World Journal of Psychiatry最新文献

{"title":"Optimizing perimenopausal mental health by integrating precision biomarkers, digital health interventions, and psychosocial care.","authors":"Uchenna E Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i7.101906","DOIUrl":"10.5498/wjp.v15.i7.101906","url":null,"abstract":"<p><p>This study addressed the critical need for an integrated, personalized approach to perimenopausal mental health, addressing both biological and psychosocial factors. Current research highlighted the influence of hormonal fluctuations, genetic predispositions, and lifestyle factors in shaping perimenopausal mental health outcomes. This transitional period is marked by significant hormonal fluctuations contributing to heightened anxiety, depression, and sleep disturbances, affecting the women's quality of life. Traditional pharmacological treatments, including selective serotonin reuptake inhibitors and hormone replacement therapy, have limitations due to variable efficacy and side effects, emphasizing the need for precision medicine. Advancements in pharmacogenomics and metabolomics provide new avenues for individualized treatments, with genetic markers <i>(e.g</i>., Solute carrier organic anion transporter family member 1B1, estrogen receptor 1/estrogen receptor 2, and tachykinin receptor 3<i>)</i> guiding hormone therapy responses. Emerging digital health technologies, such as artificial intelligence-driven diagnostics, wearable monitoring, and telehealth platforms, offer scalable, real-time mental health support, though regulatory and clinical validation challenges remain. Furthermore, integrative treatment models combining hormone-based therapy with non-pharmacological interventions demonstrate significant efficacy in alleviating perimenopausal symptoms. Future directions should prioritize the clinical validation and ethical implementation of digital health solutions, ensuring safety, efficacy, and user accessibility. A multidisciplinary, patient-centric model, incorporating genetics, endocrinology, digital health, and psychosocial interventions, is essential for optimizing perimenopausal mental health outcomes.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"101906"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of impulsive personality on suicide in adolescent depression: The chain mediating of perceived social adversity and security.","authors":"Hua Zhang, Hua-Bin Li, Fu-Sheng Sun, Xue-Qiong Su, Chun-Bo Sun","doi":"10.5498/wjp.v15.i7.104373","DOIUrl":"10.5498/wjp.v15.i7.104373","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common mental disorder among adolescents, characterized by a high rate of suicide and self-harm, which not only is devastating to families but also has a negative impact on society. Psychological factors such as impulsive personality, perceived chronic social adversity (PCSA), and sense of security are closely associated with suicide risk in adolescents with depression. Few studies have been conducted on the relationship between these factors.</p><p><strong>Aim: </strong>To explore the impact of impulsive personality on suicide risk in adolescents with depression and the chain mediating effect between PCSA and sense of security.</p><p><strong>Methods: </strong>This study is a retrospective study. A total of 200 adolescents with depression who visited the Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital from January 2021 to December 2023 comprised the study cohort. The PCSA scale, Security Questionnaire, Barratt Impulsiveness Scale, and Beck Scale for Suicide Ideation were used to evaluate depression.</p><p><strong>Results: </strong>Suicide risk was positively correlated with impulsive personality and PCSA (<i>P</i> < 0.05), whereas sense of security was negatively correlated with suicide risk, impulsive personality, and PCSA (<i>P</i> < 0.05). The total indirect effect of PCSA and sense of security on impulsive personality and suicide risk was 35.43%, with the mediating effect of PCSA and sense of security contributing 16.53% and 15.75%, respectively. PCSA and sense of security exhibited a chain mediating effect between impulsive personality and suicide risk, accounting for 3.15%.</p><p><strong>Conclusion: </strong>The suicide risk of adolescents with depression is significantly associated with impulsive personality, PCSA, and sense of security. Impulsive personality affects the suicide risk of adolescents with depression both directly and indirectly, with the latter occurring <i>via</i> PCSA and sense of security.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"104373"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Debating the link between atrial fibrillation and psychiatric diseases through Ca²⁺/cAMP signaling.","authors":"Leandro Bueno Bergantin","doi":"10.5498/wjp.v15.i7.107130","DOIUrl":"10.5498/wjp.v15.i7.107130","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is a very common tachyarrhythmia in clinical practice. Several risk factors, such as higher inflammatory marker levels, diabetes mellitus, hypertension, valvular disease, ischemic heart disease, heart failure, and obesity have been proposed to enhance the risk of AF, contributing to higher healthcare system utilization rates and socioeconomic costs. Some interesting studies also investigated the link between AF and psychiatric diseases. This article debates this link between AF and psychiatric diseases from the perspective of Ca²⁺/cAMP signaling.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107130"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering older adults: Enhancing addiction literacy to address unique vulnerabilities.","authors":"Kae Leopoldo, João Mauricio Castaldelli-Maia","doi":"10.5498/wjp.v15.i7.104254","DOIUrl":"10.5498/wjp.v15.i7.104254","url":null,"abstract":"<p><p>Addiction literacy equips older adults with the knowledge to navigate substance use risks amid unique challenges like polypharmacy and social isolation. With rising trends in cannabis use among this group, targeted education can promote safe practices and reduce preventable harms. By fostering open conversations and integrating addiction literacy into healthcare, providers can support informed decision-making.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"104254"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between death anxiety and empathy among nursing students at an early stage of their clinical internships.","authors":"Jian-Xin Ye, Li-Qiu Huang, Shi-Lai Yang","doi":"10.5498/wjp.v15.i7.106845","DOIUrl":"10.5498/wjp.v15.i7.106845","url":null,"abstract":"<p><strong>Background: </strong>Death anxiety is a common emotional response to death, and it varies in intensity across cultures and regions. However, there is a paucity of research on death anxiety among nursing students during their clinical internship, especially in relation to their emotional experiences and behavioral responses.</p><p><strong>Aim: </strong>To explore the relationship between empathy and death anxiety as well as to identify factors influencing students' empathetic skills during their initial clinical experiences.</p><p><strong>Methods: </strong>This cross-sectional study included 473 nursing students enrolled from across vocational colleges in Quanzhou (Fujian Province, China) during June-July 2023. These students were trained at three Grade-A general hospitals. The Empathy Scale and Death Anxiety Scale were applied to assess their empathetic skills and death anxiety levels during the early stages of the clinical internship. Data analyses employed descriptive statistics, correlation analyses, independent sample <i>t</i>-tests, one-way analysis of variance, and multiple linear regression analysis.</p><p><strong>Results: </strong>The mean death anxiety score was 46.33 ± 6.29, with 95.6% of participants exhibiting high death anxiety. The mean scores across dimensions were as follows: Cognitive-affective, 18.08 ± 3.15; pain and illness, 13.25 ± 2.41; awareness of the passage of time, 5.58 ± 1.40; stimuli related to death, 9.40 ± 1.56. The mean empathy score was 63.78 ± 11.49. Regression analysis revealed that students' subject major, total death anxiety level, and pain and stress dimensions acted as significant predictors of their empathetic skills during early clinical practice (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Vocational nursing students, especially those in midwifery with higher death anxiety, exhibited lower empathetic skills during the early stages of their clinical internship. Nursing educators should take measures to enhance the empathetic skills of students through appropriate training and support for students with high death anxiety levels.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106845"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression differences and relationships of endothelin-1, interleukin-6 and c-kit in hypertensive patients with and without depression.","authors":"Wei-Yi Wang, Yi Wu, Jing-Qi Zhang, Bin Li","doi":"10.5498/wjp.v15.i7.106733","DOIUrl":"10.5498/wjp.v15.i7.106733","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a chronic cardiovascular disease characterized by persistently elevated arterial blood pressure. It is not only a significant risk factor for cardiovascular and cerebrovascular diseases (such as myocardial infarction and stroke) but also closely related to multiple organ damages (such as kidney disease and retinopathy), imposing a heavy health and economic burden on individuals and society.</p><p><strong>Aim: </strong>To investigate the expression differences and relationships of endothelin-1 (ET-1), interleukin-6 (IL-6), stem cell factor (SCF), and its receptor (c-kit) in hypertensive patients with or without depression.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 163 hypertensive patients admitted to our hospital from March 2022 to January 2024. Based on the presence of depression, patients were divided into Group A (<i>n</i> = 77, with depression) and Group B (<i>n</i> = 86, without depression). Serum levels of ET-1 and IL-6 were measured using radioimmunoassay, while serum levels of SCF and c-kit were measured using ELISA. The differences in ET-1, IL-6, SCF, and c-kit levels between Groups A and B were compared. Additionally, the differences in these biomarkers among patients with varying degrees of depression in Group A were analyzed. Pearson correlation analysis was used to examine the relationship between ET-1, IL-6, SCF, c-kit levels, and Hamilton depression rating scale (HAMD) scores. Multivariate logistic regression analysis was performed to identify factors influencing hypertension with depression. The diagnostic efficacy of individual and combined biomarkers was analyzed using receiver operating characteristic (ROC) curves. Comparative statistical analysis of the area under the curve (AUC) values was performed using DeLong's test to assess the superiority of combined biomarker detection.</p><p><strong>Results: </strong>The levels of ET-1 and IL-6 in Group A were significantly higher than those in Group B, while the levels of SCF and c-kit were significantly lower in Group A compared to Group B (<i>P</i> < 0.05). In the severe depression subgroup, ET-1 and IL-6 levels were higher than those in the mild-to-moderate depression subgroup, while SCF and c-kit levels were lower (<i>P</i> < 0.05). Pearson correlation analysis showed that ET-1 and IL-6 levels were positively correlated with HAMD scores (<i>r</i> = 0.442, 0.463, <i>P</i> < 0.05), while SCF and c-kit levels were negatively correlated with HAMD scores (<i>r</i> = -0.429, -0.394, <i>P</i> < 0.05). Multivariate logistic regression analysis revealed that high ET-1, high IL-6, low SCF, and low c-kit were independent influencing factors for hypertension with depression (<i>P</i> < 0.05). ROC analysis revealed AUCs of 0.746 (ET-1), 0.801 (IL-6), 0.732 (SCF), 0.779 (c-kit), and 0.884 (combination). The combined diagnosis demonstrated significantly higher AUC than individual markers (DeLong","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"106733"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation regulates the extinction of fear memory.","authors":"Le Jiang, Rui-Xue Ma, Er-Shu He, Xiao-Ye Zheng, Xin Peng, Wen-Hao Ma, Ying Li, Han-Wei Li, Xue-Yan Zhang, Jie-Yu Ji, Yan-Jiao Li, Shang-Lan Qu, Li-Juan Li, Zhi-Ting Gong","doi":"10.5498/wjp.v15.i7.107524","DOIUrl":"10.5498/wjp.v15.i7.107524","url":null,"abstract":"<p><strong>Background: </strong>Fear-related disorders, such as post-traumatic stress disorder (PTSD), significantly impact patients and families. Exposure therapy is a common treatment, but improving its effectiveness remains a key challenge. Fear conditioning and extinction in animal models offer insights into its mechanisms. Our previous research indicates that DNA methyltransferases play a role in fear memory renewal.</p><p><strong>Aim: </strong>To investigate the role of DNA methylation in the extinction of fear memory, with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.</p><p><strong>Methods: </strong>This study investigated the role of DNA methylation in fear memory extinction in mice. DNA methylation was manipulated using N-phthalyl-L-tryptophan (RG108) to reduce methylation and L-methionine injections to enhance it. Neuronal activity, and dendritic spine density was measured following extinction training.</p><p><strong>Results: </strong>RG108 suppressed extinction, reduced spine density, and inhibited neuronal activity. Methionine injections facilitated extinction.</p><p><strong>Conclusion: </strong>DNA methylation is crucial for fear memory extinction. Enhancing methylation may improve the efficacy of exposure therapy, offering a potential strategy to treat fear-related disorders.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107524"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined preconception and prenatal myo-inositol, probiotics, and trace element supplementation on the outcomes of depressed mothers.","authors":"Shu-Fang Qi, Hong-Xia Sun, Jie Zhao","doi":"10.5498/wjp.v15.i7.103684","DOIUrl":"10.5498/wjp.v15.i7.103684","url":null,"abstract":"<p><strong>Background: </strong>Perinatal depression affects 10%-20% of pregnant women and subsequently influences maternal health and fetal development. Concerns over the safety of antidepressants during pregnancy have prompted the exploration of nutritional interventions as adjunct therapies. This study evaluated the impact of combining preconception and prenatal supplementation with myo-inositol, probiotics, and trace elements on mood, quality of life, and fetal development in depressed mothers.</p><p><strong>Aim: </strong>To identify a novel therapeutic approach to reduce pregnancy complications and improve maternal-fetal health outcomes.</p><p><strong>Methods: </strong>This retrospective cohort study included 314 pregnant women who were diagnosed with mild to moderate depression, as determined by a Zung self-rating depression scale score of less than 69. The participants were divided into an intervention group (<i>n</i> = 161) receiving myo-inositol, probiotics, and trace elements and a control group (<i>n</i> = 153) without supplementation. Supplementation commenced 3 months before conception and continued through pregnancy. Psychiatric symptoms and quality of life were evaluated using the positive and negative affect schedule-now, state-trait anxiety inventory, Patient Health Questionnaire-8, and World Health Organization Quality of life Assessment: Brief Version scales preconception and postpartum. Fetal development metrics were assessed <i>via</i> ultrasound, and neonatal outcomes were recorded.</p><p><strong>Results: </strong>The intervention group presented significant reductions in gestational diabetes mellitus (13.04% <i>vs</i> 23.53%, <i>P</i> = 0.016) and gestational hypertension (3.73% <i>vs</i> 9.15%, <i>P</i> = 0.049). Higher levels of inositol, iron, zinc, and probiotics were observed near term in the intervention group. Postpartum mood assessments indicated lower anxiety and depression scores for the intervention group, with significant improvements in the positive and negative affect schedule-now (<i>P</i> = 0.002), trait anxiety (<i>P</i> = 0.002), and Patient Health Questionnaire-8 (<i>P</i> = 0.018) scores. The World Health Organization Quality of life Assessment: Brief Version scores improved in the psychological (<i>P</i> = 0.041) and environmental (<i>P</i> = 0.009) domains postpartum. Fetal biparietal diameter and femoral length were greater in the intervention group alongside better neonatal body length and reduced neonatal unit admissions (2.48% <i>vs</i> 7.84%, <i>P</i> = 0.031).</p><p><strong>Conclusion: </strong>Combined supplementation with myo-inositol, probiotics, and trace elements from preconception through pregnancy may reduce pregnancy-related complications, enhance mood and quality of life, and improve fetal growth metrics.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"103684"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different timing nutritional support on the growth and development < 2 kg newborns and mothers' anxiety and depression.","authors":"Li Gao, Fen Xu, Jie Yan, Yan Ma","doi":"10.5498/wjp.v15.i7.104844","DOIUrl":"10.5498/wjp.v15.i7.104844","url":null,"abstract":"<p><strong>Background: </strong>Newborns with low-birth-weight may lag behind those with normal-birth-weight in terms of growth, development, and nutritional status, which increases mothers' concerns about the child's future health and leads to anxiety and depression. Providing nutritional support to newborns with low-birth-weight to facilitate optimal growth and development may help alleviate maternal anxiety and depression.</p><p><strong>Aim: </strong>To explore the effects of nutritional support timing on the growth and development of newborns born under 2 kg and their mothers' anxiety and depression.</p><p><strong>Methods: </strong>A total of 64 newborns born under 2 kg and their mothers who received treatment at the neonatology department of Suzhou Ninth Affiliated Hospital of Soochow University from January 2023 to October 2024 were selected and retrospectively evaluated. Newborns were then divided into the following two groups according to the start time of enteral nutrition support: Group S (32 cases, receiving enteral nutrition support within 24 hour of birth) and Group L (32 cases, receiving enteral nutrition support after 24 hour of birth). Thereafter, we compared the baseline data, as well as the milk intake and total bilirubin (TBIL) values, between the two groups at 1, 2, 3, and 4 weeks after nutritional support. We also compared the occurrence of adverse digestive reactions (vomiting, bloating, constipation, diarrhea, and residual symptoms), complications (neonatal necrotizing enterocolitis and infection), growth and development indicators (weight, length, and head circumference) before and after nutritional support between the two groups of patients, as well as their mother's anxiety [evaluated using the Self Rating Anxiety Scale (SAS)] and depression [evaluated using the Self Rating Depression Scale (SDS)].</p><p><strong>Results: </strong>No significant difference in baseline data was observed between the two groups (<i>P</i> > 0.05). Milk intake and TBIL levels in Group S were significantly better than those in Group L at 1, 2, 3, and 4 weeks after nutritional support (<i>P</i> < 0.05). No significant differences in vomiting, abdominal distension, constipation, diarrhea, and residual adverse reactions were observed between the two groups during nutritional support (<i>P</i> > 0.05). Group S had a significantly reduce of fewer complications (<i>i.e.</i>, neonatal necrotizing enterocolitis and infection) than did Group L during nutritional support (<i>P</i> < 0.05). Before nutritional support, no significant differences in developmental indicators (weight, length, and head circumference) were noted between the two groups (<i>P</i> > 0.05). However, after nutritional support, the weight, length, and head circumference of both groups were higher than those before intervention, with Group S having significantly higher values than did Group L (<i>P</i> < 0.05). Mothers of children who received nutritional support had decreased SAS and","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"104844"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe anxiety, depression, and sleep disorders worsen prognosis in patients with septic shock.","authors":"Jiang-Bo Li, Wei Rong","doi":"10.5498/wjp.v15.i7.107038","DOIUrl":"10.5498/wjp.v15.i7.107038","url":null,"abstract":"<p><p>Recent studies have revealed that patients with septic shock and acute skin failure (ASF) exhibit significantly higher levels of inflammatory cytokines, lactate, and C-reactive protein, along with elevated skin mottling score; modified early warning score (MEWS); and anxiety, depression, and Pittsburgh sleep quality index scores compared to those without ASF. Notably, these indicators are significantly correlated. Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9, indicating severe disease progression. Therefore, it is essential to not only manage septic shock but also mitigate anxiety, depression, sleep disorders, and disturbances of consciousness. This article explores the impact of severe anxiety, depression, and sleep disorders on the prognosis of septic shock and discusses intervention strategies.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107038"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}