Jin Lin, Si-Tong Feng, Zi-Yao Wu, Lin-Rui Dong, Dong-Qing Yin, Hong Zhu, Hong-Xiao Jia, Yan-Zhe Ning
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Interaction between the brain and multiple organ systems in schizophrenia.
Schizophrenia is characterized by psychotic symptoms, negative symptoms, and cognitive deficits, profoundly affecting individuals and their families. The etiology is multifactorial, involving genetic, endocrine, and immunological risk factors. It is thought that schizophrenia is exclusively linked to alterations in brain structure and function, while the relationship between the brain and many organs may lack sufficient attention. Increasing evidence indicates abnormalities of the interactions between the brain and many organs in patients with schizophrenia. Inter-organ crosstalk affects the onset, course, and management of schizophrenia. Besides, the complex relationship between autonomic nervous system, endocrine system, and immune system further facilitates the development of schizophrenia. The present review summarizes the relationships between the brain and multiple organ systems in schizophrenia, providing new perspectives on the underlying pathophysiological mechanisms of schizophrenia.
期刊介绍：
The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.
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