World Journal of Psychiatry最新文献

{"title":"Self-AttentionNeXt: Exploring schizophrenic optical coherence tomography image detection investigations.","authors":"Mehmet Kaan Kaya, Sermal Arslan, Suheda Kaya, Gulay Tasci, Burak Tasci, Filiz Ozsoy, Sengul Dogan, Turker Tuncer","doi":"10.5498/wjp.v15.i9.108359","DOIUrl":"10.5498/wjp.v15.i9.108359","url":null,"abstract":"<p><strong>Background: </strong>Optical coherence tomography (OCT) enables high-resolution, non-invasive visualization of retinal structures. Recent evidence suggests that retinal layer alterations may reflect central nervous system changes associated with psychiatric disorders such as schizophrenia (SZ).</p><p><strong>Aim: </strong>To develop an advanced deep learning model to classify OCT images and distinguish patients with SZ from healthy controls using retinal biomarkers.</p><p><strong>Methods: </strong>A novel convolutional neural network, Self-AttentionNeXt, was designed by integrating grouped self-attention mechanisms, residual and inverted bottleneck blocks, and a final 1 × 1 convolution for feature refinement. The model was trained and tested on both a custom OCT dataset collected from patients with SZ and a publicly available OCT dataset (OCT2017).</p><p><strong>Results: </strong>Self-AttentionNeXt achieved 97.0% accuracy on the collected SZ OCT dataset and over 95% accuracy on the public OCT2017 dataset. Gradient-weighted class activation mapping visualizations confirmed the model's attention to clinically relevant retinal regions, suggesting effective feature localization.</p><p><strong>Conclusion: </strong>Self-AttentionNeXt effectively combines transformer-inspired attention mechanisms with convolutional neural networks architecture to support the early and accurate detection of SZ using OCT images. This approach offers a promising direction for artificial intelligence-assisted psychiatric diagnostics and clinical decision support.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"108359"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing the hidden links between sadness, aggression, and peer victimization in adolescents.","authors":"Haewon Byeon","doi":"10.5498/wjp.v15.i9.110352","DOIUrl":"10.5498/wjp.v15.i9.110352","url":null,"abstract":"<p><p>This letter critically reviews a recent longitudinal network study by Bai <i>et al</i> examining the dynamic, symptom-level interplay among peer bullying victimization, depression, anxiety, and aggression in Chinese adolescents. The study highlights that key symptoms, such as persistent sad mood, sleep disturbances, and cyberbullying victimization play a pivotal role in reinforcing the vicious cycle between mental health issues and bullying experiences. While the application of cross-lagged panel network analysis offers a nuanced understanding of these bidirectional relationships, several limitations remain, including the use of self-reported measures and a region-specific sample. Nevertheless, the findings underscore the urgent need for early screening and targeted interventions in school settings, particularly those addressing both emotional symptoms and digital forms of bullying. Moving forward, integrated and culturally sensitive approaches are essential to prevent escalation and break the link between peer victimization and adolescent psychopathology. Future research should incorporate multi-informant data and broaden the cultural context to strengthen generalizability and intervention design.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"110352"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study.","authors":"Bo Gao, Yun-Fan Gao, Meng-Ting Chu, Ke-Fang Yuan","doi":"10.5498/wjp.v15.i9.106906","DOIUrl":"10.5498/wjp.v15.i9.106906","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Chronic heart failure (CHF) is a severe cardiovascular disease that significantly threatens human health. Depression, a common comorbidity, may substantially impact cardiac structure and function. However, the exact relationship between depression and cardiac remodeling and left ventricular functional changes remains incompletely understood. This study sets out to explore, with a clinically grounded perspective, how depressive states may subtly or profoundly influence the trajectory of cardiac remodeling and the functional dynamics of the left ventricle in individuals grappling with CHF. Beyond mere observation, it also aims to untangle the underlying physiological or neurohormonal pathways that might bridge emotional distress and cardiac dysfunction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To delve into how depressive symptoms might shape the progression of cardiac remodeling and impair left ventricular function among individuals living with CHF. Particular attention is given to the role of inflammatory signaling and disruptions in neuroendocrine balance as possible mediating factors. By examining these intertwined physiological and psychological processes, the study seeks to shed light on the reciprocal link between emotional distress and CHF, offering insights that may inform more precise, mechanism-based treatment strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this retrospective clinical trial, 248 patients diagnosed with CHF were analyzed in the tertiary treatment center between January 2018 and December 2022. According to Hamilton's Depression Scale score, participants were classified into two cohort of depression (score 17) and no significant depression characteristics (score 17). Cardiac morphology and functional parameters were assessed using a combination of hyperechocardiocardiocardiography, heart magnetic resonance, and associated blood biomarkers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results of this study underscore the significant effects that depression can have on both the structure and function of the heart in patients with CHF. In particular, the individuals in the cohort with depression were 42.3% ± 6.7% of the individuals without depression &lt;i&gt;vs&lt;/i&gt; 51.6% ± 5.9%, &lt;i&gt;P&lt;/i&gt; &lt; 0.01) In comparison, the left ventricular ejection fraction, an important measure of contractional performance, was significantly reduced, underlining the harmful physiological interaction between mood disorders and cardiac efficiency. The measurement of the left ventricular end-diastolic diameter showed a significant expansion of the ventricular envelope in the depression group (68.2 ± 7.5 mm &lt;i&gt;vs&lt;/i&gt; 59.6 ± 6.3 mm, &lt;i&gt;P&lt;/i&gt; &lt; 0.01). Inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α), were significantly elevated in the depressed group (hs-CRP: 8.7 ± 2.3 mg/L &lt;i&gt;vs&lt;/i&gt; 4.5 ± 1.6 mg/L; TNF-α: 42.5 ± 7.6 pg/mL &lt;i&gt;vs&lt;/i&gt; 28.3 ± 5.4 pg/mL). Both B-type natriuretic peptide (1256 ±","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"106906"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional challenges in promoting acupuncture for insomnia: Cultural, economic, and patient provider trust perspectives.","authors":"Ming-Min Zhu, Wen-Hui Qiu, Hua-Chong Xu","doi":"10.5498/wjp.v15.i9.110067","DOIUrl":"10.5498/wjp.v15.i9.110067","url":null,"abstract":"<p><p>A recent study of patient-centered perspectives by Zhao <i>et al</i>, published in the <i>World Journal of Psychiatry</i>, identified key facilitators and barriers that influence insomnia patients' choice of acupuncture therapy, offering insights for clinical practice and policy-making to enhance the integration of acupuncture therapy into comprehensive insomnia management. While acupuncture demonstrates unique advantages as a complementary medical approach, its broader adoption is hindered by complex multidimensional factors. This paper proposes a \"dynamic balance model\" encompassing the cultural, economic, and patient-provider trust dimensions, and emphasizes the need for synergistic optimization through cultural narrative transformation, institutional innovation, and digital empowerment. These strategies aim to facilitate the promotion of acupuncture for insomnia treatment and its global expansion.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"110067"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of technology-enhanced physical activity on brain and mental health in youth: An umbrella review of meta-analyses.","authors":"Zi-Qi Wang, Si-Yu Hong, Zi-Xuan Jia, Yi Zhang, Sha-Sha Ma, Xian-Gui Bu, Wen-Jun Wang","doi":"10.5498/wjp.v15.i9.108847","DOIUrl":"10.5498/wjp.v15.i9.108847","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is a key contributor to the neurocognitive and psychological development of children and adolescents. With the rapid integration of digital technologies in educational and recreational contexts, technology-enhanced PA (TEPA) interventions have emerged as promising tools for promoting mental and cognitive health. However, the effectiveness of various TEPA modalities-such as virtual reality (VR), mobile applications, and biofeedback systems-remains unclear. Prior findings are fragmented across systematic reviews with inconsistent methodologies. This umbrella review was conducted to synthesize current evidence and evaluate whether specific TEPA modalities yield differential benefits. We hypothesized that TEPA interventions with immersive and self-regulatory features provide greater enhancements in executive function (EF), cognitive function (CF), and mental health (MH) than passive or minimally interactive formats.</p><p><strong>Aim: </strong>To determine the effects of TEPA interventions and modality-specific characteristics on EF, CF, and MH outcomes in children and adolescents.</p><p><strong>Methods: </strong>An umbrella review of systematic reviews and meta-analyses was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Five databases (PubMed, Web of Science, EMBASE, EBSCOhost, and Cochrane Library) were searched up to March 2025. Eligible reviews included participants aged ≤ 18 years, assessed TEPA interventions, and reported EF, CF, or MH outcomes. Methodological quality was assessed using A Measurement Tool to Assess Systematic Reviews 2. Data synthesis was stratified by intervention modality, and heterogeneity was evaluated using the <i>I</i>² statistic.</p><p><strong>Results: </strong>A total of 11 systematic reviews and meta-analyses were included. Interventions using VR (2/2), game-based formats (2/2), biofeedback (2/2), and multicomponent programs (1/1) showed consistent evidence of improvements in EF and MH (<i>e.g.</i>, EF: 6.92 ± 3.86 <i>vs</i> 3.61 ± 1.67, <i>P</i> < 0.001). App-based interventions (3/3) demonstrated mixed or modest effects, while augmented reality-based formats showed limited efficacy. MH outcomes were most frequently improved (9/11 reviews), followed by EF (6/11 reviews) and CF (5/11 reviews). Heterogeneity ranged from moderate to high (<i>I</i>² = 42%-78%) across modalities.</p><p><strong>Conclusion: </strong>TEPA significantly improves MH and selectively enhances executive and CF in youth. Immersive, interactive, and biofeedback-driven modalities are particularly effective.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"108847"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of depression and anxiety and related influencing factors in the Chinese population with noncommunicable chronic diseases: A network perspective.","authors":"Hua-Yu Li, Dong-Yu Song, Yi-Qing Weng, Yuan-Hao Tong, Yi-Bo Wu, Hong-Mei Wang","doi":"10.5498/wjp.v15.i9.109789","DOIUrl":"10.5498/wjp.v15.i9.109789","url":null,"abstract":"<p><strong>Background: </strong>The prevalence and severity of noncommunicable chronic diseases (NCDs) among Chinese residents have been increasing with mental health emerging as a critical challenge in disease management.</p><p><strong>Aim: </strong>To examine the interactions between depression, anxiety symptoms, and related factors, and to identify key factors in the Chinese population with NCDs.</p><p><strong>Methods: </strong>Data from the Psychology and Behavior Investigation of Chinese Residents were used in a cross-sectional survey of 6182 individuals with NCDs. This study measured depression and anxiety symptoms as well as their influencing factors including social environments, individual behaviors and lifestyles, and subjective indicators. A network analysis approach was used for data assessment.</p><p><strong>Results: </strong>Network analysis demonstrated that several central factors (media exposure, family health, problematic internet use, suboptimal health status, intimate relationship violence, tired or little energy, and nervousness/anxious/on edge) and bridge factors (media exposure, problematic internet use, intimate partner violence, health literacy, and suboptimal health status) that significantly influenced the co-occurrence and interconnectedness of depression and anxiety symptoms. Additionally, gender, ethnicity, residency, and living status did not significantly influence the overall network strength.</p><p><strong>Conclusion: </strong>Depression and anxiety are prevalent among the Chinese population with NCDs. Effective interventions should focus on managing key symptoms, promoting correct media use for health information, and fostering healthier family relationships.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"109789"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anxiety, depression, sense of coherence, and post-traumatic growth in patients who underwent intertrochanteric femoral fracture surgery.","authors":"Yuan-Peng Wu, Gui Xu, Zhen Wang","doi":"10.5498/wjp.v15.i9.106196","DOIUrl":"10.5498/wjp.v15.i9.106196","url":null,"abstract":"<p><strong>Background: </strong>Postoperative anxiety, depression, irritability, and even fear in patients with intertrochanteric femoral fractures may hinder recovery, compromise treatment efficacy, and impede rehabilitation.</p><p><strong>Aim: </strong>To investigate the correlations among anxiety, depression, sense of coherence (SOC), and post-traumatic growth (PTG) in patients who underwent intertrochanteric femoral fracture surgery to improve clinical management strategies and outcomes.</p><p><strong>Methods: </strong>This study carefully selected 211 patients who received surgical treatment for intertrochanteric femoral fractures and were admitted to Dongying People's Hospital from March 2022 to March 2024. Anxiety and depression in these patients were assessed with the anxiety and depression subscales of the Hospital Anxiety and Depression Scale (HADS), respectively. SOC was evaluated using the 13-item SOC scale (SOC-13), which encompasses three key dimensions: Comprehensibility, manageability, and meaningfulness. PTG was assessed with the Chinese version of PTG Inventory (CPTGI), covering five distinct dimensions: Personal strength, appreciation of life, relating to others, new possibilities, and spiritual change. The Pearson correlation coefficient was used to meticulously analyze the associations among HADS-Anxiety, HADS-Depression, SOC-13, and CPTGI. Further, univariate and multivariate analyses were conducted to identify factors that affect PTG in patients who underwent intertrochanteric femoral fracture surgery.</p><p><strong>Results: </strong>The collected data demonstrated that 67.30% and 60.66% of the 211 patients experienced anxiety and depression, respectively, with overall anxiety levels ranging from mild to moderate and depression levels being mild. The mean SOC-13 score was 55.73 ± 8.81 points, indicating a generally low SOC level. The average CPTGI score was 54.93 ± 9.92 points, demonstrating a relatively low PTG level. Notably, both HADS-Anxiety and HADS-Depression scores were significantly negatively correlated with CPTGI, whereas SOC-13 scores were significantly positively correlated with CPTGI. Univariate and multivariate analyses identified the presence of comorbidities [odds ratio (OR) = 2.747, <i>P</i> = 0.003], monthly household income (OR = 3.292, <i>P</i> < 0.001), and exercise habits (OR = 4.651, <i>P</i> < 0.001) as independent predictors of PTG in patients.</p><p><strong>Conclusion: </strong>The results of this study indicate a significant negative correlation of anxiety and depression with PTG in patients after intertrochanteric femoral fracture surgery, whereas a significant positive association exists between SOC and PTG. This study helps more comprehensively understand the psychological status and recovery processes of such patients, thereby potentially providing valuable information for clinical practice and psychological interventions.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"106196"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-based assisted screening for mild cognitive impairment using gait and handwriting kinematic parameters analysis.","authors":"Yin-Xia Ren, Bei Wu, Jian-Lin Lou, Xiao-Rong Zhu, Chen Zhang, Qing Lang, Zhu-Qin Wei, Li-Ming Su, Heng-Nian Qi, Li-Na Wang","doi":"10.5498/wjp.v15.i9.109478","DOIUrl":"10.5498/wjp.v15.i9.109478","url":null,"abstract":"<p><strong>Background: </strong>Older adults with mild cognitive impairment (MCI) often show motor dysfunction, including slower gait and impaired handwriting. While gait and handwriting parameters are promising for MCI screening, their combined potential to distinguish MCI from cognitively normal adults is unclear.</p><p><strong>Aim: </strong>To assess gait and handwriting differences and their potential for screening MCI in older adults.</p><p><strong>Methods: </strong>Ninety-five participants, including 34 with MCI and 61 cognitively normal controls, were assessed for gait using the GAITRite^® system and handwriting with a dot-matrix pen. Five machine learning models were developed to assess the discriminative power of gait and handwriting data for MCI screening.</p><p><strong>Results: </strong>Compared to the cognitively normal group, the MCI group had slower gait velocity (<i>Z</i> = -2.911, <i>P</i> = 0.004), shorter stride and step lengths (<i>t</i> = -3.005, <i>P</i> = 0.003; <i>t</i> = 2.863, <i>P</i> = 0.005), and longer cycle, standing, and double support times (<i>t</i> = -2.274, <i>P</i> = 0.025; <i>t</i> = -2.376, <i>P</i> = 0.018; <i>t</i> = -2.717, <i>P</i> = 0.007). They also had reduced cadence (<i>t</i> = 2.060, <i>P</i> = 0.042) and increased double support time variability (<i>Z</i> = -2.614, <i>P</i> = 0.009). In handwriting, the MCI group showed lower average pressure (all tasks: Z = -2.135, <i>P</i> = 0.033) and decreased accuracy (graphic task: <i>Z</i> = -2.447, <i>P</i> = 0.014; Chinese character task: <i>Z</i> = -3.078, <i>P</i> = 0.002). In the graphic task, they demonstrated longer time in air (Z = -2.865, <i>P</i> = 0.004), reduced X-axis maximum velocities (<i>Z</i> = -3.237, <i>P</i> = 0.001), and lower accelerations (X-axis: <i>Z</i> = -2.880, <i>P</i> = 0.004; Y-axis: <i>Z</i> = -1.987, <i>P</i> = 0.047) and maximum accelerations (X-axis: <i>Z</i> = -3.998, <i>P</i> < 0.001; Y-axis: <i>Z</i> = -2.050, <i>P</i> = 0.040). The multimodal analysis achieved the highest accuracy (74.4%) with the Gradient Boosting Classifier.</p><p><strong>Conclusion: </strong>Integrating gait and handwriting kinematics parameters provides a viable method for distinguishing MCI, potentially supporting large-scale screening, especially in resource-limited settings.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"109478"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet needs in precision psychiatry.","authors":"Philipp G Sand, Timm B Poeppl, Vera Roessler","doi":"10.5498/wjp.v15.i9.108222","DOIUrl":"10.5498/wjp.v15.i9.108222","url":null,"abstract":"<p><p>A recent meta-analysis has suggested a <i>5-HTR1A</i> promoter variant may predict antidepressant response. The present review comments on the claims made in view of sensitivity issues and issues pertaining to genetic exposure. We also alert to errors in the original data that had been carried over. Specifically, primers meant to amplify the <i>HTR1A</i> gene aligned to the <i>BDNF</i> gene sequence. Alleles had been confounded owing to DNA strand ambiguities and demographic information proved inaccurate. In the light of these findings, adherence to PRISMA guidelines and use of the Newcastle-Ottawa Scale did not safeguard against bias. More after action reviews are encouraged to identify factors likely to interfere with estimates of genetic risk in large data sets. These may result from pooling of ethnic groups, the use of binary data or other formats that are not human-readable, the introduction of surrogate identifiers and a failure to reverse-engineer previously published experimental protocols. Unless the above challenges are met, sequence variants are unlikely to inform personalized medicine strategies in psychiatry.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"108222"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial voltage-gated proton channel 1 ablation in diabetic mice mitigates diabetes-driven demyelination and cognitive decline.","authors":"Bin Li","doi":"10.5498/wjp.v15.i9.109363","DOIUrl":"10.5498/wjp.v15.i9.109363","url":null,"abstract":"<p><p>This article discusses a study by Li <i>et al</i>, which investigates the role of the microglial voltage-gated proton channel 1 (Hv1) in diabetes-related cognitive decline. The authors showed that Hv1 is upregulated in the corpus callosum of diabetic mice and that its knockout improves working memory, reduces microglial production of interleukin-1β and tumour necrosis factor alpha, and decreases apoptosis of oligodendrocyte progenitor cells. Furthermore, electron microscopy revealed that the myelin thickness and the g-ratio were preserved in <i>Hv1</i> knockout mice, remaining within normal limits. In addition, <i>Hv1</i> knockdown mitigated interleukin-1β secretion and suppressed ferroptosis markers (ferritin heavy chain/ferritin light chain, CCAAT/enhancer binding protein homologous protein, glucose-regulated protein 78, <i>etc.</i>) <i>in vitro</i>, suggesting the involvement of an Hv1-reactive oxygen species-glucose-regulated protein 78 axis in diabetic demyelination. We highlight the translational implications of these findings and recommend future studies employing microglia-specific Hv1 deletion models, longitudinal cognitive assessments and preclinical evaluation of pharmacological Hv1 inhibitors.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 9","pages":"109363"},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}