Wounds : a compendium of clinical research and practice最新文献

{"title":"The importance of accurate color in wound photography and data.","authors":"Francis G James, Alisha Oropallo, Jason Woodworth, Vickie Driver, Courtney Pina, Peggy Dotson, Oscar Alvarez","doi":"10.25270/wnds/24145","DOIUrl":"https://doi.org/10.25270/wnds/24145","url":null,"abstract":"<p><strong>Background: </strong>Wound photography is widely used for clinical assessment, documentation, telemedicine, and emerging analytic applications. Despite this reliance on wound photography, it has developed largely outside the objective acquisition and accuracy standards applied to other medical imaging modalities. Thus, tissue color, a primary determinant of wound evaluation, may be inconsistently represented in routine clinical photographs.</p><p><strong>Methods: </strong>A structured literature review was conducted, synthesizing peer-reviewed studies, standards documents, and large observational analyses addressing wound photography accuracy, color calibration, acquisition standardization, analytic performance, clinical interpretation variability, and documentation use. Searches were performed across major biomedical databases, with findings synthesized narratively. Conference-reported datasets were included as corroborative evidence when peer-reviewed data were limited.</p><p><strong>Results: </strong>Across studies, uncalibrated wound photographs demonstrated substantial deviation from known color reference values, with wide dispersion of clinically relevant tissue colors. In contrast, standardized acquisition techniques and use of color reference targets were consistently associated with reductions in measured color error and with improved reproducibility. Analytic studies demonstrated that predictive performance varied with baseline image fidelity, while clinical studies reported divergent assessments and measurement variability when photographs were obtained without standardized methods.</p><p><strong>Conclusion: </strong>The literature demonstrates that color inaccuracy in wound photography is prevalent, measurable, and consequential when photographs are used for interpretation, documentation, or analysis. Standardized acquisition and objective assessment of color accuracy improve photographic fidelity and support more reliable clinical and analytic use. Adoption of objective image-quality standards aligned with other medical imaging fields represents a practical pathway to improving reliability in wound photography.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 4","pages":"90-96"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanofiber wound dressings in diabetic wound healing: a review and economic considerations.","authors":"Gemma Toogood, Harrison Smith, Meghan Underwood, Robin Evans, Junwang Xu","doi":"10.25270/wnds/25133","DOIUrl":"https://doi.org/10.25270/wnds/25133","url":null,"abstract":"<p><strong>Background: </strong>Electrospun nanofibers offer a promising solution in the treatment of diabetic wounds due to the technology's ability to integrate a therapeutic agent, as well as its biodegradability, ability to act as a temporary extracellular matrix, and desirable wound dressing characteristics.</p><p><strong>Objective: </strong>To summarize existing literature on the use of nanofiber wound dressings in diabetic models.</p><p><strong>Methods: </strong>A scoping review was conducted to include literature investigating the application of nanofiber wound dressings loaded with a therapeutic modality in diabetic models. The query was developed using the PubMed Advanced Search Builder using key words and translated to the Embase syntax using the Embase Query Translator prior to searching both databases. Studies were excluded if they did not evaluate nanofibers as wound dressings or did not evaluate diabetic models.</p><p><strong>Results: </strong>Compared with the standard of care, nanofiber dressings loaded with antibiotics, anti-inflammatory agents, antioxidants, growth factors, and stem cells have demonstrated improved wound healing through infection control, inflammatory modulation, angiogenesis, cellular proliferation and migration, and minimized systemic adverse effects through localized drug release. Although no nanofiber wound dressing is currently commercially available, these dressings are promising in terms of cost-efficacy (despite the likely higher up-front cost) due to the potential for decreased hospital stays, amputations, and infection through accelerated wound healing.</p><p><strong>Conclusion: </strong>Electrospun nanofibers offer significant promise as a dressing for diabetic wound management; however, further studies are needed to evaluate the clinical efficacy and cost-effectiveness of such treatment.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 3","pages":"60-65"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of negative pressure wound therapy on abdominal deep incisional surgical site infections in high-risk patients.","authors":"Semih Hot, Seracettin Eğin","doi":"10.25270/wnds/25091","DOIUrl":"https://doi.org/10.25270/wnds/25091","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infections (SSIs) significantly increase morbidity, mortality, and hospital stay, especially among high-risk patients with comorbidities such as diabetes or malignancy. Negative pressure wound therapy (NPWT) has improved outcomes in complex wounds, but its cost limits routine use in resource-constrained settings.</p><p><strong>Objective: </strong>To evaluate the effectiveness of NPWT on infection resolution, morbidity, and mortality in high-risk and emergency surgery patients with abdominal deep incisional SSI.</p><p><strong>Materials and methods: </strong>High-risk patients (American Society of Anesthesiologists physical status class ≥III) who received NPWT for abdominal deep incisional SSI between February 1, 2015, and February 1, 2024, were analyzed. All cases met United States Centers for Disease Control and Prevention National Healthcare Safety Network criteria for deep SSI. NPWT was applied following infection control and surgical debridement. Dressings were changed on postoperative day 3 and every 5 days thereafter. Mean patient follow-up was 1 year.</p><p><strong>Results: </strong>Sixty-five patients (36 females, 29 males; mean [standard deviation] age, 58.7 [13.4] years) were included. Emergency surgery was the initial surgical procedure in 56.9% of cases, and malignancy was the primary surgical indication in 50.8% of all 65 cases. Diabetes was the most common comorbidity (47.7%). The overall mortality rate was 4.6%. No SSI recurrence was observed during mean 1-year follow-up.</p><p><strong>Conclusion: </strong>NPWT is a safe and effective therapy for managing abdominal deep incisional SSIs in high-risk patients. In low-resource settings, its selective use in high-risk populations may optimize outcomes and cost-effectiveness.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 3","pages":"42-50"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When is a consensus paper not a consensus paper?","authors":"John C Lantis","doi":"10.25270/wnds/0326-01","DOIUrl":"https://doi.org/10.25270/wnds/0326-01","url":null,"abstract":"","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 3","pages":"A1"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a practical framework for debridement in chronic wounds: findings from a United States-based multidisciplinary consensus panel.","authors":"John C Lantis, Cyaandi Dove, Kelly McFee, Terry Treadwell, Maria Goddard, Marjana Tomic-Canic, Dot Weir, Frank Aviles, Abigail E Chaffin, Martha R Kelso, Thomas Serena","doi":"10.25270/wnds/25155","DOIUrl":"https://doi.org/10.25270/wnds/25155","url":null,"abstract":"<p><strong>Background: </strong>Effective debridement is a cornerstone of wound bed preparation and healing. Despite widespread recognition of its importance, practical guidance for selecting and sequencing debridement methods across diverse care settings remains limited.</p><p><strong>Objective: </strong>To provide United States-based, patient-centered recommendations incorporating debridement into the continuum of wound management.</p><p><strong>Methods: </strong>A 9-member panel composed of experts in vascular surgery, podiatric surgery, plastic and reconstructive surgery, general surgery, nursing, physical therapy, and basic science convened in Grapevine, Texas, in April 2025. Using nominal focus group methodology, these experts developed 20 draft statements from discussion transcripts and refined them through 2 survey rounds using a 5-point Likert scale. Interpanelist agreement was assessed using Kendall's W and Spearman rank correlation coefficient analysis.</p><p><strong>Results: </strong>Seventeen consensus statements were finalized, reflecting high agreement (Kendall's W = 0.566). Core themes included matching debridement to wound goals and patient factors, adopting a dynamic escalation/de-escalation (\"chutes and ladders\") approach, and emphasizing communication, pain control, and diagnostic adjuncts. The panel stressed flexibility, clinician judgment, and patient-centered care when integrating debridement strategies across settings.</p><p><strong>Conclusion: </strong>This United States-based multidisciplinary consensus provides practical, patient-centered guidance for selecting and sequencing debridement methods across wound types and care settings, supporting clinicians to apply flexible, evidence-informed strategies to optimize wound bed preparation and healing outcomes.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 3","pages":"S1-S20"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking compression: expanding decongestive therapy with innovative garment solutions.","authors":"Suzie Ehmann, Sandi Davis","doi":"10.25270/wnds/25106","DOIUrl":"https://doi.org/10.25270/wnds/25106","url":null,"abstract":"<p><strong>Background: </strong>Access to skilled lymphedema care is increasingly limited due to workforce shortages, financial constraints, and logistical barriers. Although compression bandaging remains the standard for the intensive phase and compression garments for maintenance, their complexity and reliance on trained clinicians pose challenges for many patients. This article explores the use of an elastic nighttime garment (ENG) and an adjustable wrap device (AWD) in both phases to optimize outcomes. The ENG used in this analysis is a specific low-profile, elastic, lymphatic alternating pressure profile-based design. The AWD used is constructed using overlapping, knitted, short-stretch bands rather than laminate textile.</p><p><strong>Objective: </strong>To evaluate the clinical viability of a dual-layer, patient-managed compression system that combines an ENG with an AWD as an alternative to traditional bandaging during the intensive phase of complete decongestive therapy (CDT) and as a tool for long-term maintenance.</p><p><strong>Methods: </strong>This prospective case-based analysis draws from 5 representative patients with complex lymphedema presentations and barriers to conventional CDT. Each case details diagnosis, intervention protocol, and outcomes using the dual-layer system. Compression combinations were tailored to individual needs, with emphasis on self-management, mobility, and wound care compatibility.</p><p><strong>Results: </strong>All patients achieved measurable limb volume reduction, improved adherence, and enhanced independence. The system facilitated transition to custom garments, reduced clinic visit frequency, and supported wound healing and mobility in diverse clinical scenarios.</p><p><strong>Conclusion: </strong>The dual-layer ENG plus AWD system offers a scalable, evidence-informed alternative to traditional compression bandaging. It enhances access, supports patient autonomy, and bridges intensive therapy with sustainable self-management, which is particularly valuable in underserved and resource-limited settings.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 3","pages":"66-77"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrosurgical debridement system combined with negative pressure wound therapy for the treatment of large chronic wounds caused by polyacrylamide hydrogel injection for breast augmentation.","authors":"Xun Xu, Ruoyu Wang, Honglin Wu, Jinxiong Xu, Yulan Miao","doi":"10.25270/wnds/25003","DOIUrl":"https://doi.org/10.25270/wnds/25003","url":null,"abstract":"<p><strong>Background: </strong>Polyacrylamide hydrogel (PAHG) is a synthetic, gelatinous chemical substance commonly used as an injectable filler in breast augmentation surgery. However, its decomposition within several years postoperative often leads to various complications, causing significant physical and psychological distress to patients. The key to treatment is thorough debridement and wound drainage. Traditional debridement methods have limitations, such as long duration, significant trauma, and incomplete debridement. A hydrosurgical debridement system offers a new approach to wound healing.</p><p><strong>Case report: </strong>This report presents 2 cases in which a hydrosurgical debridement system combined with negative pressure wound therapy was used to treat large chronic wounds of the trunk, perineum, and lower limbs caused by PAHG injection for breast augmentation.</p><p><strong>Conclusion: </strong>The hydrosurgical debridement system played a key role in the treatment of the 2 cases, resulting in a good prognosis and no recurrence at 12- to 18-month follow-up.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 2","pages":"20-24"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving limbs and lives: the role of cellular, acellular, and matrix-like products in diabetic foot ulcer care.","authors":"Abigail Royfman, Sarah Lux, Kennedy Couch, Molynna Nguyen, Mandy Wong, Emily Gong, Richard Simman","doi":"10.25270/wnds/25051","DOIUrl":"https://doi.org/10.25270/wnds/25051","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) significantly affect patients and health care systems, often resulting in amputation and high morbidity.</p><p><strong>Objective: </strong>To evaluate whether cellular, acellular, and matrix-like products (CAMPs) are more effective than the standard of care in reducing lower limb amputation (LLA) risk and improving survival in DFU patients.</p><p><strong>Methods: </strong>This retrospective cohort study used a proprietary database to identify patients with type 1 or type 2 diabetes and foot ulcers. Two cohorts were compared: those receiving debridement and those receiving CAMPs. Propensity score matching (PSM) balanced baseline characteristics. The primary outcome was 5-year LLA risk and amputation-free survival.</p><p><strong>Results: </strong>Before PSM, the CAMPs cohort (n = 2273) had higher rates of comorbidities compared with the debridement-only cohort (n = 31,050). After matching, cohorts were well-balanced (n = 2272 each). Treatment with CAMPs significantly reduced the risk of LLA compared with debridement alone, with a 4.9% absolute risk reduction (95% CI, -7.4 to -2.4%; P < .0001) and a 24% relative risk reduction (risk ratio, 0.763; 95% CI, 0.664-0.876). Kaplan-Meier analysis demonstrated improved 5-year amputation-free survival in the CAMPs cohort (75.7% vs 71.3%).</p><p><strong>Conclusion: </strong>CAMP therapy significantly reduces LLA risk and improves amputation-free survival in DFU patients.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 2","pages":"25-33"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative pressure wound therapy-assisted granulation and grafting over exposed Achilles tendon in an immunocompromised burn patient.","authors":"Mohamad Kharashgah, Qusai Nabeel Swedan, Saleh Abualhaj","doi":"10.25270/wnds/25099","DOIUrl":"https://doi.org/10.25270/wnds/25099","url":null,"abstract":"<p><strong>Background: </strong>Management of full-thickness burns over the Achilles tendon is a significant challenge due to poor vascularity, which limits granulation tissue formation and successful grafting. This is even more difficult in patients undergoing chemotherapy, whose wound healing is further compromised due to delayed cell division, migration, and angiogenesis.</p><p><strong>Case report: </strong>A 44-year-old male undergoing chemotherapy for retrobulbar glioma sustained a full-thickness scald burn to the entire lower limb below the knee. Despite multiple tangential excisions and successful grafting over most areas, the Achilles tendon remained exposed and necrotic, with no granulation tissue formation. After debridement of the necrotic tendon followed by 2 longitudinal slit incisions until bleeding was noted, a negative pressure wound therapy device was applied at -125 mm Hg. Dressing changes were done every 3 days for 2 weeks until the tendon was fully covered by granulation tissue. A 10-cm x 5-cm split-thickness mesh skin graft was then applied over the Achilles region, which fully adhered within 1 week.</p><p><strong>Conclusion: </strong>The combination of longitudinal slit incisions of the Achilles tendon and negative pressure wound therapy can enhance adequate granulation over an exposed Achilles tendon, offering a practical and effective alternative to flap coverage in immunocompromised patients.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 2","pages":"12-15"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous skin cell suspension grafting is fundamentally different from skin substitutes.","authors":"Lisa Gould","doi":"10.25270/wnds/0226-01","DOIUrl":"https://doi.org/10.25270/wnds/0226-01","url":null,"abstract":"","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 2","pages":"A1-A2"},"PeriodicalIF":1.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}