Interaction between the brain and multiple organ systems in schizophrenia.

IF 3.4 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2025-08-19 DOI:10.5498/wjp.v15.i8.107696

Jin Lin, Si-Tong Feng, Zi-Yao Wu, Lin-Rui Dong, Dong-Qing Yin, Hong Zhu, Hong-Xiao Jia, Yan-Zhe Ning

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Abstract

Schizophrenia is characterized by psychotic symptoms, negative symptoms, and cognitive deficits, profoundly affecting individuals and their families. The etiology is multifactorial, involving genetic, endocrine, and immunological risk factors. It is thought that schizophrenia is exclusively linked to alterations in brain structure and function, while the relationship between the brain and many organs may lack sufficient attention. Increasing evidence indicates abnormalities of the interactions between the brain and many organs in patients with schizophrenia. Inter-organ crosstalk affects the onset, course, and management of schizophrenia. Besides, the complex relationship between autonomic nervous system, endocrine system, and immune system further facilitates the development of schizophrenia. The present review summarizes the relationships between the brain and multiple organ systems in schizophrenia, providing new perspectives on the underlying pathophysiological mechanisms of schizophrenia.

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精神分裂症患者大脑与多器官系统的相互作用。

精神分裂症的特点是精神病性症状、阴性症状和认知缺陷，严重影响个人及其家庭。病因是多因素的，涉及遗传、内分泌和免疫危险因素。人们认为精神分裂症只与大脑结构和功能的改变有关，而大脑和许多器官之间的关系可能缺乏足够的重视。越来越多的证据表明，精神分裂症患者的大脑和许多器官之间的相互作用异常。器官间的相互作用影响精神分裂症的发病、病程和治疗。此外，自主神经系统、内分泌系统和免疫系统之间的复杂关系进一步促进了精神分裂症的发展。本文综述了精神分裂症中脑与多器官系统的关系，为精神分裂症的病理生理机制提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.