Acta Biomaterialia最新文献

{"title":"Engineering multifunctional catheters with a nitric oxide-releasing ciprofloxacin conjugate to combat thrombosis and infection","authors":"Myddelton C. Parker,&nbsp;Sumit Kumar,&nbsp;Isabel Martinez,&nbsp;Vicente D. Pinon,&nbsp;Meghan Lancaster,&nbsp;Chad Schmiedt,&nbsp;Elizabeth J. Brisbois,&nbsp;Hitesh Handa","doi":"10.1016/j.actbio.2026.07.063","DOIUrl":"10.1016/j.actbio.2026.07.063","url":null,"abstract":"<div><div>Indwelling medical devices, such as intravenous and urinary catheters, have significantly enhanced patient care and greatly improved treatment outcomes. Despite rapid advances in medical devices, infection and thrombosis continue to pose major challenges to device functionality and integrity. Given that current treatments often involve systemic administration of antibiotics and anticoagulants, there is an urgent need for medical devices that are inherently antibacterial and antithrombotic. We explore the chemical conjugation of the nitric oxide (NO) donor <em>S</em>-nitroso-<em>N</em>-acetylpenicillamine (SNAP) with the fluoroquinolone-based, broad-spectrum antibiotic Ciprofloxacin (CIP). The combination strategy integrates the directed antibacterial activity of CIP with the antithrombotic and antibiofilm properties of NO. Furthermore, the conjugate molecule (SNAP-CIP) was incorporated into silicone rubber (SR) for catheter fabrication (SR-SNAP-CIP). SR-SNAP-CIP demonstrated 14-day NO-release while remaining biocompatible. The NO release allowed SR-SNAP-CIP to reduce platelet adhesion <em>in vitro</em> by ∼45%. The dual-action material exhibited antibacterial properties when tested <em>in vitro</em> for bacterial adhesion (24 h and 14-day CDC bioreactor), planktonic viability, and biofilm biomass accumulation against <em>S. aureus</em> and <em>E. coli</em>. To assess bacterial migration across the skin barrier, an <em>ex vivo</em> skin translocation model was performed, which showed no bacterial migration on the SR-SNAP-CIP catheter. After the 14-day <em>in vivo</em> rabbit catheter model, SR-SNAP-CIP showed a significant reduction (∼84%) in thrombus area on the catheter and surrounding vein. Furthermore, SR-SNAP-CIP catheters showed a 92% reduction in adhered <em>S. aureus.</em> Overall, SR-SNAP-CIP demonstrated a combination of technologies, harnessing the antibacterial potential of CIP and the antibiofilm and antithrombotic properties of NO.</div></div><div><h3>Statement of significance</h3><div>Despite advancements in biomaterial design, catheter-associated thrombosis and infection persist as primary drivers of device failure and patient morbidity, highlighting the critical need for dual-functioning anti-thrombogenic and antimicrobial interventions. Materials capable of addressing both challenges simultaneously are vital to the development of next-generation, hemocompatible catheter biomaterials. In this work, we present the incorporation of a nitric oxide (NO)-releasing Ciprofloxacin conjugate molecule into a polymer platform to achieve extended NO release and robust antiplatelet activity. The resulting platform demonstrated antibacterial performance <em>in vitro</em>, while remaining cyto- and hemo-compatible. Furthermore, these antibacterial and antithrombotic effects were sustained in a 14-day <em>in vivo</em> rabbit catheter model, indicating strong potential for clinical translation.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 185-197"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ swelling of hydrogel microneedles facilitates suprachoroidal space expansion for targeted delivery of TOP-V122 to the posterior segment","authors":"Ahhyun Lee,&nbsp;Sohyun Park,&nbsp;Jaan Strang,&nbsp;Tobias Braun,&nbsp;Huisuk Yang,&nbsp;Reto Naef,&nbsp;Hyungil Jung","doi":"10.1016/j.actbio.2026.07.067","DOIUrl":"10.1016/j.actbio.2026.07.067","url":null,"abstract":"<div><div>Posterior segment eye diseases are leading causes of vision impairment, yet current treatments such as intravitreal injections require frequent administration and carry risks of complications, including endophthalmitis and retinal detachment, highlighting the need for minimally invasive and controllable alternatives. Here, we present an improved hydrogel-forming microneedle (HFMN) platform composed of 20% poly(methyl vinyl ether-alt-maleic acid) and 7.5% poly(ethylene glycol) for minimally invasive, targeted drug delivery to the posterior segment via the suprachoroidal space. A dispensing-based drug-loading method reduced the required drug volume from 4 mL to 50 μL (∼80-fold), enabling precise dosing of expensive ophthalmic agents. We employed TOP-V122, a clinically relevant hydrophobic compound that releases nitric oxide and inhibits phosphodiesterase 5, addressing the limitations of prior hydrophilic model-drug studies. The platform exhibited sufficient mechanical strength for scleral penetration (2.49 N per needle) and biocompatibility (higher ARPE-19 cell viability than free drug). Validation included ex vivo drug permeation studies using Nile red as a fluorescent tracer, in vitro cytotoxicity assays, and a short-term in vivo rabbit feasibility study. The platform enabled rapid ex vivo V122 permeation across porcine scleral tissue, with 64.6 ± 10.5% of loaded drug detected within 30 min, and supported suprachoroidal space-associated fluorescence distribution after short-term ex vivo application. In the rabbit study, 15-min V122-HFMN application reduced intraocular pressure and increased ocular cyclic guanosine monophosphate levels, without overt acute histological damage at the insertion site. These findings support HFMNs as a promising platform for rapid, short-duration posterior segment therapy, potentially improving patient compliance and reducing healthcare burden.</div></div><div><h3>Statement of significance</h3><div>Treating posterior segment eye diseases remains a significant clinical challenge. Repeated intravitreal injections, the standard of care, carry risks of serious complications and impose a substantial burden on patients. Here, we present a hydrogel-forming microneedle platform that penetrates the sclera, swells upon contact with ocular fluid, and transiently opens the suprachoroidal space to enable drug delivery to the posterior segment. A dispensing-based drug-loading method reduces the required drug volume by approximately 80-fold, enabling precise dosing of costly therapeutics. Using a clinically relevant hydrophobic compound with dual vascular activity, we demonstrate rapid, short-duration drug delivery and preliminary outcomes comparable to intravitreal injection, with reduced tissue disruption. This platform offers a practical, minimally invasive alternative for managing blinding posterior segment diseases.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 258-273"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-enabled tissue engineering scaffold classification using cell morphology","authors":"Fatemeh Razaviamri,&nbsp;Clémence Jégard,&nbsp;Amir Rouhollahi,&nbsp;Merlin Dassanayake,&nbsp;Marie Billaud,&nbsp;Amir Sheikhi,&nbsp;Farhad R. Nezami","doi":"10.1016/j.actbio.2026.07.061","DOIUrl":"10.1016/j.actbio.2026.07.061","url":null,"abstract":"<div><div>The physical properties and architecture of biomaterial scaffolds regulate cell morphology and function; however, evaluating these effects is often slow, low-throughput, and destructive, thereby limiting scalable biomaterial design and optimization. We investigated whether quantitative analysis of single-cell three-dimensional (3D) morphology could provide a non-destructive surrogate readout of scaffold type. We analyzed 969 high-resolution 3D reconstructions of human bone marrow stromal cells (hBMSCs) from a publicly available National Institute of Standards and Technology (NIST) dataset. Cells were cultured under ten conditions, grouped by scaffold type: flat two-dimensional (2D) surfaces, fibrous 3D scaffolds, porous 3D sponge scaffolds, and 3D hydrogel scaffolds. Stiffness was treated as contextual metadata rather than a direct classification label. We developed two complementary classifiers. The first was a radiomics pipeline that extracted hand-crafted shape descriptors and used a feed-forward neural network, achieving a best test accuracy of 73.2%. The second employed a ray-tracing pipeline that transformed 3D cell structure into 2D distance-map projections for convolutional neural network (CNN) analysis, achieving 72.7% accuracy. The radiomics model offered greater interpretability, whereas the ray-tracing model captured more subtle morphological features, demonstrating complementary strengths. These findings suggest that single-cell 3D morphology can encode scaffold type under the controlled conditions examined here and may offer a non-destructive basis for biomaterial identification that warrants further validation. Such a framework could potentially accelerate scaffold design, optimization, and automated quality control in tissue engineering applications.</div><div><em>Statement of Significance:</em> Development of advanced biomaterial scaffolds is constrained by characterization methods that are often destructive, labor-intensive, and poorly suited for high-throughput optimization. Here, we present a morphology-based computational framework in which single-cell 3D actin and nuclear morphology is used as a quantitative readout of scaffold-associated cellular phenotype. The method integrates two complementary approaches: an interpretable radiomics pipeline based on 3D geometric descriptors and a ray-tracing pipeline that converts 3D cell morphology into 2D distance maps for convolutional neural network classification. Using nearly 1000 reconstructed human bone marrow stromal cells cultured on flat, fibrous, porous, and hydrogel scaffold conditions, both pipelines classified scaffold architecture with test accuracies of approximately 73%. These findings demonstrate that 3D cell morphology encodes scaffold-associated information and support computational morphotyping as a scalable strategy for biomaterial screening, scaffold quality assessment, and phenotype-guided scaffold prioritization in regenerative medicine.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 243-257"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efferocytosis inhibition enhances the anticancer immune response of hybrid cell membrane-coated nanoparticles","authors":"Tao Huang,&nbsp;Zhibin Qiu,&nbsp;Xuewei Yang,&nbsp;Huahua Zhang,&nbsp;Zekun Zhang,&nbsp;Jin Fang,&nbsp;Mei Tu,&nbsp;Yong Wang","doi":"10.1016/j.actbio.2026.08.010","DOIUrl":"10.1016/j.actbio.2026.08.010","url":null,"abstract":"<div><div>The immunogenic cell death (ICD) of tumor cells generates abundant damage-associated molecular patterns (DAMPs) to induce efficient anti-tumor immune responses. However, dysregulated efferocytosis causes rapid clearance of DAMPs, thereby impeding immunotherapy progression. It has been revealed that the externalization of phosphatidylserine (PS) on apoptotic tumor cells serves as a key signal that drives efferocytosis imbalance. Here, we prepared a nanodrug HM-NP@SF&amp;Xs, using hybrid membranes (HM) of macrophage and hepatocellular carcinoma (HCC) cell coated polymeric micelles incorporating sorafenib (SF) and Xkr8 siRNA. The HM coating prolongs blood circulating and enhances tumor targeting of nanodrugs, leading to efficient drug delivery into tumor. In addition, SF induces HCC apoptosis to trigger tumor ICD, thereby amplifying antitumor immune responses. Most importantly, the efferocytosis of SF-induced DAMPs can be effectively inhibited by Xkr8 siRNA via inhibition of PS exposure. Besides, systemic immune-related side effects of HCC cell membranes and Xkr8 siRNA are effectively reduced. In vitro and in vivo experiments demonstrated that the HM coated nanodrug elicits potent antitumor immune responses through inhibition of efferocytosis and release of inflammatory cytokines. The study provides an innovative strategy for drug delivery to HCC for enhanced immunotherapy against HCC.</div></div><div><h3>Statement of significance</h3><div>Efferocytosis leads to the rapid clearance of immunogenic tumor debris, thereby suppressing anti-tumor immune responses. Herein, a hybrid membrane-coated nanodrug (HM-NP@SF&amp;Xs) is developed to overcome efferocytosis-driven immunosuppression in hepatocellular carcinoma (HCC). By coating sorafenib and Xkr8 siRNA-loaded polymeric micelles with macrophage &amp; tumor cell hybrid membrane, the platform achieves prolonged circulation and tumor-specific drug delivery. Sorafenib induces immunogenic cell death, while Xkr8 siRNA blocks phosphatidylserine externalization to inhibit efferocytosis of apoptotic tumor cells. This dual-action strategy amplifies antitumor immunity while reducing systemic side effects, offering a promising approach for enhanced cancer immunotherapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 488-501"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinone-amine sonosensitizer nanoplatform loaded with a GSDMD-activating agent for dual-pathway pyroptosis-augmented sonodynamic immunotherapy against glioblastoma","authors":"Ziyang Liu,&nbsp;Jiamei Zhao,&nbsp;Yuejia Ding,&nbsp;Zhangwei Yan,&nbsp;Honghuaijin An,&nbsp;Liya Yu,&nbsp;Yehui Kang,&nbsp;Xiangming Ye,&nbsp;Yu Cai,&nbsp;Qing Ye","doi":"10.1016/j.actbio.2026.07.053","DOIUrl":"10.1016/j.actbio.2026.07.053","url":null,"abstract":"<div><div>Glioblastoma (GBM) treatment is limited by the blood-brain barrier (BBB), insufficient sonodynamic efficacy, and an immunosuppressive tumor microenvironment. Here, we developed PG@dOMV, a dOMV-coated nanoplatform co-delivering a quinone-amine polymer sonosensitizer (PQANS) and a GSDMD-activating agent (GA) to integrate sonodynamic therapy with GSDMD-dependent pyroptosis. PQANS exhibited a donor-acceptor structure with a calculated HOMO-LUMO gap of 2.04 eV and a singlet-triplet energy gap of 0.78 eV, supporting ultrasound-responsive generation of singlet oxygen and other DHR123-reactive oxidative species. Under ultrasound irradiation, PG@dOMV activated the ROS/caspase-1/GSDMD-N pathway, whereas GA contributed to GSDMD-dependent membrane permeabilization without detectable GSDMD cleavage. GSDMD knockdown and disulfiram treatment attenuated IL-1β, IL-18, and LDH release, supporting the involvement of GSDMD pore-forming activity. The dOMV coating prolonged systemic retention and increased brain-associated accumulation. In an orthotopic GL261 model, PG@dOMV combined with ultrasound suppressed tumor progression and prolonged survival. CyTOF profiling further revealed treatment-associated remodeling of lymphoid and myeloid populations, including reduced Treg representation and enrichment of CD4⁺, CD8⁺, and effector-memory-like T-cell phenotypes. These findings support a biomaterial-based strategy integrating ultrasound-responsive oxidative damage, GSDMD-dependent pyroptosis, and immune-microenvironment remodeling for glioblastoma treatment.</div></div><div><h3>Statement of significance</h3><div>Glioblastoma remains difficult to treat because many therapeutics do not efficiently reach the brain, sonodynamic therapy alone produces limited tumor damage, and the tumor microenvironment suppresses antitumor immunity. This study develops a dOMV-coated quinone-amine nanoplatform that combines ultrasound-triggered reactive oxygen species generation with GSDMD-dependent pyroptosis through two complementary pathways. The system enhances brain-associated delivery, suppresses orthotopic glioma growth, prolongs survival, and remodels immune-cell populations toward a more antitumor-associated state. Compared with existing sonodynamic platforms, this work links biomimetic delivery, polymer sonosensitization, pyroptotic cell death, and immune modulation in one material system. These findings may interest readers working in biomaterials, nanomedicine, tumor immunology, and brain-cancer therapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 460-475"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering heterogeneous tissues and organs via multi-material bioprinting: Advances, challenges, and opportunities","authors":"Mohan Wu,&nbsp;Miji Yeo,&nbsp;Irem Deniz Derman,&nbsp;Jiacheng Zhang,&nbsp;Zuoxu Hou,&nbsp;Hongxun Sang,&nbsp;Ibrahim T. Ozbolat,&nbsp;Yang Wu","doi":"10.1016/j.actbio.2026.07.051","DOIUrl":"10.1016/j.actbio.2026.07.051","url":null,"abstract":"<div><div>Native tissues and organs exhibit intrinsic heterogeneity in their structural, compositional, and functional properties, which poses significant challenges towards the development of effective functional substitutes. Multi-material three-dimensional (3D) bioprinting has emerged as a promising strategy to address these challenges by enabling enhanced spatial control over the deposition of biomaterials, signaling factors, and diverse cell types. This capability facilitates the fabrication of heterogeneous tissue constructs that aim to approach the complexity of native tissues, although achieving sub-micron biomimicry remains restricted by current hardware limitations. Recent advances, such as the development of multi-nozzle systems, multi-ink platforms, and the incorporation of heterogeneous cell aggregates, have substantially enhanced the capacity to reproduce tissue heterogeneity with greater precision and scalability. This review provides a comprehensive overview of the fundamental concepts and classifications of multi-material bioprinting. Four representative heterogeneous tissues/organs–osteochondral tissue, trachea, liver, and heart–were selected for in-depth discussion, given their rising clinical significance and escalating bioprinting challenges imposed by their structural and physiological complexity. Furthermore, bioprinting of these tissues/organs covers critical concerns including stiffness, interface connection, biological function, and vascularization. In addition, this Review critically examines the current challenges in the field and offers a forward-looking perspective on emerging trends and potential breakthroughs in technologies in the context of multi-material bioprinting.</div></div><div><h3>Statement of Significance</h3><div>This review elaborates on multi-material bioprinting strategies for fabricating heterogeneous tissues and organs. It proposes a classification and definition of heterogeneity at multiple levels, including structural, compositional, and functional aspects, in both native tissues and 3D bioprinting approaches. Moreover, various 3D bioprinting modalities are discussed, encompassing both nozzle-based and nozzle-free techniques, together with their applications in representative heterogeneous organs. This work offers critical insights by addressing current limitations and future opportunities. Together, this review comprehensively categorizes heterogeneous tissue fabrication strategies across diverse multi-material bioprinting approaches, providing a holistic framework for advancing the design and fabrication of next-generation heterogeneous tissues and organs.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 67-94"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A stabilized retro-inverso peptide ligand of transferrin receptor for enhanced liposome-based hepatocellular carcinoma-targeted drug delivery” [Acta Biomaterialia 2019, Volume 83, Pages 379-389]","authors":"Jiajing Tang,&nbsp;Qiantao Wang,&nbsp;Qianwen Yu,&nbsp;Yue Qiu,&nbsp;Ling Mei,&nbsp;Dandan Wan,&nbsp;Xuhui Wang,&nbsp;Man Li,&nbsp;Qin He","doi":"10.1016/j.actbio.2026.07.066","DOIUrl":"10.1016/j.actbio.2026.07.066","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Page 708"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atomically engineered asymmetric nanozymes with enhanced photothermal-catalytic performance for periodontitis therapy and tooth whitening","authors":"Qitao Yu,&nbsp;Yue Zhan,&nbsp;Qiuyu Liu,&nbsp;Renyuan Deng,&nbsp;Wanyu Jin,&nbsp;Cuihong Chen,&nbsp;Yuan Li,&nbsp;Xiangmei Liu,&nbsp;Chaofeng Wang,&nbsp;Yufeng Zheng,&nbsp;Hanpeng Liu,&nbsp;Yongping Cao,&nbsp;Shuilin Wu,&nbsp;Congyang Mao","doi":"10.1016/j.actbio.2026.08.011","DOIUrl":"10.1016/j.actbio.2026.08.011","url":null,"abstract":"<div><div>Conventional periodontitis treatments are constrained by challenges such as antibiotic resistance and inadequate tissue regeneration. Herein, we rationally engineer a robust Fe/Mn bimetallic nanozyme (Fe/Mn-Bzyme) derived from a zeolitic imidazolate framework-8 precursor, featuring atomically asymmetric Fe-Mn dual-atom active sites with the Mn₁-Fe_1<img>O₁−Mn_1<img>N₃ coordination environment meticulously embedded within a nitrogen-doped carbon matrix. This tailored structure endows the nanozyme with peroxidase-like (POD) activity, which is synergistically amplified by robust near-infrared (NIR) photothermal conversion. The NIR-driven localized heating dramatically accelerates catalytic kinetics, orchestrating a tunable burst of hydroxyl radical (•OH) generation from endogenous H₂O₂, which confers robust antibacterial action against <em>Porphyromonas gingivalis</em> (99.47% ± 0.23%) and methicillin-resistant <em>Staphylococcus aureus</em> (99.52% ± 0.27%). Additionally, Fe/Mn-Bzyme demonstrates proactive bioactivity, promoting osteogenic differentiation of pre-osteoblasts and fostering a pro-angiogenic microenvironment. In a rat periodontitis model, a topical Fe/Mn-Bzyme ointment effectively eliminated infections, suppressed pro-inflammatory cytokine expression, mitigated systemic inflammation, and inhibited osteoclast activity, thereby creating a pro‑regenerative microenvironment conducive to subsequent periodontal tissue healing. Furthermore, its robust catalytic activity enabled superior, enamel-preserving tooth whitening compared to conventional H₂O₂. This work presents a versatile nanozyme platform that integrates synergistic antibacterial, anti-inflammatory, and pro-regenerative functions, offering a powerful strategy for managing complex oral diseases.</div></div><div><h3>Statement of significance</h3><div>The significance of this work lies in the rational design of an atomically dispersed bimetallic nanozyme that harnesses synergistic photothermal-catalytic effects for integrated oral disease management. The Fe/Mn-Bzyme outperforms conventional single-function therapies, offering a powerful and translatable strategy that simultaneously addresses infection, inflammation, tissue destruction, and aesthetic concerns.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 502-519"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan” [Acta Biomaterialia, 2016, 31, 186-196.]","authors":"Xingli Cun,&nbsp;Shaobo Ruan,&nbsp;Jiantao Chen,&nbsp;Li Zhang,&nbsp;Jianping Li,&nbsp;Qin He,&nbsp;Huile Gao","doi":"10.1016/j.actbio.2026.08.019","DOIUrl":"10.1016/j.actbio.2026.08.019","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 709-711"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microporous annealed particle scaffold integrated with autologous tumor cells for personalized postsurgical tumor therapy","authors":"Gaizhen Kuang,&nbsp;Wenzhao Li,&nbsp;Feika Bian,&nbsp;Hong Chen,&nbsp;Qingfei Zhang,&nbsp;Yuanjin Zhao","doi":"10.1016/j.actbio.2026.07.052","DOIUrl":"10.1016/j.actbio.2026.07.052","url":null,"abstract":"<div><div>Biomaterial scaffolds hold great potential for addressing tumor recurrence and tissue defects following surgical tumor resection; however, personalized therapy remains a critical barrier to their clinical translation. To address this issue, we developed an autologous tumor cell-integrated microporous annealed particle (MAP) scaffold co-delivering an immune adjuvant and an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor for tumor postoperative therapy. This scaffold was fabricated using microfluidic electrospray combined with step-by-step crosslinking technology. The injectable microspheres, prior to annealing, can be directly delivered into the defect site and conform to its shape upon crosslinking, forming a stabilized, porous structure. Featuring interconnected pores that facilitate cell infiltration and proliferation, the scaffold demonstrated effective tissue repair in mice subjected to full-thickness skin excision. Within the scaffold, cryo-inactivated tumor cells and the immune adjuvant recruit and activate dendritic cells (DCs) <em>in situ</em>, stimulating a robust antitumor immune response. This response is further amplified by the IDO1 inhibitor, which reverses immunosuppression by inhibiting regulatory T cells (Tregs). Consequently, the scaffold exhibited remarkable anti-recurrence efficacy and prolonged survival in a melanoma mouse model. These properties highlight the significant potential of our personalized microporous hydrogel particle scaffold for efficient postoperative antitumor therapy and tissue regeneration.</div></div><div><h3>Statement of significance</h3><div>Tumor recurrence and tissue defects represent significant challenges following surgical tumor removal in cancer patients. Meanwhile, a critical barrier to the clinical translation of postoperative biomaterial scaffolds is the lack of personalization for both antitumor therapy and tissue reconstruction. Here, we developed a personalized microporous annealed particle (MAP) scaffold that integrates autologous tumor cells, immune adjuvant, and IDO1 inhibitor to simultaneously address tumor recurrence and tissue defects. Personalized antitumor therapy is achieved by the injectable MAP scaffold through a tumor vaccine formed from autologous tumor-derived cells within the scaffold, eliciting tumor-specific T-cell responses that are further amplified by reversing the local immunosuppressive microenvironment. Personalized tissue repair is also enabled by such scaffold, which conforms to irregular wound shapes and supports cell infiltration. This work establishes a paradigm that unifies personalized immunotherapy with personalized tissue repair, offering substantial promise for postsurgical cancer therapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"222 ","pages":"Pages 450-459"},"PeriodicalIF":10.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}