World Journal of Psychiatry最新文献

{"title":"Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis.","authors":"Haewon Byeon","doi":"10.5498/wjp.v15.i5.102953","DOIUrl":"10.5498/wjp.v15.i5.102953","url":null,"abstract":"<p><p>Yu <i>et al</i>'s study has advanced the understanding of the neural mechanisms underlying major depressive disorder (MDD) in adolescents, emphasizing the significant role of the amygdala. While traditional diagnostic methods have limitations in objectivity and accuracy, this research demonstrates a notable advancement through the integration of machine learning techniques with neuroimaging data. Utilizing resting-state functional magnetic resonance imaging (fMRI), the study investigated functional connectivity (FC) in adolescents with MDD, identifying notable reductions in regions such as the left inferior temporal gyrus and right lingual gyrus, alongside increased connectivity in Vermis-10. The application of support vector machines (SVM) to resting-state fMRI (rs-fMRI) data achieved an accuracy of 83.91%, sensitivity of 79.55%, and specificity of 88.37%, with an area under the curve of 0.6765. These results demonstrate how SVM analysis of rs-fMRI data represents a significant improvement in diagnostic precision, with reduced FC in the right lingual gyrus emerging as a particularly critical marker. These findings underscore the critical role of the amygdala in MDD pathophysiology and highlight the potential of rs-fMRI and SVM as tools for identifying reliable neuroimaging biomarkers.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"102953"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catatonia and autism spectrum disorder: A common comorbid syndrome or a core feature?","authors":"Yassir Mahgoub, Dallas Hamlin, Hailey Kindt, Andrew Francis","doi":"10.5498/wjp.v15.i5.103967","DOIUrl":"10.5498/wjp.v15.i5.103967","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder marked by persistent deficits in social communication and interaction, alongside restricted, repetitive patterns of behaviors (RRB), interests, or activities. It often co-occurs with various neuropsychiatric disorders, though their frequency varies widely due to unclear boundaries between the core features of ASD and common comorbidities. Catatonia, increasingly noted in neurodevelopmental conditions like ASD, shares striking similarities with ASD in symptomatology, brain mechanisms, and treatment responses, prompting the question of whether it is a core feature of ASD or a distinct condition. This paper delved into this overlap, exploring the relationship between catatonia and ASD through a narrative review of peer-reviewed literature from 1943 to 2024, sourced from PubMed and psychiatric journals. Focusing on ASD diagnostic evolution, symptom overlap with catatonia, and shared neurobiological and therapeutic characteristics, we used thematic analysis to synthesize findings into key areas such as historical nosology, phenomenological overlap, neurobiological parallels, and treatment response. The evidence revealed weak support for separating catatonia from overlapping RRB features of ASD, suggesting that some RRB might align more with comorbid catatonia than intrinsic ASD traits. However, this idea needs further validation through rigorous clinical trials. Clarifying this relationship could refine diagnostic approaches and open doors to targeted treatments, potentially improving outcomes for those affected.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103967"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subsequent psychiatric disorders in attention deficit and hyperactivity children receiving speech therapy.","authors":"Ruu-Fen Tzang, Yu-Wen Lin, Kai-Liang Kao, Yue-Cune Chang, Hui-Chun Huang, Shang-Yu Wu, Shu-I Wu, Robert Stewart","doi":"10.5498/wjp.v15.i5.100731","DOIUrl":"10.5498/wjp.v15.i5.100731","url":null,"abstract":"<p><strong>Background: </strong>Speech and language therapy (ST) might moderate the prognosis in children with attention deficit and hyperactivity disorder (ADHD) comorbid with speech delay. This study investigated whether ST in children with ADHD is associated with a decreased risk of subsequent psychiatric disorders.</p><p><strong>Aim: </strong>To investigate whether ST in children with ADHD is associated with a decreased risk of subsequent psychiatric disorders.</p><p><strong>Methods: </strong>The population-based National Health Insurance Research Database in Taiwan was used. Hazards of subsequent psychiatric disorders were compared between those who received ST and a propensity-score matched comparison group by Cox regression analyses.</p><p><strong>Results: </strong>Of 11987 children with ADHD identified from the dataset, 2911 (24%) had received ST. The adjusted hazard ratio for any subsequent recorded psychiatric disorder was 0.72 (95% confidence interval: 0.63-0.82) in children who received ST compared to the matched counterparts. This protective association was only statistically significant in the subgroup that received both medication and behavioral interventions.</p><p><strong>Conclusion: </strong>ST can moderate the effects of integrated early interventions in ADHD children with speech delay.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"100731"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between uncertainty in illness and fear of progression among lung cancer patients: The chain mediation model.","authors":"Yi-Ling Yang, Xue-Qing Zhang, Yong-Qiang Yang, Er-Mao Li, Bo Zhou, You-Wen Gong","doi":"10.5498/wjp.v15.i5.104979","DOIUrl":"10.5498/wjp.v15.i5.104979","url":null,"abstract":"<p><strong>Background: </strong>Uncertainty in illness (UI) and fear of progression (FoP) are significant psychological challenges for lung cancer patients. Coping styles and social support are critical mediators, influencing patients' ability to manage the emotional and psychological burden of UI and FoP. However, limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP, particularly among Chinese lung cancer patients.</p><p><strong>Aim: </strong>To investigate the association between UI and FoP among patients with lung cancer.</p><p><strong>Methods: </strong>Convenience sampling was used to recruit inpatients diagnosed with lung cancer at a tertiary hospital in Changde City between November and December 2023. A total of 320 participants completed the Mishel Uncertainty in Illness Scale, Simplified Coping Style Questionnaire, Mandarin Chinese Version of the Medical Outcomes Study Social Support Survey, and Fear of Progression Questionnaire-Short Form. The chain mediation analysis was performed using the PROCESS macro to examine the relationships between the variables.</p><p><strong>Results: </strong>The results revealed that UI had a significant direct effect on FoP (effect = 0.224, 95%CI: 0.136-0.408). Additionally, three indirect pathways were identified: (1) Social support (effect = 0.128, 95%CI: 0.045-0.153); (2) Coping style (effect = 0.115, 95%CI: 0.048-0.157); and (3) Chain mediators involving social support and coping style (effect = 0.072, 95%CI: 0.045-0.120). The total indirect effect of the three mediation paths is 31.5%. These results confirm that social support and coping style significantly mediate the relationship between UI and FoP.</p><p><strong>Conclusion: </strong>Based on cross-sectional data and a chain mediation model, this study explored the mechanisms between UI, social support, coping style, and FOP. Patients with lung cancer have higher levels of FOP, and the results of this study revealed a correlation between these four factors. Social support and coping style partially mediated the effects of UI on FOP, and there was a chain-mediating effect between UI and FOP. Programs designed to strengthen social support networks should also incorporate training to develop adaptive coping strategies, ultimately reducing FOP and improving overall quality of life.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"104979"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-care activities mediate self-perceived burden and depression in Chinese patients with type 2 diabetes.","authors":"Rong Zhang, Mei-Yan Wang, Xue-Qing Zhang, You-Wen Gong, Ya-Fen Guo, Jin-Hua Shen","doi":"10.5498/wjp.v15.i5.104766","DOIUrl":"10.5498/wjp.v15.i5.104766","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is becoming increasingly common and has become an important global health issue. In addition to physical damage, diabetes often leads to psychological complications, such as depressive symptoms. Self-care is considered to be the cornerstone of type 2 diabetes mellitus (T2DM) management. This research evaluated depression and explored the associations between self-care activities, self-perceived burden, and depression among T2DM patients in China.</p><p><strong>Aim: </strong>To investigate the self-care activities and the association between depression and self-perceived burden among Chinese inpatients with T2DM.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in participants with T2DM. The data collected encompassed basic characteristics, diabetes self-care activities, depression levels, and self-perceived burdens. Bootstrapping was utilized to assess the mediating role of diabetes self-care activities.</p><p><strong>Results: </strong>There were 599 T2DM patients in the survey, and 71.8% had been diagnosed with the disease for 1-10 years. There were significant correlations between self-care activities, depression, and self-perceived burden. The significant coefficients for paths a (<i>B</i> = -0.281, <i>P</i> < 0.001) and b (<i>B</i> = -0.041, <i>P</i> < 0.05) suggested negative associations between self-perceived burden and self-care behavior and between self-care activities and depression. The indirect effect (path a × b) of self-perceived burden on depression through self-care behaviors was significant (<i>B</i> = 0.020, <i>P</i> < 0.05), with a 95% bias-corrected bootstrap confidence interval of 0.007-0.036.</p><p><strong>Conclusion: </strong>The mediating model presented here highlights the role of self-care activities in exerting both direct and indirect effects on depression in participants with T2DM.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"104766"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why some embrace and others hesitate? A behavioral analysis of insomnia sufferers' engagement with acupuncture treatment.","authors":"Fei-Yi Zhao, Russell Conduit, Gerard A Kennedy, Pei-Jie Xu, Wen-Jing Zhang, Yuen-Shan Ho, Qiang-Qiang Fu, Chin-Moi Chow","doi":"10.5498/wjp.v15.i5.105802","DOIUrl":"10.5498/wjp.v15.i5.105802","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is emerging as a promising treatment for insomnia. However, the determinants driving patients' decisions to pursue or adopt this treatment modality remain underexplored.</p><p><strong>Aim: </strong>To identify the key factors shaping the willingness of patients with insomnia to seek and engage in acupuncture from a patient-centered perspective.</p><p><strong>Methods: </strong>A semi-structured focus group design was used, with a research framework integrating the capability, opportunity, motivation-behavior model, and theoretical domains framework. The results were mapped onto constructs of a behavioral wheel derived from the capability, opportunity, motivation-behavior/theoretical domains framework matrix. Data analyses employed abductive thematic analysis.</p><p><strong>Results: </strong>Data saturation was achieved after ten focus group sessions, involving a total of 45 participants. Key facilitators for patients with insomnia seeking acupuncture included: (1) Cultural beliefs in ethnic medicine; (2) Concerns about the adverse effects of, and dependence on, hypnotics; (3) Expectations of improvement in comorbid symptoms; (4) Desire for more communication with the clinician; and (5) Incentives from peers and online key opinion leaders. Barriers were: (1) Limited knowledge of acupuncture indications; (2) Accessibility burden; (3) Needle-phobia; and (4) Safety concerns. Additionally, prior acupuncture experiences, family/friend attitudes, and treatment costs (reimbursement rate in health insurance) served as both facilitators and barriers.</p><p><strong>Conclusion: </strong>The interrelated facilitators and barriers underscore that the decision to use acupuncture for insomnia is a complex issue involving efficacy/safety, culture, economics, information dissemination, and communication factors. Expanding patient education on acupuncture, increasing media exposure, and improving governmental oversight of this process are essential. Investing in high-quality acupuncture services in public hospital nighttime clinics and community health centers is expected to address accessibility challenges. Acupuncturists need to improve doctor-patient communication, including guiding patients to set treatment expectations that are grounded in reality to enhance service quality. For patients with significant needle-phobia, cognitive manipulation or hypnosis techniques may be employed to improve treatment compliance.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"105802"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of heart rate variability index with depressive symptoms and lung function in chronic obstructive pulmonary disease.","authors":"Ya-Ping Yang, Mei-Jia Ji, Yue-Han Guo, Na Yao","doi":"10.5498/wjp.v15.i5.103269","DOIUrl":"10.5498/wjp.v15.i5.103269","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Depression is a common comorbidity in patients with chronic obstructive pulmonary disease (COPD). Research indicates that COPD affects cardiac autonomic control, and heart rate variability (HRV) serves as a simple, non-invasive measure of autonomic nerve activity. However, the relationship between HRV and lung function, as well as the impact of depressive symptoms, remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the correlation between HRV indicators and depressive symptoms and lung function in patients with COPD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cross-sectional study involving 120 COPD patients hospitalized from January 2018 to January 2024 at our institution was conducted. Demographic and clinical characteristics were collected, and depressive symptoms were assessed using the Beck Depression Inventory (BDI). Patients were categorized into a depressed group (BDI ≥ 16) and a non-depressed group (BDI &lt; 16). A control group consisting of 60 healthy volunteers who underwent check-ups at the same institution was also included. Statistical analyses were performed using SPSS 26.0 software. Pearson correlation coefficients were calculated to determine and compare the relationships between HRV parameters, lung function measures, and depressive symptoms across the groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 120 patients with COPD, 35.8% (43/120) were diagnosed with depression, compared to 5.0% (3/60) in the control group. The HRV index in COPD patients was significantly lower than that in the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), and the value in the depressed group was significantly lower than that in the non-depressed group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Similarly, the COPD group had a significantly lower pulmonary forced vital capacity (FVC), first-second expiratory volume (FEV1) and FEV1/FVC ratios than the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), and the depressed group was significantly lower than that in the non-depressed group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Pearson correlation analysis revealed that the standard deviation of normal R-R intervals, standard deviation of the mean of 5-minute normal R-R intervals, root mean square of successive differences of normal R-R intervals, percentage of normal R-R intervals greater than 50 ms, high-frequency, and low-frequency indices showed positive correlations with lung function parameters (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) and negative correlations with BDI scores (&lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Compared to patients without COPD, the incidence of depressive symptoms is higher among patients with COPD and is negatively correlated with the patients' HRV indices. In contrast, HRV indices are positively correlated with the patients' pulmonary function parameters. Patients and healthcare professionals should enhance their awareness of depression, actively conduct depression assessment screenings, and incorporate HRV indices into disease management. This approach aims to improve the","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103269"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential clinical benefits of probiotics, prebiotics, synbiotics, and postbiotics for depression <i>via</i> the microbiota-gut-brain axis.","authors":"Ling-Yi Dai, Ru-Ru Chen, Hao-Ran Chen, Jia-Hui Yin, Zhen-Xing Huang, Bo-Wen Yin, Xing-Yan Liu","doi":"10.5498/wjp.v15.i5.98436","DOIUrl":"10.5498/wjp.v15.i5.98436","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common mental-health disorder worldwide. Several studies have demonstrated the effects of gut microbiota-targeting interventions, such as probiotics, prebiotics, synbiotics, and postbiotics (PPSP), on depression.</p><p><strong>Aim: </strong>To assess the potential benefits of PPSP on patients diagnosed with depressive disorder.</p><p><strong>Methods: </strong>A literature search of the PubMed, Web of Science, and Elsevier Science Direct databases for relevant studies published from database inception to March 2024 was performed. Studies that used a randomized controlled trial design and evaluated differences in depression between PPSP and placebo were included. Depressive symptoms were assessed using a validated scale. Analysis was performed using Review Manager version 5.4 (The Cochrane Collaboration, 2020).</p><p><strong>Results: </strong>Fourteen studies comprising 906 patients with depressive symptoms were included. PPSP improved depression compared with placebo [SMD: -0.39 (95%CI: -0.60 to -0.17); <i>P</i> < 0.001]. PPSP resulted in significant reductions in Hamilton Depression Rating Scale [MD: -1.72 (95%CI: -2.57 to -0.88); <i>P</i> < 0.001] and Beck Depression Inventory [MD: -2.69 (95%CI: -4.67 to -0.71); <i>P</i> < 0.001] scores. Sub-analysis confirmed the antidepressant effects of probiotics on depressive symptoms [SMD: -0.32 (95%CI: -0.48 to -0.16); <i>P</i> < 0.001], with prebiotics exerting no apparent effect [SMD: -0.08 (95%CI: -0.39 to -0.23); <i>P</i> = 0.62], and synbiotics exerting statistically significant benefits [SMD: -1.09 (95%CI: -1.45 to -0.73); <i>P</i> < 0.001].</p><p><strong>Conclusion: </strong>PPSP effectively alleviates depressive symptoms, and subgroup analysis supports the benefits of probiotics and synbiotics. Nevertheless, evidence supporting the use of PPSP for the treatment of depression remains insufficient.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"98436"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life.","authors":"Maher Hendi, Bin Zhang, Jie-Min Lv, Xiu-Jun Cai","doi":"10.5498/wjp.v15.i5.104995","DOIUrl":"10.5498/wjp.v15.i5.104995","url":null,"abstract":"<p><strong>Background: </strong>Patients with middle and advanced hepatocellular carcinoma (HCC) frequently experience significant anxiety and depression, severely affecting their quality of life.</p><p><strong>Aim: </strong>To examine the anxiety and depression status of patients with middle and advanced HCC, the influencing factors, and the correlation between these psychological factors and quality of life.</p><p><strong>Methods: </strong>We collected baseline data from 100 patients with HCC, assessing anxiety and depression levels using the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD). Quality of life was evaluated with the Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire. Multivariate logistic regression analyzed clinical and psychosocial factors affecting anxiety and depression, while Pearson correlation assessed relationships among HAMA, HAMD, and Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire scores.</p><p><strong>Results: </strong>Results indicated that 64% of patients exhibited anxiety and 65% showed depression symptoms. Key influencing factors included Barcelona Clinic Liver Cancer C stage, multiple tumors, social support, prior treatments (such as liver resection and transcatheter arterial chemoembolization/hepatic artery infusion chemotherapy), as well as HAMA and HAMD scores. Anxiety and depression correlated negatively with quality of life, with coefficients of -0.671 and -0.575 for HAMA and HAMD, respectively.</p><p><strong>Conclusion: </strong>Anxiety and depression are prevalent among patients with middle and advanced HCC, impacting quality of life. This underscores the need for psychological health considerations in liver cancer treatment and establishing psychological interventions is essential.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"104995"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the effects of multimodal physical therapy on improving depression.","authors":"Bin Sun, Chao Li, Chen-Lin Zhang, Jing-Hui Li, Ming Mao, Gang Wang, Zong-Feng Zhang","doi":"10.5498/wjp.v15.i5.103937","DOIUrl":"10.5498/wjp.v15.i5.103937","url":null,"abstract":"<p><strong>Background: </strong>Depression is a widespread psychological disorder that has substantial effects on public health and society. Conventional therapies include medication and psychotherapy, recent investigations have highlighted the possible advantages of multimodal treatments, such as physical therapy, for improving depression.</p><p><strong>Aim: </strong>To perform a meta-analysis of how multimodal physical therapy can help treat depression.</p><p><strong>Methods: </strong>We searched for collection of articles that satisfied the inclusion and exclusion criteria, encompassing randomized controlled research-related sources. We incorporated these studies into the meta-analysis using terms such as \"findings\", \"intervention\", and \"population attributes\". We used statistical examination to measure the total impact magnitude and evaluate study variability.</p><p><strong>Results: </strong>The encouraging aspect is that multi-modal physical therapy is being considered for its effectiveness in treating symptoms related to depression. Sensitivity analysis was conducted to identify key factors and determine their impact on quality.</p><p><strong>Conclusion: </strong>Regarding treatment for depression, this meta-analysis extends the increasing number of studies demonstrating the effectiveness of multimodal physical therapy.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 5","pages":"103937"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}