Acta Biomaterialia最新文献

{"title":"Overcoming matrix barriers for enhanced immune infiltration using siRNA-coated metal-organic frameworks","authors":"Cheng Zeng ,&nbsp;Xiaojing Chen ,&nbsp;Mingxi Lin ,&nbsp;Yizi Jin ,&nbsp;Qing Guo ,&nbsp;Teng Zhou ,&nbsp;Xingang Wang ,&nbsp;Yiping Li ,&nbsp;Xinghui Wang ,&nbsp;Yongming Han ,&nbsp;Ling Du ,&nbsp;Qianyun Tang ,&nbsp;Peifeng Liu ,&nbsp;Jian Zhang","doi":"10.1016/j.actbio.2025.03.001","DOIUrl":"10.1016/j.actbio.2025.03.001","url":null,"abstract":"<div><div>The extracellular matrix (ECM) of solid tumor constitutes a formidable physical barrier that impedes immune cell infiltration, contributing to immunotherapy resistance. Breast cancer, particularly triple-negative breast cancer (TNBC), is characterized by a collagen-rich tumor microenvironment, which is associated with T cell exclusion and poor therapeutic outcomes. Discoidin domain receptor 2 (DDR2) and integrins, key ECM regulatory receptors on cancer cells, play pivotal role in maintaining this barrier. In this study, we developed a dual-receptor-targeted strategy using metal-organic frameworks (MOFs) to deliver DDR2-specific siRNA (siDDR2) and ITGAV-specific siRNA (siITGAV) to disrupt the ECM barrier. siDDR2 modulates immune infiltration by regulating collagen–cell interactions, while siITGAV suppresses TGF-β1 activation. The MOF@siDDR2+siITGAV complex significantly reduced collagen deposition, enhanced CD8+ <em>T</em> cell infiltration, and downregulated programmed cell death ligand 1 (PD-L1) expression in TNBC. Consequently, this approach markedly inhibited tumor growth. Our findings demonstrate that dual-receptor-targeted MOF-based nanocarriers (MOF@siDDR2+siITGAV) can effectively reprogram the tumor ECM to enhance immune cell access, offering a promising prospect for synergistic cancer immunotherapy.</div></div><div><h3>Statement of significance</h3><div>A dual-receptor-targeted MOF nanocarrier is developed to improve immune accessibility in tumors. Concurrent blockade of DDR2 and ITGAV effectively decreases collagen deposition, increases CD8+ <em>T</em> cell infiltration, and suppresses PD-L1 expression. Modulating the mechanical properties of the extracellular matrix (ECM) to enhance immune accessibility offers an innovative strategy for cancer treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 410-422"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-scale additive manufacturing of 3D porous networks integrated with hydrogel for sustained in vitro tissue growth","authors":"J. Li,&nbsp;A. Isaakidou,&nbsp;L.J. van Zanten,&nbsp;R.P. Tas,&nbsp;M.J. Mirzaali,&nbsp;L.E. Fratila-Apachitei,&nbsp;A.A. Zadpoor","doi":"10.1016/j.actbio.2025.03.005","DOIUrl":"10.1016/j.actbio.2025.03.005","url":null,"abstract":"<div><div>The development of high-fidelity three-dimensional (3D) tissue models can minimize the need for animal models in clinical medicine and drug development. However, physical limitations regarding the distances within which diffusion processes are effective impose limitations on the size of such constructs. That is because larger-size constructs experience necrosis, especially in their centers, due to the cells residing deep inside such constructs not receiving enough oxygen and nutrients. This hampers the sustained <em>in vitro</em> growth of the tissues which is required for achieving functional microtissues. To address this challenge, we used three types of 3D printing technologies to create perfusable networks at different length scales and integrate them into such constructs. Toward this aim, networks incorporating porous conduits with increasingly complex configurations were designed and fabricated using fused deposition modeling, stereolithography, and two-photon polymerization while optimizing the printing conditions for each of these technologies. Furthermore, following network embedding in hydrogels, contrast agent-enhanced micro-computed tomography and confocal fluorescence microscopy were employed to characterize one of the essential network functionalities, namely the diffusion function. The investigations revealed the effects of various design parameters on the diffusion behavior of the porous conduits over 24 h. We found that the number of pores exerts the most significant influence on the diffusion behavior of the contrast agent, followed by variations in the pore size and hydrogel concentration. The analytical approach and the findings of this study establish a solid base for a new technological platform to fabricate perfusable multiscale 3D porous networks with complex designs while enabling the customization of diffusion characteristics to meet specific requirements for sustained <em>in vitro</em> tissue growth.</div></div><div><h3>Statement of significance</h3><div>This study addresses an essential limitation of current 3D tissue engineering, namely, sustaining tissue viability in larger constructs through optimized nutrient and oxygen delivery. By utilizing advanced 3D printing techniques this research proposes the fabrication of perfusable, multiscale and customizable networks that enhance diffusion and enable cell access to essential nutrients throughout the construct. The findings highlighted the role of network characteristics on the diffusion of a model compound within a hydrogel matrix. This work represents a promising technological platform for creating advanced <em>in vitro</em> 3D tissue models that can reduce the use of animal models in research involving tissue regeneration, disease models and drug development.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 198-212"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy","authors":"Liting Lin ,&nbsp;Qingrong Li ,&nbsp;Yan Yang ,&nbsp;Cong Zhang ,&nbsp;Wenqi Wang ,&nbsp;Fan Ni ,&nbsp;Xianwen Wang","doi":"10.1016/j.actbio.2025.03.003","DOIUrl":"10.1016/j.actbio.2025.03.003","url":null,"abstract":"<div><div>Ulcerative colitis (UC) is a long-term inflammatory bowel disease characterized by intense inflammation of the colorectal mucosa. Overproduction of reactive oxygen species exacerbates the progression of UC, which is linked to mitochondrial impairment and dysbiosis of the intestinal microbiota. CaGA nanozymes have demonstrated efficacy in the treatment of UC. The modulation of M1 and M2 polarization of macrophages by CaGA nanozymes has been demonstrated to be useful in reducing inflammation. Furthermore, CaGA nanozymes regulate the M1 and M2 polarization of macrophages, efficiently decreasing inflammation. The oral delivery of CaGA nanozymes resulted in their enrichment in inflamed areas of the colon and effectively reduced colonic damage in mice with DSS-induced colitis by improving the repair of the intestinal barrier. An investigation of 16S rDNA sequencing revealed that CaGA nanozymes regulate populations of both pathogenic and helpful bacteria and impact the progression of ulcerative colitis by influencing the tricarboxylic acid (TCA) cycle. Thus, CaGA nanozymes may be employed in the management of ulcerative colitis to control the intestinal milieu and improve the preservation of the intestinal barrier by decreasing the invasion of inflammatory cells and restoring mitochondrial activity.</div></div><div><h3>Statement of significance</h3><div>CaGA nanozymes exhibit multifunctional enzymatic activity, effectively eliminating cellular RONS with robust antioxidant capacity. CaGA nanoenzymes promote macrophage M1 to M2 polarization and produce anti-inflammatory effects. CaGA nanozymes increase cell viability by restoring impaired mitochondrial function, reducing reactive oxygen species (ROS) production, and restoring the ability of mitochondria to produce ATP. CaGA nanozymes modulate intestinal flora diversity and composition, potentially influencing inflammatory pathways via aromatic compound metabolism. They participate in cellular energy and biosynthesis, regulating ulcerative colitis (UC)-related intestinal function through the tricarboxylic acid (TCA) and urea cycles. Calcium ions bind to GA nanomedicine and small particles are readily absorbed by inflammatory cells, preventing diarrhea from being rapidly excreted.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 380-398"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA nanovaccines derived from ferritin-modified glycogens for targeted delivery to immature dendritic cells and for promotion of Th1 cell differentiation","authors":"Jun Wu ,&nbsp;Jing Liang ,&nbsp;Sichen Li ,&nbsp;Jinjin Lu ,&nbsp;Juan Zhou ,&nbsp;Min Gao ,&nbsp;Yan Zhang ,&nbsp;Jinghua Chen","doi":"10.1016/j.actbio.2025.02.057","DOIUrl":"10.1016/j.actbio.2025.02.057","url":null,"abstract":"<div><div>DNA vaccines have emerged as a powerful approach for advanced cancer therapy. Despite the development of various delivery systems to enhance the immunogenicity of DNA vaccines, many still face challenges such as limited DNA condensation, rapid degradation <em>in vivo</em> and insufficient targeting to lymph nodes (LNs). Synthetic dendrimers with modifiable surfaces exhibit high efficiency in DNA condensation, but their synthesis is extremely complex. This study utilizes cationic glycogen, a natural branched dendrimer-like polymer, as the core structure for efficient DNA condensation and delivery, ensuring good biocompatibility. By connecting ferritin light chain to the glycogen surfaces, active targeting of LNs can be achieved due to its affinity for the SCARA5 receptor on immature dendritic cells (DCs), facilitating vaccine migration to the LNs. In addition, a seperate plasmid encoding adjuvant IL-12 was co-delivered to further boost the immunogenicity of the DNA nanovaccine. <em>In vivo</em> and <em>in vitro</em> experiments confirmed the effective transfection capability of this DNA vaccine, demonstrating promoted DC maturation, increased antigen presentation, and Th1 cell differentiation, resulting in improved anti-tumor efficiency <em>in vivo</em>. This innovative multi-gene co-loaded DNA vaccine offers valuable insights into combined gene therapy and broadens the research horizon on non-viral gene carriers.</div></div><div><h3>Statement of Significance</h3><div>The DNA vaccine encounters challenges such as limited DNA condensation, rapid degradation and insufficient targeting to lymph nodes (LNs), resulting in generally weak immunogenicity. In the current study, a novel nanovaccine is developed by connecting ferritin light chain to natural dendrimer glycogen, for simultaneous delivery of dual plasmids. The cationized glycogen provides strong DNA condensation ability, while ensuring excellent stability of the nanovaccine. The presence of ferritin light chain leads to effective targeting of dendritic cells (DCs), facilitating its migration to LNs. Moreover, the plasmid encoding the adjuvant IL-12 is co-incorporated with the antigen plasmid to mitigate the immunosuppression environment. This strategy significantly improves the immunogenicity of DNA vaccines, demonstrating high efficiency in cancer immunotherapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 436-452"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Donor-Acceptor-Donor small molecules for fluorescence/photoacoustic imaging and integrated photothermal therapy” [Acta Biomaterialia 2023, 164, 588-603]","authors":"Chang Wang ,&nbsp;Fang Wang ,&nbsp;Wentao Zou ,&nbsp;Yawei Miao ,&nbsp;Yaowei Zhu ,&nbsp;Mengyu Cao ,&nbsp;Bing Yu ,&nbsp;Hailin Cong ,&nbsp;Youqing Shen","doi":"10.1016/j.actbio.2025.02.019","DOIUrl":"10.1016/j.actbio.2025.02.019","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 544-547"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arsenene-Vanadene nanodots co-activate Apoptosis/Ferroptosis for enhanced chemo-immunotherapy","authors":"Li He ,&nbsp;WeiYe Ren ,&nbsp;WeiYi Cheng ,&nbsp;JingQuan Chen ,&nbsp;Jianjun Lai ,&nbsp;Yajun Wu ,&nbsp;Zhibing Wu ,&nbsp;Dandan Bao ,&nbsp;Yinghui Wei ,&nbsp;Ji-Gang Piao","doi":"10.1016/j.actbio.2025.02.059","DOIUrl":"10.1016/j.actbio.2025.02.059","url":null,"abstract":"<div><div>Triple-Negative Breast Cancer (TNBC) represents a highly aggressive subtype of breast cancer with an unfavorable prognosis, characterized by minimal immune infiltration and pronounced immune suppression, resulting in a limited response to immunotherapy. In this study, a multifunctional Arsenene-Vanadene nanodot (AsV) drug delivery system is introduced, which responds to the tumor microenvironment by releasing arsenic and vanadium. Arsenic undergoes oxidation to generate highly toxic trivalent arsenic, which induces apoptosis in tumor cells while utilizing apoptotic cell debris to transiently activate the immune system. Additionally, arsenic binds to cysteine, indirectly facilitating ferroptosis. Concurrently, vanadium's redox cycling properties are harnessed to trigger a Fenton-like reaction, promoting lipid peroxidation. Furthermore, ferroptosis is enhanced through the depletion of glutathione and inactivation of glutathione peroxidase 4 (GPX4), leading to the release of damage-associated molecular patterns and thereby amplifying the anti-tumor immune response. This study represents the first instance of integrating arsenene's apoptosis-inducing properties with vanadium's ferroptosis-enhancing effects, providing a synergistic approach to improving the immunotherapeutic response and offering a potential strategy for enhancing TNBC prognosis.</div></div><div><h3>Statement of Significance</h3><div>Triple-negative breast cancer (TNBC) exhibits resistance to immunotherapy due to its highly immunosuppressive tumor microenvironment. In this study, tumour-responsive Arsenene-Vanadene nanodots (AsV) were developed to induce a synergistic effect by triggering apoptosis and ferroptosis through microenvironment-specific mechanisms. The arsenic component generates cytotoxic trivalent arsenic, promoting apoptosis while binding to cysteine, thereby reducing GSH synthesis. Simultaneously, vanadium initiates lipid peroxidation through Fenton-like reactions and disruption of the glutathione/GPX4 axis, further amplifying ferroptotic cell death. This dual-action system transforms tumor cell debris into immune-stimulating signals while circumventing conventional immunotherapy limitations. As the first strategy integrating arsenic-induced apoptosis with vanadium-enhanced ferroptosis, this approach provides a mechanistic framework to overcome TNBC immunosuppression through coordinated cell death pathways, demonstrating potential for precision nanomedicine applications.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 453-470"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid","authors":"J.A. Romero-Antolín ,&nbsp;N. Gómez-Cerezo ,&nbsp;M. Manzano ,&nbsp;J.L. Pablos ,&nbsp;M. Vallet-Regí","doi":"10.1016/j.actbio.2025.03.015","DOIUrl":"10.1016/j.actbio.2025.03.015","url":null,"abstract":"<div><div>In the present era, the treatment of skin-infected wounds and their associated inflammation constitutes a significant challenge. These infections have the potential to impede the healing process and become a life-threatening pathology, particularly due to the rise of bacterial resistance. Hydrogels could successfully address this issue due to their unique capabilities and versatility. Among them, natural polymer-based hydrogels are especially advantageous as they resemble the extracellular matrix (ECM) and mechanical properties of natural tissues. In this study, we propose a dual-action hydrogel composed of methacrylated gelatin as a matrix and a salicylate (Sal) anion-exchanged polymerizable ionic liquid (PIL) to achieve anti-inflammatory and antibacterial activities. This material facilitated cell attachment and colonization with mouse endothelial fibroblasts. A flow cytometry assay was conducted to evaluate the anti-inflammatory effect, and demonstrated the differentiation of mouse macrophages to an M2 (reparative) phenotype. Therefore, the levels of TNF-α, interleukin-6 (IL-6), and interleukin (IL-10) were quantified to further evaluate this effect, demonstrating an inhibition on the pro-inflammatory ones. The inherent antibacterial capacity of the PIL was demonstrated against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>, thereby corroborating its potential as a wound dressing. To the best of our knowledge, this is the first reported hydrogel incorporating an anion-exchanged polymerizable ionic liquid that is capable of promoting macrophage differentiation into a reparative phenotype, of reducing pro-inflammatory cytokines, and of simultaneously retaining antibacterial activity. These features open the gate to the potential application of this hydrogel as a wound dressing.</div></div><div><h3>Statement of significance</h3><div>Bacterial wound infections may lead to severe problems due to their associate tissue inflammation and the emergence of bacterial resistance. In this sense, local therapies such as hydrogels have gathered much attention as alternative therapies for these pathologies. In this work, we have developed a natural polymer-based hydrogel copolymerized with a polymerizable ionic liquid containing salicylate as an anion. The hydrogel was shown to be biocompatible, and promoted macrophage differentiation to a reparative phenotype, while reducing the levels of pro-inflammatory cytokines. Finally, the high antibacterial capability against both gram-positive and gram-negative bacteria makes it a promising candidate for use in wound dressings.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 78-92"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets","authors":"Colton J. Kostelnik ,&nbsp;William D. Meador ,&nbsp;Chien-Yu Lin ,&nbsp;Mrudang Mathur ,&nbsp;Marcin Malinowski ,&nbsp;Tomasz Jazwiec ,&nbsp;Zuzanna Malinowska ,&nbsp;Magda L. Piekarska ,&nbsp;Boguslaw Gaweda ,&nbsp;Tomasz A. Timek ,&nbsp;Manuel K. Rausch","doi":"10.1016/j.actbio.2025.03.052","DOIUrl":"10.1016/j.actbio.2025.03.052","url":null,"abstract":"<div><div>Tricuspid valve leaflets are dynamic tissues that can respond to altered biomechanical and hemodynamic loads. Each leaflet has unique structural and mechanical properties, leading to different in vivo strains. We hypothesized that these intrinsic differences drive heterogeneous, disease-induced remodeling between the leaflets. Although we previously reported significant remodeling changes in the anterior leaflet, the responses among the other two leaflets have not been reported. Using a sheep model of biventricular heart failure, we compared the remodeling responses between all tricuspid leaflets. Our results show that the anterior leaflet underwent the most significant remodeling, while the septal and posterior leaflets exhibited similar but less pronounced changes. We found several between-leaflet differences in key structural and mechanical metrics that have been shown to contribute to valvular dysfunction. Diseased animals exhibited significantly larger septal and anterior leaflets, thicker anterior and posterior leaflets, and stiffer anterior leaflets. Additionally, the septal leaflet's anisotropy index significantly decreased. Also, the septal and anterior leaflets showed increased collagen fiber dispersion near the atrial surface. As for remodeling markers, alpha-smooth muscle actin (<em>α</em>SMA), Ki67, matrix-metalloprotease 13 (MMP13), and transforming growth factor beta-1 (TGF-β1) were upregulated in spatially and leaflet-dependent patterns. That is, we observed increased expression of these markers within septal leaflets' near-annulus and belly regions, increased expression in anterior leaflets' belly region, and varied expression in posterior leaflets. These findings underscore the need to consider leaflet-specific remodeling to fully understand tricuspid valve dysfunction and to develop targeted therapies for its treatment and more accurate computational models.</div></div><div><h3>Statement of significance</h3><div>Our study is significant as it advances our understanding of tricuspid valve remodeling by providing a comprehensive analysis of all three leaflets in a sheep model of biventricular heart failure. Unlike prior works that focused primarily on the anterior leaflet or generalized leaflet changes, we integrated morphological, histological, immunohistochemistry, biaxial mechanical testing, and two-photon microscopy to quantify differences between all three tricuspid valve leaflets (anterior, posterior, and septal) across multiple functional scales. This comprehensive approach highlights the unique remodeling response of each leaflet. Our findings offer critical insights for developing targeted therapeutic strategies and improving computational models of disease progression.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"198 ","pages":"Pages 234-244"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus micro/nanomotors for enhanced disease treatment through their deep penetration capability","authors":"Haoran Ma,&nbsp;Yuxuan Guo,&nbsp;Xia Xu,&nbsp;Lei Ye,&nbsp;Yuanyuan Cheng,&nbsp;Xiaoxiao Wang","doi":"10.1016/j.actbio.2025.02.055","DOIUrl":"10.1016/j.actbio.2025.02.055","url":null,"abstract":"<div><div>Nanotherapeutic systems have provided an innovative means for the treatment of a wide range of diseases in modern medicine. However, the limited penetration of nanoparticles into focal tissues still greatly hampered their clinical application. With their unique two-sided structure and superior motility, Janus micro/nanomotors are expected to significantly improve the penetration of nanocarriers into organisms, thereby enhancing the therapeutic effects of diseases. This review introduces Janus micro/nanomotors with different morphologies and focuses on their propulsion mechanisms, including chemical field–driven, external physical field–driven, biologically–driven, and hybrid–driven mechanisms. We explore the research progress of Janus micro/nanomotors in various disease treatment areas (including cancer, cardiovascular diseases, neurological diseases, bacterial/fungal infections, and chronic inflammatory diseases) and elucidate the implementation strategies of Janus micro/nanomotors in facilitating disease therapies. Finally, we discuss the biosafety and biocompatibility of Janus micro/nanomotor, while exploring current challenges and opportunities in the field. We look forward to the Janus micro/nanomotor therapeutic platform demonstrating surprising therapeutic effects in the clinical treatment of diseases.</div></div><div><h3>Statement of significance</h3><div>Micro/nanomotors are the highly promising nanotherapeutic systems due to their self-propelled motion capability. Janus micro/nanomotors possess an asymmetric structure with different physical or chemical properties on both sides. The flexibility of this bifunctional surface allows them to hold promise for improving the penetration of nanotherapeutic systems and enhancing therapeutic efficacy for complex diseases. This review focuses on the latest advancements in Janus micro/nanomotors for enhanced disease treatment, including the structural types and driving mechanisms, the enhancement effect to cope with different disease treatments, the biocompatibility and safety, the current challenges and possible solutions. These insights inform the design of deep-penetrating nanotherapeutic systems and the strategies of enhanced disease treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 50-77"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Development of a multifunctional nano-hydroxyapatite platform (nHEA) for advanced treatment of severely infected full-thickness skin wounds” [Acta Biomaterialia, 181, 2024, 440-452]","authors":"Shixin Zhang ,&nbsp;Tinghan He ,&nbsp;Fengxin Zhao ,&nbsp;Qinling Tan ,&nbsp;Dongxiao Li ,&nbsp;Qiguang Wang ,&nbsp;Yumei Xiao ,&nbsp;Xingdong Zhang","doi":"10.1016/j.actbio.2025.01.058","DOIUrl":"10.1016/j.actbio.2025.01.058","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 533-536"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}