World Journal of Psychiatry最新文献

{"title":"Psychological interventions for post-stroke anxiety and depression: Current approaches and future perspectives.","authors":"Xiao-Yun Lei, Lu-Huan Chen, Li-Qi Qian, Xu-Dong Lu","doi":"10.5498/wjp.v15.i6.103270","DOIUrl":"10.5498/wjp.v15.i6.103270","url":null,"abstract":"<p><p>Psychological interventions have demonstrated efficacy in improving patients' emotional state, cognition, and thinking abilities, thereby enhancing their quality of life and survival. This review examines literature from the China National Knowledge Infrastructure, Wanfang Data, Web of Science, and PubMed databases published over the past decade, focusing on the use of psychotherapy for post-stroke anxiety and depression. The prevalence of anxiety and depression is significantly higher among patients who have experienced a stroke than in the general population, possibly due to vestibular dysfunction following brain injury. Current psychological interventions for stroke patients include cognitive behavioral therapy, supportive psychotherapy, music and art therapy, and exercise therapy. These approaches have been shown to promote psychological wellbeing and physical rehabilitation.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"103270"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders and mental health: Understanding the cognitive connection.","authors":"Eguono Deborah Akpoveta, Uchenna Esther Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i6.105362","DOIUrl":"10.5498/wjp.v15.i6.105362","url":null,"abstract":"<p><p>Sleep disorders, particularly insomnia, have emerged as a critical public health challenge, with the situation worsened by the coronavirus disease-2019 pandemic. Insomnia symptoms, which affected up to 45% of the population during this period, highlight the urgent need to understand the mechanisms linking sleep disturbances to mental health outcomes. Recent findings suggest that cognitive failures, such as memory lapses and attentional deficits, mediate the relationship between insomnia and emotional disorders such as anxiety and depression. The role of personality traits, particularly neuroticism, adds further complexity, as it may either exacerbate or buffer these effects under specific conditions. This review explores the study by Li <i>et al</i>, which offers valuable insights into the cognitive-emotional pathways influenced by sleep disturbances. The study makes significant contributions by identifying key cognitive mechanisms and proposing the dual role of neuroticism in shaping emotional outcomes. To advance these findings, this letter advocates for future longitudinal research and the integration of targeted interventions, such as cognitive-behavioral therapy for insomnia, into public health frameworks. By addressing insomnia-induced cognitive dysfunction, these strategies can enhance emotional regulation and foster resilience, particularly in vulnerable populations facing the mental health impacts of the pandemic.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105362"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting muscarinic receptors in schizophrenia treatment: Novel antipsychotic xanomeline/trospium chloride.","authors":"Ana V Pejčić","doi":"10.5498/wjp.v15.i6.105409","DOIUrl":"10.5498/wjp.v15.i6.105409","url":null,"abstract":"<p><p>This minireview explores the role of acetylcholine and muscarinic receptors in the pathophysiology of schizophrenia and summarizes the latest data on xanomeline/trospium chloride, a novel antipsychotic approved by the United States Food and Drug Administration in September 2024. Evidence suggests that cholinergic dysfunction, particularly an imbalance in the expression of the M1 and M4 muscarinic receptors, may contribute to the pathophysiology and symptoms of schizophrenia. Xanomeline/trospium chloride combines xanomeline, an M1 and M4 receptor agonist, with trospium chloride, a non-selective peripheral muscarinic receptor antagonist that reduces peripheral cholinergic side effects. Clinical trials have demonstrated significant reductions in the positive and negative symptoms of schizophrenia, with improvements in Positive and Negative Syndrome Scale scores observed as early as two weeks. A post-hoc analysis of one trial revealed cognitive improvements in patients with baseline cognitive impairment. This medication was generally well-tolerated, with mild-to-moderate gastrointestinal symptoms being the most common adverse events. While these results are promising, further research is needed to better understand its effectiveness and safety in real-world clinical practice, and to define its optimal role in managing this complex psychiatric disorder.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105409"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral hemodynamic characteristics of patients with auditory verbal hallucinations and the construction of nomogram models.","authors":"Zi-Yao Cai, Ce Chen, Zi-Ye Huang, Xin-Wu Ye, Xiao-Zhuang Jin, Hao-Ran Chen, Jian-Min Sha","doi":"10.5498/wjp.v15.i6.106775","DOIUrl":"10.5498/wjp.v15.i6.106775","url":null,"abstract":"<p><strong>Background: </strong>The characteristics of cerebral hemodynamic indexes of patients with different types of auditory verbal hallucinations (AVHs) was not clear.</p><p><strong>Aim: </strong>To explore the characteristics of cerebral hemodynamic indexes of patients with different types of AVHs and construct the risk nomogram prediction model of patients with different types of AVHs.</p><p><strong>Methods: </strong>Patients with different types of verbal hallucinations who visited Wenzhou Seventh People's Hospital were retrospectively selected from March 2021 to March 2023, and these patients were classified into 117 cases of schizophrenia (SCZ) with AVHs, 108 cases of post-traumatic stress disorder (PTSD) with AVHs, and 105 cases of recurrent depressive disorder with AVHs according to type. Transcranial doppler was performed to measure the hemodynamic parameters of the anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), basilar artery (BA) and vertebral artery (VA). Logistic regression modelling was used to explore the factors affecting patients with different types of AVHs and odds ratio, 95% confidence interval (CI). A clinical prediction model was constructed, and the efficacy of the clinical prediction model was evaluated by using receiver operating characteristic, Hosmer-Lemeshow Goodness-of-Fit test, calibration curves and decision curve analysis.</p><p><strong>Results: </strong>The differences between the three groups of patients in mean velocity (Vm)-MCA, end-diastolic velocity (Vd)-MCA, Vm-ACA, pulsatility index (PI)-ACA, Vm-PCA, peak systolic velocity (Vs)-PCA, Vd-PCA, Vm-BA, Vs-BA, Vd-BA, PI-BA, resistance index (RI)-BA, Vm-VA, Vs-VA, Vd-VA, PI-VA, and RI-VA indexes were statistically significant. Rising Vm-ACA is an independent risk factor for SCZ with AVHs, and falling Vm-VA, Vd-MCA, and Vd-VA are independent risk factors for SCZ with AVHs. Rising Vm-ACA, Vm-PCA, Vs-PCA, Vd-PCA, Vm-BA, and Vs-BA are independent risk factors for PTSD with AVHs, and Vm-MCA, Vs-MCA, Vd-MCA, PI-PCA, and RI-BA are independent protective factors for PTSD with AVHs. Elevated Vm-MCA, Vd-MCA, RI-BA, Vm-VA, and Vd-VA were independent risk factors, and elevated Vm-ACA, Vs-ACA, Vm-PCA, Vs-PCA, and Vd-PCA were independent protective factors. The areas under the curve of the three models were 0.82 (95%CI: 0.76-0.87), 0.88 (95%CI: 0.83-0.92), and 0.81 (95%CI: 0.77-0.86), respectively; the Hosmer-Lemeshow Goodness-of-Fit test of the calibration curves of the three models suggests that <i>P</i> > 0.05.</p><p><strong>Conclusion: </strong>Monitoring the cerebral hemodynamic indexes of patients with AVHs is of practical significance in determining the type of mental disorder, which helps clinicians identify the type of AVHs and adopt more efficient treatment strategies to help patients recover.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"106775"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining smart healthcare care for mental health and substance use disorders: A patient-centred, evidence-based approach.","authors":"Manmeet Kaur Brar, Siddharth Sarkar","doi":"10.5498/wjp.v15.i6.100438","DOIUrl":"10.5498/wjp.v15.i6.100438","url":null,"abstract":"<p><p>In this article, we comment on the article by Zhang <i>et al</i>, which explores the familiarity, awareness, and usage of smart medical care and its correlation with mental health and personality traits. The use of intelligent healthcare technologies in treating mental disorders and substance use disorders shows significant promise, but involves certain challenges, such as limited access, low technological literacy, and privacy concerns. These barriers disproportionately affect deprived populations and individuals with severe mental health conditions. We highlight the positive impact of smart healthcare solutions, such as telemedicine and wearable technologies, on patient engagement, remote monitoring, and treatment adherence. To overcome these challenges, we propose strategies, such as improving user-friendliness, ensuring equitable access to digital interventions, enhancing cybersecurity, and integrating smart healthcare into clinical workflows. Training healthcare providers and developing policies to ensure the ethical use of patient data are essential. When implemented thoughtfully, smart healthcare technologies can revolutionize mental health and substance use disorder treatment, improve patient outcomes, and reduce healthcare inequities.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"100438"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for depression in patients in perimenopause with cervical cancer.","authors":"Yuan Zhang, Jing-Bo Liu, Meng-Jun Liu, Jing Liu, Jing Zhang","doi":"10.5498/wjp.v15.i6.105568","DOIUrl":"10.5498/wjp.v15.i6.105568","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a significant health concern among females in perimenopause, with a high prevalence of depression in this population. The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer. We hypothesized that socioeconomic status, disease characteristics, and quality of life factors contributed to the development of depression in these patients.</p><p><strong>Aim: </strong>To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.</p><p><strong>Methods: </strong>A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center. Patients were divided into a non-depression group (<i>n</i> = 152) and a depression group (<i>n</i> = 102) based on whether depression occurred after treatment. Data collection included demographic, clinical, and psychosocial factors. The Hamilton Depression Rating Scale was used to assess depression. Logistic regression analysis was performed to identify risk factors.</p><p><strong>Results: </strong>Patients with depression more often had low income (< 4000 China yuan: 66.7% <i>vs</i> 6.6%, <i>P</i> < 0.001), initial disease onset (70.6% <i>vs</i> 57.2%, <i>P</i> = 0.001), low social support (70.6% <i>vs</i> 55.3%, <i>P</i> = 0.014), pathological stages III-IV (70.6% <i>vs</i> 41.5%, <i>P</i> < 0.001), high pain level (65.7% <i>vs</i> 34.2%, <i>P</i> < 0.001), and poor sleep quality (67.6% <i>vs</i> 32.2%, <i>P</i> < 0.001). Logistic regression identified low income [odds ratio (OR) = 32.606, <i>P</i> < 0.001], initial disease onset (OR = 4.282, <i>P</i> = 0.001), pathological stages III-IV (OR = 4.123, <i>P</i> = 0.0005), high pain level (OR = 1.181, <i>P</i> = 0.0000434), and poor sleep quality (OR = 3.094, <i>P</i> = 0.0041) as key risk factors.</p><p><strong>Conclusion: </strong>Low income, initial onset, low support, advanced stages, high pain, and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer. Studies investigating interventions for this population are needed.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105568"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and hypertensive disorders of pregnancy: Epidemiology, mechanisms, and management strategies.","authors":"Chun-Hua Liu, Hai-Yan Zhang, Fang Wang, Sha-Sha Mu, Feng-Yun Wen","doi":"10.5498/wjp.v15.i6.105944","DOIUrl":"10.5498/wjp.v15.i6.105944","url":null,"abstract":"<p><p>This article comprehensively explores the relationship between anxiety and hypertensive disorders of pregnancy (HDP), covering epidemiology, potential mechanisms, and management strategies. HDP is the second leading cause of maternal and perinatal morbidity and mortality, encompassing subtypes such as gestational hypertension, preeclampsia, and eclampsia. Research indicates that anxiety is closely associated with the occurrence of HDP, potentially influencing blood pressure regulation and vascular function through neuroendocrine, inflammatory, genetic, and gut microbiota effects. Epidemiological data show that anxiety is prevalent during pregnancy and is linked to an increased risk of HDP. Biological mechanism studies reveal that anxiety can increase the risk of HDP by activating the hypothalamic-pituitary-adrenal axis, promoting inflammation, and affecting gut microbiota. In terms of treatment and management, psychological interventions (such as relaxation training, yoga, and mindfulness meditation) and pharmacological treatments (such as labetalol and nifedipine) play important roles in alleviating anxiety and improving the prognosis of HDP. Additionally, multidisciplinary collaboration and long-term postpartum follow-up are crucial for reducing the long-term risk of cardiovascular diseases. Despite significant progress in research on anxiety and HDP, many issues still require further exploration, including in-depth mechanism studies, optimization of clinical interventions, improvement of multidisciplinary collaboration models, long-term follow-up studies, and the impact of cultural and social factors.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105944"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of anxiety and depression with pain in patients with diabetic foot ulcers and analysis of risk factors.","authors":"Jiang-Qiang Chen, Zu-Hui Chen, Wei-Bin Zheng, Xiang-Qian Shen","doi":"10.5498/wjp.v15.i6.105334","DOIUrl":"10.5498/wjp.v15.i6.105334","url":null,"abstract":"<p><strong>Background: </strong>Pain often predisposes patients with diabetic foot ulcers (DFUs) to negative emotional states, such as anxiety and depression, which can significantly impair treatment outcomes and recovery. However, very few studies have explored the relationship between anxiety, depression, and pain in DFUs, as well as the associated risk factors.</p><p><strong>Aim: </strong>To analyze the correlation between anxiety, depression, and pain in patients with DFUs and to identify the associated risk factors.</p><p><strong>Methods: </strong>This study included 106 patients diagnosed with DFUs who were admitted to Tiantai County People's Hospital between March 2022 and March 2024. The patients' anxiety levels were evaluated using Zung's self-rating anxiety scale (SAS), depression status was assessed using Zung's self-rating depression scale (SDS), and pain intensity was assessed using the visual analog scale (VAS). Subsequently, correlations between SAS, SDS, and VAS scores were analyzed. Univariate and multivariate analyses were conducted to explore the risk factors that contributed to anxiety and depression in patients with DFUs.</p><p><strong>Results: </strong>Among the 106 patients, 39.62% exhibited anxiety and 43.40% presented with depression. Most patients experiencing anxiety or depression exhibited mild symptoms, with no severe cases observed. Compared with asymptomatic patients, those with anxiety or depression had significantly higher VAS scores. Correlation analysis indicated a significant positive relationship between both SAS and SDS scores and the VAS score. Univariate analysis identified sex, age, Wagner's grade, presence of other complications, and smoking history as factors significantly associated with anxiety and depression. Multivariate analysis further confirmed that younger age, higher Wagner's grade, and higher VAS scores were independent predictors of anxiety and depression.</p><p><strong>Conclusion: </strong>This study reveals a significant positive correlation between anxiety, depression, and pain in patients with DFUs. This finding suggests that timely and effective pain intervention may be beneficial in alleviating negative emotions such as anxiety and depression. In addition, younger age (< 50 years), higher Wagner's grade, and higher VAS scores increase the risk of developing anxiety and depression in this patient population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"105334"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment.","authors":"Ling Sun, Meng-Rong Xu, Cheng-Yu Zhou, Shao-Dong Cao, Xiao-Liang Zhang, Si-Qi Guan, Wen-Xu Sang, Xu-Ling Li","doi":"10.5498/wjp.v15.i6.103661","DOIUrl":"10.5498/wjp.v15.i6.103661","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The role of cerebral microvascular dysfunction in early cognitive impairment and dementia has become increasingly recognized. Furthermore, pathological changes in both Alzheimer's disease and vascular dementia are almost always associated with cerebral hemodynamic deficits.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) assessment of the blood-brain barrier (BBB) in combination with relevant plasma biomarkers for mild cognitive impairment (MCI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study selected 50 patients with non-amnestic MCI (na-MCI group), 52 patients with amnestic MCI (a-MCI group), and 55 healthy elderly controls (control group). The Chinese version of the Montreal cognitive assessment (MoCA), auditory verbal learning test (AVLT), Hamilton anxiety/depression scale (HAMA/HAMD), and activity of daily living (ADL) scales were used to analyze the characteristics of mental and behavioral symptoms of patients with MCI. The DCE-MRI technique was used to assess the contrast enhancement kinetics. The Patlak model was utilized to analyze the BBB permeability (volume transfer constants). Further, fasting blood was was used to quantify plasma homocysteine (Hcy), β-amyloid protein (Aβ) 40, Aβ42, human phosphorylated tau-181 protein (p-tau181), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and plasminogen activator inhibitor-1 (PAI-1) levels, as well as serum neurofilament light chain (NFL) and glial fibrillary acidic protein (GFAP) concentrations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The na-MCI and a-MCI groups demonstrated significantly lower MoCA and AVLT-Huashan version scores, and statistically higher HAMA, HAMD, and ADL scores compared to the control group. Moreover, the a-MCI group showed notably higher HAMA, HAMD, and ADL scores compared to the na-MCI group. Cranial MRI results revealed significant disparities in cerebral blood flow in the left and right frontal lobes, temporal lobes, hippocampi, cuneus, precuneus, parietal lobes, basal ganglia, and occipital lobes between the a-MCI and na-MCI groups. Compared to healthy controls, patients with MCI demonstrated a smaller amplitude of hippocampal contrast enhancement kinetics and a slower decay rate, indicating smaller vascular volume and increased BBB permeability. Further, Hcy, p-tau181, ICAM-1, VCAM-1, PAI-1, and NFL levels were substantially higher in the a-MCI group than in the na-MCI group, whereas the Aβ42 level was significantly lower. We did not observe any significant differences in Aβ40 and GFAP levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients with MCI may have experienced cerebrovascular system changes in the hippocampal region. Disorders associated with changes in cerebral blood supply may begin before pathophysiological changes are visible by imaging, which provides references for the assessment and treatment of patients wi","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"103661"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central obesity and post-stroke depression: Implications for stroke recovery.","authors":"Eguono Deborah Akpoveta, Uchenna Esther Okpete, Haewon Byeon","doi":"10.5498/wjp.v15.i6.107795","DOIUrl":"10.5498/wjp.v15.i6.107795","url":null,"abstract":"<p><p>Post-stroke depression (PSD) is a prevalent but often underdiagnosed complication affecting stroke survivors, with significant implications for recovery and quality of life. Emerging evidence suggests that central obesity, as measured by the weight-to-waist index (WWI), may play a crucial role in PSD risk and severity. Traditional obesity metrics, such as body mass index, may not accurately capture the impact of visceral fat distribution on neuropsychiatric outcomes. This letter highlights the growing recognition of WWI as a precise indicator of metabolic and inflammatory disturbances linked to post-stroke mental health. Integrating WWI into routine stroke rehabilitation assessments could facilitate early identification of high-risk patients and improve intervention strategies. Further research is needed to establish standardized WWI cutoff values and explore potential therapeutic targets for PSD prevention.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 6","pages":"107795"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}