World Journal of Psychiatry最新文献

{"title":"Acceptance and commitment therapy for enhancing mental health in military personnel: A comprehensive review and meta-analysis.","authors":"Jun-Qiao Wang, Xin-Zhe Wang, Wen-Xiao Wang","doi":"10.5498/wjp.v15.i3.100959","DOIUrl":"10.5498/wjp.v15.i3.100959","url":null,"abstract":"<p><strong>Background: </strong>Military personnel frequently face unique psychological challenges due to high-stress environments, which increase the risk of mental health issues like anxiety and depression. Acceptance and commitment therapy (ACT) has shown potential in addressing these issues by enhancing psychological flexibility and resilience.</p><p><strong>Aim: </strong>To systematically evaluate the effectiveness of ACT in improving the mental health of military personnel. Through a scoping review and meta-analysis, we quantitatively assess the impact of ACT on psychological outcomes, guiding future research and clinical practice.</p><p><strong>Methods: </strong>Relevant literature was searched systematically from database inception to June 30, 2023, across multiple databases, including PubMed, Web of Science, Cochrane Library, and Embase. The Joanna Briggs Institute's (JBI) scoping review guidelines were used as the methodological framework. Meta-analysis was performed using a random-effects model, and publication bias was assessed through Egger's regression test and Begg's funnel plot.</p><p><strong>Results: </strong>Twenty-six studies were included, highlighting the application of ACT in addressing PTSD, chronic pain, anxiety, and depression among military personnel. The meta-analysis of eight studies demonstrated a significant positive effect of ACT on mental health, with a pooled mean difference of -4.99 (95%CI: -6.53 to -3.45). Despite high heterogeneity (<i>I²</i> = 63%), sensitivity analyses confirmed the robustness of the findings.</p><p><strong>Conclusion: </strong>This study underscores the potential of ACT as an effective intervention for improving the mental health of military personnel. Future research should focus on large-scale, multi-center RCTs to further validate these findings, particularly within diverse military populations.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 3","pages":"100959"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical and psychological characteristics of 225 children with autism spectrum disorder based on the C-PEP-3 scale.","authors":"Qian-Qian Kang, Yu-Feng Gao, Wei Su, Ya-Lan Fan, Heng-Bai Kong","doi":"10.5498/wjp.v15.i3.101101","DOIUrl":"10.5498/wjp.v15.i3.101101","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that affect children's social interaction and communication skills and exert a serious effect on children's perception, language, emotion, and especially social interaction development.</p><p><strong>Aim: </strong>To determine the clinical and psychological characteristics of children with ASD according to the C-PEP-3.</p><p><strong>Methods: </strong>This retrospective study included 225 children with autism aged 2-7 years who were treated in our hospital from 2021 to 2024. The C-PEP-3 scale was used for assessment, and the evaluation results were analyzed.</p><p><strong>Results: </strong>The comparison of children with ASD in the age groups of < 3.5 years and > 3.5 years revealed significant differences in the scores of imitation, fine motor, gross motor, hand-eye coordination, cognitive performance, and verbal cognition development areas (P: Pass) (<i>P</i> < 0.01). However, no significant differences in the scores of perception, emotion, interpersonal relationships, play, sensation, and language (S: Severe) were observed on pathological scales (<i>P</i> > 0.05). The difference in age in the gross motor developmental delay of the scale was the smallest, whereas that of the verbal cognition was the largest, followed by the imitation functional area. An inverse correlation was found between the scores of imitation, perception, hand-eye coordination, and cognitive performance (P) developmental function areas in children with ASD and those of emotion, interpersonal relationships, game and item preferences, sensory patterns, and emotion (S) in the pathological scale (<i>P</i> < 0.05). Fine and gross motor skills were negatively correlated with interpersonal relationships, game and item preferences, and emotions in the pathological scale (<i>P</i> < 0.05). Age was significantly positively correlated with the scores of imitation, perception, fine motor, gross motor, hand-eye coordination, cognitive performance, and verbal cognition developmental function areas (P) (<i>P</i> < 0.05). Further, age was not associated with emotions, interpersonal relationships, game and item preferences, sensory patterns, and emotions (<i>P</i> > 0.05). No gender difference was observed between the scores of each developmental area (P) of the scale and the scores of each functional area (S) of the pathological scale.</p><p><strong>Conclusion: </strong>The C-PEP-3 scale reflects the differences in clinical characteristics of children with autism, and the pathological scale is associated with the severity of developmental function areas. The C-PEP-3 scale can be utilized to assess the effect of age changes on children with autism. Attention in rehabilitation should be focused on addressing the pathological behaviors of children with autism.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 3","pages":"101101"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined microscopic and neuroendoscopic treatment effects on psychological and cognitive outcomes in ruptured intracranial aneurysms.","authors":"Li-Ke Shi, Xian-Feng Cai, Jian-Qing He, Yu-Hai Wang","doi":"10.5498/wjp.v15.i3.100565","DOIUrl":"10.5498/wjp.v15.i3.100565","url":null,"abstract":"<p><strong>Background: </strong>Intracranial aneurysms, characterized by focal arterial wall dilation, pose significant neurosurgical challenges due to their potential for rupture and hemorrhage, leading to severe clinical outcomes, including fatality. Patients often experience profound psychological and social impacts, such as depression, anxiety, and cognitive impairment, affecting their quality of life. Rapid progression and high mortality necessitate timely intervention. Advances in neurosurgical techniques, including microscopic surgery and neuroendoscopy, offer distinct advantages. Microscopic surgery provides precision and direct visualization, while neuroendoscopy ensures minimally invasive access and reduced tissue trauma. Integrating these methods optimizes treatment efficacy and clinical outcomes.</p><p><strong>Aim: </strong>To evaluate the impact of combined microscopic and neuroendoscopic techniques on psychological, cognitive outcomes, and quality of life in patients with ruptured intracranial aneurysms.</p><p><strong>Methods: </strong>The study focused on 189 patients with intracranial aneurysm rupture and hemorrhage from January 2020 to May 2024 as the objects of observation and analysis. They were randomly divided into a control group (treated with simple microscope surgery, <i>n</i> = 94) and an observation group (treated with microscope combined with neuroendoscopy, <i>n</i> = 95). The treatment effects of the two groups were observed, mainly including depression and anxiety scale scores, cognitive function assessment results and quality of life assessment data.</p><p><strong>Results: </strong>Before treatment, the depression and anxiety scale scores, cognitive function assessment results and quality of life assessment data of the two groups of patients at different time points were compared, and there was no statistically significant difference (<i>P</i> > 0.05). After microscope combined with neuroendoscopy treatment, the study revealed that the observation group surpassed the control group in alleviating depression and anxiety, accelerating cognitive function recovery, and enhancing quality of life, with these differences being statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Surgical treatment combined with microscopy and neuroendoscopy has a significant positive effect on the mental health, cognitive function and overall quality of life of patients with intracranial aneurysm rupture and bleeding, can shorten the operation time and treatment time, and provides a new strategic reference for clinical treatment.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 3","pages":"100565"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the THINC-integrated tool to compare the characteristics of cognitive dysfunction in patients with unipolar and bipolar depression.","authors":"Na Zhu, Qi Zhang, Jia Huang, Jie Tong, Heng-Fen Gong, Ming-Huan Zhu, Wei Lu, Jie Zhang, Xi-Rong Sun","doi":"10.5498/wjp.v15.i3.99408","DOIUrl":"10.5498/wjp.v15.i3.99408","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) and bipolar depression (BD-D) are both intricate, enduring, and profound psychiatric conditions characterized primarily by depressive episodes and cognitive dysfunction. However, distinguishing the characteristics and influencing factors of cognitive impairment in unipolar and BD-D is crucial for identification and intervention.</p><p><strong>Aim: </strong>To compare neurocognitive characteristics and investigate associations between cognitive function and clinical features in unipolar and BD-D.</p><p><strong>Methods: </strong>The THINC-integrated tool (THINC-it) as a cognitive assessment tool was applied to 295 individuals: 75 patients with depressive disorders (MDD), 120 individuals with BD-D, and 100 healthy controls. The Hamilton Depression Scale-17 (HAMD), Hamilton Anxiety Scale-14 (HAMA), and Pittsburgh Sleep Quality Index (PSQI) were employed to assess depression, anxiety, and sleep. Neurocognitive function characteristics and the relationships between cognitive impairment and general clinical attributes were analyzed.</p><p><strong>Results: </strong>There were no statistically significant differences in the overall THINC-it with each objective subscale. However, the subjective subscale (Perceived Deficits Questionnaire for Depression-5-item) showed significant differences between MDD and BD-D (<i>P</i> < 0.001). Linear regression analyses were explored to determine associations. Age, years of education, age at onset, and HAMD were significantly co-associated with the overall THINC-it and each subscale in both MDD and BD-D (<i>P</i> < 0.05). Furthermore, years of education showed a positive correlation with objective cognitive impairment (<i>e.g.</i>, Codebreaker, Trails) (<i>P</i> < 0.05). There was a notable difference in that the number of depressive episodes, disease duration, hospitalizations, HAMA, and PSQI were significantly associated with the overall THINC-it with each subscale between MDD and BD-D (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Although both unipolar and BD-D showed similar objective cognitive impairments, there was a significant difference in subjective cognitive impairment. Our findings suggest that factors like age, years of education, age at onset, and depression severity might not be significantly difference in the influence of cognitive impairment. Furthermore, we found that education was a protective factor for cognitive impairment in both unipolar and BD-D. Our analysis revealed that distinct factors including disease duration, number of depressive episodes, hospitalizations, anxiety levels, and sleep quality influenced cognitive impairment between unipolar and BD-D. Therefore, it was important to investigate the specific characteristics of cognitive impairment and influencing factors to identify differentiating unipolar and BD-D.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 3","pages":"99408"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived neurotrophic factor.","authors":"Qi Zhang, Yue Zhao, Guang-Yu Cheng","doi":"10.5498/wjp.v15.i2.99573","DOIUrl":"10.5498/wjp.v15.i2.99573","url":null,"abstract":"<p><strong>Background: </strong>Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress, which can hinder their rehabilitation. Acupuncture has shown potential to relieve this condition.</p><p><strong>Aim: </strong>To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.</p><p><strong>Methods: </strong>Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled. Patients were divided into two groups using the random throwing method: Observation (250 cases, fluoxetine hydrochloride + acupuncture treatment) and control (250 cases, fluoxetine hydrochloride treatment). Changes in negative emotions Hamilton Depression Scale 24, serum inflammatory factors [tumor necrosis factor α, interleukin (IL)-1β, IL-6], miR-155 expression levels, and BDNF levels were assessed.</p><p><strong>Results: </strong>Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks (<i>P</i> < 0.05). This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.</p><p><strong>Conclusion: </strong>Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment. In addition, it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99573"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil gelatinase-associated lipocalin as a biomarker for neuropsychiatric complications in acute ischemic stroke.","authors":"Uchenna E Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i2.102598","DOIUrl":"10.5498/wjp.v15.i2.102598","url":null,"abstract":"<p><p>This study evaluates the findings of Gu <i>et al</i>, who investigated the role of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting neuropsychiatric complications in acute ischemic stroke (AIS) patients. The results revealed that elevated serum NGAL levels at admission are associated with a higher risk of cognitive impairment, anxiety, and depressive symptoms at discharge. The study analyzed 150 AIS patients (mean age 65.4 years, 58% male) using the Mini-Mental State Examination and the Hospital Anxiety and Depression Scale to assess neuropsychiatric outcomes. Multivariate analysis demonstrated that higher NGAL levels were independent predictors of cognitive impairment [odds ratio (OR) = 1.42], anxiety (OR = 1.28), and depression (OR = 1.39). Notably, NGAL exhibited strong predictive power for cognitive impairment, with an area under the curve of 0.78. Despite these promising findings, NGAL's clinical utility is limited by its non-specificity across various conditions. Nevertheless, NGAL levels could help identify AIS patients at risk for neuropsychiatric complications, enabling timely intervention and comprehensive neuropsychiatric evaluation. The study emphasizes the need for further research to validate NGAL's predictive accuracy and specificity in diverse AIS populations and advocates for its integration with other diagnostic modalities to enhance clinical decision-making.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"102598"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress.","authors":"Si-Hai Chen, Bo Lan, Ying-Ying Zhang, Guo-Hui Li, Yu-Long Qian, Ming-Xing Hu, Yin-Lin Tian, Wei-Dong Zang, Jing Cao, Guang-Hai Wang, Yi-Gang Wang","doi":"10.5498/wjp.v15.i2.101807","DOIUrl":"10.5498/wjp.v15.i2.101807","url":null,"abstract":"<p><strong>Background: </strong>Depression is a prevalent affective disorder, but its pathophysiology remains unclear. Dysfunction in the gamma-aminobutyric acid (GABA)-ergic system may contribute to its onset. Recently, antidepressants (<i>e.g.,</i> brexanolone, zuranolone) targeting the GABA-A receptor were introduced. The zona incerta (ZI), an inhibitory subthalamic region mainly composed of GABAergic neurons, has been implicated in emotional regulation. Deep brain stimulation of the ZI in humans affects anxiety and depression symptoms, while activation of ZI neurons in mice can either worsen or alleviate anxiety. Currently, there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in rodents.</p><p><strong>Aim: </strong>To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in mice.</p><p><strong>Methods: </strong>A chronic restraint stress (CRS) model was utilized to induce depression in mice. Whole-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ZI. Additionally, chemogenetic techniques were employed to modulate ZI GABAergic neurons. The performance of the mice in behavioral tests for depression and anxiety was observed.</p><p><strong>Results: </strong>The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in mice. Twenty-eight days after the CRS model was established, depression-like and anxiety-like behaviors were observed in the mice. The excitability of GABAergic neurons in the ZI was reduced. Chemogenetic activation of these neurons alleviated CRS-induced depression-like and anxiety-like behaviors. Conversely, inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in mice.</p><p><strong>Conclusion: </strong>Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice, suggesting that these neurons could be a potential therapeutic target for treating depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101807"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive view of suicide: A neuro-immune-endocrine approach.","authors":"María D Ponce-Regalado, Enrique Becerril-Villanueva, José Luis Maldonado-García, Martha C Moreno-Lafont, Gabriela Martínez-Ramírez, Salomón Jacinto-Gutiérrez, Rodrigo Arreola, Karla Sánchez-Huerta, Arturo Contis-Montes de Oca, Karla María López-Martínez, Elizabeth Bautista-Rodríguez, José Miguel Chin-Chan, Lenin Pavón, Gilberto Pérez-Sánchez","doi":"10.5498/wjp.v15.i2.98484","DOIUrl":"10.5498/wjp.v15.i2.98484","url":null,"abstract":"<p><p>Suicide is defined as the act of a person attempting to take their own life by causing death. Suicide is a complex phenomenon that is influenced by a multitude of factors, including psychosocial, cultural, and religious aspects, as well as genetic, biochemical, and environmental factors. From a biochemical perspective, it is crucial to consider the communication between the endocrine, immune, and nervous systems when studying the etiology of suicide. Several pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines, hormones, and neurotransmitters. These humoral signals, when present in optimal quantities, are responsible for maintaining physiological homeostasis, including mood states. Stress elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance, thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal behavior. This review provides an integrative perspective about the neurochemical, immunological, and endocrinological disturbances associated with suicidal behavior, with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"98484"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catatonia induced by antipsychotics in an adolescent male patient with systemic lupus erythematosus: A case report.","authors":"Wen-Qi Geng, Xiao-Xi Yang, Jin-Ya Cao, Jing Wei","doi":"10.5498/wjp.v15.i2.102259","DOIUrl":"10.5498/wjp.v15.i2.102259","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) can affect multiple organs or systems. The involvement of the central nervous system can result in the manifestation of epilepsy, an acute confusional state, and other rare neuropsychiatric presentations, such as catatonia.</p><p><strong>Case summary: </strong>We present a case of an adolescent male patient with first-onset SLE who presented with neuropsychiatric symptoms including epilepsy and delirium. The initial utilization of olanzapine to alleviate symptoms of agitation precipitated the emergence of catatonia, which was mitigated by discontinuing olanzapine and supplementing with lorazepam. In this case, whether the catatonia was secondary to the utilization of antipsychotics or to an organic disease is a question that warrants differential diagnosis.</p><p><strong>Conclusion: </strong>Multidisciplinary collaborative management is the cornerstone for the successful management of severe cases of SLE.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"102259"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue.","authors":"Fa-Yang Xiang, Xin-Ke Li","doi":"10.5498/wjp.v15.i2.99299","DOIUrl":"10.5498/wjp.v15.i2.99299","url":null,"abstract":"<p><p>Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu <i>et al</i>, published in the <i>World Journal of Psychiatry</i>. We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment approach that includes social support, psychological interventions, and individualized treatment plans. Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99299"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}