Wounds : a compendium of clinical research and practice最新文献

{"title":"Efficacy of cellular and/or tissue-based product applications on all non-pressure injury chronic wound types in a Medicare private practice model.","authors":"Shaun Carpenter, Angelina Ferguson, Devinna Bahadur, Amanda Estapa, Jamie Bahm, Sadie Burst","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This retrospective analysis is a derivative cohort study based on a prior retrospective investigation by this author group.</p><p><strong>Objective: </strong>To assess the effect of the number of cellular and/or tissue-based product (CTP) applications on healing outcomes and wound area reduction (WAR) rates in patients with chronic wounds of multiple etiologies.</p><p><strong>Methods: </strong>Data from a multicenter private wound care practice electronic health record database were analyzed for Medicare patients receiving CTPs from January 2018 through December 2023. Wound treatments were administered in nursing homes (4.77%), private clinics (80.11%), and home settings (15.65%), excluding hospital outpatient department settings. This retrospective analysis evaluated WAR and closure rates following each CTP application.</p><p><strong>Results: </strong>A total of 446 wounds were included in the analysis, comprising 123 diabetic foot ulcers (DFUs), 134 venous leg ulcers (VLUs), 62 surgical wounds, 51 trauma wounds, and 76 other chronic wounds. Significant reductions in average wound areas (cm²) were observed after completing the CTP application series (ie, ≤10 CTPs within 16 weeks) for all chronic wounds (P < .001). Further, there were more total healed wounds noted for the chronic surgical and trauma wounds compared with DFUs and VLUs.</p><p><strong>Conclusion: </strong>This retrospective real-world analysis of Medicare patients undergoing CTP therapy in conjunction with standard of care for chronic trauma and surgical wounds demonstrates substantial reductions in wound area following completion of a CTP application series. Findings from this study may guide governing bodies regarding CTP best practice recommendations in the treatment of chronic wounds of various etiologies.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"292-304"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kirschner wires combined with elastic tape for multilayer tension-reducing repair of a large stage 4 pressure injury of the greater trochanter: a case report.","authors":"Xu Qiliang, Liang XiaoHua, Chen Haoxiong, Zhao Liang, Tan Jingchao, Zhang Linlin, Yang Junxing","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pressure injuries are common, difficult to manage, and carry a high economic burden. They are challenging to physicians and a burden to society.</p><p><strong>Case report: </strong>An 89-year-old male, who had previously undergone internal fixation with screws and rods for a right intertrochanteric fracture, developed a deep circular open ulcer measuring 11 cm × 7.5 cm on his right hip after being bedridden for over 20 consecutive days because of symptoms of coughing and fatigue. Upon examination, the ulcer exhibited extensive necrotic tissue, purulent discharge, and a foul odor at its base. Following multiple debridement procedures, a multilayer tension reduction and repair surgery using the Kirschner wire technique in conjunction with elastic tape was performed on the 31st day of hospitalization. The wound achieved complete healing, and the patient was discharged on the 102nd day of admission. During the 6-month postoperative follow-up period, the appearance and sensory function of the wound skin were observed to have recovered satisfactorily.</p><p><strong>Conclusion: </strong>In this case, the use of Kirschner wires combined with elastic tape for multilayer tension reduction resulted in the repair of a large stage 4 pressure injury at the greater trochanter. The mechanism of action is discussed and analyzed to provide clinical evidence for such treatment.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"329-332"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The trial design of the concurrent optical and magnetic stimulation (COMS) therapy study for refractory diabetic foot ulcers (MAVERICKS): a multicenter, randomized, sham-controlled, double-blind investigational device exemption clinical study.","authors":"Robert D Galiano, Rena A Li, John C Lantis, Alisha Oropallo, Jesus Ulloa, Mark Iafrati, Lawrence A Lavery, Jessica O'Connell, Aksone Nouvong, Viviane Mamede Vasconcelos Cavalcante","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) are a major clinical challenge, particularly among patients with refractory ulcers, that often lead to severe complications such as infection, amputation, and high mortality. Innovations supported by strong clinical evidence have the potential to improve healing outcomes, enhance quality of life, and reduce the economic burden on individuals and health care systems.</p><p><strong>Objective: </strong>To describe the design of the concurrent optical and magnetic stimulation (COMS) therapy Investigational Device Exemption (IDE) study for refractory DFUs (MAVERICKS) trial.</p><p><strong>Materials and methods: </strong>The MAVERICKS trial is a pivotal, multicenter, randomized, sham-controlled, double-blind study designed to evaluate the efficacy and safety of COMS therapy as an adjunct to standard of care for hard-to-heal DFUs. What differentiates MAVERICKS is its extended screening phase, ensuring the inclusion of truly refractory ulcers, thus addressing a critical gap in previous DFU research. With an expected enrollment of 224 patients across diverse clinical settings, the trial incorporates robust methodologies to eliminate bias, and comprehensive inclusion and exclusion criteria to ensure data integrity. The study's primary outcome measure, time to complete wound closure, as well as secondary end points including wound area reduction and time to amputation, will provide credible insights into the therapeutic potential of COMS.</p><p><strong>Conclusion: </strong>The MAVERICKS trial is particularly significant for investigating a novel, accessible, and cost-effective approach to advance DFU treatment. This trial sets a high standard in DFU research and seeks to provide reliable evidence to improve patient outcomes and guide future clinical practice. Upon trial completion, the authors look forward to sharing the findings and outcome analysis with wound care stakeholders. The study is registered under ClinicalTrials.gov identifier NCT05758545, effective March 7, 2023.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"275-282"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating patient transitions from hospital to home in the United Kingdom with single-use negative pressure wound therapy: a discharge pathway.","authors":"Mark J Portou, Ashley W Collinsworth, Siobhan Lookess","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Initially limited to inpatient use, negative pressure wound therapy (NPWT) is now frequently used in community settings. However, complexities in wound management step-down strategies in the United Kingdom, including regional variations in referral processes, lack of consensus on funding criteria, and limited availability of NPWT units, have led to extended hospital length of stay (LOS) for patients ready for discharge but still needing NPWT. Single-use NPWT (sNPWT) can serve as a bridge between hospital and community NPWT.</p><p><strong>Objective: </strong>To assess the feasibility, effectiveness, and potential cost savings of the implementation of a discharge pathway utilizing sNPWT.</p><p><strong>Methods: </strong>This case series included 5 patients with open lower limb wounds treated at a National Health Service facility using an sNPWT discharge pathway. Wounds were assessed before and after sNPWT use. Differences in average inpatient LOS and costs were calculated and compared with those for patients who remained hospitalized until community NPWT was available.</p><p><strong>Results: </strong>The sNPWT discharge pathway was well tolerated by patients and resulted in good clinical outcomes. Patients discharged on sNPWT had an average reduction in LOS of 20.2 days, resulting in a projected £12 350 savings in hospital costs per patient.</p><p><strong>Conclusion: </strong>Preliminary findings indicate use of an sNPWT discharge pathway is feasible and may result in reduced LOS and associated costs while improving patient care. Additional studies are needed to understand the effect on wound management, patient outcomes, and overall care costs.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"305-313"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a novel zipper device for wound closure of cutaneous abscesses in pediatric outpatients: a case series.","authors":"Wei Bingting, Yang Chen, Ma Wei, Xie Mingjing, Xiong Yang, Wu Tingting, Zhang Xuebing","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Current management of pediatric cutaneous abscesses involves either spontaneous healing by secondary intention or suturing through tertiary intention, which are often lengthy processes that cause discomfort and distress among children. As it is noninvasive and simple, a novel zipper device is widely used for the primary wound closure of surgical incisions.</p><p><strong>Objective: </strong>To describe the effectiveness of novel zipper device use for pediatric cutaneous abscess wound closure in an outpatient context.</p><p><strong>Materials and methods: </strong>A total of 26 pediatric outpatients with simple cutaneous abscesses were included. After incision and drainage (I and D), the novel zipper device was applied once pus decreased significantly and fresh granulation tissue emerged. Wound healing time and pain score were tracked over the intervention period. Linear regression and restricted cubic spline models were also used to analyze the relationship between the intervention interval of time from I and D to zipper application and wound healing time.</p><p><strong>Results: </strong>The average (SD) wound healing time was 12.73 (3.16) days. Pain scores decreased significantly from a median of 2 during zipper use to 0 at removal. Linear regression analysis revealed 2 healing time predictors: infection size (B = 0.260, SE = 0.090, β = 0.260, t = 2.924, P = .008) and intervention interval of zipper use (B = 0.850, SE = 0.090, β = 0.810, t = 9.187, P = .001). A linear dose-response relationship was observed between intervention interval and healing time (Ptotal < .001, Pnonlinear = .406).</p><p><strong>Conclusion: </strong>This case series identifies the fifth day post-I and D as a potential threshold, and suggests that the optimal period of zipper device use is 3 days to 5 days following I and D of skin abscess to enhance early wound healing, beyond which extended intervention intervals prolong wound healing time.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"314-322"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of biofilm in chronic wounds: systematic review with meta-analysis.","authors":"Manuela de Mendonça Figueirêdo Coelho, Beatriz Moreira Alves Avelino, Beatriz Alves de Oliveira, Mariana Araújo Rios, Fabiane do Amaral Gubert, Mariana Cavalcante Martins, Janaína Fonseca Victor Coutinho, Paula Sacha Frota Nogueira, Rachel Gabriel Bastos Barbosa, Viviane Mamede Vasconcelos Cavalcante","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>To estimate the prevalence of biofilms in chronic wounds.</p><p><strong>Methods: </strong>The authors performed a systematic review of prevalence studies and meta-analysis, structured according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Articles were searched in Scopus (Elsevier), Web of Science (Clarivate), MEDLINE/PubMed (National Institutes of Health), and Embase (Elsevier) databases. Data collected included the author and year of publication, total number of lesions evaluated, number of lesions with biofilm, detected bacteria, biofilm levels, country where the research was conducted, and the methodological quality of the studies. The meta-analysis was performed using a random effects model in R software (The R Foundation for Statistical Computing).</p><p><strong>Results: </strong>A total of 281 articles were retrieved; after applying the reading and exclusion criteria, 24 studies were included. The meta-analysis incorporated 24 studies from 12 countries, evaluating 2666 lesions with a biofilm prevalence of 68% (95% CI, 58%-79%; I² = 92%). A high prevalence was observed in Asian publications (73%; 95% CI, 62%-84%; I² = 98%), with of Staphylococcus aureus (71%; 95% CI, 51%-90%; I² = 98%) and Pseudomonas aeruginosa (65%; 95% CI, 47%-82%; I² = 98%) being the most common found in all publications.</p><p><strong>Conclusions: </strong>Despite the methodological heterogeneity of the studies included in this review, the findings indicate a high prevalence of biofilms in chronic wounds presented in the studies that made up the sample.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"283-291"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed electromagnetic field stimulation therapy for Charcot foot ulcer: a randomized controlled trial.","authors":"Norhan Mohamed Eltayeb, Marwa Mahdy Abdelhamid, Hossam Zaghloul Yousuf, Nessrein Afifi Abd-Elrashid","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Charcot foot is a debilitating complication of peripheral neuropathy and is primarily associated with diabetes, leading to structural damage, ulceration, and osteomyelitis. Pulsed electromagnetic field (PEMF) therapy is a promising treatment modality for wound healing and bone metabolism.</p><p><strong>Objective: </strong>To evaluate the efficacy of PEMF therapy in promoting bone growth and ulcer healing in patients with Charcot foot ulcers.</p><p><strong>Materials and methods: </strong>This prospective, single-blinded, controlled trial included 34 patients with stage 2 or 3 chronic Charcot foot with ulceration who were randomized into 2 groups. Group A (study group) received PEMF therapy in addition to transcutaneous electrical nerve stimulation (conventional TENS), medical treatment, and standard wound care, while group B (control group) received conventional TENS and the same medical treatment and standard wound care as those in group A, 3 times per week for 3 months. Primary outcomes were assessed with plain radiographs and wound surface area tracing pre-intervention, 6 weeks post-intervention, and 12 weeks post-intervention.</p><p><strong>Results: </strong>No significant differences were evident at baseline analysis. After 6 weeks, both groups showed significant change in Charcot foot signs as well as a reduction in wound surface area (P < .05). In the study group, 23.5% of participants showed complete resolution of Charcot signs (normal appearance), 5.9% progressed to stage 2 (bone sclerosis), and 70.6% remained at stage 1. Regarding wound healing, the study group showed greater reduction in wound surface area, with a median (IQR) of 8.5 cm2 (9.4 cm2-12.2 cm2) compared with 11.5 cm2 (9.4 cm2-15.5 cm2) in the control group. By 12 weeks, 94.1% of the study group showed complete radiological resolution of Charcot signs vs 5.9% in the control group (P < .001). Median wound surface area was significantly reduced in the study group to 0.0 cm² (0.0 cm²-1.0 cm²) compared with 6.6 cm2 (5.7 cm²-7.9 cm²) in the control group (P < .05), indicating superior healing outcomes with PEMF therapy.</p><p><strong>Conclusion: </strong>PEMF therapy is an efficacious adjunctive treatment for Charcot foot ulcers, facilitating both wound healing and bone regeneration.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 8","pages":"323-328"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-fast bacilli staining for nonhealing ulcers: a case report of cutaneous Mycobacterium chelonae infection.","authors":"Stephanie Behme, Shiwei Zhou, Andrew Brown, Gary M Rothenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous infections due to nontuberculous mycobacteria (NTM) are rare, and they can be challenging to treat, often requiring prolonged therapy with multiple antibiotics. Although recent literature challenges the idea of routine acid-fast bacilli (AFB) testing in diabetic foot infections, this report presents a case of Mycobacterium chelonae (M chelonae) infection in a patient with nonhealing ulceration.</p><p><strong>Case report: </strong>A 64-year-old female with no history of immunocompromise and no recent surgical history presented with a rapidly growing ulceration despite appropriate antibiotic therapy based on routine aerobic culture results. After AFB cultures were obtained, she was found to have NTM infection with M chelonae, and the ulceration was healed without recurrence after treatment for 4 months with linezolid and clarithromycin.</p><p><strong>Conclusion: </strong>This case highlights the potential inoculation of M chelonae, even in immunocompetent patients without known inoculation injury, and it highlights the value of AFB cultures in patients who do not progress with standard wound care therapies and routine aerobic cultures.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 7","pages":"264-268"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive sleep apnea is an independent risk factor for split-thickness skin graft failure.","authors":"Karen R Li, Rachel N Rohrich, Christian X Lava, Perry J Diaz, Sabrina F DeLeonibus, Winnie Li, Medhat S Hannallah, Christopher E Attinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is an underdiagnosed and undertreated disease that has been significantly associated with diabetes, cardiovascular disease, peripheral arterial disease, and poor wound healing.</p><p><strong>Objective: </strong>To determine whether or not OSA is an independent risk factor for split-thickness skin graft (STSG) failure in patients with chronic lower extremity (LE) wounds, given OSA's disease burden to common comorbidities in the LE wound population.</p><p><strong>Methods: </strong>A retrospective chart review of chronic LE wounds managed with STSG between December 2014 and December 2022 was conducted. Patients with a diagnosis of OSA (\"OSA\") were compared with patients without an OSA diagnosis (\"Non-OSA\").</p><p><strong>Results: </strong>Overall, 14.9% of patients had OSA (n = 25) and 85.1% (n = 143) did not have OSA. Patients with OSA had a significantly higher median body mass index than the Non-OSA group (32.9 and 28.2, respectively; P = .013) and a higher rate of chronic obstructive pulmonary disease (16.0% and 4.2%, respectively; P = .043). Compared with patients without OSA, patients with OSA had more superficial wounds (P = .027) and received thinner skin grafts (P = .016). Compared with the Non-OSA group, wounds in the OSA group had significantly higher rates of graft failure (OSA 30.6% vs Non-OSA 15.9%; P = .034), infection (OSA 27.8% vs Non-OSA 10.6%; P = .005), and reoperation (OSA 52.8% vs Non-OSA 31.1%; P = .010). On multivariate logistic regression, OSA remained a significant risk factor for graft failure, increasing the odds of graft failure by 8.6 times (P = .040).</p><p><strong>Conclusion: </strong>OSA is an independent predictor of graft failure in a highly comorbid population with chronic LE wounds. Preoperative identification of these high-risk patients should be undertaken by anesthesia, sleep medicine, and surgical teams to improve outcomes.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 7","pages":"253-263"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chronic wounds on health-related quality of life: a cross-sectional study in Hail, Saudi Arabia.","authors":"Alia Dakheel Alshammari, Dareen Abdullah Alrdaian, Awatif Ahmad Alsadiq, Rayana Khalid Alqubali, Shomokh Mohaya Alshammari, Milaf Meshal Alshammari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic wounds are a growing public health concern, particularly among individuals with diabetes and other comorbidities. These wounds often lead to prolonged treatment, pain, and psychological distress, significantly impairing patients' quality of life (QoL).</p><p><strong>Objective: </strong>To evaluate the QoL of patients with chronic wounds and identify the factors that influence their health-related QoL (HRQoL), using the Arabic-language version of the 17-item Wound-QoL questionnaire.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted between June and September 2023, involving 60 patients with chronic wounds treated at a diabetic foot center. Participants were interviewed independently using the Arabic-language version of the Wound-QoL-17, a questionnaire used to assess QoL in patients with chronic wounds.</p><p><strong>Results: </strong>The study sample had a mean (standard deviation) age of 50 (16.19) years, with 60% female (40% male) and 95% Saudi Arabian participants. Diabetic foot ulcer was the most common wound etiology, present in 30% of cases. Wound etiology affected patients' fears of worsening and their levels of frustration. Participants with diabetes reported higher levels of distress and fear. Longer wound duration was associated with greater limitations in social activities. Additionally, differences between males and females were observed in the perception of wound pain and the burden of treatment.</p><p><strong>Conclusion: </strong>This study highlights the significant effect of chronic wounds on patients' QoL, with specific factors, such as wound location, etiology, and duration, playing critical roles. These findings underscore the need for targeted interventions to improve HRQoL in this patient population.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 7","pages":"235-240"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}