Prevalence of biofilm in chronic wounds: systematic review with meta-analysis.

IF 1.1 4区医学 Q3 DERMATOLOGY

Wounds : a compendium of clinical research and practice Pub Date : 2025-08-01

Manuela de Mendonça Figueirêdo Coelho, Beatriz Moreira Alves Avelino, Beatriz Alves de Oliveira, Mariana Araújo Rios, Fabiane do Amaral Gubert, Mariana Cavalcante Martins, Janaína Fonseca Victor Coutinho, Paula Sacha Frota Nogueira, Rachel Gabriel Bastos Barbosa, Viviane Mamede Vasconcelos Cavalcante

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引用次数: 0

Abstract

Background: To estimate the prevalence of biofilms in chronic wounds.

Methods: The authors performed a systematic review of prevalence studies and meta-analysis, structured according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Articles were searched in Scopus (Elsevier), Web of Science (Clarivate), MEDLINE/PubMed (National Institutes of Health), and Embase (Elsevier) databases. Data collected included the author and year of publication, total number of lesions evaluated, number of lesions with biofilm, detected bacteria, biofilm levels, country where the research was conducted, and the methodological quality of the studies. The meta-analysis was performed using a random effects model in R software (The R Foundation for Statistical Computing).

Results: A total of 281 articles were retrieved; after applying the reading and exclusion criteria, 24 studies were included. The meta-analysis incorporated 24 studies from 12 countries, evaluating 2666 lesions with a biofilm prevalence of 68% (95% CI, 58%-79%; I² = 92%). A high prevalence was observed in Asian publications (73%; 95% CI, 62%-84%; I² = 98%), with of Staphylococcus aureus (71%; 95% CI, 51%-90%; I² = 98%) and Pseudomonas aeruginosa (65%; 95% CI, 47%-82%; I² = 98%) being the most common found in all publications.

Conclusions: Despite the methodological heterogeneity of the studies included in this review, the findings indicate a high prevalence of biofilms in chronic wounds presented in the studies that made up the sample.

本刊更多论文

慢性伤口中生物膜的流行：系统回顾与荟萃分析。

目的：评估慢性伤口中生物膜的患病率。方法：作者根据系统评价和荟萃分析指南的首选报告项目对患病率研究和荟萃分析进行了系统评价。文章在Scopus（爱思唯尔）、Web of Science （Clarivate）、MEDLINE/PubMed（美国国立卫生研究院）和Embase（爱思唯尔）数据库中检索。收集的数据包括作者和发表年份、评估的病变总数、带有生物膜的病变数量、检测到的细菌、生物膜水平、开展研究的国家和研究的方法学质量。meta分析采用R软件（The R Foundation for Statistical Computing）中的随机效应模型进行。结果：共检索到281篇文献；应用阅读和排除标准后，纳入24项研究。荟萃分析纳入了来自12个国家的24项研究，评估了2666个病变，生物膜患病率为68% （95% CI, 58%-79%; I²= 92%）。在亚洲出版物中观察到较高的患病率（73%;95% CI, 62%-84%; I²= 98%），其中金黄色葡萄球菌（71%;95% CI, 51%-90%; I²= 98%）和铜绿假单胞菌（65%;95% CI, 47%-82%; I²= 98%）是所有出版物中最常见的。结论：尽管本综述中纳入的研究在方法学上存在异质性，但研究结果表明，在构成样本的研究中，慢性伤口中生物膜的患病率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.