Topical timolol for calciphylaxis: a case report.

IF 1.4 4区医学 Q3 DERMATOLOGY

Wounds : a compendium of clinical research and practice Pub Date : 2025-04-01

Lamis Elyamani, Ouissal Hormi, Nada Benaini, Nassiba Zerrouki, Nada Zizi

引用次数: 0

Abstract

Background: Calciphylaxis is a rare multifactorial skin disease characterized by thrombosis and calcification of skin subcutaneous vessels, leading to chronic and painful ulcers with skin necrosis. Despite its high morbidity and mortality rates, effective treatments are lacking.

Case report: A 65-year-old female with chronic kidney disease who developed painful bilateral ulcers was successfully treated with topical timolol. Clinical examination and imaging confirmed the diagnosis of calciphylaxis. Treatment with topical timolol resulted in rapid wound healing and pain relief.

Conclusion: This case highlights the potential of topical timolol in promoting wound healing in calciphylaxis ulcers, a novel therapeutic approach not previously reported. Further studies are warranted to validate the efficacy of topical timolol and explore its role in managing calciphylaxis. Despite the challenges in diagnosis and management of calciphylaxis, topical timolol appears promising for improving outcomes in affected patients.

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局部替洛尔治疗钙化反应1例报告。

背景：钙化反应是一种罕见的多因素皮肤病，其特征是皮肤皮下血管血栓形成和钙化，导致慢性疼痛溃疡伴皮肤坏死。尽管其发病率和死亡率很高，但缺乏有效的治疗方法。病例报告：65岁女性慢性肾脏疾病谁发展痛苦的双侧溃疡成功治疗局部噻莫洛尔。临床检查和影像学证实了钙化反应的诊断。局部使用噻莫洛尔治疗导致伤口快速愈合和疼痛缓解。结论：本病例强调了局部噻莫洛尔在促进钙化性溃疡伤口愈合方面的潜力，这是一种以前未报道的新型治疗方法。进一步的研究是必要的，以验证局部噻莫洛尔的疗效，并探讨其在管理钙化反应中的作用。尽管在钙化反应的诊断和管理方面存在挑战，局部噻莫洛尔似乎有望改善受影响患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.