World Journal of Psychiatry最新文献

{"title":"Association between anxiety-depression status and psychological resilience in patients with Parkinson's disease: A risk factor analysis.","authors":"Yu-Xiang Cai, Yan-Jin Wang, Jian Liu","doi":"10.5498/wjp.v15.i8.108704","DOIUrl":"10.5498/wjp.v15.i8.108704","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is commonly accompanied by neuropsychiatric symptoms, such as anxiety and depression, which can significantly impair patients' cognitive function, social engagement, and quality of life. Psychological resilience has been identified as a critical factor influencing the severity of these emotional disturbances.</p><p><strong>Aim: </strong>To explore the relationship between anxiety-depression status and psychological resilience in patients with PD and to identify associated risk factors.</p><p><strong>Methods: </strong>A total of 188 consecutive patients with PD treated at our institution between January 2023 and December 2024 were enrolled. Anxiety was assessed using the Beck Anxiety Inventory (BAI), depressive symptoms were measured with the Geriatric Depression scale (GDS), and psychological resilience was evaluated using the Connor-Davidson Resilience Scale (CD-RISC). Pearson correlation analysis was conducted to examine the relationships among these variables. Furthermore, clinical and sociodemographic characteristics-including gender, age, disease duration, disease severity, comorbidity burden, marital status, gross monthly household income, and educational attainment-were analyzed using univariate analysis and multivariate binary logistic regression to identify the factors influencing psychological resilience.</p><p><strong>Results: </strong>The mean BAI score was 22.05 ± 10.52 (indicative of moderate anxiety), the mean GDS score was 15.81 ± 5.49 (mild depression), and the mean CD-RISC score was 51.03 ± 9.32 (moderate resilience). Correlational analysis revealed an inverse relationship between psychological resilience and both anxiety and depression scores, whereas anxiety and depression were positively correlated. Univariate analysis identified disease duration, disease severity, comorbidity burden, gross monthly household income, educational attainment, BAI scores, and GDS scores as variables significantly associated with psychological resilience. Multivariate regression analysis showed that advanced disease stage, a high comorbidity burden, lower gross monthly household income, lower educational attainment, and elevated anxiety and depression scores were independent predictors of reduced psychological resilience.</p><p><strong>Conclusion: </strong>The findings highlight the prevalence of anxiety and depression among patients with PD and the presence of moderate psychological resilience. Patients with advanced disease stages, multiple comorbidities, lower socioeconomic status, limited education, and higher anxiety and depression scores are particularly vulnerable to diminished psychological resilience.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"108704"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking the cycle: Premenstrual and menstrual exacerbation of psychiatric disorders and impact on female mental health.","authors":"Marianna Mazza, Giuseppe Marano","doi":"10.5498/wjp.v15.i8.107132","DOIUrl":"10.5498/wjp.v15.i8.107132","url":null,"abstract":"<p><p>Premenstrual and menstrual exacerbation of psychiatric disorders is a significant area of concern in female mental health. Many females experience a worsening of psychiatric symptoms in the premenstrual and menstrual phases of their menstrual cycle, including heightened anxiety, depression, irritability, and mood swings. These exacerbations are most commonly associated with premenstrual syndrome and premenstrual dysphoric disorder that are characterized by severe emotional and physical symptoms that interfere with daily functioning. The hormonal fluctuations during the menstrual cycle, particularly changes in estrogen and progesterone levels, are believed to play a pivotal role in these exacerbations. Psychiatric disorders such as depression, anxiety, bipolar disorder, and schizophrenia may be influenced by these hormonal changes, with many females reporting an increase in symptom severity during specific phases of the cycle. The mechanisms behind this phenomenon remain complex, with both biological and psychosocial factors contributing to the heightened vulnerability. Clinical management includes careful monitoring of symptom patterns in relation to the menstrual cycle, with treatment options ranging from lifestyle modifications and psychotherapy to pharmacological interventions such as antidepressants and hormonal therapies. Understanding the link between menstruation and psychiatric disorders is essential for improving diagnosis and tailoring effective treatment strategies for affected individuals.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"107132"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and efficacy of quetiapine in patients with high-risk factors for bipolar disorder: A randomized controlled trial.","authors":"Li-Lei Lei, Chen-Jie Ge, Hong Wang, Yu Fang, Lei Zeng, Shi-Liang Wang, Min-Cai Qian","doi":"10.5498/wjp.v15.i8.104221","DOIUrl":"10.5498/wjp.v15.i8.104221","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorder (BD), marked by recurring manic and depressive episodes, often coexists with anxiety disorder (AD), which increases treatment complexity and morbidity. Although quetiapine, an atypical antipsychotic, has demonstrated efficacy in treating BD and AD, further investigation is needed regarding its effectiveness and safety in patients with AD at high-risk factors for BD.</p><p><strong>Aim: </strong>To explore the application and efficacy of quetiapine in combination therapy for patients with AD at high-risk factors for BD.</p><p><strong>Methods: </strong>This study included 67 patients, with two excluded, leaving 65 divided into Group A (sertraline treatment) and Group B (combination treatment). All patients received sertraline, with Group B additionally receiving quetiapine. Efficacy was assessed using the Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), and Bech-Rafaelsen Mania sale (BRMS) throughout the treatment period. Side effects and physiological indicators were also monitored.</p><p><strong>Results: </strong>No significant baseline differences existed between the two groups at treatment onset. Over the treatment course, Group B exhibited significantly lower HAMA scores than Group A at the end of weeks 1 and 24. HAMD scores gradually decreased over time, with Group B consistently showing lower scores than Group A. BRMS scores decreased significantly from baseline by week 8. In Group A, 27.27% of patients received zolpidem treatment compared to 10.53% in Group B, which was a significant difference. Incidence of adverse reactions did not differ significantly between groups at treatment onset, but most patients experienced relief from adverse reactions within 4 weeks.</p><p><strong>Conclusion: </strong>Combination of quetiapine and sertraline can more rapidly alleviate anxiety and depressive symptoms in patients with AD at high-risk factors for BD, improving treatment outcomes.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"104221"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia.","authors":"Yu-Long Bai, Shi-Fa Ma, Dong-Dong Qi, Chuang Guo, Peng Liu, Kuan-Jun He","doi":"10.5498/wjp.v15.i8.107404","DOIUrl":"10.5498/wjp.v15.i8.107404","url":null,"abstract":"<p><p>Schizophrenia (SCZ) is a severe mental disorder with significant impacts on individuals, families, and society. Previous research has indicated that SCZ patients will commonly face substantial impairments in mitochondrial function and oxidative phosphorylation in the brain. Cell-free DNA (cf-DNA), serving as a direct biomarker of apoptosis, offers a valuable vantage point to understand the complex cellular mechanisms underlying SCZ. This review is to explore the role of cf-DNA in the etiology and progression of SCZ and evaluate the potential of cf-DNA within extracellular vesicles (EVs) as a diagnostic biomarker. A review approach was employed to gather and analyze relevant literature on the role of cf-DNA in SCZ, especially focusing on the potential of cf-DNA within EVs as a diagnostic biomarker. This review found that cf-DNA within EVs holds the potential to improve diagnostic methods. It can offer more accurate and sensitive means for detecting SCZ. Moreover, it has the ability to optimize disease management strategies by providing information about the disease state. Also, it can promote the development of pharmacological treatments for SCZ. Integrating cf-DNA analysis into clinical practice can help clinicians utilize cf-DNA levels and its unique characteristics for early and accurate diagnosis. The analysis of cf-DNA, particularly cf-DNA within EVs, has significant potential in the context of SCZ. It can transform our understanding of the disorder, improve diagnostic approaches, optimize disease management, and foster the development of pharmacological treatments.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"107404"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of resilience with anxiety and depression in patients with prostate cancer and analysis of influencing factors.","authors":"Jiang-Lei Qu, Hai-Yang Lu, Xiao-Bo Fu, Wen-Tao Gai","doi":"10.5498/wjp.v15.i8.102835","DOIUrl":"10.5498/wjp.v15.i8.102835","url":null,"abstract":"<p><strong>Background: </strong>The development of prostate cancer (PC) frequently intensifies negative emotional states, such as anxiety and depression, which compromise the effectiveness of radical surgery and reduce treatment adherence. In this study, we hypothesized that psychological resilience plays a crucial role in this process and explored its impact.</p><p><strong>Aim: </strong>To investigate the association of resilience with anxiety and depression in patients with PC and to analyze the influencing factors.</p><p><strong>Methods: </strong>We selected 147 patients with PC who visited Qingdao Traditional Chinese Medicine Hospital from January 2022 to June 2024. The resilience scores of patients with PC were assessed using the Connor-Davidson Resilience Scale (CD-RISC) from the tenacity, self-improvement, and optimism dimensions. Based on the total CD-RISC score, patients were categorized into groups A (total CD-RISC score > 63 points, <i>n</i> = 69) and B (total CD-RISC score ≤ 63 points, <i>n</i> = 78) for comparative analysis of anxiety [Hamilton Anxiety Rating Scale (HAMA)], depression [Hamilton Depression Rating Scale (HAMD)], sexual function [International Index of Erectile Function-5 (IIEF-5) and Sexual Life Quality Questionnaire-Quality of Life (SLQQ-QOL)], and quality of life [the EORTC Core Quality of Life Questionnaire (QLQ-C30)]. The association between CD-RISC and the above indicators was analyzed with Spearman correlation coefficients, and the influencing factors of resilience in patients with PC were identified with binary logistic regression.</p><p><strong>Results: </strong>Group A demonstrated statistically lower HAMA and HAMD scores and markedly higher scores of IIEF-5, SLQQ-QOL, and various QLQ-C30 aspects. Correlation analysis revealed that CD-RISC was significantly negatively correlated with HAMA and HAMD scores and significantly positively correlated with IIEF-5, SLQQ-QOL, and QLQ-C30 total scores. Binary logistic regression analysis revealed educational and per capita monthly household income levels as significant influencing factors of resilience in patients with PC.</p><p><strong>Conclusion: </strong>Our results indicate a significant correlation of resilience with anxiety and depression in patients with PC. The milder the anxiety and depression emotions in patients, the higher their resilience. Further, assisting patients with PC to improve their educational and per capita monthly household income levels will help their resilience to some extent.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"102835"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between sleep disturbances and depressive symptoms in patients after general anesthesia: A retrospective case-control study.","authors":"Xiu-Ping Jia, Qian-Xing Lou, Xiao-Zhen Chen, Yun-Zhen Zhang","doi":"10.5498/wjp.v15.i8.105770","DOIUrl":"10.5498/wjp.v15.i8.105770","url":null,"abstract":"<p><strong>Background: </strong>Evaluating the relationship between sleep quality and depressive symptoms after laparoscopic hysterectomy under general anesthesia can help improve postoperative depressive symptoms.</p><p><strong>Aim: </strong>To evaluate the correlation between sleep quality and depression symptoms in patients after laparoscopic hysterectomy under general anesthesia and explore factors associated with postoperative sleep disturbances and depression.</p><p><strong>Methods: </strong>This retrospective case-control study included 102 females who underwent laparoscopic hysterectomy under general anesthesia at our hospital between January 2022 and June 2024, excluding those with severe cardiovascular/cerebrovascular disease, liver/kidney dysfunction, or other underlying conditions. Sleep quality and depressive symptoms were evaluated preoperatively and at 1-week, 1-month, and 3-months postoperatively using the Pittsburgh Sleep Quality Index (PSQI) and the Hamilton Depression Rating Scale (HAMD). Physiological indicators (heart rate, blood pressure, and oxygen saturation) and laboratory parameters were monitored. Pearson correlation and logistic regression analyses were performed to examine the association between sleep quality and depressive symptoms.</p><p><strong>Results: </strong>Mean age of participants was (52.30 ± 8.39) years, with a body mass index of (23.56 ± 2.79) kg/m². Preoperative comorbidities included hypertension (25.49%), diabetes (14.71%), and heart disease (9.80%). Patients with poor preoperative sleep quality (higher PSQI scores) exhibited significantly more severe depressive symptoms (<i>P</i> < 0.05). Postoperative PSQI scores improved at 1-week, 1-month, and 3-months compared to baseline (<i>P</i> < 0.05). HAMD scores decreased at 1-week and 1-month postoperatively but returned to near preoperative levels at 3-months. Physiological indicators remained within normal ranges, and the postoperative complication rate was < 5%. Logistic regression showed that poor postoperative sleep quality was an independent predictor of depressive symptoms (odds ratio = 1.64, 95%CI: 1.22-2.20, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Sleep quality was significantly correlated with depressive symptoms after laparoscopic hysterectomy under general anesthesia. Patients with poor postoperative sleep quality were more prone to depression. Early interventions for sleep disturbances are potentially beneficial for mitigating depression and improve mental health.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"105770"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can reinforcement learning effectively prevent depression relapse?","authors":"Haewon Byeon","doi":"10.5498/wjp.v15.i8.106025","DOIUrl":"10.5498/wjp.v15.i8.106025","url":null,"abstract":"<p><p>Depression is a prevalent mental health disorder characterized by high relapse rates, highlighting the need for effective preventive interventions. This paper reviews the potential of reinforcement learning (RL) in preventing depression relapse. RL, a subset of artificial intelligence, utilizes machine learning algorithms to analyze behavioral data, enabling early detection of relapse risk and optimization of personalized interventions. RL's ability to tailor treatment in real-time by adapting to individual needs and responses offers a dynamic alternative to traditional therapeutic approaches. Studies have demonstrated the efficacy of RL in customizing e-Health interventions and integrating mobile sensing with machine learning for adaptive mental health systems. Despite these advantages, challenges remain in algorithmic complexity, ethical considerations, and clinical implementation. Addressing these issues is crucial for the successful integration of RL into mental health care. This paper concludes with recommendations for future research directions, emphasizing the need for larger-scale studies and interdisciplinary collaboration to fully realize RL's potential in improving mental health outcomes and preventing depression relapse.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"106025"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.","authors":"Li-Na Zhou, Yan Mao, Bai-Jia Li, Xian-Cang Ma, Wei Wang","doi":"10.5498/wjp.v15.i8.106303","DOIUrl":"10.5498/wjp.v15.i8.106303","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of coronary heart disease (CHD) is higher in patients with depression than in the general population. Recently, multiple novel biomarkers have been proposed to predict CHD risk, and these factors have been reported to be altered in patients with depression.</p><p><strong>Aim: </strong>To explore whether these new biomarkers are associated with an increased risk of CHD in patients with depression.</p><p><strong>Methods: </strong>We recruited 279 healthy controls and 164 sex- and age-matched patients with depression and collected their clinical characteristics and laboratory values of novel cardiovascular biomarkers. The Framingham CHD risk score was used to assess the CHD risk of all individuals, and the cardiovascular markers related to the CHD risk in patients with depression were analyzed.</p><p><strong>Results: </strong>Patients with depression had an increased CHD risk of 5.3% (95% confidence interval: 4.470-6.103) and altered novel cardiovascular biomarkers compared to healthy controls, which included lower levels of thyroid stimulating hormone, albumin, total bilirubin, total cholesterol, high-density lipoprotein cholesterol, and higher levels of triglyceride (TG) and uric acid. Further regression analysis showed that illness duration, family history of depression, serum TG, and urea acid levels were significantly correlated with the Framingham risk score in patients with depression.</p><p><strong>Conclusion: </strong>Patients with depression had a higher CHD risk and that their illness duration, family history of depression, serum TG, and uric acid levels could play important roles in predicting CHD risk. Moreover, elevated CHD risk in patients with depression was not only related to physiological changes caused by depression but also to their genetic susceptibility.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"106303"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluctuating course of attention-deficit/hyperactivity disorder across development: Multifactorial influences.","authors":"Xi-Wen Zeng, Lan-Fang Hu, Xiao-Lan Cao, Bin-Rang Yang, Zhao-Min Wu","doi":"10.5498/wjp.v15.i8.107780","DOIUrl":"10.5498/wjp.v15.i8.107780","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) is increasingly conceptualized as a dynamic neurodevelopmental condition, marked by fluctuating symptom trajectories across development rather than the traditional static patterns of persistence or remission. This review synthesizes empirical evidence on the varied trajectories of ADHD symptoms-including late-onset, partial remission, and recurrent fluctuation patterns-and underscores their clinical significance in long-term functioning. We adopt a multifactorial framework to explore how genetic, environmental, and gene-environment interactions contribute to the emergence and evolution of ADHD symptoms over time. In addition, we consider how medication-related variables-particularly tolerance and adherence-may influence symptom fluctuation. Characterizing these developmental dynamics offers critical guidance for designing flexible, personalized interventions that align with individual trajectories and transitional vulnerabilities.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"107780"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and risk factor analysis of anxiety and depression in patients with lower extremity arteriosclerosis obliterans.","authors":"Xiao-Gao Wang, Ying Wang, Yong Gao, Ran Lu, Ze-Yu Guan, Shi-Yuan Chen","doi":"10.5498/wjp.v15.i8.105760","DOIUrl":"10.5498/wjp.v15.i8.105760","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The prevalence of lower extremity arteriosclerosis obliterans (LEASO) in China is progressively increasing with the increment in age. Certain patients may be diagnosed with lower extremity arterial stenosis and occlusion that resist complete curative efforts, which will invariably impose a substantial psychological strain on them.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the anxiety and depression conditions among patients with LEASO and analyze the associated risk factors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The Affiliated Hospital of Bengbu Medical University from January 2019 to December 2022. Their demographic and clinical data were obtained through the basic information questionnaire. The social support situation was assessed with the social support rating scale, and the hospital anxiety and depression scale were used to analyze their depression and anxiety levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The prevalence rate of anxiety was 44.0% among the 159 patients, with a total Self-Rating Anxiety Scale score of 49.01 ± 9.65. The incidence of depression was 40.9%, and the total self-rating depression scale score reached 49.91 ± 9.18. The overall social support score for all participants averaged 24.82 ± 5.80. The correlation analysis between social support scores and anxiety and depression scores revealed that the total social support score, subjective social support, objective social support, as well as the degree of social support utilization, all exhibited a significant negative correlation with the anxiety and depression scores, which was statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The univariate analysis revealed statistically significant differences in the depression and anxiety states among patients with varying pain manifestations, disease stages, disease durations, and social support magnitudes (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The multivariate analysis further demonstrated that patients presenting with intermittent claudication, rest pain, and pain, whose disease course was within half a year, and who had relatively low social support, were more predisposed to anxiety. Intriguingly, a monthly income of &gt; 6000 yuan was considered a protective factor in this context (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Similarly, patients with intermittent claudication, rest pain, gangrene, and pain, and who had relatively low social support, were more liable to succumb to depressive moods (&lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients with LEASO typically receive relatively scant social support. Notably, those who concurrently present with symptoms, such as pain, claudication, and gangrene, are at a substantially increased risk of developing depression and anxiety disorders. A significant negative correlation is manifested between the social support level that patients receive and the severity of their anxiety and depression symptoms. Hence, the lower the social support score, the greater the propensity for patients to experience anxiety an","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 8","pages":"105760"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}