World Journal of Psychiatry最新文献

{"title":"Analysis the incidence and related risk factors of depression in patients with esophageal cancer combined with bone metastasis.","authors":"Hao-Jie Shi, Shi-Chao Huang, Bing-Wu Wang","doi":"10.5498/wjp.v16.i1.110875","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.110875","url":null,"abstract":"<p><strong>Background: </strong>Esophageal cancer is highly malignant and frequently metastasizes to bones. Concomitant depression worsens prognosis; however, its incidence and determinants in this specific population remain poorly defined.</p><p><strong>Aim: </strong>To determine the incidence of depression and its independent risk factors in patients with esophageal cancer and bone metastasis.</p><p><strong>Methods: </strong>A total of 100 consecutive eligible patients admitted between March 2022 and March 2025 were recruited. Depression was assessed with the Beck Depression Inventory-II; scores > 4 defined the depression group (<i>n</i> = 42) and scores ≤ 4 the non-depression group (<i>n</i> = 58). Demographic, clinical, and laboratory variables were compared between the groups. Multivariate logistic regression was used to identify independent risk factors.</p><p><strong>Results: </strong>Depression prevalence was 42.0% (42/100). Univariate analysis demonstrated significant differences in monthly per-capita household income, education level, social support, sleep disorders, and serum high-sensitivity C-reactive protein (all <i>P</i> < 0.05); no differences were observed in sex, age, tumor characteristics, or other laboratory indices (all <i>P</i> > 0.05). Multivariable analysis revealed the following independent risk factors for depression: Low income [odds ratio (OR) = 2.66, 95% confidence interval (CI): 1.17-6.03], low education (OR = 2.46, 95%CI: 1.08-5.61), low social support (OR = 5.10, 95%CI: 1.81-14.39), sleep disorders (OR = 2.79, 95%CI: 1.23-6.35), and elevated high-sensitivity C-reactive protein (OR = 1.31 per unit increase, 95%CI: 1.18-1.46).</p><p><strong>Conclusion: </strong>Depression is common among patients with esophageal cancer and bone metastasis. Low socioeconomic status, limited education, insufficient social support, sleep disturbances, and systemic inflammation were independent predictors. Interventions that address these modifiable factors may reduce depression risk in this population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"110875"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients.","authors":"Fu-Gang Luo, Hao-Yu Xing, Jun-Jie Wang, Wen-Ye Wu, Kai-Jie Fang, Hai-Dong Song, Juan Yan","doi":"10.5498/wjp.v16.i1.111840","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.111840","url":null,"abstract":"<p><strong>Background: </strong>Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks, including QT interval prolongation, myocardial injury, and functional impairment. Guanxinning, a traditional Chinese medicine formulation, has demonstrated cardioprotective potential in preclinical studies, but clinical evidence in this population remains limited.</p><p><strong>Aim: </strong>To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.</p><p><strong>Methods: </strong>A randomized, double-blind, placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy. Participants were allocated to: Intervention group: Conventional antipsychotics + Guanxinning tablets (0.38 g × 4 tablets, ter in die); Control group: Conventional antipsychotics + identical placebo; Cardiac assessments at baseline and 12 months included: Electrocardiography (corrected QT interval), echocardiography (left ventricular ejection fraction, left ventricular end-diastolic diameter), serum biomarkers (cardiac troponin I, B-type natriuretic peptide, superoxide dismutase, malondialdehyde, high-sensitivity C-reactive protein).</p><p><strong>Results: </strong>Compared to controls, the Guanxinning group showed: Electrophysiological improvement: Corrected QT shortening (438 ± 25 milliseconds <i>vs</i> 465 ± 30 milliseconds, <i>P</i> < 0.01). Functional enhancement: Left ventricular ejection fraction increase (58.5% ± 5.2% <i>vs</i> 53.8% ± 4.8%, <i>P</i> < 0.05), left ventricular end-diastolic diameter reduction (49.8 ± 3.5 mm <i>vs</i> 52.6 ± 3.8 mm, <i>P</i> < 0.05), Biochemical modulation: Reduced myocardial injury markers (cardiac troponin I: 0.009 ng/mL <i>vs</i> 0.014 ng/mL; B-type natriuretic peptide: 52 pg/mL <i>vs</i> 78 pg/mL, <i>P</i> < 0.001), improved oxidative stress (superoxide dismutase: ↑13.3 U/mL; malondialdehyde: ↓0.9 nmol/mL, <i>P</i> < 0.001), attenuated inflammation (high-sensitivity C-reactive protein: 2.0 mg/L <i>vs</i> 3.2 mg/L, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients, demonstrating: Normalization of electrophysiological parameters, Preservation of systolic/diastolic function, suppression of oxidative stress and inflammation. These findings support its clinical application as an adjunctive cardioprotective therapy, potentially through inhibition of myocardial apoptosis and antioxidant upregulation.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"111840"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis.","authors":"Xin Liu, Qing Fang, Yin-Di Sun, Na Liu, Hao-Hao Liang, Liang Li","doi":"10.5498/wjp.v16.i1.110298","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.110298","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA), a common disabling pathology characterized by knee joint pain, swelling, and functional impairment, primarily affects middle-aged and older adults. In addition to physical limitations, chronic pain often leads to psychological problems, including anxiety and depression, which further impact patients' quality of life.</p><p><strong>Aim: </strong>To examine the efficacy and safety of celecoxib plus duloxetine in managing chronic pain, anxiety, and depression in patients with KOA.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 123 patients with KOA treated at our center between February 2020 and February 2023. Of these, 66 received celecoxib plus duloxetine, and 57 received celecoxib alone. Outcomes were assessed using the Visual Analog Scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Self-Rating Anxiety Scales (SAS)/Self-Rating Depression Scales (SDS). Safety was evaluated by monitoring changes in liver function enzymes (alanine aminotransferase, aspartate aminotransferase), creatinine, and blood urea nitrogen.</p><p><strong>Results: </strong>Patients receiving celecoxib plus duloxetine showed significantly greater reductions in VAS and WOMAC and greater improvements in SAS and SDS scores compared with those receiving celecoxib alone. Hepatorenal function did not differ significantly between the treatment groups. Logistic regression analysis identified patient age, educational background, and treatment regimen as independent predictors of inadequate improvement in negative emotional symptoms.</p><p><strong>Conclusion: </strong>In patients with KOA, celecoxib plus duloxetine effectively mitigates chronic pain and improves anxiety and depressive symptoms without increasing adverse hepatic or renal effects. These findings support its use as a safe and effective treatment option.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"110298"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender and common mental disorders: A perspective from India.","authors":"Vibha K V, Swati Chandramouli, Luke Joshua Salazar, Krishnamachari Srinivasan","doi":"10.5498/wjp.v16.i1.108360","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.108360","url":null,"abstract":"<p><p>Common mental disorders (CMDs), such as depressive and anxiety disorders, constitute a significant public health problem in low- and middle-income countries, such as India, where they rank among the leading causes of disability and impaired quality of life. Outcomes are further compromised by a large treatment gap, poor adherence to therapeutic regimens, and high attrition rates. The prevalence and severity of CMDs are disproportionately higher in women. Additionally, structural factors influencing healthcare access, along with sociocultural factors, such as gender-based violence, limited autonomy in healthcare decisions, and greater levels of discrimination and stigma, result in poorer outcomes among women with CMDs. Therefore, there is a pressing need for care packages that are culturally sensitive, gender-responsive, and designed to address these structural and sociocultural factors, as highlighted in the literature from India.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"108360"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive behavioral therapy enhances psychological and physiological outcomes in high-altitude respiratory patients.","authors":"De-Feng Meng, Dong-You Zhang, Fan Yang, Peng-Li Meng, Ting-Ting Wen, Yu-Zhao Wang","doi":"10.5498/wjp.v16.i1.111581","DOIUrl":"10.5498/wjp.v16.i1.111581","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Due to the dry and cold climate, the obvious temperature difference between day and night, and the low oxygen content of the air in the plateau area, people are prone to upper respiratory tract diseases, and often the condition is prolonged, and the patients are prone to anxiety and uneasiness, which may be related to the harshness of the plateau environment, somatic discomfort due to the lack of oxygen, anxiety about the disease, and other factors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the effects of cognitive behavioral therapy (CBT) on anxiety, sleep disorders, and hypoxia tolerance in patients with high-altitude respiratory diseases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 2337 patients with high-altitude-related respiratory diseases treated at our hospital between November 2023 and January 2024 were selected as the study subjects. The subjects' pre-high-altitude residential altitude was approximately 1700 meters. They were divided into two groups. Both groups were given symptomatic treatment, and the control group implemented conventional nursing intervention, while the research group simultaneously conducted CBT intervention; assessed the degree of health knowledge of the two groups, and applied the Hamilton Anxiety Scale and the Pittsburgh Sleep Quality Index to assess the anxiety and sleep quality of the patients before and after the intervention, respectively. It also observed the length and efficiency of sleep, and detected the level of serum hypoxia inducible factor-1α, erythropoietin (EPO) and clinical intervention before and after intervention. EPO levels, and investigated satisfaction with the clinical intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The rate of excellent health knowledge in the intervention group was 93.64%, which was higher than that in the control group (74.23%; &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Before the intervention, there was no significant difference in Hamilton Anxiety Scale and Pittsburgh Sleep Quality Index scores between the two groups (&lt;i&gt;P&lt;/i&gt; &gt; 0.05), and after the intervention, the scores of the study group were significantly lower than those of the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). There was no significant difference in sleep duration and sleep efficiency between the groups before the intervention (&lt;i&gt;P&lt;/i&gt; &gt; 0.05), and after the intervention, the scores of the study group were significantly larger than those of the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). There was no significant difference in serum hypoxia inducible factor-1α and EPO between the two groups before intervention (&lt;i&gt;P&lt;/i&gt; &gt; 0.05), and both research groups were significantly lower than the control group after intervention (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). According to the questionnaire survey, the intervention satisfaction of the study group was 95.53%, which was higher than that of the control group (80.14%; &lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The CBT intervention in the treatment of patients with high-altitude-related ","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"111581"},"PeriodicalIF":3.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of ocular surface function with sleep quality, anxiety, and depression in patients with dry eye disease.","authors":"Yi-Long Lin, Hai-Hua Liu, Shu-Jin Chen, Qi-Hua Wan, Kai-Ping Zhang","doi":"10.5498/wjp.v16.i1.112013","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.112013","url":null,"abstract":"<p><strong>Background: </strong>Dry eye disease (DED) is a multifactorial ocular surface disorder with rising prevalence. It is closely related to systemic health and psychological factors, such as sleep and mood disorders, which significantly impact the quality of life of patients.</p><p><strong>Aim: </strong>To explore the correlations between ocular surface function, sleep quality, and anxiety/depression in patients with DED.</p><p><strong>Methods: </strong>This was a cross-sectional investigative study that included 358 patients with DED between January 2022 and January 2025. Ocular surface was assessed using the ocular surface disease index (OSDI), tear film break-up time, fluorescein staining score, and Schirmer I test. The Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) were used to evaluate sleep quality and anxiety/depression levels. Correlation and linear regression analyses were used to explore the relationships.</p><p><strong>Results: </strong>The mean PSQI score of the patients was 9.94 ± 2.18; the mean SAS score was 47.30 ± 4.90, and the mean SDS score was 50.08 ± 5.52. These suggested a prevalence of sleep and psychological abnormalities. There was a significant correlation between the indicators of ocular surface function (OSDI, tear film break-up time, fluorescein staining, and Schirmer I test) and PSQI, SAS, and SDS scores (<i>P</i> < 0.05). Moreover, multiple regression revealed that age ≥ 50 years (<i>β</i> = 1.55, <i>P</i> = 0.029), PSQI scores (<i>β</i> = 0.58, <i>P</i> < 0.001), SAS scores (<i>β</i> = 0.17, <i>P</i> = 0.017), and SDS scores (<i>β</i> = 0.15, <i>P</i> = 0.019) were independent predictors of the OSDI scores.</p><p><strong>Conclusion: </strong>Ocular surface function in patients with DED is closely related to sleep quality and anxiety/depression, emphasizing the need for holistic clinical management.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"112013"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.","authors":"Qing-Qing Wang, Zhong-Sheng Sun, Jie-Si Wang","doi":"10.5498/wjp.v16.i1.111010","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.111010","url":null,"abstract":"<p><p>Non-right-handedness (NRH), encompassing left-handedness and mixed-handedness, has been frequently reported at elevated rates in individuals with various psychiatric disorders. The consistency of this association across multiple conditions and its underlying mechanisms is the subject of ongoing investigation. This review synthesized current evidence to explore the association between NRH and psychiatric disorders from epidemiological, genetic, and neurobiological perspectives. We systematically identified and appraised relevant literature investigating NRH prevalence in psychiatric populations and potential explanatory mechanisms. Epidemiological evidence indicates an elevated prevalence of NRH, particularly within neurodevelopmental disorders. Potential contributing mechanisms identified include early developmental disruptions, shared genetic predispositions, and atypical patterns of brain lateralization. While the association between NRH and psychiatric conditions, especially neurodevelopmental disorders, is evident, the causal pathways and relative contributions of identified mechanisms are complex and debated. This review highlighted key areas requiring further research to elucidate these relationships.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"111010"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative anxiety among patients and its correlation with their personality type and pain: A cross-sectional study.","authors":"Nariman Salem, Abdul Hadi Moursel, Ali Zahweh, Dana Shhadi, Fedaa Saad, Mahdi Reda, Mariam Mghames, Rami Roumieh, Rawan Tfaily, Salim M Ramadan, Bahaa Bou Dargham, Omar Rajab, Fatima Akel","doi":"10.5498/wjp.v16.i1.112129","DOIUrl":"10.5498/wjp.v16.i1.112129","url":null,"abstract":"<p><strong>Background: </strong>Preoperative anxiety is a significant concern for patients, as it affects surgical outcomes, satisfaction, and pain perception. Although both anxiety and pain are common in surgical settings, their relationship with personality traits has not been previously investigated in the Lebanese population.</p><p><strong>Aim: </strong>To examine the prevalence of preoperative anxiety, pain perception, and personality traits among Lebanese surgical patients, and to assess the associations between these factors.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted between April 2024 and January 2025 across Lebanese hospitals. A total of 392 adult patients were recruited through convenience sampling. Data were collected using a questionnaire that included sociodemographic, clinical, and surgical variables, the Amsterdam Preoperative Anxiety and Information Scale for anxiety, the Visual Analog Scale and Numerical Pain Rating Scale for preoperative pain, and the Ten-Item Personality Inventory for personality traits. Ethical approval was obtained from the Institutional Review Boards of Makassed General Hospital and Hammoud University Medical Center.</p><p><strong>Results: </strong>Overall, 25% of participants experienced preoperative anxiety, and 34.5% reported moderate pain. Personality assessment showed that the majority of participants had moderate extraversion (84.1%), moderate emotional stability (65.1%), high conscientiousness (61%), high agreeableness (54.1%), and moderate openness (49.2%). High conscientiousness was significantly associated with higher pain perception (<i>P</i> < 0.05), while high emotional stability was associated with lower levels of anxiety (<i>P</i> < 0.05). No significant association was found between preoperative anxiety and pain (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>This study challenges the assumption that preoperative anxiety and pain are directly correlated and highlights the role of personality traits in shaping patient experience. These findings support the potential value of integrating psychological profiling into preoperative care and lay the groundwork for developing personalized interventions to improve patient-centered surgical outcomes.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"112129"},"PeriodicalIF":3.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a mental health literacy evaluation index system for adolescents with mental disorders.","authors":"Ying-Qiong Ge, Xiao-Shuang Ouyang, Zheng-Min Zhu, Bi-Can Tan, Xiao-Jian Jiang","doi":"10.5498/wjp.v16.i1.112756","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.112756","url":null,"abstract":"<p><strong>Background: </strong>Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.</p><p><strong>Aim: </strong>To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders, providing a scientific, comprehensive, and reliable tool for the monitoring and intervention of mental health literacy of such patients.</p><p><strong>Methods: </strong>From December 2022 to June 2023, the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews, semi-structured interviews, expert letter consultations, and the analytic hierarchy process. Based on this index system, a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.</p><p><strong>Results: </strong>The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators, 10 second-level indicators, and 52 third-level indicators. The overall Cronbach's <i>α</i> coefficient of the index system was 0.957, with a partial reliability of 0.826 and a content validity index of 0.975. The cumulative variance contribution rate of 10 common factors was 66.491%. The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724, while the correlation coefficients in each dimension ranged from 0.389 to 0.705.</p><p><strong>Conclusion: </strong>The evaluation index system for mental health literacy of adolescents with mental disorders, developed in this study, demonstrated notable reliability and validity, making it a valuable tool for evaluating mental health literacy in this population.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"112756"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and early identification markers for post-ischemic stroke anxiety and depression.","authors":"Jie-Dong Zhao, Song-Wang Qiu, Kai-Yan Lin, Hui-Yan Lin, Chang-Wei Yu","doi":"10.5498/wjp.v16.i1.113104","DOIUrl":"https://doi.org/10.5498/wjp.v16.i1.113104","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is one of the leading global causes of disability and death. Despite advances in modern medical technology that improve acute treatment and rehabilitation measures, post-stroke anxiety and depression (PSD) do not receive sufficient attention.</p><p><strong>Aim: </strong>To systematically evaluate risk factors and early identification markers for PSD for more precise screening and intervention strategies in clinical practice.</p><p><strong>Methods: </strong>This retrospective study analyzed clinical data from 112 patients with ischemic stroke admitted between January 2022 and December 2024. Based on assessments using the Hamilton Rating Scale for Anxiety (HAMA) and Hamilton Rating Scale for Depression (HAMD) at 2 weeks (± 3 days) post-stroke, patients were classified into the PSD group (HAMA ≥ 7 and/or HAMD ≥ 7) and the non-PSD group (HAMA < 7 and HAMD < 7). Observation indicators included psychological assessment, demographic and clinical characteristics, stroke-related clinical indicators, neuroimaging assessments, and laboratory biomarkers. Multivariate logistic regression analysis was used to identify independent risk factors for PSD, and receiver operating characteristic curve analysis was used to evaluate the diagnostic value of potential biomarkers.</p><p><strong>Results: </strong>Of the 112 patients, 46 (41.1%) were diagnosed with PSD. Multivariate analysis identified five independent risk factors: Female gender [Odds ratio (OR) = 2.32, 95% confidence interval (CI): 1.56-3.45], history of mental disorders prior to stroke (OR = 3.17, 95%CI: 1.89-5.32), infarct location in the frontal lobe or limbic system (OR = 2.86, 95%CI: 1.73-4.71), stroke severity with National Institutes of Health Stroke Scale ≥ 8 at admission (OR = 2.54, 95%CI: 1.62-3.99), and low social support (Social Support Rating Scale < 35, OR = 2.18, 95%CI: 1.42-3.36). Subgroup analysis showed that depression patients more commonly had left hemisphere lesions (68.4% <i>vs</i> 45.2%), while anxiety patients more frequently presented with right hemisphere lesions (59.5% <i>vs</i> 39.5%). The PSD group exhibited larger infarct volumes (8.7 cm³ <i>vs</i> 5.3 cm³), more severe white matter hyperintensities, and more pronounced frontal lobe atrophy. Analysis of inflammatory markers showed significantly elevated levels of interleukin-6 (7.8 pg/mL <i>vs</i> 4.5 pg/mL) and tumor necrosis factor-alpha (15.6 pg/mL <i>vs</i> 9.8 pg/mL) in the PSD group, while hypothalamic-pituitary-adrenal axis function assessment revealed higher cortisol levels (386.5 ± 92.3 nmol/L <i>vs</i> 328.7 ± 75.6 nmol/L) and flattened diurnal rhythm in the PSD group.</p><p><strong>Conclusion: </strong>PSD is a complex neuropsychiatric consequence of stroke involving disruption of the frontal-limbic circuitry, neuroinflammatory responses, and dysfunction of the hypothalamic-pituitary-adrenal axis.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"16 1","pages":"113104"},"PeriodicalIF":3.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}