World Journal of Psychiatry最新文献

{"title":"Evaluation of the prevalence and risk factors of burnout syndrome among healthcare workers: A cross-sectional study.","authors":"Nur Adam Mohamed, Yusuf Abdirisak Mohamed, Rahma Yusuf Haji Mohamud, Adan Ali Gabow","doi":"10.5498/wjp.v15.i2.98496","DOIUrl":"10.5498/wjp.v15.i2.98496","url":null,"abstract":"<p><strong>Background: </strong>Burnout syndrome is a significant issue among healthcare professionals worldwide, marked by depersonalization, emotional exhaustion, and a reduced sense of personal achievement. This psychological and physical burden profoundly affects healthcare professionals' quality of care and overall well-being. In Somalia, where the healthcare system faces numerous challenges, the escalating demand for medical services and inadequate resources, coupled with overwhelming workloads, long hours, and high-stress levels, make healthcare providers particularly vulnerable to burnout syndrome. This, in turn, affects both the mental health of healthcare personnel and the quality of care they provide.</p><p><strong>Aim: </strong>To examine the prevalence and determinants of burnout syndrome among healthcare practitioners in Mogadishu, Somalia.</p><p><strong>Methods: </strong>This cross-sectional prospective study was performed among 246 healthcare providers employed at a tertiary care hospital in Mogadishu, Somalia, who were recruited <i>via</i> random sampling. Data were collected using questionnaires that covered sociodemographic, psychological, work-related characteristics, and burnout syndrome. Bivariate and multivariate logistic regression analyses were performed to identify the variables that correlated with burnout syndrome. The results were presented using adjusted odds ratios (AORs), 95%CIs, and <i>P</i> values, with a cutoff of 0.05 for identifying significant associations.</p><p><strong>Results: </strong>Among the participants, 24% (95%CI: 18.8%-29.8%) exhibited symptoms of burnout syndrome. Factors associated with burnout included female gender (AOR = 6.60; 95%CI: 2.29-19.04), being married (AOR = 3.07; 95%CI: 1.14-8.28), being divorced or widowed (AOR = 5.84; 95%CI: 1.35-25.35), working more than 7 night shifts (AOR = 3.19; 95%CI: 1.30-7.82), having less than 5 years of job experience (AOR = 5.28; 95%CI: 1.29-21.65), experiencing poor sleep quality (AOR = 5.29; 95%CI: 1.88-14.89), and exhibiting depressive (AOR = 4.46; 95%CI: 1.59-12.53) and anxiety symptoms (AOR = 7.34; 95%CI: 2.49-21.60).</p><p><strong>Conclusion: </strong>This study found that nearly one in four healthcare professionals suffers from burnout syndrome. Improving sleep quality, monitoring, and providing mental health support could enhance their well-being and patient care.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"98496"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction note to: Shugan Jieyu capsule effects on peripheral blood micro-124, micro-132, and brain-derived neurotrophic factor in patients with mild to moderate depression.","authors":"Xian Zhang, Yang Liu, Hua-Fei Tang, Feng Jiang, Chun-Liang Chen, Ting-Ting Wang, Hui-Zhong Gu, Qiang Zhao, Rui Ma","doi":"10.5498/wjp.v15.i2.103118","DOIUrl":"10.5498/wjp.v15.i2.103118","url":null,"abstract":"<p><p>[This retracts the article on p. 1354 in vol. 14, PMID: 39319232.].</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"103118"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between psychological, family social support, and home nursing quality for an implanted venous access port.","authors":"Heng-Ya Jia, Li-Qun Yan, Xiao-Bei Liu, Jie Cao","doi":"10.5498/wjp.v15.i2.99252","DOIUrl":"10.5498/wjp.v15.i2.99252","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients with an implanted venous access port (IVAP) often manage their care at home during chemotherapy intervals, including maintaining the device, monitoring complications, and following medication instructions. Home care ensures continued support after discharge. However, due to factors such as age, gender, culture, psychological status, and family support, the quality of home care varies significantly. Understanding these factors can help provide targeted guidance to improve the care of cancer patients.</p><p><strong>Aim: </strong>To explore IVAP chemotherapy on home care quality and its association with mental health and family support for cancer patients.</p><p><strong>Methods: </strong>This investigative study was based on a medical records system. It investigated the relationship between psychological status, family support, and home care quality in 180 patients with cancer undergoing IVAP chemotherapy. Psychological status was assessed using the State Anxiety Inventory (S-AI); family support was assessed using the Perceived Social Support Scale (PSSS), and home care quality was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Pearson's correlation and Structural Equation Modeling were used to analyze the interplay between these factors.</p><p><strong>Results: </strong>The average S-AI score was 47.52 ± 14.47, PSSS was 52.48 ± 12.64, and EORTC QLQ-C30 was 70.09 ± 17.32. A substantial inverse relationship was observed between the EORTC QLQ-C30 and S-AI scores (<i>r</i> = -0.712). A significant positive correlation was found between the EORTC QLQ-C30 and the PSSS, with a correlation coefficient of (<i>r</i> = 0.744). The multiple linear regression analysis indicated that family social support, psychological status, and average monthly family income were the main factors influencing the variation in the quality of home care, explaining 71.9% of the variation. The Structural Equation Modeling results indicated that psychological status acted as a partial mediator in the association between family social support and home care quality of life, explaining 32.78% of the mediation effect.</p><p><strong>Conclusion: </strong>Psychological status and family social support positively impacted cancer patients' home care quality, with psychology partially mediating this effect.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99252"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of insomnia on anxiety and depression: Mediation of cognitive failures and moderated mediation of neuroticism.","authors":"Yue Li, Jia-Long Yu, Shu-Yi Wang, Lu-Xin Xie, Jia-Long Hong, Sha Liu","doi":"10.5498/wjp.v15.i2.101026","DOIUrl":"10.5498/wjp.v15.i2.101026","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 pandemic has had an ongoing impact on the public's mental health that requires long-term attention. Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.</p><p><strong>Aim: </strong>To investigate the prevalence of anxiety, depression, and insomnia and explore the relationship among neuroticism, cognitive failures, and mental health.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants. The neuroticism, subjective cognitive function, and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version, cognitive failures questionnaire, generalized anxiety disorder-7, patient health questionnaire-9, and insomnia severity index. Pearson's correlation analysis, independent samples <i>t</i>-tests, one-way analysis of variance, and structural equation model were used to examine the relationship between mental health indicators.</p><p><strong>Results: </strong>A total of 1011 valid questionnaires were collected, of which 343 were completed by male (33.93%) respondents and 668 were completed by female (66.07%) respondents. The rates of anxiety, depression, and insomnia were 41.3%, 44.6%, and 36.3%, respectively, most cases of which were mild. Among the mental health indicators, there were significant differences by age and between those with siblings and those who were only children. Neuroticism and cognitive failures were significantly positively correlated with mental health indicators. Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression, with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.</p><p><strong>Conclusion: </strong>Cognitive failures and neuroticism play important roles in mental health. Therefore, enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101026"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.","authors":"Lan-Ying Wang, Qi-Qin Wang, Jia-Nan Xu, Si-Yuan Wang, Yao Shi","doi":"10.5498/wjp.v15.i2.100062","DOIUrl":"10.5498/wjp.v15.i2.100062","url":null,"abstract":"<p><strong>Background: </strong>Despite laparoscopic total hysterectomy provided more benefits to patients and has become one of the most commonly used surgical methods for total hysterectomy. However, vaginal cuff dehiscence is a serious complication after laparoscopic total hysterectomy and so far, there are limited studies on vaginal cuff dehiscence after a total hysterectomy.</p><p><strong>Aim: </strong>To investigate the factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.</p><p><strong>Methods: </strong>This study retrospectively, univariately, and multivariately analyzed the clinical data of patients who experienced vaginal cuff dehiscence after laparoscopic hysterectomy in Yuyao People's Hospital from January 2015 to December 2021. Logistic regression was utilized to analyze the high-risk factors of vaginal cuff dehiscence.</p><p><strong>Results: </strong>Among 1459 cases with laparoscopic hysterectomy, 9 reported vaginal cuff dehiscence postoperatively, with an incidence of 0.617%. Univariate logistic regression analysis revealed that preoperative hemoglobin value [odds ratio (OR) = 5.12, <i>P</i> = 0.016], vaginal cuff suture method (OR = 0.26, <i>P</i> = 0.048), and postoperative first sexual lifetime (OR = 15.86, <i>P</i> = 0.002) were associated with vaginal cuff dehiscence following laparoscopic hysterectomy. Multivariate logistic regression analysis revealed that preoperative hemoglobin value of < 90 g/L (OR = 5.17, <i>P</i> = 0.015) and time interval between postoperative first sexual life and operation of < 3 months (OR = 54.00, <i>P</i> = 0.004) are independent risk factors for vaginal cuff dehiscence after laparoscopic hysterectomy.</p><p><strong>Conclusion: </strong>Postoperative hemoglobin and the time interval between postoperative first sexual life and operation were the independent factors of developing vaginal cuff dehiscence after laparoscopic hysterectomy.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100062"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023.","authors":"Biao Huang, Wei-Ning Chen, Chun-Mei Peng, Xiu-Li Shen, Jin Xue, Chun-Chuan Yan, Fa-Ming Zhong","doi":"10.5498/wjp.v15.i2.102344","DOIUrl":"10.5498/wjp.v15.i2.102344","url":null,"abstract":"<p><strong>Background: </strong>Depression significantly threatens human health. Purinergic receptors are reported to be associated with depression. However, there is no bibliometric research in this field have been published.</p><p><strong>Aim: </strong>To provide some reference for the further research in the field of purinergic receptors and depression utilizing bibliometric analysis.</p><p><strong>Methods: </strong>Relevant researches were retrieved from the Web of Science Core Collection database. The period of the search was from January 1, 2003 to December 31, 2023. The CiteSpace (6.2.R7) and VOSviewer (1.6.19) were applied to identify the main contributors of countries, authors, institutions, references and journals. Besides, we evaluate keywords to assess the hotspots and trends over the previous 2 decades.</p><p><strong>Results: </strong>Totally, 247 articles were identified, showing an increasing trend over time. The most productive country, institution, and journal in this field are China, Harvard University, and Biological Psychiatry, respectively. Liang SD and Rodrigues, Ana Lucia S were the most prolific authors. Burnstock G ranked first among the cited authors. The cooperation among countries and disciplines is crucial. The P2X7 receptor provides promising prospects for treating depression and further studies are warranted to validate the scope and significance of depression therapeutic strategies.</p><p><strong>Conclusion: </strong>This study provides an overview of the worldwide research status and future trends in purinergic receptors and depression. P2X7 receptor is considered an appropriate target for the treatment of depression, as well as neurological diseases. It is implied that based on purinergic system, the future prospects for interventions aimed at depression treatment are promising, showing the way for both augmentation strategies and new drug treatments in the context of the pharmacology of depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"102344"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-suicidal self-injury risk among left-behind children and adolescents in China: A systematic review and meta-analysis.","authors":"Qi Zheng, Xin-Chao Chen, Ying-Jian Deng, Ya-Juan Ji, Qi Liu, Chen-Yun Zhang, Tian-Tian Zhang, Ling-Jiang Li","doi":"10.5498/wjp.v15.i2.101595","DOIUrl":"10.5498/wjp.v15.i2.101595","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence has shown an increased risk of non-suicidal self-injury (NSSI) in left-behind children and adolescents (LBCAs). However, a systematic summary of studies comparing the risk of NSSI between LBCAs and non-LBCAs in China is lacking.</p><p><strong>Aim: </strong>To investigate the risk of NSSI among LBCAs in China.</p><p><strong>Methods: </strong>We performed a systematic search of Embase, PubMed, and Web of Science from initiation to October 25, 2024, for all relevant studies of NSSI and LBCAs. The effect sizes were reported as odds ratios (ORs) with 95% confidence intervals (CI). Sensitivity analyses were conducted to further confirm the stability of the findings.</p><p><strong>Results: </strong>A total of 10 studies with 165276 children and adolescents were included in this study. LBCAs had significantly higher rates of NSSI compared with non-LBCAs (OR = 1.33, 95%CI: 1.19-1.49), with high heterogeneity observed (<i>I</i> ² = 77%, <i>P</i> < 0.001). Further sensitivity analyses were consistent with the primary analysis (OR = 1.29, 95%CI: 1.21-1.39, <i>I</i> ² = 0%).</p><p><strong>Conclusion: </strong>LBCAs are found to be at an increased risk of NSSI compared with children and adolescents of non-migrants. More attention and intervention are urgently needed for LBCAs, especially those living in developing countries.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101595"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work-family behavioral role conflict and daytime sleepiness on suicide risk among Chinese nurses: A cross-sectional study.","authors":"Qing-Wen Gan, Yi-Ling Yuan, Yuan-Ping Li, Yi-Wen Du, Li-Lan Zheng","doi":"10.5498/wjp.v15.i2.100859","DOIUrl":"10.5498/wjp.v15.i2.100859","url":null,"abstract":"<p><strong>Background: </strong>Work-family conflicts and daytime sleepiness are related to the risk of suicide. At present, no study has investigated the relationship between nurses' work-family behavioral role conflict and suicide risk. Moreover, it has not been confirmed whether, considering the effect of daytime sleepiness on suicide risk, daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.</p><p><strong>Aim: </strong>To explore the pathway relationships among nurses' work-family behavioral role conflict, daytime sleepiness, and suicide risk.</p><p><strong>Methods: </strong>Convenience and purposive sampling methods were used to select 750 nurses from six provinces, including Jiangxi, Sichuan, and Shanxi. The work-family behavioral role conflict scale, the Chinese adult daytime sleepiness scale, and the suicide behavior questionnaire were used for the survey. The data were statistically analyzed <i>via</i> SPSS 25.0 software, Pearson correlation analysis was used to explore the correlations between the variables, the PROCESS 4.0 program was used for the mediation effect analysis, and the mediation effect model was tested <i>via</i> the bootstrap method.</p><p><strong>Results: </strong>Nurses' work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk (<i>r</i> = 734, 0.717). Work-family behavioral role conflict positively predicted suicide risk (<i>β</i> = 0.118), and daytime sleepiness positively predicted suicide risk (<i>β</i> = 0.152). Daytime sleepiness partially mediated the role of nurses' work-family behavioral role conflict and suicide risk, with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.</p><p><strong>Conclusion: </strong>The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses' work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"100859"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune indicators and depression in adolescents: Associations with monocytes, lymphocytes, and direct bilirubin.","authors":"Jian Dai, Xiao-Tong Lin, Lu-Lu Shen, Xi-Wen Zhang, Zi-Wen Ding, Jing Wang, Xi-Wang Fan, Wei-Dong Ning","doi":"10.5498/wjp.v15.i2.101818","DOIUrl":"10.5498/wjp.v15.i2.101818","url":null,"abstract":"<p><strong>Background: </strong>Depression is a significant psychiatric disorder with particularly high prevalence among adolescents. This mental health condition can have severe consequences, including academic failure, social withdrawal, and suicidal behavior. Given the increasing rate of depression in this age group, understanding the underlying biological mechanisms is essential for early detection and intervention. Recent studies have suggested that immune markers play a role in the pathophysiology of depression, prompting further investigation of their potential association with depressive symptoms in adolescents.</p><p><strong>Aim: </strong>To investigate the relationship between immune markers (monocytes, lymphocytes, and direct bilirubin) and the incidence and severity of depression among adolescents.</p><p><strong>Methods: </strong>This cross-sectional study recruited 145 adolescent patients with depression [male (M)/female (F) = 38/107] from Jiangbin Hospital in Guangxi, Zhuang and 163 healthy controls (M/F = 77/86) from routine health check-ups. Blood samples were collected after an overnight fast. Depression severity was measured using the Zung Self-Rating Depression Scale. The inclusion criteria were age 12-24 years, diagnosis of depressive disorder (ICD-10), and no recent antidepressant use. The exclusion criteria included psychiatric comorbidities and serious somatic diseases. Key statistical methods included group comparisons and correlation analyses.</p><p><strong>Results: </strong>There was a higher prevalence of females in the depression group (<i>P</i> < 0.001). Significant age differences were observed between the groups (<i>Z</i> = 9.43, <i>P</i> < 0.001). The depression group had higher monocyte (<i>Z</i> = 3.43, <i>P</i> < 0.001) and lymphocyte (<i>t</i> = 2.29, <i>P</i> < 0.05) counts, and higher serum direct bilirubin levels (<i>Z</i> = 4.72, <i>P</i> < 0.001). Monocyte count varied significantly according to depression severity, with lower counts in the mild group (<i>Z</i> = -2.90, <i>P</i> < 0.05). A negative correlation between age and lymphocyte counts was observed (<i>ρ</i> = -0.22, <i>P</i> < 0.01). Logistic regression analysis showed that serum direct bilirubin levels significantly predicted depression.</p><p><strong>Conclusion: </strong>The potential role of elevated levels of immune markers in the early detection of depression in adolescents has been highlighted. Therefore, it is necessary to explore further the relationships between these immune markers and depression.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"101818"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer's disease patients.","authors":"Xue-Lian Wang, Yi-Ran Zhao, Ying Yu, Zhi-Fang Mao, Su-Xian Tan, Shan-Shan Yu","doi":"10.5498/wjp.v15.i2.99008","DOIUrl":"10.5498/wjp.v15.i2.99008","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential in providing nutritional guidance for patients with Alzheimer's disease (AD) remains relatively unexplored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024. Based on data from previous similar studies, the patients were randomly assigned to either a routine diet (RD) group (&lt;i&gt;n&lt;/i&gt; = 48) or a personalized nutrition (PN) group (&lt;i&gt;n&lt;/i&gt; = 48). The RD group received conventional dietary guidance, while the PN group received individualized diet intervention measures based on human BCA. The intervention period lasted for 12 weeks. Bone mineral density (BMD), body mass index (BMI), muscle mass, mineral content, osteocalcin, 25-hydroxyvitamin D, procollagen type I N-terminal propeptide (PINP), beta C-terminal telopeptide of type I collagen (β-CTX), and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No significant differences were observed between groups in terms of age, sex, height, BMI, or other baseline data (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). In both groups, BMI did not show significant changes after the intervention (&lt;i&gt;P&lt;/i&gt; &gt; 0.05), whereas muscle mass and mineral content were significantly increased (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). After the intervention, BMI in the PN group did not differ significantly from that of the RD group, but muscle mass and mineral content were significantly higher in the PN group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). After the intervention, a higher proportion of patients in the PN group had a T score &gt; -1 compared to the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The mini-mental state examination (MMSE) score was similar in both groups before the intervention. However, 12 weeks after the intervention, the MMSE score in the PN group was significantly higher than that in the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In both groups, the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Before the intervention, the levels of osteocalcin, serum calcium, PINP, β-CTX, and 25-hydroxyvitamin D were not significantly different between the two groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05). After 12 weeks of intervention, the PN group exhibited higher levels of osteocalcin, serum calcium, and 25-hydroxyvitamin D, as well as lower levels of PINP and β-CTX, compared to the RD group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). In both groups, osteocalcin, serum calcium, and 25-hydroxyvitamin D levels were significantly higher, while PINP and β-CTX levels were significantly lower after 12 weeks of intervention compared to baseline (&lt;i&gt;P&lt;/i&gt; ","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 2","pages":"99008"},"PeriodicalIF":3.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}