Wounds : a compendium of clinical research and practice最新文献

{"title":"Managing complex ischial pressure injury in a patient with congenital amelia: a multistage freestyle flap reconstructive strategy.","authors":"Jacob C Koster, Taylor Kreul, David Rincon, Agustin Herber, Jimmy Chim","doi":"10.25270/wnds/26020","DOIUrl":"10.25270/wnds/26020","url":null,"abstract":"<p><strong>Background: </strong>Management of complex stage 4 ischial pressure injuries (PIs) is challenging, particularly in patients with congenital anomalies, severe comorbidities, and limited reconstructive options. Ethical and functional considerations may further constrain surgical decision-making.</p><p><strong>Case report: </strong>The present report discusses a paraplegic patient with congenital amelia who developed a chronic, recurrent stage 4 ischial-perineal PI complicated by osteomyelitis and prior reconstructive failure. A multidisciplinary, staged approach was used, including serial debridement, infection control, nutritional optimization, negative pressure wound therapy, and delayed freestyle flap reconstruction. Intraoperative perfusion was assessed via intraoperative laser angiography using indocyanine green. Definitive reconstruction was achieved using a pelvic torso V-Y advancement flap with adjunctive groin advancement scrotoplasty to address testicular exposure. Ethical considerations, including preservation of the patient's only viable site for noninvasive blood pressure monitoring, directly influenced reconstructive planning. Durable wound closure was achieved without major complications, and satisfactory healing was noted at 3-month follow-up.</p><p><strong>Conclusion: </strong>This case highlights the importance of individualized, patient-centered, and ethically informed decision-making in the management of complex PIs. Multidisciplinary collaboration and tailored reconstructive strategies can achieve successful outcomes in patients with rare congenital conditions and limited surgical options.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 6","pages":"172-177"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a novel negative pressure wound therapy all-in-one seven-day dressing.","authors":"Lydia Galarza, Jessica Peña, Kristine Kieswetter","doi":"10.25270/wnds/25134","DOIUrl":"https://doi.org/10.25270/wnds/25134","url":null,"abstract":"<p><strong>Background: </strong>While use of polyurethane foam dressings for negative pressure wound therapy (NPWT) is well-established, the dressings may be difficult to apply and they promote granulation tissue ingrowth, potentially causing wound bed disruption, bleeding, and pain upon removal. An all-in-one dressing with an encapsulated polyurethane foam core and silicone-acrylic adhesive drape is available for longer wear.</p><p><strong>Objective: </strong>To present the findings of a pilot evaluation of an all-in-one dressing.</p><p><strong>Materials and methods: </strong>Ten patients from 2 hospitals in Chile were treated by 3 clinicians experienced with NPWT. After removing the release liner, an all-in-one dressing was applied to the wound and periwound, and -125 mm Hg or -150 mm Hg continuous negative pressure was initiated. The first dressing change occurred after 3 days to 5 days, and subsequent dressing changes were performed once or twice weekly.</p><p><strong>Results: </strong>Evaluation results indicated a dressing application time of less than 3 minutes, with removal time less than 20 seconds for all patients. No patients reported pain at dressing removal. No adverse events or concerns were noted. Users reported that the all-in-one dressing was easier and faster to apply and remove, and less traumatic for patients, compared with polyurethane foam dressings. The dressing remained sealed for the intended 4- to 7-day duration for all patients. NPWT with the all-in-one dressing was preferred over polyurethane foam dressings by all clinician users.</p><p><strong>Conclusion: </strong>Use of the all-in-one dressing may improve patient and clinician experience with NPWT. Larger, controlled clinical trials and scientific studies are needed to evaluate the efficacy of this dressing with NPWT across various wound types.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 6","pages":"166-171"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical characteristics according to etiological classification of pressure injuries in pediatric patients: a retrospective cohort study.","authors":"Mehmet Can, İlknur Mert, Özkan Okur, Arzu Şencan, Hasan Ağın, Sinem Akbay Ak, Nilgün Harputluoğlu, Hurşit Apa","doi":"10.25270/wnds/25117","DOIUrl":"https://doi.org/10.25270/wnds/25117","url":null,"abstract":"<p><strong>Background: </strong>Pressure injuries remain a significant problem in health care, and more studies are needed on their recognition, prevention, and treatment in the pediatric population.</p><p><strong>Objective: </strong>To evaluate pressure injuries in hospitalized pediatric patients according to etiology (medical device-related pressure injury [MDRPI] vs immobility-related pressure injury [IRPI]) and compare demographic, clinical, and treatment characteristics, in order to inform etiology-specific prevention and management strategies.</p><p><strong>Materials and methods: </strong>This single-center retrospective cohort study included pediatric patients (age at pressure injury identification, 0-211 months) hospitalized between August 2020 and December 2024. Wounds were classified as MDRPI or IRPI. Healing response was categorized as either medical (dressing and local care) or surgical treatment.</p><p><strong>Results: </strong>Of 283 pressure injuries in 149 patients, 225 (128 patients) were IRPI and 58 (37 patients) MDRPI; 16 patients had both. Localization differed significantly (P < .001): IRPIs predominated in occipital and sacral regions, MDRPIs in the ear and neck. IRPIs were larger at baseline (median, 3.0 vs 1.0 cm²; P < .001) and more often unstageable (20.8%) or deep tissue (3.6%) injuries, neither observed in MDRPIs (P = .001). Surgical intervention was required for 35.0% of IRPIs vs. 7.4% of MDRPIs (P < .001); median treatment duration was longer in IRPIs (29 vs 18 days; P = .002).</p><p><strong>Conclusions: </strong>This study shows significant differences between IRPIs and MDRPIs in terms of localization, initial wound size, wound stage, healing response, and treatment duration. The findings suggest a need for etiology-specific treatment strategies for pediatric pressure injuries, as well as the importance of developing risk management protocols specific to each wound type.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 6","pages":"145-154"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of over-the-counter aerosolized triamcinolone acetonide in the treatment of peristomal pyoderma gangrenosum: a case series.","authors":"Jordan Z Hill, Varshita Chirumamilla, Benjamin H Kaffenberger","doi":"10.25270/wnds/25128","DOIUrl":"10.25270/wnds/25128","url":null,"abstract":"<p><strong>Background: </strong>Peristomal pyoderma gangrenosum (PPG) is a rare neutrophilic dermatosis characterized by painful ulcerations near an abdominal stoma. While topical therapy is a key component of its often multimodal management, many agents risk compromising ostomy seal integrity, thus limiting their effectiveness. Over-the-counter aerosolized steroids may offer a promising alternative, combining anti-inflammatory benefit with minimal disruption to appliance adhesion.</p><p><strong>Case series: </strong>The cases of 5 patients who developed PPG between 2 weeks and 10 years after surgical creation of an ostomy are presented. Three patients had underlying inflammatory bowel disease, although multiple inflammatory triggers were identified across the cohort. All patients incorporated triamcinolone acetonide 55 mcg/spray into their treatment regimens. Each case demonstrated complete resolution of PPG without disruption of the ostomy appliance adhesion.</p><p><strong>Conclusion: </strong>This case series underscores the potential of over-the-counter aerosolized steroids as both adjunctive and primary therapy in the treatment of PPG. Their ease of access, cost-effectiveness, and compatibility with ostomy systems make them especially appealing for early intervention. Thus, over-the-counter aerosolized steroids represent a practical and promising addition to current PPG management strategies.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 6","pages":"137-140"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse large B-cell lymphoma of the axilla clinically mimicking hidradenitis suppurativa.","authors":"Nedim Uysal, Ismail H Unal, Mukerrem Safalı, Ayca Atas, Aysenur Botsalı","doi":"10.25270/wnds/25102","DOIUrl":"https://doi.org/10.25270/wnds/25102","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disease that primarily affects intertriginous areas. Its heterogeneous and sometimes nonspecific presentation can lead to diagnostic uncertainty, particularly in unilateral, treatment-resistant lesions. Cutaneous lymphomas, although rare, may mimic HS both clinically and radiologically, leading to delays in appropriate diagnosis and therapy.</p><p><strong>Case report: </strong>A 60-year-old male presented with a 7-month history of a painful, draining axillary lesion that was initially managed as HS. Despite prolonged antibiotic and intralesional corticosteroid treatment, the lesion progressed, with increasing edema and limited arm and hand mobility. Magnetic resonance imaging revealed a multilobular mass with necrosis and matted lymph nodes. Histopathologic examination of a punch biopsy identified diffuse large B-cell lymphoma, not otherwise specified, germinal center B-cell subtype. Due to reduced ejection fraction from recent myocardial infarction, rituximab monotherapy was initiated, resulting in clinical improvement. Wound necrosis was managed with negative pressure wound therapy.</p><p><strong>Conclusion: </strong>This case highlights the critical need to consider lymphomas in the differential diagnosis of atypical or refractory HS-like presentations. Prompt histopathologic evaluation in such cases enables accurate diagnosis and timely initiation of appropriate oncologic treatment, which ultimately may lead to improved patient outcomes.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 6","pages":"141-144"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Rhizophora mangle cream in venous ulcer: a randomized controlled clinical trial.","authors":"Jéssica Guido de Araújo Sá, Jeymesson Raphael Cardoso Vieira, Jerrar Janedson Xavier Silva, Natalia Araújo Lopes, Guilherme Rêis de Carvalho Pinheiro, Vinícius Salcedo Crusco, Camila Brito Segatti, Luiz Eugênio Peres de Freitas Filho, Pedro Henrique Vanderley da Silva Carneiro, Eduarda Santos de Santana, Esdras Marques Lins","doi":"10.25270/wnds/25042","DOIUrl":"10.25270/wnds/25042","url":null,"abstract":"<p><strong>Background: </strong>Compression therapy is the primary treatment for venous ulcers (VU). Topical treatments are used as an adjunct to accelerate healing, but they can be costly, and there is currently no standard medication.</p><p><strong>Objective: </strong>To evaluate reduction in venous ulcer area in patients treated with 5% aqueous extract of Rhizophora mangle L. leaves in cream form.</p><p><strong>Methods: </strong>Patients were randomized into 2 groups: the experimental group (EG) (55 ulcers) received 5% Rhizophora mangle cream, and the control group (CG) (45 ulcers) received medium chain triglyceride oil. Ulcers were evaluated using the MEASURE (measurement, exudate, appearance, suffering, weakening, reassess, edge) methodology, and area was measured using software on day 1, 4 weeks, 8 weeks, and 12 weeks.</p><p><strong>Results: </strong>At 12 weeks, the EG showed a mean 51.69% reduction in ulcer area (mean [SD] 3.97 [6.18] cm²), whereas the CG exhibited lesion worsening, with a mean increase in ulcer area corresponding to a -187.82% variation (mean [SD], 12.17 [20.17] cm²). Complete healing was observed in 34.5% of ulcers in the EG compared with 15.6% in the CG (P = .002). Furthermore, the EG demonstrated greater improvement across all clinical ulcer parameters than the CG.</p><p><strong>Conclusion: </strong>The 5% Rhizophora mangle cream was effective in venous ulcer area reduction and clinical healing, which suggests that it may be an effective an alternative treatment for venous ulcers in the lower limbs.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 5","pages":"117-126"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and nurse perceptions of a bordered silicone superabsorbent polymer dressing for pressure injury prevention: a prospective noncomparative pilot study in a long-term acute care hospital.","authors":"Jennifer Godfrey, Chrystalbelle Rogers, Syed Naqvi, Emily Goddu, Anthony P Nunes","doi":"10.25270/wnds/25124","DOIUrl":"10.25270/wnds/25124","url":null,"abstract":"<p><strong>Background: </strong>Prophylactic dressings for pressure injury (PI) prevention have been investigated in a range of hospital settings, but there is limited evidence supporting their use in long-term acute care (LTAC) hospitals.</p><p><strong>Objective: </strong>To evaluate patient and nurse perceptions of incorporating a bordered silicone superabsorbent polymer (SAP) dressing into an LTAC PI prevention protocol.</p><p><strong>Materials and methods: </strong>This pilot study included 50 adult patients at risk for sacral PIs, with intervention and data collection occurring between January 2024 and April 2025. Dressings were applied to the sacrum, with assessments at least daily and dressing changes no less than every 7 days. Patient- and nurse-reported outcomes (primary outcomes) included comfort, satisfaction, and usability indices. Secondary outcomes included PI incidence, adverse events, and dressing utilization.</p><p><strong>Results: </strong>The median follow-up was 15 days, with a median of 6 dressings used per patient. Patients reported minimal discomfort, and approximately 90% rated comfort and satisfaction as good-to-excellent. Nursing staff also reported high usability. No PIs or device-related serious adverse events occurred.</p><p><strong>Conclusion: </strong>The bordered silicone SAP dressing was well-tolerated by patients and nursing staff within an LTAC PI prevention protocol. These findings support its consideration for integration into prevention protocols. Further research is needed to evaluate comparative PI reduction and adverse events.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 5","pages":"127-136"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of synthetic electrospun fiber matrix in the sealing of tunneling, undermining, and cavity wounds.","authors":"Thea Price, Katie Meador","doi":"10.25270/wnds/25018","DOIUrl":"https://doi.org/10.25270/wnds/25018","url":null,"abstract":"<p><strong>Background: </strong>Tunneling, undermining, and cavity wounds created by pressure, infection, or surgery present unique treatment challenges. These wound complications are prone to infection and may necessitate reconstructive flap procedures. Often patients are sarcopenic and malnourished, leading to complications or poor outcomes. The synthetic electrospun fiber matrix (SEFM) studied in this series is a fully synthetic, resorbable extracellular matrix that has shown promise in stimulating healing responses in challenging wound environments.</p><p><strong>Objective: </strong>To evaluate whether the SEFM, in conjunction with proper wound care, supports rapid closure of wound tunneling or undermining, thus obviating the need for complex reconstruction.</p><p><strong>Methods: </strong>A retrospective review of 9 patients with 11 multifactorial wounds treated with the SEFM was conducted. Patients who underwent a single application or serial applications of the SEFM to cavity, tunneling, or undermining wounds were included. All wounds underwent initial surgical sterilization with sharp excision prior to application. Healing progress, resolution of tunneling or undermining, and incidence of complications were assessed and documented at follow-up visits.</p><p><strong>Results: </strong>These wound complications were successfully managed without extensive surgical reconstruction or amputation. Wounds ranged from acute to chronic (>2 years' duration) and were traumatic, iatrogenic, or secondary to pressure injuries or hidradenitis. Complete wound healing or granulation was achieved in all cases and, as possible to perform after healing, neither magnetic resonance imaging nor white blood cell sequestration showed further evidence of osteomyelitis. Durable results with no wound breakdown or signs of infection were noted at 6- to 18-month follow-up.</p><p><strong>Conclusion: </strong>The SEFM successfully supported healing and collapse of wound tunneling and undermining in a complex patient population. The rapid resolution of these wound complications mitigated the need for large flap reconstructions and recommended amputations. More studies are needed to determine patient populations who would be best served by this technique.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 4","pages":"78-83"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The STEADY diabetic foot ulcer registry: methods, insights, and future directions.","authors":"Jared R Adams, Jennifer N Lannon, Vickie R Driver, David Alper, Cyaandi R Dove, John C Lantis, Joseph Rolley, Robert Snyder","doi":"10.25270/wnds/26010","DOIUrl":"10.25270/wnds/26010","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) are a major cause of morbidity, amputation, and mortality among individuals with diabetes, with disproportionate impact on underserved populations. Comprehensive real-world data on DFU management and outcomes are lacking.</p><p><strong>Objective: </strong>To describe the design and methodology of the STEADY (Structured Evaluation and Analysis of Diabetic Foot Ulcers in the US) registry, a national prospective cohort study of patients with DFUs in the United States whose objective is to evaluate DFU treatment patterns, outcomes, and health care resource utilization in real-world settings, to assess comparative effectiveness, cost effectiveness, and safety of DFU therapies and therapy combinations, and to advance disease management through risk- and site-stratified treatment optimization models.</p><p><strong>Methods: </strong>STEADY is a 10-year prospective multicenter observational study with an aim of enrolling 5000 adults with active DFUs in the United States. Data sources include electronic case report forms, electronic medical records (EMRs), patient-reported outcomes via mobile app, and optional insurance claims. Primary and secondary end points will include time and incidence of partial and complete wound closure; wound and disease characteristics; rates of recurrence, infection, ischemic events, and amputation; health care utilization, including surgical procedures; health-related quality of life; work productivity; and additional patient reported outcomes. Descriptive, survival, and comparative effectiveness analyses will be performed. Data governance ensures full regulatory compliance and robust data security and integrity, supporting the potential use of the registry dataset as a synthetic control arm in future clinical research.</p><p><strong>Conclusion: </strong>STEADY leverages an artificial intelligence (AI)-enabled platform to integrate multisource data, including wound photography, social determinants of health, patient reported outcomes and caregiver information. The platform uses AI for transcription and interpretation of patient and provider dictation, supports patient-controlled EMR synchronization for comprehensive longitudinal tracking across providers, offers participant incentives to enhance engagement, and ensures rigorous, automated data quality assurance at all stages.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 4","pages":"97-106"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous safety evaluation of pure hypochlorous acid solution in preterm infants and neonates with complex wounds.","authors":"Rene Amaya, Emily Heisler","doi":"10.25270/wnds/25126","DOIUrl":"https://doi.org/10.25270/wnds/25126","url":null,"abstract":"<p><strong>Background: </strong>Preterm infants are at heightened risk of skin injury and infection due to the immaturity of their epidermal barrier and immune defenses. Safe wound cleansing options remain limited in this population.</p><p><strong>Objective: </strong>To evaluate cutaneous safety and tolerability associated with use of a pure hypochlorous acid-preserved cleanser (pHA) in preterm and neonatal patients with complex wounds.</p><p><strong>Materials and methods: </strong>This retrospective study evaluated the cutaneous safety of a pHA in 100 preterm and neonatal patients with complex wounds admitted to a tertiary care facility between January 2023 and July 2025. Demographic, clinical, and wound data were extracted from the electronic medical record. pHA was applied at each wound care encounter and was continued until wound closure, discharge, or transfer of care.</p><p><strong>Results: </strong>Patients received a mean of 7.6 pHA applications over a mean treatment duration of 18.7 days. The youngest treated infant was born at 21 weeks' gestation. Across 766 cumulative applications, no cutaneous adverse effects or wound-related complications were observed, including contact dermatitis, erythema, chemical burns, infection, or secondary breakdown. In patients receiving pHA concurrently with other advanced wound therapies, no cutaneous adverse effects attributable to combined use were identified.</p><p><strong>Conclusion: </strong>This retrospective series represents the largest reported evaluation to date of cutaneous safety and tolerability associated with pHA use in neonatal patients. Future prospective multicenter studies are warranted to further characterize cutaneous safety of pHA use and to evaluate efficacy outcomes in neonatal wound care.</p>","PeriodicalId":23752,"journal":{"name":"Wounds : a compendium of clinical research and practice","volume":"38 4","pages":"84-89"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}