World journal of radiology最新文献

{"title":"Advances in ultrasound-based imaging for diagnosis of endometrial cancer.","authors":"Mohamad Tlais, Hussein Hamze, Ali Hteit, Karim Haddad, Issam El Fassih, Issa Zalzali, Sally Mahmoud, Sabine Karaki, Diana Jabbour","doi":"10.4329/wjr.v17.i9.111493","DOIUrl":"10.4329/wjr.v17.i9.111493","url":null,"abstract":"<p><strong>Background: </strong>Endometrial cancer (EC) is the most common gynecological malignancy in high-income countries, with incidence rates rising globally. Early and accurate diagnosis is essential for improving outcomes. Transvaginal ultrasound (TVUS) remains a cost-effective first-line tool, and emerging techniques such as three-dimensional (3D) ultrasound (US), contrast-enhanced US (CEUS), elastography, and artificial intelligence (AI)-enhanced imaging may further improve diagnostic performance.</p><p><strong>Aim: </strong>To systematically review recent advances in US-based imaging techniques for the diagnosis and staging of EC, and to compare their performance with magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>A systematic search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify studies published between January 2010 and March 2025. Eligible studies evaluated TVUS, 3D-US, CEUS, elastography, or AI-enhanced US in EC diagnosis and staging. Methodological quality was assessed using the QUADAS-2 tool. Sensitivity, specificity, and area under the curve (AUC) were extracted where available, with narrative synthesis due to heterogeneity.</p><p><strong>Results: </strong>Forty-one studies met the inclusion criteria. TVUS demonstrated high sensitivity (76%-96%) but moderate specificity (61%-86%), while MRI achieved higher specificity (84%-95%) and superior staging accuracy. 3D-US yielded accuracy comparable to MRI in selected early-stage cases. CEUS and elastography enhanced tissue characterization, and AI-enhanced US achieved pooled AUCs up to 0.91 for risk prediction and lesion segmentation. Variability in performance was noted across modalities due to patient demographics, equipment differences, and operator experience.</p><p><strong>Conclusion: </strong>TVUS remains a highly sensitive initial screening tool, with MRI preferred for definitive staging. 3D-US, CEUS, elastography, and AI-enhanced techniques show promise as complementary or alternative approaches, particularly in low-resource settings. Standardization, multicenter validation, and integration of multi-modal imaging are needed to optimize diagnostic pathways for EC.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 9","pages":"111493"},"PeriodicalIF":1.5,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-cardiac arrest imaging: Unraveling etiology and predicting neurological outcome.","authors":"George Latsios, Elias Sanidas, Maria Velliou, Marina Kalogridaki, Pavlos Bounas, Andreas Synetos, Constantina Aggeli, Konstantinos Toutouzas, Costas Tsioufis","doi":"10.4329/wjr.v17.i9.111884","DOIUrl":"10.4329/wjr.v17.i9.111884","url":null,"abstract":"<p><p>Cardiac arrest is associated with high rates of mortality and significant long-term neurological disability in survivors. Timely and accurate assessment following successful resuscitation is critical for optimizing outcomes. Imaging plays a central role in this evaluation process, providing crucial insights into the etiology of arrest, the extent of cerebral and cardiac injury, and guiding both acute management and long-term prognostication. A structured, multimodal imaging approach utilizing tools such as computed tomography, magnetic resonance imaging, echocardiography, and angiography is increasingly recognized as essential in the post-cardiac arrest setting. This review aims to consolidate current evidence related to the use of various imaging modalities across neurological, cardiac and systemic contexts. Particular emphasis is placed on the prognostic value and optimal timing of neuroimaging, the detection of potentially reversible causes of arrest, such as coronary occlusion or pulmonary embolism, and the emerging role of whole-body imaging in evaluating patients with non-traumatic out-of-hospital cardiac arrest.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 9","pages":"111884"},"PeriodicalIF":1.5,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-low dose computed tomography chest <i>vs</i> chest radiography in paediatric primary ciliary dyskinesia: A prospective study.","authors":"Michael G Waldron, Patrick W O'Regan, Michael Lane, Sahil S Shet, Eid Kakish, Fiachra Moloney, Niamh Moore, Mary Jane Murphy, Louise Beagan, Barry J Plant, David Mullane, Muireann Ni Chroinin, David J Ryan, Kevin O'Regan, Stephen P Power, Michael M Maher","doi":"10.4329/wjr.v17.i8.110407","DOIUrl":"10.4329/wjr.v17.i8.110407","url":null,"abstract":"<p><strong>Background: </strong>Primary ciliary dyskinesia (PCD) is a rare condition characterised by dysmotile, immotile, or absent cilia. As a result of the impairment in respiratory mucociliary clearance, patients with PCD typically develop neonatal respiratory distress, nasal congestion, otitis media and recurrent respiratory infections leading to bronchiectasis and structural lung changes. These changes have been shown by chest computed tomography (CT) to develop in infancy and early childhood. Recent development and refinement of radiation-reducing CT techniques have allowed significant radiation dose reductions, with chest CT doses now in the range of chest radiography (CR).</p><p><strong>Aim: </strong>To evaluate the efficacy of ultra-low dose CT (ULDCT) chest in identifying pulmonary changes within a PCD paediatric patient cohort.</p><p><strong>Methods: </strong>Paediatric patients with PCD who presented for routine clinical outpatient follow-up within the study period, were eligible for inclusion in the study. ULDCT and CR were performed on these patients and the results compared. Comparison metrics included radiation dose, subjective and objective image quality and disease severity.</p><p><strong>Results: </strong>Six paediatric patients (mean age 9 years) underwent clinically indicated ULDCT chest examinations and CR for surveillance of their PCD. The mean effective dose was 0.08 ± 0.02 mSv, a dose that approximates that of a frontal and lateral chest radiograph. The average Brody II score across the entire cohort was 12.92, with excellent inter-rater reliability and intra-class correlation coefficient (ICC) of 0.98. The average Chrispin-Norman score on CR was 1 with excellent inter-rater reliability and ICC of 0.92.</p><p><strong>Conclusion: </strong>ULDCT demonstrates superior diagnostic capabilities, minimal radiation dose penalty, and high interobserver reliability in comparison to CR. Thus, we advocate for ULDCT to be the preferred modality for surveillance imaging in paediatric PCD.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"110407"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of arterial spin-labeling perfusion in anoxic brain injury: A retrospective cohort study.","authors":"Bryce D Beutler, Daniel Antwi-Amoabeng, Dane Weinert, Ishan Shah, Mark B Ulanja, Alastair E Moody, Xiaomeng Lei, Alexander Lerner, Mark S Shiroishi, Reza Assadsangabi","doi":"10.4329/wjr.v17.i8.111065","DOIUrl":"10.4329/wjr.v17.i8.111065","url":null,"abstract":"<p><strong>Background: </strong>Anoxic brain injury is a potentially lethal condition characterized by cerebral hypoperfusion and irreversible neuronal injury. Arterial spin-labeling (ASL) perfusion and diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) have been proposed as tools to detect cerebral ischemic changes and may aid in the assessment of anoxic injury.</p><p><strong>Aim: </strong>To explore the relationship between regional ASL perfusion patterns and clinical outcomes following cardiac arrest.</p><p><strong>Methods: </strong>We performed a retrospective review to identify patients with clinical suspicion of anoxic brain injury who underwent MRI within 15 days of cardiac arrest. Receiver operator characteristic (ROC) analysis and univariate logistic regression were used to evaluate associations between ASL perfusion scores, DWI signal intensity, and the following clinical features: (1) Myoclonus status epilepticus (MSE) within 24 hours; (2) Absent extensor or motor reflexes (EMR) at day 3 post-arrest; and (3) Absent brainstem reflexes (BSR) within 15 days.</p><p><strong>Results: </strong>Twenty-eight patients met inclusion criteria. Increased ASL signal in the left occipital lobe was significantly associated with MSE (<i>P</i> = 0.038), while a trend was observed between right frontal ASL signal and EMR (<i>P</i> = 0.078). ROC analysis showed that ASL scores ≥ 7 were associated with higher odds of absent BSR (OR 2.14, <i>P</i> = 0.53), though this did not reach statistical significance. DWI signal intensity did not show significant associations with clinical outcomes. The overall discriminatory performance of ASL for predicting outcomes was limited (AUC ≈ 0.52).</p><p><strong>Conclusion: </strong>This exploratory study suggests that regional ASL hyperperfusion, particularly in the left occipital and right frontal lobes, may be associated with adverse clinical signs following cardiac arrest. However, most findings did not reach statistical significance, and the study was underpowered to detect small-to-moderate effects. These preliminary results should be interpreted with caution and considered hypothesis-generating. Larger, prospective studies are warranted to clarify the prognostic value of ASL perfusion imaging in anoxic brain injury.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"111065"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and validating a computed tomography radiomics strategy to predict lymph node metastasis in pancreatic cancer.","authors":"Shuai Ren, Bin Qin, Marcus J Daniels, Liang Zeng, Ying Tian, Zhong-Qiu Wang","doi":"10.4329/wjr.v17.i8.109373","DOIUrl":"10.4329/wjr.v17.i8.109373","url":null,"abstract":"<p><strong>Background: </strong>Lymph node metastasis (LNM) is a key prognostic factor in pancreatic cancer (PC). Accurate preoperative prediction of LNM remains challenging. Radiomics offers a noninvasive method to extract quantitative imaging features that may aid in predicting LNM.</p><p><strong>Aim: </strong>To investigate the potential value of a computed tomography (CT)-based radiomics model in prediction of LNM in PC.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 168 pathologically confirmed PC patients who underwent contrast-enhanced-CT. Among them, 107 cases had no LNM, while 61 cases had confirmed LNM. These patients were randomly divided into a training cohort (<i>n</i> = 135) and a validation cohort (<i>n</i> = 33). A total of 792 radiomics features were extracted, comprising 396 features from the arterial phase and another 396 from the portal venous phase. The Minimum Redundancy Maximum Relevance and Least Absolute Shrinkage and Selection Operator methods were used for feature selection and Radiomics model construction. The receiver operating characteristic curve was employed to assess the diagnostic potential of the model, and DeLong test was used to compare the area under the curve (AUC) values of the model.</p><p><strong>Results: </strong>Six radiomics features from the arterial phase and nine from the portal venous phase were selected. The Radscore model demonstrated strong predictive performance for LNM in both the training and test cohorts, with AUC values ranging from 0.86 to 0.94, sensitivity between 66.7% and 91.7%, specificity from 71.4% to 100.0%, accuracy between 78.8% and 91.1%, PPV ranging from 64.7% to 100.0%, and negative predictive value between 84.0% and 93.8%. No significant differences in AUC values were observed between the arterial and portal venous phases in either the training or test set.</p><p><strong>Conclusion: </strong>The preoperative CT-based radiomics model exhibited robust predictive capability for identifying LNM in PC.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"109373"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of imaging in chronic otitis media and its complications.","authors":"Kemal Bugra Memis, Sonay Aydin","doi":"10.4329/wjr.v17.i8.109447","DOIUrl":"10.4329/wjr.v17.i8.109447","url":null,"abstract":"<p><p>Chronic otitis media (COM) is a long-standing inflammatory condition affecting the middle ear and mastoid cavity, often resulting in progressive structural damage and functional deficits. Radiological imaging is fundamental in diagnosing the disease, assessing its severity, and identifying possible complications. The literature indicates that the prevalence rates of extracranial and intracranial complications range from 0.69% to 5%, while the mortality rate for intracranial complications is 26%. While magnetic resonance imaging is particularly useful in distinguishing soft tissue abnormalities and detecting intracranial extensions like meningitis, brain abscess, and sigmoid sinus thrombosis, high-resolution computed tomography remains the preferred modality for evaluating bony erosion, cholesteatoma, and mastoid involvement. Key complications such as ossicular chain destruction, facial nerve damage, and labyrinthine fistulae can be precisely identified using advanced imaging modalities, allowing for timely and effective surgical intervention. This minireview underscores the essential role of radiology in both diagnosing and managing COM, highlighting critical imaging findings that facilitate early detection and inform treatment decisions. A collaborative approach among radiologists, otolaryngologists, and infectious disease specialists is crucial for improving clinical outcomes in affected patients.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"109447"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of photon-counting CT in oncologic imaging: A systematic review.","authors":"Arosh S Perera Molligoda Arachchige, Anna Dashiell, Anton Shiraan Jesuraj, Antonia Immacolata D'Urso, Benedetta Fiore, Martina Cattaneo, Emilia Pierzynska, Sandra Szydelko, Francesca Romana Centini, Yash Verma","doi":"10.4329/wjr.v17.i8.107732","DOIUrl":"10.4329/wjr.v17.i8.107732","url":null,"abstract":"<p><strong>Background: </strong>Photon-counting detector (PCD) CT represents a transformative advancement in radiological imaging, offering superior spatial resolution, enhanced contrast-to-noise ratio, and reduced radiation dose compared with the conventional energy-integrating detector CT.</p><p><strong>Aim: </strong>To evaluate PCD CT in oncologic imaging, focusing on its role in tumor detection, staging, and treatment response assessment.</p><p><strong>Methods: </strong>We performed a systematic PubMed search from January 1, 2017 to December 31, 2024, using the keywords \"photon-counting CT\", \"cancer\", and \"tumor\" to identify studies on its use in oncologic imaging. We included experimental studies on humans or human phantoms and excluded reviews, commentaries, editorials, non-English, animal, and non-experimental studies. Study selection followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of 175 initial studies, 39 met the inclusion criteria after screening and full-text review. Data extraction focused on study type, country of origin, and oncologic applications of photon-counting CT. No formal risk of bias assessment was performed, and the review was not registered in PROSPERO as it did not include a meta-analysis.</p><p><strong>Results: </strong>Key findings highlighted the advantages of PCD CT in imaging renal masses, adrenal adenomas, ovarian cancer, breast cancer, prostate cancer, pancreatic tumors, hepatocellular carcinoma, metastases, multiple myeloma, and lung cancer. Additionally, PCD CT has demonstrated improved lesion characterization and enhanced diagnostic accuracy in oncology. Despite its promising capabilities challenges related to data processing, storage, and accessibility remain.</p><p><strong>Conclusion: </strong>As PCD CT technology evolves, its integration into routine oncologic imaging has the potential to significantly enhance cancer diagnosis and patient management.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"107732"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological insights into diverticulitis: Clinical manifestations, complications, and differential diagnosis.","authors":"Mehmet Simsar, Yesim Y Yuruk, Olgun Sahin, Hilal Sahin","doi":"10.4329/wjr.v17.i8.107463","DOIUrl":"10.4329/wjr.v17.i8.107463","url":null,"abstract":"<p><p>Diverticulitis is an infection of the diverticular sacs protruding from the intestinal wall. It typically presents as elevated inflammatory markers and left lower quadrant abdominal pain. Although clinical symptoms and biomarkers are essential for diagnosis, imaging methods, particularly computed tomography (CT), are critical due to the inability to perform endoscopic procedures in the acute phase because of the risk of perforation. Various classification systems that include imaging findings have been developed. The most recent and widely accepted system is the Sartelli classification, which is endorsed by the World Society of Emergency Surgery. This classification describes stages of diverticulitis ranging from edematous bowel wall thickening and phlegmon in the adjacent mesentery to microperforation, localized or distant abscess formation, and generalized peritonitis with free fluid and air. Imaging findings are also pivotal in diagnosing and managing complications such as abscesses, pylephlebitis, fistulas, and gastrointestinal bleeding. Moreover, imaging can differentiate diverticulitis from infectious colitis, epiploic appendagitis, ischemic colitis, colorectal carcinoma, and inflammatory bowel disease. This review focuses on the radiological findings of diverticulitis. We specifically discuss CT imaging and emphasize its clinical manifestations, significant complications, and differential diagnosis.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"107463"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does ultrasound detect joint and intestinal changes in psoriatic arthritis and ulcerative colitis after immunobiological treatment: A case report.","authors":"José Alexandre Mendonça, José Luís Braga de Aquino","doi":"10.4329/wjr.v17.i8.109146","DOIUrl":"10.4329/wjr.v17.i8.109146","url":null,"abstract":"<p><strong>Background: </strong>Ultrasound (US) can be a valuable tool for assessing arthritis associated with inflammatory bowel disease (IBD), especially in cases of psoriatic disease. The clinical case reviewed in this article addresses an exploratory finding that evaluates the effects of immunobiological treatments on dactylitis and IBD with the use of US techniques.</p><p><strong>Case summary: </strong>A 40-year-old Caucasian woman with psoriatic arthritis (PsA) and ulcerative colitis (UC) reported experiencing finger pain, knee arthritis, and bloody diarrhea. She showed a high Disease Activity index for PsA score and a severe Mayo score. She began treatment with adalimumab. Over the course of six months, the 18 MHz US procedure was performed on her joints and a 3.5 MHz US on her intestines. The joint US indicated dactylitis and swelling in her finger joints, while the intestinal US revealed 6.6 mm swelling in the sigmoid colon, increased abdominal fat, and high Doppler signal. Her fecal calprotectin level was 5984 mg/kg, and a colonoscopy showed that UC extended to the hepatic flexure, along with mild narrowing of the transverse colon. After six months treatment, all parameters showed improvement, including a remission of the Mayo score, better colonoscopy results, and Limberg score of 0.</p><p><strong>Conclusion: </strong>More research is needed to find out the importance of using US in patients with PsA and UC as this could improve treatment strategies.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"109146"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic radiotherapy for brain metastases of non-small cell lung cancer: A comprehensive review.","authors":"Aamir Khan, Hong-Fu Zhao, Hao Meng, Ning Wu, Lin-Lin Liu","doi":"10.4329/wjr.v17.i8.111076","DOIUrl":"10.4329/wjr.v17.i8.111076","url":null,"abstract":"<p><p>Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related death globally, and a significant number of patients develop brain metastasis (BM) as the disease progresses. The presence of BM, which affects up to 60% of patients with NSCLC, is correlated with an unfavorable prognosis and markedly decreased quality of life. Standard treatment options for BMs, such as whole-brain radiation therapy and surgery, have displayed limited efficacy in controlling disease progression, and they can cause significant neurocognitive side effects. Stereotactic radiotherapy (SRT), including stereotactic radiosurgery, fractionated SRT, and stereotactic body radiotherapy, represents an advanced and precise approach for treating BM that minimizes damage to surrounding healthy tissues. This review highlights recent advances in the application of SRT for treating BM of NSCLC, focusing on its underlying biological principles and mechanisms of action as well as the quality standards necessary for effective SRT implementation. The ability of SRT to deliver substantial radiation doses in a precisely targeted manner has resulted in better local tumor management, fewer side effects, and increased patient survival rates. Future research is crucial to improve SRT procedures and successfully incorporate them into multimodal therapy plans for patients with NSCLC and BM.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"17 8","pages":"111076"},"PeriodicalIF":1.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}