Use of polyhexamethylene biguanide in the treatment of atopic dermatitis with Staphylococcus aureus hypercolonization.

IF 1.4 4区医学 Q3 DERMATOLOGY

Wounds : a compendium of clinical research and practice Pub Date : 2025-06-01

Gleice Freire, Leticia Midori Kondo Iwamoto, Tatiana de Fátima Pinto, Caio César de Silva Castro

引用次数: 0

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant global prevalence. Clinically, AD is characterized by xerosis, intense pruritus, and recurrent eczematous lesions. The pathogenesis of AD is complex and multifactorial, involving genetic predisposition, epidermal barrier dysfunction, immune dysregulation, and dysbiosis. These factors collectively increase susceptibility to infections in patients with AD. AD lesions are frequently colonized by Staphylococcus aureus and Staphylococcus epidermidis. An important aspect of Staphylococcus spp is the propensity to form biofilms that exhibit enhanced resistance to antibiotics and host immune responses.

Case report: This report describes 2 cases of AD associated with biofilm formation that was successfully treated with polyhexamethylene biguanide (PHMB).

Conclusion: This report highlights the potential of PHMB in the treatment of AD lesions and biofilm reduction.

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应用聚六亚甲基双胍治疗金黄色葡萄球菌过度定植的特应性皮炎。

背景：特应性皮炎（AD）是一种全球流行的慢性炎症性皮肤病。在临床上，AD的特点是干燥、强烈瘙痒和反复发作的湿疹病变。阿尔茨海默病的发病机制复杂且多因素，涉及遗传易感性、表皮屏障功能障碍、免疫失调和生态失调。这些因素共同增加了AD患者对感染的易感性。AD病变通常由金黄色葡萄球菌和表皮葡萄球菌定植。葡萄球菌的一个重要方面是倾向于形成生物膜，表现出对抗生素和宿主免疫反应的增强抗性。病例报告：本报告描述了2例与生物膜形成相关的阿尔茨海默病，成功地用聚六亚甲基双胍（PHMB）治疗。结论：本报告强调了PHMB在治疗AD病变和生物膜减少方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.