Wounds : a compendium of clinical research and practice最新文献

{"title":"A combined multistep reconstruction of the heel after skin tumor resection in posttraumatic chronic ulcers: a case series.","authors":"Fedele Lembo, Liberato Roberto Cecchino, Domenico Parisi, Aurelio Portincasa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Heel reconstruction following wide resection of Marjolin ulcer represents a challenge for surgeons. Local or free flaps are usually used, but they present some disadvantages, such as donor site morbidity, high risk of necrosis, and long surgical time and hospital stay.</p><p><strong>Objective: </strong>To use a combined multistep protocol of heel reconstruction after wide resection of Marjolin ulcer using a biosynthetic extracellular matrix and negative wound pressure therapy.</p><p><strong>Materials and methods: </strong>Demographic, clinical, and surgical data for 4 patients treated at a single institution were retrospectively collected.</p><p><strong>Results: </strong>All patients healed with a good scar appearance and high satisfaction. No complications or tumor recurrence were observed at 12 months postoperative.</p><p><strong>Conclusion: </strong>The findings of this clinical series suggest that the combined protocol described is an effective option for the resolution of these complex wounds.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 6","pages":"220-225"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of COVID-19 on diabetic foot ulcer surgery at a safety net hospital.","authors":"Hau Pham, Ewald Mendeszoon, Vitaliy Volansky, Justin Ogbonna, Wei Tseng, Elizabeth Sanders, David Coker, Ashley Daniel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Management of diabetic foot ulcers requires detailed and continuous work. Social distancing and lockdown restrictions instituted during the COVID-19 pandemic of 2020 were essential to saving lives and preventing hospital overflow, but they caused many difficulties for patients and health care providers.</p><p><strong>Objective: </strong>To show the changes in wound care surgery affected by COVID-19 at a safety net hospital.</p><p><strong>Methods: </strong>All ulcer-related surgeries performed at a single institution from March 2018 through February 2023-that is, 2 years before, the year of, and 2 years after the first year of the COVID-19 pandemic-were reviewed. Because the imposed outpatient and elective surgery restrictions started in March 2020, the period from March through February was used for the review. Wound-related surgeries included wound debridement, incision and drainage, exostectomy, digit amputations, midfoot amputations, and major amputations.</p><p><strong>Results: </strong>During the entire period, 1858 ulcer-related surgeries were performed at the authors' institution. A total of 723 surgeries were performed in the 2 years before COVID (pre), with 368 performed in the initial year of COVID (Covid) and 767 in the 2 years after the first year of the pandemic (post).</p><p><strong>Conclusion: </strong>COVID-19 significantly impacted various aspects of ulcer management at the clinic. The authors' wound clinic remained open on a limited basis, and the number of patients seen was markedly lower. After the restrictions were lifted, wound care visits remained significantly lower than the pre-pandemic level; the fear of COVID-19 had a lasting impact on the number of visits. The number of exostectomy and digit amputations has increased since the first year of the pandemic. Midfoot amputation and major amputation did not change much after the initial year of the pandemic, which may be due to death from COVID-19. The fear and death associated with COVID-19 affected wound care and continue to affect wound care and limb salvage, but determining the actual number affected is challenging.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 6","pages":"226-231"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of polyhexamethylene biguanide in the treatment of atopic dermatitis with Staphylococcus aureus hypercolonization.","authors":"Gleice Freire, Leticia Midori Kondo Iwamoto, Tatiana de Fátima Pinto, Caio César de Silva Castro","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant global prevalence. Clinically, AD is characterized by xerosis, intense pruritus, and recurrent eczematous lesions. The pathogenesis of AD is complex and multifactorial, involving genetic predisposition, epidermal barrier dysfunction, immune dysregulation, and dysbiosis. These factors collectively increase susceptibility to infections in patients with AD. AD lesions are frequently colonized by Staphylococcus aureus and Staphylococcus epidermidis. An important aspect of Staphylococcus spp is the propensity to form biofilms that exhibit enhanced resistance to antibiotics and host immune responses.</p><p><strong>Case report: </strong>This report describes 2 cases of AD associated with biofilm formation that was successfully treated with polyhexamethylene biguanide (PHMB).</p><p><strong>Conclusion: </strong>This report highlights the potential of PHMB in the treatment of AD lesions and biofilm reduction.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 6","pages":"232-234"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance in Wound Care: Expert Panel Consensus Statements.","authors":"Windy Cole, Emily Greenstein, Ira M Herman, John Lantis, Catherine Milne, Irena Pastar, Ronald Beaulieu, Terry Swanson, Anthony Tickner, Naz Wahab","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) presents a growing global health crisis, with significant implications for the management of chronic, hard-to-heal wounds. These wounds often serve as reservoirs for resistant pathogens, particularly when complicated by biofilms that impede healing and shield microbes from host defenses and antimicrobial therapies. In October 2024, a multidisciplinary panel of wound care experts from the United States and Australia convened to develop a consensus document aimed at guiding clinicians in the responsible management of microbial burden throughout wound care. This comprehensive guidance outlines the core physiological processes involved in wound healing, the role of microbial colonization and infection in healing delays, and the mechanisms by which resistance develops and spreads. It provides best practices for wound cleansing, debridement, and the appropriate use of systemic antibiotics, emphasizing that systemic agents should only be used when clinically indicated. The document also explores the use of topical antimicrobials and nonantibiotic alternatives, such as topical oxygen, nitric oxide, probiotics, and chelating agents, to help limit reliance on systemic therapies. A key theme throughout the consensus is the importance of antimicrobial stewardship. The panel calls for targeted therapy guided by culture data, limited treatment durations, and the incorporation of education for clinicians, patients, and caregivers to ensure effective and sustainable wound care practices. By integrating emerging technologies, personalized care approaches, and coordinated interdisciplinary collaboration, these recommendations aim to reduce complications, improve healing outcomes, and slow the spread of AMR in wound care settings. This consensus document serves as a practical, evidence-based guide to support clinicians in making informed decisions that balance infection control with the urgent need to preserve the effectiveness of antimicrobial therapies.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5 Suppl","pages":"S1-S24"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health care costs and clinical outcomes of necrotizing soft tissue infections: an evaluation of skin-sparing surgery.","authors":"Travis L Perry, Jordan Silverman, Courtney Johnson, Benjamin Kleeman, Priti Parikh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing soft tissue infection (NSTI) is a debilitating disease process that is characterized by rapid clinical progression and extensive tissue destruction, necessitating early surgical excision. Long-term care and outcomes of the resulting complex morbid wounds remain daunting.</p><p><strong>Objective: </strong>To review the skin-sparing surgery (SSS) approach to NSTIs and patient outcomes, including mortality rate, length of stay (LOS), and health care costs (HCC).</p><p><strong>Methods: </strong>The electronic medical records of patients treated at an adult regional burn and wound center between 2011 and 2021 and who underwent a SSS approach to wound closure were reviewed. Patients were excluded if surgical reports did not characterize widespread fulminant tissue destruction at multiple levels and use of a SSS approach. LOS, mortality rate, readmission rates, and HCC were also evaluated.</p><p><strong>Results: </strong>Seventy-one patients were included in the study. The mean number of SSS per patient during initial hospitalization was 3.56, and the mean number including revisions of all anatomic locations was 7.34. The initial hospital LOS averaged 23 days, and the initial encounter mortality rate was 1.4% (n = 1). The readmission rate within 30 days and within 90 days was 17% (n = 12) and 18% (n = 13), respectively. Further, 39.4% of patients were partially managed as outpatients during wound closure. The mean HCC over the treatment course, including indirect costs and direct costs, was $64 645.18 and $44 543.61, respectively.</p><p><strong>Conclusion: </strong>The results of this study show that the SSS approach to NSTI correlates with low mortality rates, decreased LOS, and low HCC. These findings can inform future studies involving the SSS approach as well as increase awareness of this alternative technique to surgeons caring for patients with NSTI.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"179-185"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative pressure wound therapy for management of Achilles region defects: a systematic review of the literature.","authors":"Marco Gratteri, Claudia Luciano, Fara Desiree Romano, Luigi Abate, Carlo Mirra, Luca Savani, Giuseppe Francesco Papalia, Rocco Papalia, Pasquale Farsetti, Giovanni Francesco Marangi, Paolo Persichetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Despite the efforts of plastic and orthopedic surgeons to elaborate the most appropriate treatment for lesions of the Achilles region and their reconstruction, no universal guideline exists. Regenerative treatments such as negative pressure wound therapy (NPWT) are increasingly being used in the management of these defects.</p><p><strong>Objective: </strong>To research the different usage protocols, roles, and outcomes of NPWT in the management and reconstruction of Achilles region defects.</p><p><strong>Methods: </strong>A scientific literature search was performed by querying Medline and Scopus using the terms \"(Achilles tendon) AND ((vac) OR (vacuum assisted closure) OR (negative pressure) OR (NPWT)).\" The authors used an online screening software. The investigation followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for systematic review.</p><p><strong>Results: </strong>Of the initial 153 studies identified, only 14 fulfilled the eligibility criteria and were included in this review. Analyzed protocols mainly included surgical debridement combined with the use of NPWT as a primary dressing directly on the tendon or as a secondary dressing covering a split-thickness skin graft (STSG) or a flap. Additionally, the combination of negative pressure with matrices was found to provide optimal results even after STSG failure. Most of the reported complications described in the included studies involved partial loss of graft or flap.</p><p><strong>Conclusion: </strong>NPWT can be used either as a primary dressing (directly on the lesion) or as a secondary dressing (over a flap or a skin graft) for management of Achilles region defects. The combined use of negative pressure with matrices can also aid in wound reduction.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"186-197"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical timolol reduces the number of electrocauterization treatments required for treatment of pyogenic granulation after bromhidrosis surgery.","authors":"Wen-Tsao Ho, Chin-Yi Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pyogenic granulation is a common complication of bromhidrosis surgery, and multiple electrocauterization sessions are usually required to treat this condition.</p><p><strong>Objective: </strong>To investigate the effectiveness of topical timolol for improving electrocauterization outcomes for pyogenic granulation.</p><p><strong>Methods: </strong>The medical data of 20 patients who underwent bilateral bromhidrosis surgery followed by electrocauterization treatments for pyogenic granulation between January 2021 and December 2022 were retrospectively reviewed. The first 10 patients did not use topical timolol (non-timolol group), and the second 10 patients applied topical timolol maleate 0.5% drops twice daily (timolol group) after each session of electrocauterization. The total number of electrocauterization sessions received by the patients were compared between the 2 groups.</p><p><strong>Results: </strong>The number of electrocauterization sessions was significantly less in the timolol group compared with the non-timolol group (median [range]: 3.5 [2-5] vs 5.5 [2-9]; P = .007). There was no statistically significant difference in age and sex distribution between the groups.</p><p><strong>Conclusion: </strong>Application of topical timolol twice daily is effective in decreasing the number of electrocauterization treatments required to treat pyogenic granulation after bromhidrosis surgery. Topical timolol can enhance wound healing and improve electrocauterization treatment outcomes.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"174-178"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview and survey of US Food and Drug Administration-registered wound imaging devices capable of determining percentage area reduction and/or percentage volume reduction.","authors":"Holly Korzendorfer, Peggy Dotson, Francis James, Windy Cole, Alisha Oropallo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>A key element in achieving high-quality research lies in the use of validated tools for effective data collection. To enhance this process, the authors have created comprehensive reporting guidelines for these essential tools.</p><p><strong>Objective: </strong>As members of the Wound Care Collaborative Community (WCCC) Tools Work Group, to identify tools capable of measuring percentage area reduction (PAR) and/or percentage volume reduction (PVR) and to assess the various features associated with these wound imaging devices.</p><p><strong>Methods: </strong>Data from publicly available databases and surveys of manufacturers meeting the inclusion criteria were collected in the fourth quarter of 2023 and the second quarter of 2024. The inclusion criteria were medical devices with the US Food and Drug Administration (FDA) FXN (Tape, Camera, Surgical) product code classification capable of length and width wound measurements currently marketed by FDA-listed establishments.</p><p><strong>Results: </strong>Thirteen FDA-registered establishments with 14 wound imaging devices met the inclusion/exclusion criteria. Representatives from 10 of those establishments engaged in the survey process by completing and returning their WCCC questionnaires. Seven tables were created to summarize the findings across the devices.</p><p><strong>Conclusion: </strong>More wound imaging devices measure PAR than PVR, and most utilize the perimeter alone or in conjunction with square surface area and/or oval or other shapes for area calculations. While variations in length or width (up to 5%), and area (up to 10%) may occur with the device calculations, these variations are less than is seen with ruler measurements. Several imaging devices incorporate methods to correct for skew, have sophisticated 3-dimensional modeling, and/or use reference markers to enhance overall accuracy and reliability, supporting their measurements as reliable indicators of wound trajectory.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"210-219"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in burn wound management: innovative strategies for healing and infection control.","authors":"Alosh Greeny, Rekha R Shenoy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Burn wounds are insults to the skin that can be caused by various sources, including thermal, electrical, or chemical sources, and even natural sources such as the sun. A burn wound is conventionally categorized into 3 distinct zones: (1) coagulation, (2) ischemia/stasis, and (3) hyperemia. In addition to the potential for physiological scarring, burn wounds can lead to microbial infections, such as pneumonia and methicillin-resistant Staphylococcus aureus, that are difficult to treat using conventional antimicrobial therapy. Patients whose burn wounds trigger a systemic inflammatory response experience further deterioration of their medical condition. Moreover, an increase in the incidence of antibiotic resistance poses a major challenge in the treatment of wounds. Researchers are shifting their focus to newer techniques, such as acellular fish skin, hydrogels, negative pressure wound therapy, nanotherapeutics, and stem cell therapy to counter the disadvantages associated with conventional therapy. This review provides an overview of burn wound causes, classifications, and treatments, and it discusses the healing phases of wounds, possible types of infections, the complexities associated with existing conventional treatments, and the advanced techniques currently used in burn wound management that have proven to reduce hospital stays and make treatment more cost-effective.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 5","pages":"198-209"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of social determinants of health on clinical trials conducted for diabetic foot ulcer and venous leg ulcer at a safety net hospital.","authors":"Nolan Patrick Joyce, Aniket Vazirani, Connor Roddy, Marina A Malikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Failure to adhere to study protocol is among the most common observations during inspections conducted by competent authorities for clinical trials.</p><p><strong>Objective: </strong>To evaluate patterns of protocol deviations, and to analyze how social determinants of health (SDoH) correlate with the rate of protocol deviations as indicators of study protocol noncompliance.</p><p><strong>Materials and methods: </strong>Data obtained at a single clinical site from 19 clinical trials with a total of 186 subjects enrolled were analyzed retrospectively, and correlations between SDoH (eg, race/ethnicity, gender [eg, male/female], socioeconomic status, distance traveled, etc) and study protocol noncompliance (ie, rate of deviations) were examined. The Kruskal-Wallis test was performed to compare SDoH variables with rate of deviations per subjects enrolled. Associations between SDoH and deviations were examined using the Spearman correlation test.</p><p><strong>Results: </strong>A retrospective analysis showed that the majority of deviations were attributed to study visits that had not been performed in a timely manner or were missed, and study procedures that either were not performed or were completed late. The tests demonstrated no statistical significance between age, gender, and race and rates of dropout from the study (P = .1857, P = .3836, and P = .2150, respectively). Increased body mass index was associated with higher dropout rates (P = .0340), which can be an indicator of higher disease burden and an obstacle to trial participation.</p><p><strong>Conclusion: </strong>Further studies are warranted to investigate how quality in wound care clinical trials can be improved with identification of patients who need more resources based on their SDoH to efficiently mitigate risks, increase access to trials for disadvantaged populations, and improve study protocol compliance.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"37 4","pages":"158-165"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}