{"title":"Severe anxiety, depression, and sleep disorders worsen prognosis in patients with septic shock.","authors":"Jiang-Bo Li, Wei Rong","doi":"10.5498/wjp.v15.i7.107038","DOIUrl":null,"url":null,"abstract":"<p><p>Recent studies have revealed that patients with septic shock and acute skin failure (ASF) exhibit significantly higher levels of inflammatory cytokines, lactate, and C-reactive protein, along with elevated skin mottling score; modified early warning score (MEWS); and anxiety, depression, and Pittsburgh sleep quality index scores compared to those without ASF. Notably, these indicators are significantly correlated. Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9, indicating severe disease progression. Therefore, it is essential to not only manage septic shock but also mitigate anxiety, depression, sleep disorders, and disturbances of consciousness. This article explores the impact of severe anxiety, depression, and sleep disorders on the prognosis of septic shock and discusses intervention strategies.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 7","pages":"107038"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305136/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5498/wjp.v15.i7.107038","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
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Abstract
Recent studies have revealed that patients with septic shock and acute skin failure (ASF) exhibit significantly higher levels of inflammatory cytokines, lactate, and C-reactive protein, along with elevated skin mottling score; modified early warning score (MEWS); and anxiety, depression, and Pittsburgh sleep quality index scores compared to those without ASF. Notably, these indicators are significantly correlated. Patients with septic shock accompanied by ASF tend to have a mean MEWS greater than 9, indicating severe disease progression. Therefore, it is essential to not only manage septic shock but also mitigate anxiety, depression, sleep disorders, and disturbances of consciousness. This article explores the impact of severe anxiety, depression, and sleep disorders on the prognosis of septic shock and discusses intervention strategies.
期刊介绍：
The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.
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