Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.

IF 3.4 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2025-08-19 DOI:10.5498/wjp.v15.i8.106303

Li-Na Zhou, Yan Mao, Bai-Jia Li, Xian-Cang Ma, Wei Wang

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Abstract

Background: The prevalence of coronary heart disease (CHD) is higher in patients with depression than in the general population. Recently, multiple novel biomarkers have been proposed to predict CHD risk, and these factors have been reported to be altered in patients with depression.

Aim: To explore whether these new biomarkers are associated with an increased risk of CHD in patients with depression.

Methods: We recruited 279 healthy controls and 164 sex- and age-matched patients with depression and collected their clinical characteristics and laboratory values of novel cardiovascular biomarkers. The Framingham CHD risk score was used to assess the CHD risk of all individuals, and the cardiovascular markers related to the CHD risk in patients with depression were analyzed.

Results: Patients with depression had an increased CHD risk of 5.3% (95% confidence interval: 4.470-6.103) and altered novel cardiovascular biomarkers compared to healthy controls, which included lower levels of thyroid stimulating hormone, albumin, total bilirubin, total cholesterol, high-density lipoprotein cholesterol, and higher levels of triglyceride (TG) and uric acid. Further regression analysis showed that illness duration, family history of depression, serum TG, and urea acid levels were significantly correlated with the Framingham risk score in patients with depression.

Conclusion: Patients with depression had a higher CHD risk and that their illness duration, family history of depression, serum TG, and uric acid levels could play important roles in predicting CHD risk. Moreover, elevated CHD risk in patients with depression was not only related to physiological changes caused by depression but also to their genetic susceptibility.

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抑郁症患者Framingham风险评分的新生物标志物：一项横断面研究。

背景：抑郁症患者冠心病（CHD）的患病率高于普通人群。最近，人们提出了多种新的生物标志物来预测冠心病的风险，据报道，这些因素在抑郁症患者中发生了改变。目的：探讨这些新的生物标志物是否与抑郁症患者冠心病风险增加有关。方法：招募279名健康对照和164名性别和年龄匹配的抑郁症患者，收集其临床特征和新型心血管生物标志物的实验室值。采用Framingham冠心病风险评分评估所有个体的冠心病风险，并分析抑郁症患者与冠心病风险相关的心血管标志物。结果：与健康对照组相比，抑郁症患者冠心病风险增加5.3%(95%可信区间：4.470-6.103)，新型心血管生物标志物发生改变，包括促甲状腺激素、白蛋白、总胆红素、总胆固醇、高密度脂蛋白胆固醇水平降低，甘油三酯（TG）和尿酸水平升高。进一步回归分析发现，病程、抑郁症家族史、血清TG、尿素水平与抑郁症患者Framingham风险评分显著相关。结论：抑郁症患者有较高的冠心病风险，病程、抑郁家族史、血清TG、尿酸水平是预测冠心病风险的重要因素。此外，抑郁症患者冠心病风险升高不仅与抑郁症引起的生理变化有关，而且与其遗传易感性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.