World Journal of Psychiatry最新文献

{"title":"Sociodemographic characteristics of suicide attempters treated in the emergency department and the effect of psychological care.","authors":"En-Sheng Tang, Wan-Li Ren, Hua Zou","doi":"10.5498/wjp.v16.i1.108761","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.108761","url":null,"abstract":"<p><strong>Background: </strong>Appropriate care for individuals who attempt suicide and are admitted to the emergency department (ED) can prevent future suicidal behavior. It is vital to understand their sociodemographic characteristics and the effects of targeted psychological care.</p><p><strong>Aim: </strong>To analyze sociodemographic characteristics of suicide attempters treated in the ED and evaluate the efficacy of psychological care.</p><p><strong>Methods: </strong>Data from 239 suicide attempters treated in the ED of the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (Hubei Province, China) between January 2021 and February 2025 were divided into 2: Control (<i>n</i> = 108) and psychological care (<i>n</i> = 131). The demographic characteristics and effects of the psychological care were analyzed.</p><p><strong>Results: </strong>The mean (± SD) age of the 239 patients [114 male (47.7%), 125 female (52.3%)] was 26.25 ± 9.3 years, of whom 122 (45.2%) were single, 117 (48.9%) were married, and 106 (44.4%) had secondary education. Thirty-eight (15.9%) patients had suicidal intent, with a mean of 1.26 ± 0.59 suicide attempts each. Twenty-two (9.21%) patients had a family history of suicide, while 8 (3.34%) had a family history of suicide attempt(s). Before intervention, mean Suicidal Intent Scale scores in the psychological nursing and control groups were 21.57 ± 5.28 and 19.86 ± 5.92, respectively (<i>P</i> > 0.05). After 1 month of nursing intervention, the respective scores were 10.09 ± 1.11 and 16.48 ± 0.87 (<i>P</i> < 0.001); and the re-suicide rates were 11.45% (15/131) and 24.07% (26/108) (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Psychological care significantly reduces suicide risk; EDs should provide comprehensive mental health care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"108761"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing anxiety and depression among patients with digestive tract subepithelial lesions.","authors":"Chun-Hui Xi, Chun-Tao Xiao, Ji Zuo, Ying Ling, Juan Liu, Xian-Fei Wang","doi":"10.5498/wjp.v16.i1.109993","DOIUrl":"10.5498/wjp.v16.i1.109993","url":null,"abstract":"<p><strong>Background: </strong>Digestive tract subepithelial lesions (SELs) are relatively common, and early diagnosis and treatment are critical for improving patient quality of life and prognosis. However, diagnostic uncertainty often leads to negative psychological effects, including anxiety and depression.</p><p><strong>Aim: </strong>To investigate the prevalence of anxiety and depressive symptoms and identify associated factors among patients with digestive tract SELs.</p><p><strong>Methods: </strong>This retrospective study included 296 consecutive patients diagnosed with digestive tract SELs at the Affiliated Hospital of North Sichuan Medical College Endoscopy Center between October 2024 and April 2025. Demographic and clinical data were collected through standardized questionnaires. Anxiety and depression were assessed using the Self-Rating Anxiety Scale and the Self-Rating Depression Scale, respectively, while sleep quality was evaluated using the Pittsburgh Sleep Quality Index. Participants were classified into anxiety <i>vs</i> non-anxiety and depression <i>vs</i> non-depression groups based on established cutoff scores, and potential determinants were examined.</p><p><strong>Results: </strong>Anxiety symptoms were observed in 35.8% of cases (mean Self-Rating Anxiety Scale score: 46.56 ± 9.13) and depressive symptoms in 33.1% (mean Self-Rating Depression scale score: 48.64 ± 8.30). Pittsburgh Sleep Quality Index scores were positively correlated with both anxiety and depression (<i>P</i> < 0.05). Univariate analysis identified age, annual income, sleep disorders, and endoscopic ultrasonography (EUS) evaluation status as significant factors (<i>P</i> < 0.05). Multivariable analysis revealed that low annual income (< 10000 Chinese yuan) and sleep disorders were independent risk factors, whereas undergoing EUS examination and having disease awareness were protective factors against anxiety and depression (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Patients with digestive tract SELs are at increased risk for anxiety and depression, with poor sleep strongly linked to worsening psychological symptoms. Early diagnostic assessment with EUS appears to serve a protective role against the onset of these psychological disorders.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"109993"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the silent signals: Motor kinematics as a new frontier in early detection of mild cognitive impairment.","authors":"Takahiko Nagamine","doi":"10.5498/wjp.v16.i1.112073","DOIUrl":"10.5498/wjp.v16.i1.112073","url":null,"abstract":"<p><p>The increasing global prevalence of mild cognitive impairment (MCI) necessitates a paradigm shift in early detection strategies. Conventional neuropsychological assessment methods, predominantly paper-and-pencil tests such as the Mini-Mental State Examination and the Montreal Cognitive Assessment, exhibit inherent limitations with respect to accessibility, administration burden, and sensitivity to subtle cognitive decline, particularly among diverse populations. This commentary critically examines a recent study that champions a novel approach: The integration of gait and handwriting kinematic parameters analyzed <i>via</i> machine learning for MCI screening. The present study positions itself within the broader landscape of MCI detection, with a view to comparing its advantages against established neuropsychological batteries, advanced neuroimaging (<i>e.g.</i>, positron emission tomography, magnetic resonance imaging), and emerging fluid biomarkers (<i>e.g.</i>, cerebrospinal fluid, blood-based assays). While the study demonstrates promising accuracy (74.44% area under the curve 0.74 with gait and graphic handwriting) and addresses key unmet needs in accessibility and objectivity, we highlight its cross-sectional nature, limited sample diversity, and lack of dual-task assessment as areas for future refinement. This commentary posits that kinematic biomarkers offer a distinctive, scalable, and ecologically valid approach to widespread MCI screening, thereby complementing existing methods by providing real-world functional insights. Future research should prioritize longitudinal validation, expansion to diverse cohorts, integration with multimodal data including dual-tasking, and the development of highly portable, artificial intelligence-driven solutions to achieve the democratization of early MCI detection and enable timely interventions.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"112073"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial lurasidone dosing in acute schizophrenia: Pragmatic and trajectory-aware clinical implications.","authors":"Yang Liu, Tao Liu","doi":"10.5498/wjp.v16.i1.113548","DOIUrl":"10.5498/wjp.v16.i1.113548","url":null,"abstract":"<p><p>Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia. A randomized study found that starting lurasidone at 80 mg/day for 1 week (then flexible titration) produced earlier reductions in Positive and Negative Syndrome Scale positive symptoms than 40 mg/day, without higher discontinuations for adverse events or a metabolic penalty over 6 weeks. These data support an individualized approach: Start at 80 mg/day when rapid control of positive symptoms or agitation is needed and tolerance permits; start at 40 mg/day when akathisia risk or patient preference argues for caution, with a planned day-7 review for up-titration. The open-label design, dose convergence after week 1, and the lack of stratified randomization limit attribution of longer-term advantages to starting dose. Even so, the trial reframes initial dose as a modifiable lever for the early course rather than a one-size-fits-all rule and warrants confirmation in larger, double-blind randomized trials.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"113548"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between anxiety, depression, and fatigue in elderly patients with Parkinson's disease.","authors":"Meng-Na Yang, Xiao-Yu Peng, Ye-Ping Chen","doi":"10.5498/wjp.v16.i1.109403","DOIUrl":"10.5498/wjp.v16.i1.109403","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a common neurodegenerative disorder in the elderly population. Non-motor symptoms such as anxiety and depression are often subtle, hindering early detection and intervention, yet they markedly affect quality of life and clinical outcomes.</p><p><strong>Aim: </strong>To investigate the prevalence of anxiety and depression in elderly PD patients, identify associated risk factors, and assess their relationship with fatigue severity.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted in 123 elderly PD patients treated at The Second Rehabilitation Hospital of Shanghai between January 2023 and December 2024. Demographic and clinical data were obtained using standardized questionnaires. Anxiety, depression, and fatigue were assessed using the Beck Anxiety Inventory (BAI), Geriatric Depression Scale (GDS), and Fatigue Scale-14 (FS-14), respectively. Binary logistic regression identified risk factors for anxiety and depression, whereas Spearman's correlation assessed associations with fatigue.</p><p><strong>Results: </strong>Anxiety and depression prevalence rates were 64.2% (mean BAI score: 19.59 ± 10.92) and 56.1% (mean GDS score: 12.82 ± 6.37), respectively. The mean FS-14 total score was 9.46 ± 1.89, comprising physical (5.77 ± 1.51) and mental (3.69 ± 1.20) fatigue components. Significant positive correlations were observed between fatigue scores (total, physical, and mental) and both anxiety and depression (all <i>P</i> < 0.05). Univariate analysis revealed statistically significant associations between anxiety/depression and monthly income, disease duration, and disease severity (all <i>P</i> < 0.05). Multivariate logistic regression indicated higher anxiety risk in patients with lower monthly income, prolonged disease duration, advanced disease severity, or multimorbidity. Depression risk was elevated in patients with lower monthly income and severe disease, whereas longer disease duration unexpectedly served as a protective factor.</p><p><strong>Conclusion: </strong>Elderly PD patients show high rates of anxiety and depression, both of which are significantly correlated with fatigue severity. These findings highlight the importance of psychological monitoring and targeted mental health interventions in PD management among the elderly.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"109403"},"PeriodicalIF":3.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and suicide risk in adolescents with self-injury: Expanding the role of mental health nursing.","authors":"Giuliano Anastasi","doi":"10.5498/wjp.v16.i1.113965","DOIUrl":"10.5498/wjp.v16.i1.113965","url":null,"abstract":"<p><p>Recently, inflammatory cytokine profiles have been linked to suicide risk in adolescents with non-suicidal self-injury, highlighting a promising biological dimension of suicide risk assessment. Clinical translation of the cytokine profiles into practice will require frontline engagement of the workforce. Mental health nurses are frequently the most accessible professionals in schools, communities, and low-resource settings and are prime candidates to bridge this gap. By integrating psychosocial evaluation with emerging biomarker data, they can deliver systematic risk assessment, continuous monitoring, and timely intervention. This role would not replace psychiatric expertise; it would extend the reach of psychiatric services, embedding suicide prevention across the continuum of care. For health systems, nurse-led integration may enhance capacity, equity, and resilience in responding to adolescent suicide risk. This editorial demonstrates that empowering nurses to operationalize biomarker-informed strategies is needed for advancing effective and sustainable suicide prevention in this vulnerable population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"113965"},"PeriodicalIF":3.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between life satisfaction, pleasure level, and negative emotion in patients with chronic renal failure.","authors":"Lin-Lin Zhang, You-Li Zhang, Ting Liu, Jian Wang, Chen Chen, Xiao-Yu Wang","doi":"10.5498/wjp.v16.i1.112733","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.112733","url":null,"abstract":"<p><strong>Background: </strong>Anxiety, depression, and other negative emotions are common among patients with chronic renal failure (CRF). Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.</p><p><strong>Aim: </strong>To explore the correlations among life satisfaction, pleasure levels, and negative emotions in patients with CRF.</p><p><strong>Methods: </strong>One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included. The Depression, Anxiety, and Stress Scale (DASS-21), Satisfaction with Life Scale (SWLS), and Temporal Experience of Pleasure Scale (TEPS) were used to evaluate negative emotions, life satisfaction, and pleasure level, respectively. Pearson's correlation coefficient analyzed the correlation between life satisfaction, pleasure level, and negative emotions. Linear regression analysis identified the factors affecting negative emotions.</p><p><strong>Results: </strong>The average DASS-21 score among patients with CRF was 51.90 ± 2.30, with subscale scores of 17.90 ± 1.50 for depression, 18.53 ± 1.18 for anxiety, and 15.47 ± 2.36 for stress, all significantly higher than the domestic norm (<i>P</i> < 0.05). The average SWLS score was 22.17 ± 4.90. Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores (<i>P</i> < 0.05), but not with the individual depression, anxiety, or stress dimensions. The average TEPS score was 67.80 ± 8.34. TEPS scores were negatively correlated with the DASS-21 score and the stress dimension (<i>P</i> < 0.05), but not with depression or anxiety. Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Patients with CRF experience high levels of negative emotions, which are negatively correlated with life satisfaction and pleasure. Furthermore, pleasure level had an impact on negative emotions.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"112733"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis on the efficacy of liver-soothing formulas for perimenopausal anxiety and depression.","authors":"Rui Wang, Ming-Xia Wu, Xiao-Fang Wang, Zong-Tao Chen","doi":"10.5498/wjp.v16.i1.111471","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.111471","url":null,"abstract":"<p><strong>Background: </strong>Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels, which significantly impair their quality of life. The current treatments have certain limitations. In traditional Chinese medicine, liver-soothing formulas are commonly prescribed for mood-related disorders, but their overall efficacy in perimenopausal anxiety and depression remains uncertain and requires verification through meta-analysis.</p><p><strong>Aim: </strong>To provide evidence-based support for clinical decision-making and research, a meta-analysis was conducted to evaluate the effectiveness of liver-soothing formulas in treating perimenopausal anxiety and depression.</p><p><strong>Methods: </strong>Relevant studies published up to April 2025 were retrieved from ClinicalTrials.gov, PubMed, Web of Science, EMBASE, and the Cochrane Library. Eligible studies were screened according to predefined inclusion and exclusion criteria. Data were extracted and analyzed using the Stata 12.0 software.</p><p><strong>Results: </strong>After searching and screening, 12 articles involving 1798 patients (922 in the treatment group and 876 in the control group) were included in the analysis. Meta-analysis showed that the standardized scores for anxiety [standardized mean difference (SMD) = -0.71, 95% confidence interval (95%CI): -1.06 to -0.36] and depression (SMD = -0.67, 95%CI: -1.06 to -0.27) of the treatment group were lower than those of the control group. Subgroup analysis results revealed that for anxiety, liver-soothing formulas used alone (SMD = -0.34, 95%CI: -0.50 to -0.18) or in combination (SMD = -0.88, 95%CI: -1.43 to -0.34) both significantly reduced scores compared with the control group. For depression, monotherapy of liver-soothing formulas showed no significant statistical difference between the treatment and control groups (SMD = -0.47, 95%CI: -1.11 to 0.17), whereas combination therapy produced significantly lower standardized scale scores in the treatment group than in the control group, with a statistically significant difference (SMD = -0.83, 95%CI: -1.39 to -0.28). Regarding Greene scores, no statistically significant difference was observed with monotherapy (SMD = 0.87, 95%CI: -0.32 to 2.06), whereas combination therapy had significantly lower Greene scores (SMD = -0.24, 95%CI: -0.44 to -0.04). No statistically significant difference was found between the groups in the occurrence of adverse reactions (odds ratio = 0.90, 95%CI: 0.57-1.43). However, liver-soothing formulas did not affect estrogen levels in perimenopausal women.</p><p><strong>Conclusion: </strong>Compared with placebo, conventional Western medicine, or other interventions, the monotherapy of liver-soothing formulas demonstrates superior efficacy in treating perimenopausal anxiety. When used as an adjuvant, they exert a synergistic effect in alleviating negative emotions and improving overall perimenopausal symptoms.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"111471"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic psychological vulnerability and adaptation in rheumatoid arthritis: Trajectories, predictors, and interventions.","authors":"Xue-Meng Chen, Xian Cheng, Wei Wu","doi":"10.5498/wjp.v16.i1.111812","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.111812","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) patients face significant psychological challenges alongside physical symptoms, necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course. This review examined 95 studies (2000-2025) from PubMed, Web of Science, and CNKI databases including longitudinal cohorts, randomized controlled trials, and mixed-methods research, to characterize the complex interplay between biological, psychological, and social factors affecting RA patients' mental health. Findings revealed three distinct vulnerability trajectories (45% persistently low, 30% fluctuating improvement, 25% persistently high) and four adaptation stages, with critical intervention periods occurring 3-6 months post-diagnosis and during disease flares. Multiple factors significantly influence psychological outcomes, including gender (females showing 1.8-fold increased risk), age (younger patients experiencing 42% higher vulnerability), pain intensity, inflammatory markers, and neuroendocrine dysregulation (48% showing cortisol rhythm disruption). Early psychological intervention (within 3 months of diagnosis) demonstrated robust benefits, reducing depression incidence by 42% with effects persisting 24-36 months, while different modalities showed complementary advantages: Cognitive behavioral therapy for depression (Cohen's d = 0.68), mindfulness for pain acceptance (38% improvement), and peer support for meaning reconstruction (25.6% increase). These findings underscore the importance of integrating routine psychological assessment into standard RA care, developing stage-appropriate interventions, and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"111812"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study.","authors":"Xiao-Fang Hou, Bo-Hui Mei, Xia Wang, Fu-Tao Zhao, Lei He, Qian-Yu Chen, Chen Zang, Chong Wang, Yu-Feng Tang, Xiao-Xin Li, Hui-Fang Zhang, Na Wang, Bing Cao","doi":"10.5498/wjp.v16.i1.113064","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.113064","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) and obesity (OB) are bidirectionally comorbid conditions with common neurobiological underpinnings. However, the neurocognitive mechanisms of their comorbidity remain poorly understood.</p><p><strong>Aim: </strong>To examine regional abnormalities in spontaneous brain activity among patients with MDD-OB comorbidity.</p><p><strong>Methods: </strong>This study adopted a regional homogeneity (ReHo) analysis of resting-state functional magnetic resonance imaging. The study included 149 hospital patients divided into four groups: Patients experiencing their first episode of drug-naive MDD with OB, patients with MDD without OB, and age- and sex-matched healthy individuals with and without OB. Whole-brain ReHo analysis was conducted using SPM12 software and RESTplus toolkits, with group comparisons <i>via</i> ANOVA and post-hoc tests. Correlations between ReHo values and behavioral measures were examined.</p><p><strong>Results: </strong>ANOVA revealed significant whole-brain ReHo differences among the four groups in four key regions: The left middle temporal gyrus (MTG.L), right cuneus, left precuneus, and left thalamus. Post-hoc analyses confirmed pairwise differences between all groups across these regions (<i>P</i> < 0.05). OB was associated with ReHo alterations in the MTG.L, right cuneus, and left thalamus, whereas abnormalities in the precuneus suggested synergistic pathological mechanisms between MDD and OB. Statistically significant correlations were found between the drive and fun-seeking dimensions of the behavioral activation system, as well as behavioral inhibition and the corresponding ReHo values.</p><p><strong>Conclusion: </strong>Our findings provide novel evidence for the neuroadaptive mechanisms underlying the MDD-OB comorbidity. Further validation could lead to personalized interventions targeting MTG.L hyperactivity and targeting healthy food cues.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"113064"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}