Neuropsychiatric symptoms in the context of hemodynamic disruption during septic shock.

IF 3.4 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2025-07-19 DOI:10.5498/wjp.v15.i7.105992

Hai-Ning Li, Jia-Lin Wang, Wei Chen

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Abstract

Background: Septic shock represents one of the most severe critical illness types, characterized by significant hemodynamic disorders and neuropsychiatric symptoms. This study aimed to investigate the association mechanism between hemodynamic indicators and neuropsychiatric symptoms in patients with septic shock, revealing potential pathophysiological connections.

Aim: To investigate the link between hemodynamic parameters and neuropsychiatric symptoms in septic shock.

Methods: A retrospective case-control study involving 132 patients with septic shock. Multiple assessment tools were employed, including the Confusion Assessment Method, Hospital Anxiety and Depression Scale, Posttraumatic Stress Disorder Scale, and Mini-Mental State Examination, systematically evaluating patients' neuropsychiatric symptoms and hemodynamic indicators.

Results: Patient mean age was 52.4 ± 12.3 years, with 68.5% males. Multivariate analysis revealed significant correlations between neuropsychiatric symptom severity and mean arterial pressure < 65 mmHg [odds ratio (OR) = 2.7], lactate levels > 4 mmol/L (OR = 3.1), and elevated interleukin-6 inflammatory factors (OR = 2.4). Neuropsychiatric symptom incidence rates were: Delirium 37.1%; anxiety 28.8%; depression 24.2%; and posttraumatic stress disorder 19.7%.

Conclusion: Hemodynamic disorders in patients with septic shock are closely associated with neuropsychiatric symptoms, influencing central nervous system function through complex inflammatory and neurotransmitter pathways.

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脓毒性休克中血流动力学中断的神经精神症状

背景：感染性休克是最严重的危重疾病类型之一，其特征是明显的血流动力学障碍和神经精神症状。本研究旨在探讨脓毒性休克患者血流动力学指标与神经精神症状的关联机制，揭示其潜在的病理生理联系。目的：探讨感染性休克患者血流动力学参数与神经精神症状的关系。方法：对132例脓毒性休克患者进行回顾性病例对照研究。采用《困惑评定法》、《医院焦虑抑郁量表》、《创伤后应激障碍量表》、《精神状态小量表》等多种评估工具，系统评估患者神经精神症状及血流动力学指标。结果：患者平均年龄52.4±12.3岁，男性占68.5%。多因素分析显示，神经精神症状严重程度与平均动脉压< 65 mmHg[比值比(OR) = 2.7]、乳酸水平bbbb4 mmol/L （OR = 3.1）、白细胞介素-6炎症因子升高（OR = 2.4）有显著相关性。神经精神症状发生率为：谵妄37.1%；焦虑28.8%;抑郁症的24.2%;创伤后应激障碍19.7%。结论：脓毒性休克患者血流动力学障碍与神经精神症状密切相关，通过复杂的炎症和神经递质通路影响中枢神经系统功能。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.