World Journal of Psychiatry最新文献

{"title":"Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis.","authors":"Haewon Byeon","doi":"10.5498/wjp.v15.i5.102953","DOIUrl":"10.5498/wjp.v15.i5.102953","url":null,"abstract":"<p><p>Yu <i>et al</i>'s study has advanced the understanding of the neural mechanisms underlying major depressive disorder (MDD) in adolescents, emphasizing the significant role of the amygdala. While traditional diagnostic methods have limitations in objectivity and accuracy, this research demonstrates a notable advancement through the integration of machine learning techniques with neuroimaging data. Utilizing resting-state functional magnetic resonance imaging (fMRI), the study investigated functional connectivity (FC) in adolescents with MDD, identifying notable reductions in regions such as the left inferior temporal gyrus and right lingual gyrus, alongside increased connectivity in Vermis-10. The application of support vector machines (SVM) to resting-state fMRI (rs-fMRI) data achieved an accuracy of 83.91%, sensitivity of 79.55%, and specificity of 88.37%, with an area under the curve of 0.6765. These results demonstrate how SVM analysis of rs-fMRI data represents a significant improvement in diagnostic precision, with reduced FC in the right lingual gyrus emerging as a particularly critical marker. These findings underscore the critical role of the amygdala in MDD pathophysiology and highlight the potential of rs-fMRI and SVM as tools for identifying reliable neuroimaging biomarkers.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102953"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catatonia and autism spectrum disorder: A common comorbid syndrome or a core feature?","authors":"Yassir Mahgoub, Dallas Hamlin, Hailey Kindt, Andrew Francis","doi":"10.5498/wjp.v15.i5.103967","DOIUrl":"10.5498/wjp.v15.i5.103967","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder marked by persistent deficits in social communication and interaction, alongside restricted, repetitive patterns of behaviors (RRB), interests, or activities. It often co-occurs with various neuropsychiatric disorders, though their frequency varies widely due to unclear boundaries between the core features of ASD and common comorbidities. Catatonia, increasingly noted in neurodevelopmental conditions like ASD, shares striking similarities with ASD in symptomatology, brain mechanisms, and treatment responses, prompting the question of whether it is a core feature of ASD or a distinct condition. This paper delved into this overlap, exploring the relationship between catatonia and ASD through a narrative review of peer-reviewed literature from 1943 to 2024, sourced from PubMed and psychiatric journals. Focusing on ASD diagnostic evolution, symptom overlap with catatonia, and shared neurobiological and therapeutic characteristics, we used thematic analysis to synthesize findings into key areas such as historical nosology, phenomenological overlap, neurobiological parallels, and treatment response. The evidence revealed weak support for separating catatonia from overlapping RRB features of ASD, suggesting that some RRB might align more with comorbid catatonia than intrinsic ASD traits. However, this idea needs further validation through rigorous clinical trials. Clarifying this relationship could refine diagnostic approaches and open doors to targeted treatments, potentially improving outcomes for those affected.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103967"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential clinical benefits of probiotics, prebiotics, synbiotics, and postbiotics for depression <i>via</i> the microbiota-gut-brain axis.","authors":"Ling-Yi Dai, Ru-Ru Chen, Hao-Ran Chen, Jia-Hui Yin, Zhen-Xing Huang, Bo-Wen Yin, Xing-Yan Liu","doi":"10.5498/wjp.v15.i5.98436","DOIUrl":"10.5498/wjp.v15.i5.98436","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common mental-health disorder worldwide. Several studies have demonstrated the effects of gut microbiota-targeting interventions, such as probiotics, prebiotics, synbiotics, and postbiotics (PPSP), on depression.</p><p><strong>Aim: </strong>To assess the potential benefits of PPSP on patients diagnosed with depressive disorder.</p><p><strong>Methods: </strong>A literature search of the PubMed, Web of Science, and Elsevier Science Direct databases for relevant studies published from database inception to March 2024 was performed. Studies that used a randomized controlled trial design and evaluated differences in depression between PPSP and placebo were included. Depressive symptoms were assessed using a validated scale. Analysis was performed using Review Manager version 5.4 (The Cochrane Collaboration, 2020).</p><p><strong>Results: </strong>Fourteen studies comprising 906 patients with depressive symptoms were included. PPSP improved depression compared with placebo [SMD: -0.39 (95%CI: -0.60 to -0.17); <i>P</i> < 0.001]. PPSP resulted in significant reductions in Hamilton Depression Rating Scale [MD: -1.72 (95%CI: -2.57 to -0.88); <i>P</i> < 0.001] and Beck Depression Inventory [MD: -2.69 (95%CI: -4.67 to -0.71); <i>P</i> < 0.001] scores. Sub-analysis confirmed the antidepressant effects of probiotics on depressive symptoms [SMD: -0.32 (95%CI: -0.48 to -0.16); <i>P</i> < 0.001], with prebiotics exerting no apparent effect [SMD: -0.08 (95%CI: -0.39 to -0.23); <i>P</i> = 0.62], and synbiotics exerting statistically significant benefits [SMD: -1.09 (95%CI: -1.45 to -0.73); <i>P</i> < 0.001].</p><p><strong>Conclusion: </strong>PPSP effectively alleviates depressive symptoms, and subgroup analysis supports the benefits of probiotics and synbiotics. Nevertheless, evidence supporting the use of PPSP for the treatment of depression remains insufficient.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"98436"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life.","authors":"Maher Hendi, Bin Zhang, Jie-Min Lv, Xiu-Jun Cai","doi":"10.5498/wjp.v15.i5.104995","DOIUrl":"10.5498/wjp.v15.i5.104995","url":null,"abstract":"<p><strong>Background: </strong>Patients with middle and advanced hepatocellular carcinoma (HCC) frequently experience significant anxiety and depression, severely affecting their quality of life.</p><p><strong>Aim: </strong>To examine the anxiety and depression status of patients with middle and advanced HCC, the influencing factors, and the correlation between these psychological factors and quality of life.</p><p><strong>Methods: </strong>We collected baseline data from 100 patients with HCC, assessing anxiety and depression levels using the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD). Quality of life was evaluated with the Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire. Multivariate logistic regression analyzed clinical and psychosocial factors affecting anxiety and depression, while Pearson correlation assessed relationships among HAMA, HAMD, and Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire scores.</p><p><strong>Results: </strong>Results indicated that 64% of patients exhibited anxiety and 65% showed depression symptoms. Key influencing factors included Barcelona Clinic Liver Cancer C stage, multiple tumors, social support, prior treatments (such as liver resection and transcatheter arterial chemoembolization/hepatic artery infusion chemotherapy), as well as HAMA and HAMD scores. Anxiety and depression correlated negatively with quality of life, with coefficients of -0.671 and -0.575 for HAMA and HAMD, respectively.</p><p><strong>Conclusion: </strong>Anxiety and depression are prevalent among patients with middle and advanced HCC, impacting quality of life. This underscores the need for psychological health considerations in liver cancer treatment and establishing psychological interventions is essential.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"104995"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the effects of multimodal physical therapy on improving depression.","authors":"Bin Sun, Chao Li, Chen-Lin Zhang, Jing-Hui Li, Ming Mao, Gang Wang, Zong-Feng Zhang","doi":"10.5498/wjp.v15.i5.103937","DOIUrl":"10.5498/wjp.v15.i5.103937","url":null,"abstract":"<p><strong>Background: </strong>Depression is a widespread psychological disorder that has substantial effects on public health and society. Conventional therapies include medication and psychotherapy, recent investigations have highlighted the possible advantages of multimodal treatments, such as physical therapy, for improving depression.</p><p><strong>Aim: </strong>To perform a meta-analysis of how multimodal physical therapy can help treat depression.</p><p><strong>Methods: </strong>We searched for collection of articles that satisfied the inclusion and exclusion criteria, encompassing randomized controlled research-related sources. We incorporated these studies into the meta-analysis using terms such as \"findings\", \"intervention\", and \"population attributes\". We used statistical examination to measure the total impact magnitude and evaluate study variability.</p><p><strong>Results: </strong>The encouraging aspect is that multi-modal physical therapy is being considered for its effectiveness in treating symptoms related to depression. Sensitivity analysis was conducted to identify key factors and determine their impact on quality.</p><p><strong>Conclusion: </strong>Regarding treatment for depression, this meta-analysis extends the increasing number of studies demonstrating the effectiveness of multimodal physical therapy.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103937"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital cognitive behavioral therapy as a novel treatment for insomnia.","authors":"Xu-Tong Tian, Yao Meng, Ru-Lan Wang, Rong Tan, Mei-Shan Liu, Wen Xu, Shuai Cui, Yun-Xiang Tang, Meng-Yang He, Wen-Peng Cai","doi":"10.5498/wjp.v15.i4.104042","DOIUrl":"https://doi.org/10.5498/wjp.v15.i4.104042","url":null,"abstract":"<p><strong>Background: </strong>As a substitute for traditional drug therapy, digital cognitive-behavioral therapy positively impacts the regulation of brain function, which can improve insomnia. However, there is currently a paucity of studies on digital cognitive behavioral therapy as a treatment for insomnia.</p><p><strong>Aim: </strong>To assess digital cognitive behavioral therapy for insomnia regarding its positive impact on brain function.</p><p><strong>Methods: </strong>Participants were randomly assigned to either a go/no-go group or a dot-probe group. The primary outcome was quality of sleep as assessed by the actigraphy sleep monitoring bracelet, Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI), and depression anxiety and stress scale (DASS-21).</p><p><strong>Results: </strong>Eighty patients were included in the analysis (go/no-go group: <i>n</i> = 40; dot-probe group: <i>n</i> = 40). We combined the total scale scores of the two groups before and after the intervention in the analysis of covariance. Our study explored whether insomnia symptoms in both groups can be improved by using digital cognitive behavioral therapy instead of trying to compare the two trials; therefore, only one <i>P</i> value is listed. In both groups, we found a short-term time effect on insomnia symptom severity (PSQI: <i>P</i> < 0.001, <i>η</i> ² = 0.336; ISI: <i>P</i> < 0.001, <i>η</i> ² = 0.667; DASS-depression: <i>P</i> < 0.001, <i>η</i> ² = 0.582; DASS-anxiety: <i>P</i> < 0.001, <i>η</i> ² = 0.337; DASS-stress: <i>P</i> < 0.001, <i>η</i> ² = 0.443) and some effect on sleep efficiency (but it was not significant, <i>P</i> = 0.585, <i>η</i> ² = 0.004).</p><p><strong>Conclusion: </strong>Go/no-go task training of inhibitory function had a short-term positive effect on sleep efficiency, whereas dot-probe task training had a positive short-term effect on emotion regulation.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 4","pages":"104042"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From health literacy to organ donation and transplantation awareness: The path through self-control.","authors":"Amil Huseynov, Begum Satici","doi":"10.5498/wjp.v15.i4.104859","DOIUrl":"https://doi.org/10.5498/wjp.v15.i4.104859","url":null,"abstract":"<p><strong>Background: </strong>Organ donation and transplantation are vital for saving lives, yet awareness remains limited. Health literacy, the ability to understand and use health information, and self-control, which influences decision-making, are crucial factors in promoting awareness. Understanding their relationship can guide efforts to increase participation in organ donation.</p><p><strong>Aim: </strong>To investigate the effect of health literacy on organ donation and transplantation awareness, with self-control acting as a mediator, and to emphasize its importance.</p><p><strong>Methods: </strong>The study comprised 345 adults recruited from five different cities in Türkiye. The sample included 208 women (60.29%) and 137 men (39.71%). The age range of the sample group varies between 18 and 49 (median age = 24.13; SD = 8.81). Self-report data were collected including psychometric measures assessing organ donation and transplantation awareness, health literacy, and self-control. Reliability analysis, descriptive statistics, correlational analysis, and mediational analysis of the data were carried.</p><p><strong>Results: </strong>The analysis showed that health literacy was positively correlated with organ donation and transplantation awareness (<i>r</i> = 0.340) and self-control (<i>r</i> = 0.376). Self-control was positively related to organ donation and transplantation awareness (<i>r</i> = 0.531). Mediating analysis supported a mediation model where health literacy was found to influence organ donation and transplantation awareness <i>via</i> self-control (bootstrap = 0.158, 95% confidence interval = 0.105-0.215).</p><p><strong>Conclusion: </strong>The results indicate that self-control mediates the positive relationship between health literacy and organ donation and transplantation awareness. Enhancing individuals' health literacy may therefore increase awareness of organ donation and transplantation through improvements in self-control.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 4","pages":"104859"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive bibliometric analysis of transcranial magnetic stimulation-based depression treatment from 2003 to 2022: Research hotspots and trends.","authors":"Zheng-Yu Li, Yu-Wei Zhang, Hao-Ran Yang, Yu-Qing Ren, Hong-Jin Wu, Meng-Yun Zhang, Song Zhang, Ying-Fu Jiao, Wei-Feng Yu, Jie Xiao, Po Gao, Heng Yang","doi":"10.5498/wjp.v15.i4.104600","DOIUrl":"https://doi.org/10.5498/wjp.v15.i4.104600","url":null,"abstract":"<p><strong>Background: </strong>Depression has become a global public health problem. In recent years, transcranial magnetic stimulation (TMS) has gained considerable attention as a non-invasive treatment for depression.</p><p><strong>Aim: </strong>To investigate the research hotspots and trends in the field of TMS-based depression treatment from a bibliometric perspective.</p><p><strong>Methods: </strong>Using the Web of Science Core Collection, articles published between 2003 and 2022 on TMS-based depression treatment were retrieved from the science citation index expanded. The publication trends and research hotspots were analyzed using VOSviewer, CiteSpace, and the bibliometric online analysis platform. Regression analysis was performed using Microsoft Excel 2021 to predict publication growth trends.</p><p><strong>Results: </strong>We identified a total of 702 articles on TMS-based depression treatment with a predominance of clinical studies. Analysis of collaborative networks showed that the United States, the University of Toronto, and Daskalakis ZJ were identified as the most impactful country, institution, and researcher, respectively. In keyword burst analysis, it was found that theta burst stimulation (TBS), functional connectivity, and frequency were the most recent research hotspots.</p><p><strong>Conclusion: </strong>TMS provides a novel therapeutic option for patients with treatment-resistant depression. Neuroimaging technology enables more precise TMS treatment, while the novel TMS modality, TBS, enhances both therapeutic efficacy and patient experience in TMS-based depression treatment. The integration of neuroimaging techniques with TBS represents a promising research direction for advancing TMS-based depression treatment. This study presents systematic information and recommendations to guide future research on TMS-based depression treatment.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 4","pages":"104600"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motoric cognitive risk syndrome: A review of fall risk assessment and management strategies.","authors":"Hao Peng, Na Yao, Yan-Ping Song, Li Huang, Hong-Bo Chen, Yang Jiang, Qi-Gang Chen","doi":"10.5498/wjp.v15.i4.101800","DOIUrl":"https://doi.org/10.5498/wjp.v15.i4.101800","url":null,"abstract":"<p><p>The aging global population is driving an increase in dementia, making the early identification of at-risk individuals crucial. Studies have shown that elderly people often exhibit a slowing gait before dementia diagnosis, which is linked to cognitive decline and predicts dementia risk. With 30% of those over 65 years of age experiencing falls annually, managing fall risk is essential. Motoric cognitive risk syndrome (MCR), characterized by subjective memory impairment and slow gait, is a pre-dementia condition that can identify high-risk individuals without extensive evaluation. The prevalence of MCR varies globally and is associated with an increased risk of falls, disability, and death. Early screening and intervention for MCR can delay dementia and improve fall regulation, offering a new perspective on elderly health management. This review synthesizes the current understanding of MCR-related falls, evaluates risk assessment methods, and discusses health strategies to provide a theoretical basis for fall prevention in community-dwelling older adults.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 4","pages":"101800"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of anxiety and depression and influencing factors in non-Hodgkin's lymphoma of the nasal cavity and paranasal sinus.","authors":"Xu-Dong Gao, Jin Zhang, An Li, Yu Ding, Bo Zhao, Lan Li","doi":"10.5498/wjp.v15.i4.99346","DOIUrl":"https://doi.org/10.5498/wjp.v15.i4.99346","url":null,"abstract":"<p><strong>Background: </strong>Natural killer (NK)/T-cell non-Hodgkin's lymphoma (NHL) in the nasal cavities and paranasal sinuses accounts for approximately 10% of all lymphomas, and the occurrence of nasal NHL is related to Epstein-Barr virus infection.</p><p><strong>Aim: </strong>To explore the anxiety and depression status of patients with NK/T-cell NHL in the nasal cavities and paranasal sinuses and analyzes the relevant influencing factors.</p><p><strong>Methods: </strong>A retrospective analysis was performed, which included 30 patients with primary nasal NK/T-cell NHL treated in Shaanxi Provincial People's Hospital from January 2017 to January 2023. An additional 50 healthy volunteers were selected as the control group. Both groups were assessed using the self-rating anxiety scale (SAS) and Self-rating (SDS). SDS and SAS scores of patients with NHL at different disease stages were analyzed, and they were further grouped into negative emotion (NE) (<i>n</i> = 19) and non-NE (<i>n</i> = 11) groups based on their depression and anxiety. Factors affecting the occurrence of NEs in patients with NHL were analyzed using univariate and multivariate logistic regression models.</p><p><strong>Results: </strong>Patients with NHL exhibited higher SDS and SAS scores than healthy controls. Moreover, patients with NHL at stages III and IV had higher SDS and SAS scores than those in stage I. Among the 30 patients, there were 13 patients with depression (43.3%), 16 patients with anxiety (53.3%), and 10 patients with both anxiety and depression (33.3%). Univariate analysis identified a higher proportion of people in the NE group with stage III-IV NHL, an educational level ≤ high school, and a monthly household income < 5000 yuan compared with the non-NE group. Multiple logistic regression analysis further revealed that stage III-IV was a risk factor for NEs in patients with NHL.</p><p><strong>Conclusion: </strong>The stage of NK/T-cell NHL in nasal cavities and paranasal sinuses is closely related to patient anxiety and depression. The higher the staging, the greater the incidence of anxiety and depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 4","pages":"99346"},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}