Wounds : a compendium of clinical research and practice最新文献_第3页

A prospective, open-label, nonrandomized clinical trial using polyvinyl alcohol antibacterial foam for debridement of diabetic foot ulcers. 使用聚乙烯醇抗菌泡沫清创糖尿病足溃疡的前瞻性、开放标签、非随机临床试验。

IF 1.4 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-05-01

Eric Lullove

{"title":"A prospective, open-label, nonrandomized clinical trial using polyvinyl alcohol antibacterial foam for debridement of diabetic foot ulcers.","authors":"Eric Lullove","doi":"","DOIUrl":"","url":null,"abstract":"Background: Diabetic foot ulcers (DFUs) pose significant challenges for patients, often leading to chronic inflammation, reduced mobility, and chronic pain. Despite being less prevalent in the United States compared to other nations, the economic burden of DFUs remains substantial, with an estimated annual cost ranging from $9 billion to $13 billion. Furthermore, DFUs are a leading cause of nontraumatic lower extremity amputations and significantly impact health care systems and work productivity.Objective: This study aimed to evaluate the effectiveness of a polyvinyl alcohol (PVA) foam dressing containing gentian violet/methylene blue (GV/MB) in managing chronic DFUs.Materials and methods: A single-center study was conducted involving 20 patients with full-thickness chronic lower extremity wounds, including DFUs. Patients received treatment with a PVA foam dressing with GV/MB applied in an outpatient setting over a period of 4 weeks. Wound size, bacterial presence, and healing progress were assessed using fluorescence imaging and wound measurements.Results: The study included 13 males and 7 females with an average age of 64.2 years. After 4 weeks of treatment, the average DFU size decreased by 53%, with 4 patients achieving complete wound closure. Reduction in ulcer size was strongly correlated with the use of surgical debridement and PVA GV/MB foam. Fluorescence imaging demonstrated a significant reduction in bacterial presence in all patients by the end of the study. Follow-up at 3 and 6 months showed no recurrent ulcerations, indicating the potential for long-term efficacy.Conclusion: The findings suggest that PVA GV/MB foam dressings, when combined with surgical debridement, are effective in promoting the healing of chronic DFUs. Further research with larger, controlled studies is warranted to confirm these findings and assess cost-effectiveness.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of negative pressure wound therapy in the management of complex deep cardiothoracic surgical site infections. 负压伤口疗法在治疗复杂的深部心胸手术部位感染中的作用。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-05-01

Yasser Aljehani, Farouk Alrashaid, Hatem El-Bawab, Naif Alkhaldi, Hmood Alsadery, Norah Alayyaf, Jana AlSaikhan, Sumiyah AlShamekh

{"title":"The utility of negative pressure wound therapy in the management of complex deep cardiothoracic surgical site infections.","authors":"Yasser Aljehani, Farouk Alrashaid, Hatem El-Bawab, Naif Alkhaldi, Hmood Alsadery, Norah Alayyaf, Jana AlSaikhan, Sumiyah AlShamekh","doi":"","DOIUrl":"","url":null,"abstract":"Background: Complex deep surgical site infection in the cardiothoracic surgery patient that reaches the sternum and even the mediastinum, causing osteomyelitis and mediastinitis, is associated with high rates of morbidity and mortality. Negative pressure wound therapy (NPWT) can aid in achieving favorable outcomes in patients with complex surgical site infections by promoting wound healing and shortening the hospital stay. NPWT is widely recognized for its advantages and has recently been used in both cardiothoracic and non-cardiothoracic settings.Objective: To evaluate the efficacy of NPWT in the management of complex deep surgical site infection after cardiothoracic surgery.Materials and methods: A retrospective chart review of all complex cardiothoracic cases admitted to the cardiac and thoracic surgery divisions for surgical intervention to treat postoperative surgical wound infections.Results: A total of 18 patients were included, with a male-to-female ratio of 5:4. The mean (SD) age was 48.7 (16.5) years. The cases reviewed were complex, and the duration of the NPWT application ranged from 4 days to 120 days, with an average hospital stay of 62.8 days. Seventy-eight percent of patients required antibiotics (or had positive wound cultures); in 55.6% of these patients, polymicrobial infection was detected. No major complications were related to NPWT.Conclusion: The study findings show that using NPWT in complex deep sternal and thoracic infections can enhance wound healing, shorten the hospital stay, and decrease morbidity and mortality secondary to wound infection in cardiothoracic patients.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leg skin ulcer with atypical features: vascular wound or advanced melanoma? 具有非典型特征的腿部皮肤溃疡：血管伤口还是晚期黑色素瘤？

IF 1.4 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-04-01

Paola Monari, Benedetta Galli, Piergiacomo Calzavara Pinton

{"title":"Leg skin ulcer with atypical features: vascular wound or advanced melanoma?","authors":"Paola Monari, Benedetta Galli, Piergiacomo Calzavara Pinton","doi":"","DOIUrl":"","url":null,"abstract":"Background: Leg ulcers have various etiologies, including malignancy, although vascular issues are the most frequent cause. Malignant wounds present diagnostic challenges, with a reported prevalence rate ranging from 0.4% to 23%. This significant variability in reported prevalence appears to be due to the different settings in which data are collected, which suggests potential influence by medical specialty. Consequently, the misdiagnosis of neoplastic ulcers (eg, ulcerated melanoma) as vascular wounds is relatively common, leading to delayed diagnosis, inadequate treatment, and a dramatic worsening of the patient's prognosis. Identifying malignancy in nonresponsive wounds involves recognizing signs such as hypertrophic granulation tissue, bleeding, unusual pigmentation, and raised edges. The appearance of the perilesional skin, together with dermoscopic observation, is also crucial to differentiation. Ultimately, a biopsy may provide valuable diagnostic clarification.Case report: A case is presented of lower limb melanoma that for years was misdiagnosed as a vascular wound by multiple specialists, with delayed referral to a dermatologist and resulting recognition and diagnosis, at which time nodular satellite metastases were found. Dermoscopy and biopsy confirmed the diagnosis. The disease was already advanced, with in-transit and distant site metastases, and the prognosis was regrettably poor.Conclusion: This case underscores the importance of early detection and accurate diagnosis of malignant wounds, emphasizing the need to refer patients with suspicious nonresponsive ulcers to a dermatologist.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic clinical application of synthetic electrospun fiber wound matrix in the management of a complex traumatic wound: degloving left groin and thigh auger injury. 合成电纺纤维伤口基质在处理复杂创伤伤口中的协同临床应用：左腹股沟和大腿螺旋损伤的脱脂治疗。

IF 1.4 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-04-01

Luis G Fernandez, Carolina Orsi, Brandon Okeoke, Paige Moudy, Paul A Critelli, Scott Norwood, Marc R Matthews, Paul J Kim, Matthew MacEwan, Emily Sallade

{"title":"Synergistic clinical application of synthetic electrospun fiber wound matrix in the management of a complex traumatic wound: degloving left groin and thigh auger injury.","authors":"Luis G Fernandez, Carolina Orsi, Brandon Okeoke, Paige Moudy, Paul A Critelli, Scott Norwood, Marc R Matthews, Paul J Kim, Matthew MacEwan, Emily Sallade","doi":"","DOIUrl":"","url":null,"abstract":"Background: Managing complex traumatic soft tissue wounds involving a large surface area while attempting to optimize healing, avoid infection, and promote favorable cosmetic outcomes is challenging. Regenerative materials such as ECMs are typically used in wound care to enhance the wound healing response and proliferative phase of tissue formation.Case report: The case reported herein is an example of the efficacious use of an SEFM in the surgical management of a large complex traumatic wound involving the left lower extremity and lower abdominal region. The wound bed was successfully prepared for skin grafting over an area of 1200 cm2, making this among the largest applications of the SEFM reported in the literature.Conclusion: This case report demonstrates the clinical versatility of the SEFM and a synergistic approach to complex traumatic wound care. The SEFM was successfully used to achieve tissue granulation for a successful skin graft across a large surface in an anatomic region with complex topography.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary expert consensus statements and recommendations for use of hypochlorous acid as a solution for negative pressure wound therapy with instillation. 关于使用次氯酸作为负压伤口灌注疗法溶液的多学科专家共识声明和建议。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-04-01

Paul J Kim, Luis Fernandez, Mary Ann Obst, Abigail Chaffin, Elizabeth Faust, John Lantis, Kara Couch, Michael Desvigne, Mark Suski, Neilendu Kundu, Marc Matthews, Richard Simman, Christine Murphy, Natalie E Nierenberg, Luc Téot

{"title":"Multidisciplinary expert consensus statements and recommendations for use of hypochlorous acid as a solution for negative pressure wound therapy with instillation.","authors":"Paul J Kim, Luis Fernandez, Mary Ann Obst, Abigail Chaffin, Elizabeth Faust, John Lantis, Kara Couch, Michael Desvigne, Mark Suski, Neilendu Kundu, Marc Matthews, Richard Simman, Christine Murphy, Natalie E Nierenberg, Luc Téot","doi":"","DOIUrl":"","url":null,"abstract":"Background: HOCl (eg, pHAp) preserved solutions have antimicrobial properties and are considered safe and effective for wound management. NPWTi-d (or NPWTi) is an established adjunctive wound modality for a variety of wound etiologies in various anatomic locations in which an instillate solution dwells on the surface of the wound to assist in wound bed preparation. A variety of solutions have been used, including 0.9% normal saline wound cleansers and antiseptics. pHAp is growing in popularity as the solution of choice for NPWTi-d.Objective: To evaluate consensus statements on the use of NPWTi-d with pHAp.Methods: A 15-member multidisciplinary panel of expert clinicians in the United States, Canada, and France convened in person in April 2023 in Washington, D.C. and/or corresponded later to discuss 10 statements on the use of pHAp with NPWTi-d. The panelists then replied \"agree\" or \"disagree\" to each statement and had the option to provide comments.Results: Ten consensus statements are presented, along with the proportion of agreement or disagreement and summary comments. Although agreement with the statements on NPWTi-d with pHAp varied, the statements appear to reflect individual preferences for use rather than concerns about safety or efficacy.Conclusion: The consensus indicates that NPWTi-d with pHAp can have a beneficial effect in wound care.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating micronized adipose tissue niche and artificial dermis grafts following nonmelanoma skin cancer excision: a pilot study. 评估非黑色素瘤皮肤癌切除术后的微粉化脂肪组织龛和人工真皮移植：一项试点研究。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-04-01

Yu-Kyeong Yun, Seung-Kyu Han, In-Jae Yoon, Sik Namgoong, Seong-Ho Jeong, Eun-Sang Dhong, Jee-Hee Kim, Min-Chae Lee

{"title":"Evaluating micronized adipose tissue niche and artificial dermis grafts following nonmelanoma skin cancer excision: a pilot study.","authors":"Yu-Kyeong Yun, Seung-Kyu Han, In-Jae Yoon, Sik Namgoong, Seong-Ho Jeong, Eun-Sang Dhong, Jee-Hee Kim, Min-Chae Lee","doi":"","DOIUrl":"","url":null,"abstract":"Background: Recently, micronized adipose tissue (MAT) grafts have shown promising results in wound healing, including diabetic ulcers.Objective: To assess the possibility of using 3D printed MAT niche grafts in the management of skin and soft tissue defects resulting from non-melanoma skin cancer (NMSC) resections.Materials and methods: A retrospective feasibility study was conducted on patients with skin and soft tissue defects resulting from NMSC resections. Twenty-one patients were treated using either artificial dermis (n = 11) or MAT niche (n = 10) grafting. Healing time and POSAS scores were compared. The Mann-Whitney U test and the Pearson chi-square test were used in statistical analysis to compare between and within groups based on preoperative and postoperative measurements.Results: Wounds in the MAT niche group reepithelialized significantly faster than those in the artificial dermis group (mean [SD] 39.2 [11.4] days vs 63.7 [34.8] days; P = .04). In the 21 scar parameters evaluated, the MAT niche group demonstrated significantly superior outcomes in only 2 parameters based on operator assessment scores: relief (mean [SD] 1.6 [0.7] vs 2.2 [0.6]; P = .047) and scar contracture (mean [SD] 1.3 [0.5] vs 2.5 [1.0]; P = .011).Conclusion: This study proves the feasibility of exploring the effects of MAT niche grafting following NMSC excision on healing time and specific parameters of scarring, including scar relief and scar contracture.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A referral pathway for treating patients with severe venous disease using mechanical thrombectomy. 使用机械血栓切除术治疗严重静脉疾病患者的转诊途径。

IF 1.4 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-04-01

Nicolas J Mouawad

{"title":"A referral pathway for treating patients with severe venous disease using mechanical thrombectomy.","authors":"Nicolas J Mouawad","doi":"","DOIUrl":"","url":null,"abstract":"Background: DVT is associated with clinically significant sequelae, and the most widely used therapies for severe venous disease are often ineffective. Mechanical thrombectomy (MT) offers a promising approach, but most patients with a history of DVT are not evaluated for such intervention.Objective: To present overall outcomes and the outcome of a single case after use of an MT procedure to manage advanced deep venous disease.Materials and methods: This retrospective, single-center analysis included all patients with a CEAP score of C6 secondary to DVT who were referred from a wound clinic and underwent an MT-based procedure.Results: Eleven patients with 14 affected limbs were referred for treatment from an associated care network and were treated with MT. As necessary, adjunctive venoplasty and stent placement were also used. The endovascular treatment was successful in removing fibrous obstructions from veins and supporting the improvement or resolution of C6 venous disease in all cases, including the 66-year-old male discussed in the current report.Conclusion: Collaboration between endovascular interventionists and local postacute wound care specialists to identify and refer patients with severe venous disease for advanced treatment may lead to improved outcomes.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Observatoire en Ville des Plaies ExSudatives (VIPES) study: insight into the patient characteristics, epidemiology, previous management, and features of wounds treated in the French community setting. 法国VIPES（Observatoire en Ville des Plaies ExSudatives）研究：深入了解患者特征、流行病学、既往管理以及在法国社区环境中治疗伤口的特点。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-03-01

Pascal Vasseur, Nayla Ayoub, Christine Juhel, Romain Schueller, Adoración Pegalajar-Jurado, Florence Armstrong

{"title":"The Observatoire en Ville des Plaies ExSudatives (VIPES) study: insight into the patient characteristics, epidemiology, previous management, and features of wounds treated in the French community setting.","authors":"Pascal Vasseur, Nayla Ayoub, Christine Juhel, Romain Schueller, Adoración Pegalajar-Jurado, Florence Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"Background: Wounds that become complex and hard-to-heal are a challenge for all health care systems. Identifying and understanding the nature of these wounds is necessary to allow appropriate intervention.Objective: To present the epidemiological outcomes of the VIPES study.Materials and methods: The prospective, observational VIPES study aimed to describe the use and investigate the performance of 2 wound dressings-a silicone foam and a gelling fiber-in the management of chronic and acute wounds in a community setting in France.Results: Of 407 patients recorded, 285 were included in the analysis. The 184 chronic wounds included ulcers (venous/arterial/mixed, diabetic foot, and pressure) and malignant wounds. The 101 acute wounds included surgical and traumatic wounds. Of all wounds, 98.2% were exuding and 77.9% showed exudate pooling. Unhealthy wound edges and periwound skin were reported in 57.2% and 35.4% of wounds, respectively. Of all wounds, 78.6% were in treatment failure (poor exudate management or stagnant wound). The silicone foam dressing (n = 86) and the gelling fiber (n = 199) were generally used in wounds with low or moderate exudation, or moderate or high exudation, respectively.Conclusions: The VIPES study highlights that wounds can be complex and that community care practices in France warrant improvement. Practical and up-to-date wound management recommendations are needed.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between hemoglobin levels and diabetic foot ulcer in patients with type 2 diabetes: a cross-sectional study. 2 型糖尿病患者血红蛋白水平与糖尿病足溃疡之间的关系：一项横断面研究。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-03-01

Fengying Jiang, Qingyang Liu, Qiubo Wang

{"title":"Association between hemoglobin levels and diabetic foot ulcer in patients with type 2 diabetes: a cross-sectional study.","authors":"Fengying Jiang, Qingyang Liu, Qiubo Wang","doi":"","DOIUrl":"","url":null,"abstract":"Background: Anemia is prevalent among patients with T2DM with DFU. However, there is limited research on the relationship between Hb level and DFU.Objective: To investigate the characteristics and relationship between Hb level and prognosis in patients with DFU.Materials and methods: A total of 212 patients with T2DM were included and grouped according to the presence (n = 105) or absence (n = 107) of DFU. The independent t test and multiple logistic regression analysis were used to analyze the effect of different factors on the occurrence of anemia in patients with DFU and whether Hb level could be used to predict prognosis.Results: There were significant differences in clinical indicators that directly or indirectly contributed to anemia in patients with DFU (P < .05). Hb level was independently associated with DFU (OR, 0.899; P < .05). Hb levels were significantly decreased in patients aged 65 years or older (P < .05). Mild anemia was prevalent among most patients with DFU (59.62%). Hb level decreased with the severity of foot ulcer (P < .05) and was correlated with the duration of diabetes (R2 = 0.653; P < .05). The AUC value was 0.82, with a cutoff value of 122.5 g/L to identify patients with DFU at high risk of adverse outcomes.Conclusion: Anemia is common in patients with DFU. Anemia is a marker of DFU severity, and Hb level can predict poor prognosis in patients with DFU.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Crohn disease presenting as "knife-edged" ulcers: a case report. 表现为 "刀刃状 "溃疡的皮肤克罗恩病：病例报告。

IF 1.7 4区医学

Wounds : a compendium of clinical research and practice Pub Date : 2024-03-01

Melissa A Nickles, Saman S Karimi, Heidi Kurn, Marylee Braniecki, Anne Polick, Itishree Trivedi, Nadera Sweiss, Igor A Altman

{"title":"Cutaneous Crohn disease presenting as \"knife-edged\" ulcers: a case report.","authors":"Melissa A Nickles, Saman S Karimi, Heidi Kurn, Marylee Braniecki, Anne Polick, Itishree Trivedi, Nadera Sweiss, Igor A Altman","doi":"","DOIUrl":"","url":null,"abstract":"Background: CCD presents as non-caseating granulomas within the skin at a site distant from the GI tract. CCD is a debilitating extraintestinal sequela of CD that can sometimes precede its GI manifestations. In the absence of GI symptoms, the histopathologic and clinical features of CCD can present as a variety of inflammatory skin conditions that can range from ruptured follicle-associated granulomas to cutaneous ulcerations. While a variety of therapeutic options for patients with CCD and concurrent luminal CD have been described in the literature, there is no standard treatment algorithm for the management of refractory CCD with limited or covert GI involvement.Case report: The authors discuss the case of a 33-year-old female who presented to the wound care clinic with multiple \"knife-edged\" cutaneous ulcerations involving the intertriginous spaces, found to be consistent with CCD. Her original cutaneous symptoms and diagnosis manifested with minimal GI involvement and responded to IVIG treatment.Conclusions: This case supports the inclusion of CCD in the differential diagnosis in patients with knife-edged granulomatous skin lesions in intertriginous locations. This clinical condition may present in the setting of no or limited GI symptoms. The management of CCD and a proposed treatment algorithm are also presented.","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0