T14502C mutation did not exhibit any functionally significant mutations in their mtDNA. Therefore, the phenotypic expression of the T14502C mutation related to MDD may be influenced by the nuclear modifier gene(s) or environmental factors.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"14 11","pages":"1746-1754"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}