Wounds : a compendium of clinical research and practice最新文献

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Antimicrobial Resistance in Wound Care: Expert Panel Consensus Statements. 伤口护理中的抗菌素耐药性:专家小组共识声明。
IF 1.4 4区 医学
Windy Cole, Emily Greenstein, Ira M Herman, John Lantis, Catherine Milne, Irena Pastar, Ronald Beaulieu, Terry Swanson, Anthony Tickner, Naz Wahab
{"title":"Antimicrobial Resistance in Wound Care: Expert Panel Consensus Statements.","authors":"Windy Cole, Emily Greenstein, Ira M Herman, John Lantis, Catherine Milne, Irena Pastar, Ronald Beaulieu, Terry Swanson, Anthony Tickner, Naz Wahab","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) presents a growing global health crisis, with significant implications for the management of chronic, hard-to-heal wounds. These wounds often serve as reservoirs for resistant pathogens, particularly when complicated by biofilms that impede healing and shield microbes from host defenses and antimicrobial therapies. In October 2024, a multidisciplinary panel of wound care experts from the United States and Australia convened to develop a consensus document aimed at guiding clinicians in the responsible management of microbial burden throughout wound care. This comprehensive guidance outlines the core physiological processes involved in wound healing, the role of microbial colonization and infection in healing delays, and the mechanisms by which resistance develops and spreads. It provides best practices for wound cleansing, debridement, and the appropriate use of systemic antibiotics, emphasizing that systemic agents should only be used when clinically indicated. The document also explores the use of topical antimicrobials and nonantibiotic alternatives, such as topical oxygen, nitric oxide, probiotics, and chelating agents, to help limit reliance on systemic therapies. A key theme throughout the consensus is the importance of antimicrobial stewardship. The panel calls for targeted therapy guided by culture data, limited treatment durations, and the incorporation of education for clinicians, patients, and caregivers to ensure effective and sustainable wound care practices. By integrating emerging technologies, personalized care approaches, and coordinated interdisciplinary collaboration, these recommendations aim to reduce complications, improve healing outcomes, and slow the spread of AMR in wound care settings. This consensus document serves as a practical, evidence-based guide to support clinicians in making informed decisions that balance infection control with the urgent need to preserve the effectiveness of antimicrobial therapies.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5 Suppl","pages":"S1-S24"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health care costs and clinical outcomes of necrotizing soft tissue infections: an evaluation of skin-sparing surgery. 坏死性软组织感染的医疗费用和临床结果:保留皮肤手术的评估。
IF 1.4 4区 医学
Travis L Perry, Jordan Silverman, Courtney Johnson, Benjamin Kleeman, Priti Parikh
{"title":"Health care costs and clinical outcomes of necrotizing soft tissue infections: an evaluation of skin-sparing surgery.","authors":"Travis L Perry, Jordan Silverman, Courtney Johnson, Benjamin Kleeman, Priti Parikh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing soft tissue infection (NSTI) is a debilitating disease process that is characterized by rapid clinical progression and extensive tissue destruction, necessitating early surgical excision. Long-term care and outcomes of the resulting complex morbid wounds remain daunting.</p><p><strong>Objective: </strong>To review the skin-sparing surgery (SSS) approach to NSTIs and patient outcomes, including mortality rate, length of stay (LOS), and health care costs (HCC).</p><p><strong>Methods: </strong>The electronic medical records of patients treated at an adult regional burn and wound center between 2011 and 2021 and who underwent a SSS approach to wound closure were reviewed. Patients were excluded if surgical reports did not characterize widespread fulminant tissue destruction at multiple levels and use of a SSS approach. LOS, mortality rate, readmission rates, and HCC were also evaluated.</p><p><strong>Results: </strong>Seventy-one patients were included in the study. The mean number of SSS per patient during initial hospitalization was 3.56, and the mean number including revisions of all anatomic locations was 7.34. The initial hospital LOS averaged 23 days, and the initial encounter mortality rate was 1.4% (n = 1). The readmission rate within 30 days and within 90 days was 17% (n = 12) and 18% (n = 13), respectively. Further, 39.4% of patients were partially managed as outpatients during wound closure. The mean HCC over the treatment course, including indirect costs and direct costs, was $64 645.18 and $44 543.61, respectively.</p><p><strong>Conclusion: </strong>The results of this study show that the SSS approach to NSTI correlates with low mortality rates, decreased LOS, and low HCC. These findings can inform future studies involving the SSS approach as well as increase awareness of this alternative technique to surgeons caring for patients with NSTI.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"179-185"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative pressure wound therapy for management of Achilles region defects: a systematic review of the literature. 负压伤口治疗跟腱区缺损:系统文献综述。
IF 1.4 4区 医学
Marco Gratteri, Claudia Luciano, Fara Desiree Romano, Luigi Abate, Carlo Mirra, Luca Savani, Giuseppe Francesco Papalia, Rocco Papalia, Pasquale Farsetti, Giovanni Francesco Marangi, Paolo Persichetti
{"title":"Negative pressure wound therapy for management of Achilles region defects: a systematic review of the literature.","authors":"Marco Gratteri, Claudia Luciano, Fara Desiree Romano, Luigi Abate, Carlo Mirra, Luca Savani, Giuseppe Francesco Papalia, Rocco Papalia, Pasquale Farsetti, Giovanni Francesco Marangi, Paolo Persichetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Despite the efforts of plastic and orthopedic surgeons to elaborate the most appropriate treatment for lesions of the Achilles region and their reconstruction, no universal guideline exists. Regenerative treatments such as negative pressure wound therapy (NPWT) are increasingly being used in the management of these defects.</p><p><strong>Objective: </strong>To research the different usage protocols, roles, and outcomes of NPWT in the management and reconstruction of Achilles region defects.</p><p><strong>Methods: </strong>A scientific literature search was performed by querying Medline and Scopus using the terms \"(Achilles tendon) AND ((vac) OR (vacuum assisted closure) OR (negative pressure) OR (NPWT)).\" The authors used an online screening software. The investigation followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for systematic review.</p><p><strong>Results: </strong>Of the initial 153 studies identified, only 14 fulfilled the eligibility criteria and were included in this review. Analyzed protocols mainly included surgical debridement combined with the use of NPWT as a primary dressing directly on the tendon or as a secondary dressing covering a split-thickness skin graft (STSG) or a flap. Additionally, the combination of negative pressure with matrices was found to provide optimal results even after STSG failure. Most of the reported complications described in the included studies involved partial loss of graft or flap.</p><p><strong>Conclusion: </strong>NPWT can be used either as a primary dressing (directly on the lesion) or as a secondary dressing (over a flap or a skin graft) for management of Achilles region defects. The combined use of negative pressure with matrices can also aid in wound reduction.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"186-197"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical timolol reduces the number of electrocauterization treatments required for treatment of pyogenic granulation after bromhidrosis surgery. 局部噻莫洛尔减少了腋臭手术后治疗化脓性肉芽所需的电灼治疗次数。
IF 1.4 4区 医学
Wen-Tsao Ho, Chin-Yi Yang
{"title":"Topical timolol reduces the number of electrocauterization treatments required for treatment of pyogenic granulation after bromhidrosis surgery.","authors":"Wen-Tsao Ho, Chin-Yi Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pyogenic granulation is a common complication of bromhidrosis surgery, and multiple electrocauterization sessions are usually required to treat this condition.</p><p><strong>Objective: </strong>To investigate the effectiveness of topical timolol for improving electrocauterization outcomes for pyogenic granulation.</p><p><strong>Methods: </strong>The medical data of 20 patients who underwent bilateral bromhidrosis surgery followed by electrocauterization treatments for pyogenic granulation between January 2021 and December 2022 were retrospectively reviewed. The first 10 patients did not use topical timolol (non-timolol group), and the second 10 patients applied topical timolol maleate 0.5% drops twice daily (timolol group) after each session of electrocauterization. The total number of electrocauterization sessions received by the patients were compared between the 2 groups.</p><p><strong>Results: </strong>The number of electrocauterization sessions was significantly less in the timolol group compared with the non-timolol group (median [range]: 3.5 [2-5] vs 5.5 [2-9]; P = .007). There was no statistically significant difference in age and sex distribution between the groups.</p><p><strong>Conclusion: </strong>Application of topical timolol twice daily is effective in decreasing the number of electrocauterization treatments required to treat pyogenic granulation after bromhidrosis surgery. Topical timolol can enhance wound healing and improve electrocauterization treatment outcomes.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"174-178"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview and survey of US Food and Drug Administration-registered wound imaging devices capable of determining percentage area reduction and/or percentage volume reduction. 美国食品和药物管理局注册的伤口成像设备的概述和调查,能够确定百分比面积缩小和/或百分比体积缩小。
IF 1.4 4区 医学
Holly Korzendorfer, Peggy Dotson, Francis James, Windy Cole, Alisha Oropallo
{"title":"An overview and survey of US Food and Drug Administration-registered wound imaging devices capable of determining percentage area reduction and/or percentage volume reduction.","authors":"Holly Korzendorfer, Peggy Dotson, Francis James, Windy Cole, Alisha Oropallo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>A key element in achieving high-quality research lies in the use of validated tools for effective data collection. To enhance this process, the authors have created comprehensive reporting guidelines for these essential tools.</p><p><strong>Objective: </strong>As members of the Wound Care Collaborative Community (WCCC) Tools Work Group, to identify tools capable of measuring percentage area reduction (PAR) and/or percentage volume reduction (PVR) and to assess the various features associated with these wound imaging devices.</p><p><strong>Methods: </strong>Data from publicly available databases and surveys of manufacturers meeting the inclusion criteria were collected in the fourth quarter of 2023 and the second quarter of 2024. The inclusion criteria were medical devices with the US Food and Drug Administration (FDA) FXN (Tape, Camera, Surgical) product code classification capable of length and width wound measurements currently marketed by FDA-listed establishments.</p><p><strong>Results: </strong>Thirteen FDA-registered establishments with 14 wound imaging devices met the inclusion/exclusion criteria. Representatives from 10 of those establishments engaged in the survey process by completing and returning their WCCC questionnaires. Seven tables were created to summarize the findings across the devices.</p><p><strong>Conclusion: </strong>More wound imaging devices measure PAR than PVR, and most utilize the perimeter alone or in conjunction with square surface area and/or oval or other shapes for area calculations. While variations in length or width (up to 5%), and area (up to 10%) may occur with the device calculations, these variations are less than is seen with ruler measurements. Several imaging devices incorporate methods to correct for skew, have sophisticated 3-dimensional modeling, and/or use reference markers to enhance overall accuracy and reliability, supporting their measurements as reliable indicators of wound trajectory.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"210-219"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in burn wound management: innovative strategies for healing and infection control. 烧伤创面管理的进展:治疗和感染控制的创新策略。
IF 1.4 4区 医学
Alosh Greeny, Rekha R Shenoy
{"title":"Advances in burn wound management: innovative strategies for healing and infection control.","authors":"Alosh Greeny, Rekha R Shenoy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Burn wounds are insults to the skin that can be caused by various sources, including thermal, electrical, or chemical sources, and even natural sources such as the sun. A burn wound is conventionally categorized into 3 distinct zones: (1) coagulation, (2) ischemia/stasis, and (3) hyperemia. In addition to the potential for physiological scarring, burn wounds can lead to microbial infections, such as pneumonia and methicillin-resistant Staphylococcus aureus, that are difficult to treat using conventional antimicrobial therapy. Patients whose burn wounds trigger a systemic inflammatory response experience further deterioration of their medical condition. Moreover, an increase in the incidence of antibiotic resistance poses a major challenge in the treatment of wounds. Researchers are shifting their focus to newer techniques, such as acellular fish skin, hydrogels, negative pressure wound therapy, nanotherapeutics, and stem cell therapy to counter the disadvantages associated with conventional therapy. This review provides an overview of burn wound causes, classifications, and treatments, and it discusses the healing phases of wounds, possible types of infections, the complexities associated with existing conventional treatments, and the advanced techniques currently used in burn wound management that have proven to reduce hospital stays and make treatment more cost-effective.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"198-209"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of social determinants of health on clinical trials conducted for diabetic foot ulcer and venous leg ulcer at a safety net hospital. 健康的社会决定因素对在一家安全网医院进行的糖尿病足溃疡和静脉腿溃疡临床试验的影响。
IF 1.4 4区 医学
Nolan Patrick Joyce, Aniket Vazirani, Connor Roddy, Marina A Malikova
{"title":"Effect of social determinants of health on clinical trials conducted for diabetic foot ulcer and venous leg ulcer at a safety net hospital.","authors":"Nolan Patrick Joyce, Aniket Vazirani, Connor Roddy, Marina A Malikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Failure to adhere to study protocol is among the most common observations during inspections conducted by competent authorities for clinical trials.</p><p><strong>Objective: </strong>To evaluate patterns of protocol deviations, and to analyze how social determinants of health (SDoH) correlate with the rate of protocol deviations as indicators of study protocol noncompliance.</p><p><strong>Materials and methods: </strong>Data obtained at a single clinical site from 19 clinical trials with a total of 186 subjects enrolled were analyzed retrospectively, and correlations between SDoH (eg, race/ethnicity, gender [eg, male/female], socioeconomic status, distance traveled, etc) and study protocol noncompliance (ie, rate of deviations) were examined. The Kruskal-Wallis test was performed to compare SDoH variables with rate of deviations per subjects enrolled. Associations between SDoH and deviations were examined using the Spearman correlation test.</p><p><strong>Results: </strong>A retrospective analysis showed that the majority of deviations were attributed to study visits that had not been performed in a timely manner or were missed, and study procedures that either were not performed or were completed late. The tests demonstrated no statistical significance between age, gender, and race and rates of dropout from the study (P = .1857, P = .3836, and P = .2150, respectively). Increased body mass index was associated with higher dropout rates (P = .0340), which can be an indicator of higher disease burden and an obstacle to trial participation.</p><p><strong>Conclusion: </strong>Further studies are warranted to investigate how quality in wound care clinical trials can be improved with identification of patients who need more resources based on their SDoH to efficiently mitigate risks, increase access to trials for disadvantaged populations, and improve study protocol compliance.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"158-165"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical timolol for calciphylaxis: a case report. 局部替洛尔治疗钙化反应1例报告。
IF 1.4 4区 医学
Lamis Elyamani, Ouissal Hormi, Nada Benaini, Nassiba Zerrouki, Nada Zizi
{"title":"Topical timolol for calciphylaxis: a case report.","authors":"Lamis Elyamani, Ouissal Hormi, Nada Benaini, Nassiba Zerrouki, Nada Zizi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Calciphylaxis is a rare multifactorial skin disease characterized by thrombosis and calcification of skin subcutaneous vessels, leading to chronic and painful ulcers with skin necrosis. Despite its high morbidity and mortality rates, effective treatments are lacking.</p><p><strong>Case report: </strong>A 65-year-old female with chronic kidney disease who developed painful bilateral ulcers was successfully treated with topical timolol. Clinical examination and imaging confirmed the diagnosis of calciphylaxis. Treatment with topical timolol resulted in rapid wound healing and pain relief.</p><p><strong>Conclusion: </strong>This case highlights the potential of topical timolol in promoting wound healing in calciphylaxis ulcers, a novel therapeutic approach not previously reported. Further studies are warranted to validate the efficacy of topical timolol and explore its role in managing calciphylaxis. Despite the challenges in diagnosis and management of calciphylaxis, topical timolol appears promising for improving outcomes in affected patients.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"141-144"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative pressure wound therapy using a new pressure monitoring device for wound treatment: results of an animal model. 负压创面治疗使用一种新的压力监测装置:动物模型的结果。
IF 1.4 4区 医学
Fengzhen Meng, Jianwen Ye, Xiaomin Wu, Jianchi Li, Bin Bian, Wensong Li, Xiaohua Pan
{"title":"Negative pressure wound therapy using a new pressure monitoring device for wound treatment: results of an animal model.","authors":"Fengzhen Meng, Jianwen Ye, Xiaomin Wu, Jianchi Li, Bin Bian, Wensong Li, Xiaohua Pan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Negative pressure wound therapy (NPWT) is a widely used therapeutic approach for skin and soft tissue defects, and selecting an appropriate negative pressure value is critically important.</p><p><strong>Objective: </strong>To develop a wound pressure monitoring dressing (WPMD) integrating a novel pressure sensing chip with a previously developed polyvinyl acetate foam dressing.</p><p><strong>Materials and methods: </strong>Sprague-Dawley male rats were randomly divided into 3 groups to receive -125 mm Hg pressure with the WPMD, -75 mm Hg pressure with the WPMD, or wound dressing without negative pressure (control). Data on pressure changes and wound conditions were collected over 7 consecutive days. Monitoring included pressure changes, gross wound morphology observations, and histopathological analyses.</p><p><strong>Results: </strong>Monitoring data revealed pressure variations during wound healing ranging from -128 mm Hg to -63 mm Hg in the -125 mm Hg preset group, and from -72 mm Hg to -37 mm Hg in the -75 mm Hg preset group. The WPMD groups exhibited higher wound closure rates than the control group. Ki67, vascular endothelial growth factor receptor 2, transforming growth factor β1, and CD31 expression levels were elevated in the WPMD groups compared with the control group.</p><p><strong>Conclusion: </strong>The WPMD accurately and sensitively detected real-time pressure changes on wound surfaces under different preset negative pressure values (-125 mm Hg and -75 mm Hg). Furthermore, NPWT significantly accelerated wound healing in the rat model, and the healing rates were better in the -75 mm Hg group than in the -125 mm Hg group at day 5 and day 7. These results underscore the potential application of the WPMD in investigating the relationship between negative pressure values and wound healing rates across various wound types during treatment.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"145-151"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the effectiveness of two prophylactic single-use negative pressure wound therapy devices in reducing surgical site complications after cesarean delivery: insights from a large US claims database. 两种预防性一次性负压伤口治疗装置在减少剖宫产术后手术部位并发症方面的效果比较:来自美国大型索赔数据库的见解。
IF 1.4 4区 医学
Annmarie Vilkins, Leo Nherera, Richard Searle, Tia Welsh
{"title":"Comparison of the effectiveness of two prophylactic single-use negative pressure wound therapy devices in reducing surgical site complications after cesarean delivery: insights from a large US claims database.","authors":"Annmarie Vilkins, Leo Nherera, Richard Searle, Tia Welsh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Single-use negative pressure wound therapy (sNPWT) has emerged as a promising intervention for patients at high risk of surgical site complications (SSCs) after a cesarean delivery. However, the available studies primarily compare negative pressure wound therapy to standard dressings rather than evaluating differences between negative pressure wound therapy devices or pressure settings.</p><p><strong>Objective: </strong>To compare the effectiveness of 2 commonly used sNPWT devices, a -80 mm Hg device and a -125 mm Hg device, in reducing the risk of SSCs following cesarean delivery.</p><p><strong>Materials and methods: </strong>Real-world data were obtained from a large claims database in the United States from January 2017 through June 2022. Adult patients who had an inpatient encounter in which the -80 mm Hg device or the -125 mm Hg device was used after a cesarean delivery were included. Propensity score matching was used to balance the cohorts. Study end points included incidence of overall surgical site infection (SSI), superficial SSI, dehiscence, seroma, hematoma, deep SSI, length of stay (LOS), and costs.</p><p><strong>Results: </strong>The study included 5332 cases in each group. Overall SSI, superficial SSI, dehiscence, seroma, and costs were significantly lower with the -80 mm Hg device compared with the -125 mm Hg device (P ≤ .05). No differences between the 2 devices were observed for hematoma, deep SSI, and LOS (P > .05).</p><p><strong>Conclusion: </strong>Of the 2 commonly used sNPWT devices, use of the -80 mm Hg device was associated with a lower likelihood of developing overall SSI, superficial SSI, dehiscence, and seroma, and was associated with lower costs after cesarean delivery compared with the -125 mm Hg device. There were nonsignificant differences in LOS, deep SSI, and hematoma. Further studies are required to confirm these findings.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"152-157"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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